scholarly journals Multifunctional Hydroxyapatite/Silver Nanoparticles/Cotton Gauze for Antimicrobial and Biomedical Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 429
Author(s):  
Mohamed M. Said ◽  
Mohamed Rehan ◽  
Said M. El-Sheikh ◽  
Magdy K. Zahran ◽  
Mohamed S. Abdel-Aziz ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Antimicrobial Activities ◽  
Uv Protection ◽  
Hydroxyapatite Nanoparticles ◽  
Ag Nps ◽  
Cotton Gauze ◽  
Cationic Modification ◽  
Medical Textiles ◽  
Anti Inflammation

Medical textiles have played an increasingly important protection role in the healthcare industry. This study was aimed at improving the conventional cotton gauze for achieving advanced biomedical specifications (coloration, UV-protection, anti-inflammation, and antimicrobial activities). These features were obtained by modifying the cotton gauze fabrics via in-situ precipitation of hydroxyapatite nanoparticles (HAp NP), followed by in-situ photosynthesis of silver (Ag) NPs with ginger oil as a green reductant with anti-inflammation properties. The HAp-Ag NPs coating provides good UV-protection properties. To further improve the HAp and Ag NPs dispersion and adhesion on the surface, the cotton gauze fabrics were modified by cationization with chitosan, or by partial carboxymethylation (anionic modification). The influence of the cationic and anionic modifications and HAp and Ag NPs deposition on the cotton gauze properties (coloration, UV-protection, antimicrobial activities, and water absorption) was thoroughly assessed. Overall, the results indicate that chemical (anionic and cationic) modification of the cotton gauze enhances HAp and Ag NPs deposition. Chitosan can increase biocompatibility and promotes wound healing properties of cotton gauze. Ag NP deposition onto cotton gauze fabrics brought high antimicrobial activities against Candida albicans, Gram-positive and Gram-negative bacteria, and improved UV protection.

scholarly journals Effect of Synthesis Temperature on the Crystallization and Growth of In Situ Prepared Nanohydroxyapatite in Chitosan Matrix

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Habiba Elhendawi ◽  
R. M. Felfel ◽  
Bothaina M. Abd El-Hady ◽  
Fikry M. Reicha
Keyword(s):  
Particle Size ◽  
Biomedical Applications ◽  
Particle Growth ◽  
Synthesis Temperature ◽  
Molar Ratio ◽  
Processing Temperature ◽  
Hydroxyapatite Nanoparticles ◽  
Chitosan Matrix ◽  
Coprecipitation Technique

Hydroxyapatite nanoparticles (nHA) have been used in different biomedical applications where certain particle size distribution and morphology are required. Chitosan/hydroxyapatite (CS/HA) nanocomposites were prepared using in situ coprecipitation technique and the effect of the reaction temperature on the crystallization and particle growth of the prepared nanohydroxyapatite particles was investigated. The composites were prepared at different synthesis temperatures (−10, 37, and 60°C). XRD, FTIR, thermal analysis, TEM and SEM techniques were used to characterize the prepared specimens. It was found that the increase in processing temperature had a great affect on particle size and crystal structure of nHA. The low temperature (−10°C) showed inhabitation of the HA growth in c-direction and low crystallinity which was confirmed using XRD and electron diffraction pattern of TEM. Molar ratio of the bone-like apatite layer (Ca/P) for the nanocomposite prepared at 60°C was higher was higher than the composites prepared at lower temperatures (37 and −10°C).

A hybrid hydrogel with in situ formed Ag-nanoparticles within 3D networks that exhibits broad antibacterial activities

2020 ◽  
Vol 44 (18) ◽  
pp. 7265-7269
Author(s):  
Chuan-Wan Wei ◽  
Xiao-Qing Gong ◽  
Xiao-Juan Wang ◽  
Xin-Zhi Yang ◽  
Shu-Qin Gao ◽  
...  
Keyword(s):  
Ag Nanoparticles ◽  
Biomedical Applications ◽  
Antibacterial Activities ◽  
Potential Candidate ◽  
Ag Nps ◽  
Hybrid Hydrogel ◽  
3D Network ◽  
3D Networks

