scholarly journals Interfacial Effects and the Nano-Scale Disruption in Adsorbed-Layer of Acrylate Polymer-Tween 80 Fabricated Steroid-Bearing Emulsions: A Rheological Study of Supramolecular Materials

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1612
Author(s):  
Nana Adu-Gyamfi ◽  
Dipak K. Sarker
Keyword(s):  
Adsorbed Layer ◽  
Tween 80 ◽  
Ionic Surfactant ◽  
Low Molecular Weight ◽  
Supramolecular Materials ◽  
Oil In Water ◽  
Acrylate Polymers ◽  
The Stability ◽  
Acrylate Polymer

The effect of polymer adsorption on the stability and viable shelf life of 55 μm diameter oil-in-water (O/W) emulsions containing the steroid, betamethasone 21-phosphate was investigated. Two acrylate polymers, Carbopol® 971P and 974P, were added in the role of emulsion stabilizers to a model system, representing a non-ionic low molecular weight surfactant-stabilized emulsion (topically applied medicinal cream). For the purposes of this study the dosage of the viscosifier was maintained below 1% w/v and consequently, the consistency of the emulsion was measured in the diluted form. One of the polymers was responsible for elevated degrees of droplet creaming and coalescence and this was closely linked to its surface tension lowering capacity. This lowering was seen at 62 mN/m compared to the routine values at equivalent concentrations of 68 mN/m and 35 mN/m for the betamethasone drug and non-ionic surfactant-Tween 80, respectively. The same polymer also demonstrated a predisposition to form low-micron and greater sized aggregates of nanoparticles that led to extensive flocculation and the formation of a sedimentary precipitate, formed from an amalgam of the components found in the creamed droplet layer.

scholarly journals Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer

2006 ◽  
Vol 3 (1) ◽  
pp. 8-21
Author(s):  
Mahdi Jufri ◽  
◽  
Effionora Anwar ◽  
Putri Margaining Utami
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Tween 80 ◽  
Microemulsion System ◽  
Hydrophobic Drug ◽  
Dextrose Equivalent ◽  
Oil In Water ◽  
External Phase ◽  
The Stability ◽  
Made In

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.

Role of Proteins in Oil-in-Water Emulsions on the Stability of Lipid Hydroperoxides

2006 ◽  
Vol 54 (20) ◽  
pp. 7879-7884 ◽  
Author(s):  
Sarah S. Kellerby ◽  
D. Julian McClements ◽  
Eric A. Decker
Keyword(s):  
Lipid Hydroperoxides ◽  
Oil In Water ◽  
The Stability

The Role of Oil Phase in the Stability and Physicochemical Properties of Oil‐in‐Water Emulsions in the Presence of Gum Tragacanth

2019 ◽  
Vol 96 (7) ◽  
pp. 795-803 ◽  
Author(s):  
Khadije Abdolmaleki ◽  
Mohammad Amin Mohammadifar ◽  
Zhian Sheikhi ◽  
Golshan Matinfar ◽  
Kooshan Nayebzadeh
Keyword(s):  
Physicochemical Properties ◽  
Gum Tragacanth ◽  
Oil In Water ◽  
The Stability

Freeze-Drying of Low Molecular Weight Poly(L-lactic acid) Nanoparticles: Effect of Cryo- and Lyoprotectants

2006 ◽  
Vol 6 (9) ◽  
pp. 3110-3117 ◽  
Author(s):  
Samuli Hirsjärvi ◽  
Leena Peltonen ◽  
Laura Kainu ◽  
Jouni Hirvonen
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Polymeric Nanoparticles ◽  
Physical Stability ◽  
Tween 80 ◽  
Particle Dispersion ◽  
Low Molecular Weight ◽  
Freeze Dried ◽  
Original Size ◽  
The Stability

The chemical and physical stability of polymeric nanoparticles is poor in aqueous suspensions, and the drying of these particles is often problematic. In the present study, the stability of freeze-dried low molecular weight poly(L-lactic acid) (PLA) nanoparticles was enhanced by adding glucose and/or lactose to the formulation as cryo- and lyoprotectants, respectively. Also the effect of an extra stabilizer, Tween 80, was studied. The best freeze-dried PLA nanoparticle formulations were achieved, when glucose and lactose were added in combination so that the amount of lactose was double the amount of glucose. With this combination the redispersion of high-quality nanoparticles (homogenous particle dispersion with original size and without aggregates) was achieved. The addition of Tween 80 further improved the quality of freeze-dried PLA nanoparticles by facilitating the redispersion of the lyophilized cake into optimal nanoparticles.

