Research and Preparation for Nanoemulsion of Macadamia integrifolia Oil

Oil-in-water (O/W) nanoemulsion of Macadamia integrifoblia oil was prepared. The nanoemulsion with the minimum diameter (22.13 nm) would be gained at the ratio of surfactant (Tween-80): cosurfactant (olive oil): oil phase (ethanol)=9:2:1, 86.4% distributing between 10~30 nm, spherical. The Macadamia integrifoblia oil nanoemulsion was still clarity, homogeneous and stable after the stability tests.

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Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer

Pharmaceutical Sciences and Research ◽

10.7454/psr.v3i1.3396 ◽

2006 ◽

Vol 3 (1) ◽

pp. 8-21

Author(s):

Mahdi Jufri ◽

◽

Effionora Anwar ◽

Putri Margaining Utami

Keyword(s):

Drug Delivery ◽

Dosage Form ◽

Tween 80 ◽

Microemulsion System ◽

Hydrophobic Drug ◽

Dextrose Equivalent ◽

Oil In Water ◽

External Phase ◽

The Stability ◽

Made In

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35Â–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.

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Interfacial Effects and the Nano-Scale Disruption in Adsorbed-Layer of Acrylate Polymer-Tween 80 Fabricated Steroid-Bearing Emulsions: A Rheological Study of Supramolecular Materials

Nanomaterials ◽

10.3390/nano11061612 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1612

Author(s):

Nana Adu-Gyamfi ◽

Dipak K. Sarker

Keyword(s):

Adsorbed Layer ◽

Tween 80 ◽

Ionic Surfactant ◽

Low Molecular Weight ◽

Supramolecular Materials ◽

Oil In Water ◽

Acrylate Polymers ◽

The Stability ◽

Acrylate Polymer

The effect of polymer adsorption on the stability and viable shelf life of 55 μm diameter oil-in-water (O/W) emulsions containing the steroid, betamethasone 21-phosphate was investigated. Two acrylate polymers, Carbopol® 971P and 974P, were added in the role of emulsion stabilizers to a model system, representing a non-ionic low molecular weight surfactant-stabilized emulsion (topically applied medicinal cream). For the purposes of this study the dosage of the viscosifier was maintained below 1% w/v and consequently, the consistency of the emulsion was measured in the diluted form. One of the polymers was responsible for elevated degrees of droplet creaming and coalescence and this was closely linked to its surface tension lowering capacity. This lowering was seen at 62 mN/m compared to the routine values at equivalent concentrations of 68 mN/m and 35 mN/m for the betamethasone drug and non-ionic surfactant-Tween 80, respectively. The same polymer also demonstrated a predisposition to form low-micron and greater sized aggregates of nanoparticles that led to extensive flocculation and the formation of a sedimentary precipitate, formed from an amalgam of the components found in the creamed droplet layer.

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Effect of Water Content and Tween 80 to the Stability of Emulsified Biodiesel

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.465-466.191 ◽

2013 ◽

Vol 465-466 ◽

pp. 191-195 ◽

Cited By ~ 2

Author(s):

Amir Aziz ◽

Asraf Jusoh ◽

Rizalman Mamat ◽

A. Adam Abdullah

Keyword(s):

Water Content ◽

Tween 80 ◽

Destructive Effect ◽

Oil Emulsion ◽

Long Term Stability ◽

Three Phase ◽

Oil In Water ◽

The Stability ◽

Water In Oil Emulsion ◽

Emulsified Biodiesel

Emulsified biodiesel are often stabilized using a combination ratio water, biodiesel and surfactant in achieving stable emulsions. The objective of this study was to evaluate the long-term stability of three phase oil-in-water-in-oil (O/W/O) with respect to the water content and Tween 80. Biodiesel emulsions containing 5 mL, 10 mL and 15 mL water were produce with combination of 95 mL, 90 mL and 85 mL B20 (80 % diesel + 20 % biodiesel) and surfactant by using a mechanical stirrer machine. The experimental results show that increasing concentration of Tween 80 more than 1.5g gave destructive effect on water in oil emulsion stability. In addition, lowering concentration of water content contribute to low polydispersity of emulsion which produced the high emulsification stability.

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The role of endogenous amphiphiles on the stability of virgin olive oil-in-water emulsions

Journal of the American Oil Chemists Society ◽

10.1007/s11746-005-1086-1 ◽

2005 ◽

Vol 82 (6) ◽

pp. 415-420 ◽

Cited By ~ 17

Author(s):

T. G. Sotiroudis ◽

G. T. Sotiroudis ◽

N. Varkas ◽

A. Xenakis

Keyword(s):

Olive Oil ◽

Virgin Olive Oil ◽

Oil In Water ◽

The Stability

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Emulsion Formation and Stabilizing Properties of Olive Oil Cake Crude Extracts

Processes ◽

10.3390/pr9040633 ◽

2021 ◽

Vol 9 (4) ◽

pp. 633

Author(s):

Firdaous Fainassi ◽

Noamane Taarji ◽

Fatiha Benkhalti ◽

Abdellatif Hafidi ◽

Marcos A. Neves ◽

...