A new hybrid hydrogel was constructed by in situ forming Ag NPs within the 3D network of a hydrogel that exhibits both excellent injectability and broad antibacterial activities, which makes it a potential candidate for various biomedical applications.

scholarly journals Silver Micro-Nanoparticle-Based Nanoarchitectures: Synthesis Routes, Biomedical Applications, and Mechanisms of Action

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2870
Author(s):  
Md Abdul Wahab ◽  
Li Luming ◽  
Md Abdul Matin ◽  
Mohammad Rezaul Karim ◽  
Mohammad Omer Aijaz ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Biomedical Applications ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Structural Parameters ◽  
Antimicrobial Activities ◽  
Mechanisms Of Action ◽  
Ag Nps ◽  
Food Industries ◽  
Synthesis Routes

Silver has become a potent agent that can be effectively applied in nanostructured nanomaterials with various shapes and sizes against antibacterial applications. Silver nanoparticle (Ag NP) based-antimicrobial agents play a major role in different applications, including biomedical applications, as surface treatment and coatings, in chemical and food industries, and for agricultural productivity. Due to advancements in nanoscience and nanotechnology, different methods have been used to prepare Ag NPs with sizes and shapes reducing toxicity for antibacterial applications. Studies have shown that Ag NPs are largely dependent on basic structural parameters, such as size, shape, and chemical composition, which play a significant role in preparing the appropriate formulation for the desired applications. Therefore, this review focuses on the important parameters that affect the surface interaction/state of Ag NPs and their influence on antimicrobial activities, which are essential for designing future applications. The mode of action of Ag NPs as antibacterial agents will also be discussed.

scholarly journals The Antimicrobial and Anti-Inflammatory Effects of Silver Nanoparticles Synthesised from Cotyledon orbiculata Aqueous Extract

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1343
Author(s):  
Caroline Tyavambiza ◽  
Abdulrahman Mohammed Elbagory ◽  
Abram Madimabe Madiehe ◽  
Mervin Meyer ◽  
Samantha Meyer
Keyword(s):  
Staphylococcus Aureus ◽  
Silver Nanoparticles ◽  
Metallic Nanoparticles ◽  
Methicillin Resistance ◽  
Antimicrobial Activities ◽  
Transmission Electron ◽  
Anti Inflammatory ◽  
Anti Inflammation ◽  
Important Medicinal Plant ◽  
Pro Inflammatory Cytokines

Cotyledon orbiculata, commonly known as pig’s ear, is an important medicinal plant of South Africa. It is used in traditional medicine to treat many ailments, including skin eruptions, abscesses, inflammation, boils and acne. Many plants have been used to synthesize metallic nanoparticles, particularly silver nanoparticles (AgNPs). However, the synthesis of AgNPs from C. orbiculata has never been reported before. The aim of this study was to synthesize AgNPs using C. orbiculata and evaluate their antimicrobial and immunomodulatory properties. AgNPs were synthesized and characterized using Ultraviolet-Visible Spectroscopy (UV-Vis), Dynamic Light Scattering (DLS) and High-Resolution Transmission Electron Microscopy (HR-TEM). The antimicrobial activities of the nanoparticles against skin pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Methicillin Resistance Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans) as well as their effects on cytokine production in macrophages (differentiated from THP-1 cells) were evaluated. The AgNPs from C. orbiculata exhibited antimicrobial activity, with the highest activity observed against P. aeruginosa (5 µg/mL). The AgNPs also showed anti-inflammatory activity by inhibiting the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1 beta) in lipopolysaccharide-treated macrophages. This concludes that the AgNPs produced from C. orbiculata possess antimicrobial and anti-inflammation properties.