Effect of Water Content and Tween 80 to the Stability of Emulsified Biodiesel

2013 ◽  
Vol 465-466 ◽  
pp. 191-195 ◽  
Author(s):  
Amir Aziz ◽  
Asraf Jusoh ◽  
Rizalman Mamat ◽  
A. Adam Abdullah
Keyword(s):  
Water Content ◽  
Tween 80 ◽  
Destructive Effect ◽  
Oil Emulsion ◽  
Long Term Stability ◽  
Three Phase ◽  
Oil In Water ◽  
The Stability ◽  
Water In Oil Emulsion ◽  
Emulsified Biodiesel

Emulsified biodiesel are often stabilized using a combination ratio water, biodiesel and surfactant in achieving stable emulsions. The objective of this study was to evaluate the long-term stability of three phase oil-in-water-in-oil (O/W/O) with respect to the water content and Tween 80. Biodiesel emulsions containing 5 mL, 10 mL and 15 mL water were produce with combination of 95 mL, 90 mL and 85 mL B20 (80 % diesel + 20 % biodiesel) and surfactant by using a mechanical stirrer machine. The experimental results show that increasing concentration of Tween 80 more than 1.5g gave destructive effect on water in oil emulsion stability. In addition, lowering concentration of water content contribute to low polydispersity of emulsion which produced the high emulsification stability.

scholarly journals The interaction of copper(II) and glycyl-l-histidyl-l-lysine, a growth-modulating tripeptide from plasma

1981 ◽  
Vol 199 (3) ◽  
pp. 649-656 ◽  
Author(s):  
S J Lau ◽  
B Sarkar
Keyword(s):  
Stability Constants ◽  
Equilibrium Dialysis ◽  
Physiological Role ◽  
Ternary Complexes ◽  
Low Molecular Weight ◽  
Visible Absorption ◽  
Multiple Species ◽  
The Stability ◽  
Ph Range

The interaction between Cu(II) and the growth-modulating tripeptide glycyl-L-histidyl-L-lysine in the presence and absence of L-histidine was investigated by potentiometric titration and visible-absorption spectrophotometry at 25 degrees C in 0.15 M-NaCl. Analyses of the results in the pH range 3.5--10.6 indicated the presence of multiple species in solution in the binary system and extensive amounts of the ternary complexes in the ternary system. The species distribution and the stability constants, as well as the visible-absorption spectra of the species, were evaluated. The combined results were used to propose the structure of some of the complexes. The influence of the epsilon-amino group of the peptide in the enhancement of the stability constants was reflected prominently when compared with those complexes formed by either glycyl-L-histidine or glycyl-L-histidylglycine. The results obtained from the equilibrium-dialysis experiments showed that this tripeptide was able to compete with albumin for Cu(II) at pH 7.5 and 6 degrees C. At equimolar concentrations of albumin and the peptide, about 42% of the Cu(II) was bound to the peptide. At the physiologically relevant concentrations of Cu(II), albumin, L-histidine and this peptide, about 6% of the Cu(II) was associated with the low-molecular-weight components. This distribution could be due to the binary as well as the ternary complexes. The possible physiological role of these complexes in the transportation of Cu(II) from blood to tissues is discussed.

The role of endogenous amphiphiles on the stability of virgin olive oil-in-water emulsions

2005 ◽  
Vol 82 (6) ◽  
pp. 415-420 ◽  
Author(s):  
T. G. Sotiroudis ◽  
G. T. Sotiroudis ◽  
N. Varkas ◽  
A. Xenakis
Keyword(s):  
Olive Oil ◽  
Virgin Olive Oil ◽  
Oil In Water ◽  
The Stability

Research and Preparation for Nanoemulsion of Macadamia integrifolia Oil

2013 ◽  
Vol 423-426 ◽  
pp. 378-381
Author(s):  
Bing Qing Zhu ◽  
Li Jing Lin ◽  
Ji Hua Li ◽  
Mao Fang Huang ◽  
Kang Yi Zhang
Keyword(s):  
Olive Oil ◽  
Tween 80 ◽  
Stability Tests ◽  
Minimum Diameter ◽  
Macadamia Integrifolia ◽  
Oil In Water ◽  
The Stability

Oil-in-water (O/W) nanoemulsion of Macadamia integrifoblia oil was prepared. The nanoemulsion with the minimum diameter (22.13 nm) would be gained at the ratio of surfactant (Tween-80): cosurfactant (olive oil): oil phase (ethanol)=9:2:1, 86.4% distributing between 10~30 nm, spherical. The Macadamia integrifoblia oil nanoemulsion was still clarity, homogeneous and stable after the stability tests.

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