Anodic synthesis of TiO2 nanotubes by step-up voltages

2021 ◽  
pp. 002199832110237
Author(s):  
V Sivaprakash ◽  
R Narayanan
Keyword(s):  
Corrosion Resistance ◽  
Tio2 Nanotubes ◽  
Biomedical Applications ◽  
Phase Changes ◽  
Electrochemical Anodization ◽  
Corrosion Resistant ◽  
Anodization Process ◽  
Anodic Synthesis ◽  
Input Potential

Fabrication of TiO2 nanotubes (NTs) has extensive application properties due to their high corrosion resistant and compatibility with biomedical applications, the synthesis of TiO2 nanotubes over titanium has drawn interest in various fields. The synthesis of TiO2 NTs using novel in-situ step-up voltage conditions in the electrochemical anodization process is recorded in this work. For manufacturing the NTs at 1 hour of anodization, the input potential of 30, 40 and 50 V was selected. With increasing step-up voltage during the anodization process, an improvement in the NTs was observed, favoring corrosion resistance properties. The surface of NTs enhances the structure of the ribs, raising the potential for feedback over time. XRD was used to analyze phase changes, and HR-SEM analyzed surface topography. Impedance tests found that longer NTs improved the corrosion resistance.

scholarly journals Variability and improvement of optical and antimicrobial performances for CQDs/mesoporous SiO2/Ag NPs composites via in situ synthesis

2021 ◽  
Vol 10 (1) ◽  
pp. 403-411
Author(s):  
Youliang Cheng ◽  
Mingjie Wang ◽  
Changqing Fang ◽  
Ying Wei ◽  
Jing Chen ◽  
...  
Keyword(s):  
Uv Light ◽  
Carbon Quantum Dots ◽  
Diffusion Method ◽  
Ag Nps ◽  
Uniform Size ◽  
High Antibacterial Activity ◽  
Fluorescent Materials ◽  
Potential Applications ◽  
Mesoporous Sio2

Abstract To change the optical properties and improve the antibacterial performances of carbon quantum dots (CQDs) and Ag NPs, mesoporous SiO2 spheres were combined with them to form the composites. In this paper, CQDs with a uniform size of about 3.74 nm were synthesized using glucose as carbon source. Then, CQDs/mesoporous SiO2/Ag NPs composites were obtained in situ under UV light irradiating by using mesoporous SiO2 and Ag NO3 as the carrier and silver resource, respectively. The diameter of CQDs/mesoporous SiO2/Ag NPs particles was in the range of 200–250 nm. With the increase in irradiating time, the red-shift in the UV-Vis spectrum for as-prepared CQDs/mesoporous SiO2/Ag NPs composites was found, and the adsorption peak was widened. In addition, the composites showed a high antibacterial activity against Staphylococcus aureus and Escherichia coli via disc diffusion method. These results indicated that inhibition circles for Ag NPs/mesoporous SiO2/CQDs and mesoporous SiO2/Ag NPs were similar in diameter. Furthermore, the two composites had a better bactericidal performance compared with other particles. Therefore, as-prepared CQDs/mesoporous SiO2/Ag NPs composites in this paper have great potential applications for fluorescent materials and antibacterial materials.

scholarly journals Preparation of Silver Nanoparticles and Their Industrial and Biomedical Applications: A Comprehensive Review

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Adnan Haider ◽  
Inn-Kyu Kang
Keyword(s):  
Silver Nanoparticles ◽  
Biomedical Applications ◽  
Consumer Products ◽  
Ag Nps ◽  
New Techniques ◽  
Governing Factor ◽  
Wide Range ◽  
Microbial Proliferation ◽  
Synthetic Routes ◽  
Biomedical Fields

Silver nanoparticles (Ag-NPs) have diverted the attention of the scientific community and industrialist itself due to their wide range of applications in industry for the preparation of consumer products and highly accepted application in biomedical fields (especially their efficacy against microbes, anti-inflammatory effects, and wound healing ability). The governing factor for their potent efficacy against microbes is considered to be the various mechanisms enabling it to prevent microbial proliferation and their infections. Furthermore a number of new techniques have been developed to synthesize Ag-NPs with controlled size and geometry. In this review, various synthetic routes adapted for the preparation of the Ag-NPs, the mechanisms involved in its antimicrobial activity, its importance/application in commercial as well as biomedical fields, and possible application in future have been discussed in detail.

scholarly journals Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

2021 ◽  
Vol 7 (23) ◽  
pp. eabe8739
Author(s):  
Xin Peng ◽  
Xianfeng Xia ◽  
Xiayi Xu ◽  
Xuefeng Yang ◽  
Boguang Yang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Gastric Perforation ◽  
Interfacial Water ◽  
Wet Adhesion ◽  
Tissue Interactions ◽  
Tissue Surface ◽  
Strong Adhesion ◽  
Surface Irregularities ◽  
Physical Interactions

Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications.

CLINICAL APPLICATIONS OF ELECTROCHEMOTHERAPY

2019 ◽  
Author(s):  
Gregor Serša
Keyword(s):  
Biomedical Applications ◽  
Liver Tumors ◽  
Checkpoint Inhibitors ◽  
Combined Treatment ◽  
Local Treatment ◽  
Industrial Applications ◽  
Interleukin 12 ◽  
Nice Guidelines ◽  
Or Gene

Electroporation has several biomedical and industrial applications. The biomedical applications are in the field of drug or gene delivery. Electrochemotherapy utilizes electroporation for the increased delivery of cytotoxic drugs like bleomycin or cisplatin into tumors. The use of electrochemotherapy has spread throughout Europe for the treatment of cutaneous tumors or metastases. It is in the NICE guidelines and is becoming standard ablative technique in treatment of cancer. The technological advancements have also enabled the use of electrochemotherapy for the treatment of deep seated tumors, such as soft tissue or liver tumors. Clinical studies demonstrate good effectiveness on fibrosarcomas, colorectal liver metastases and hepatocellular carcinoma. However, electrochemotherapy is a local treatment that also induces moderate local immune response. This so called “in situ vaccination” induced by electrochemotherapy can be exploited in combined treatment with immune checkpoint inhibitors or electrogene therapy with immunostimulating effect. Therefore, gene electrotransfer of plasmid coding for interleukin 12 (IL-12), in combination with electrochemotherapy could result in transformation of electrochemotherapy from local into systemic treatment. This is also of our current interest, and we are undertaking steps to bring this idea from preclinical into clinical testing.

A green in situ synthesis of silver nanoparticles on cotton fabrics using Aloe vera leaf extraction for durable ultraviolet protection and antibacterial activity

2016 ◽  
Vol 87 (19) ◽  
pp. 2407-2419 ◽  
Author(s):  
Qingqing Zhou ◽  
Jingchun Lv ◽  
Yu Ren ◽  
Jiayi Chen ◽  
Dawei Gao ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Aloe Vera ◽  
Cotton Fabrics ◽  
In Situ Synthesis ◽  
Uv Protection ◽  
X Ray ◽  
Jcpds File ◽  
Laundering Durability

This study presented a simple and environmentally friendly method of in situ synthesis of silver nanoparticles (AgNPs) on cotton fabrics for durable ultraviolet (UV) protection and antibacterial activity using Aloe vera leaf extraction (AVE) as a reducing and stabilizing agent. Cotton fabrics were pretreated in water, and then immersed in AgNO3 and AVE, respectively. Cotton fabrics were characterized by small angle X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis, UV protection, antibacterial activity, and laundering durability. Comparing with the smooth surface of the control cotton fabric, SEM and energy dispersive X-ray spectrometry (EDX) results showed that there were a considerable number of Ag2O and AgNPs loading on the surface of the pretreated and Ag loaded cotton fabrics. The XRD pattern indicated, respectively, the existence of Ag2O and AgNPs, the structures of which were similar to JCPDS File No.65-3289 and JCPDS File No. 01-071-4613 on the pretreated and Ag loaded cotton fabrics. The pretreated and Ag loaded cotton fabrics showed excellent UV protection, antibacterial activity, and laundering durability, especially the Ag loaded cotton fabric, of which the UV protection factor value and transmission of UVA were 148 and 1.11%, respectively, after 20 washing cycles, and the clear zone width was more than 4 mm against E. coli or S. aureus. AgNPs facilitated the improvement of the thermal property of the cotton fabrics. Thus this facile in situ reduction of AgNPs with AVE may bring a promising and green strategy to produce functional textiles.

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