Keyword(s):

Olive Oil ◽

Ethanol Extract ◽

Active Components ◽

Oil In Water ◽

Surface Active ◽

Ph Conditions ◽

Oil Water ◽

Surface Active Compounds ◽

Ionizable Groups ◽

Emulsifying Ability

The surface-active and emulsifying properties of crude aqueous ethanolic extracts from untreated olive oil cake (OOC) were investigated. OOC extracts contained important concentrations of surface-active components including proteins, saponins and polyphenols (1.2–2.8%, 7.8–9.5% and 0.7–4.5% (w/w), respectively) and reduced the interfacial tension by up to 46% (14.0 ± 0.2 mN m−1) at the oil–water interface. The emulsifying ability of OOC extracts was not correlated, however, with their interfacial activity or surface-active composition. Eighty percent aqueous ethanol extract produced the most stable oil-in-water (O/W) emulsions by high-pressure homogenization. The emulsions had average volume mean droplet diameters of approximately 0.4 µm and negative ζ-potentials of about -45 mV, and were stable for up to 1 month of storage at 5, 25 and 50 °C. They were sensitive, however, to acidic pH conditions (<5) and NaCl addition (≥25 mM), indicating that the main stabilization mechanism is electrostatic due to the presence of surface-active compounds with ionizable groups, such as saponins.

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Influence of Whey Protein Micro-Gel Particles and Whey Protein Micro-Gel Particles-Xanthan Gum Complexes on the Stability of O/W Emulsions

Polymers ◽

10.3390/polym13142301 ◽

2021 ◽

Vol 13 (14) ◽

pp. 2301

Author(s):

Man Zhang ◽

Bin Liang ◽

Hongjun He ◽

Changjian Ji ◽

Tingting Cui ◽

...

Keyword(s):

Oxidative Stability ◽

Whey Protein ◽

High Speed ◽

Xanthan Gum ◽

Physical Stability ◽

Theoretical Support ◽

Gel Particles ◽

Oil In Water ◽

The Stability ◽

The Impact

Appropriate pretreatment of proteins and addition of xanthan gum (XG) has the potential to improve the stability of oil-in-water (O/W) emulsions. However, the factors that regulate the enhancement and the mechanism are still not clear, which restricts the realization of improving the emulsion stability by directional design of its structure. Therefore, the effects of whey protein micro-gel particles (WPMPs) and WPMPs-XG complexes on the stability of O/W emulsion were investigated in this article to provide theoretical support. WPMPs with different structures were prepared by pretreatment (controlled high-speed shear treatment of heat-set WPC gels) at pH 3.5–8.5. The impact of initial WPC structure and XG addition on Turbiscan Indexes, mean droplet size and the peroxide values of O/W emulsions was investigated. The results indicate that WPMPs and XG can respectively inhibit droplet coalescence and gravitational separation to improve the physical stability of WPC-stabilized O/W emulsions. The pretreatment significantly enhanced the oxidative stability of WPC-stabilized O/W emulsions. The addition of XG did not necessarily enhance the oxidative stability of O/W emulsions. Whether the oxidative stability of the O/W emulsion with XG is increased or decreased depends on the interface structure of the protein-XG complex. This study has significant implications for the development of novel structures containing lipid phases that are susceptible to oxidation.

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Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Pharmaceutics ◽

10.3390/pharmaceutics13050744 ◽

2021 ◽

Vol 13 (5) ◽

pp. 744

Author(s):

Ijeoma F. Uchegbu ◽

Jan Breznikar ◽

Alessandra Zaffalon ◽

Uche Odunze ◽

Andreas G. Schätzlein

Keyword(s):

Polymeric Micelles ◽

Rabbit Model ◽

Penetration Enhancer ◽

Hydrophobic Drugs ◽

Ocular Tissues ◽

Ocular Penetration ◽

Self Assembling ◽

Similar Dose ◽

Oil In Water ◽

The Stability

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritant ocular penetration enhancer is showcased, which may be used for the formulation of hydrophobic actives. The activity of this penetration enhancer is demonstrated in a healthy rabbit model. The Molecular Envelope Technology (MET) polymer (N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan), a self-assembling, micelle-forming polymer, was used to formulate CsA into sterile filtered nanoparticulate eye drop formulations and the stability of the formulation tested. Healthy rabbits were dosed with a single dose of a MET–CsA (NM133) 0.05% formulation and ocular tissues analyzed. Optically clear NM133 formulations were prepared containing between 0.01–0.1% w/v CsA and 0.375–0.75% w/v MET polymer. NM133 0.01%, NM133 0.02% and NM133 0.05% were stable for 28 days when stored at refrigeration temperature (5–6 °C) and room temperature (16–23 °C), but there was evidence of evaporation of the formulation at 40 °C. There was no change in drug content when NM133 0.05% was stored for 387 days at 4 °C. On topical dosing to rabbits, corneal, conjunctival and scleral AUC0–24 levels were 25,780 ng.h g−1, 12,046 ng.h g−1 and 5879 ng.h g−1, respectively, with NM133 0.05%. Meanwhile, a similar dose of Restasis 0.05% yielded lower values of 4726 ng.h/g, 4813 ng.h/g and 1729 ng.h/g for the drug corneal, conjunctival and scleral levels, respectively. NM133 thus delivered up to five times more CsA to the ocular surface tissues when compared to Restasis. The MET polymer was non-irritant up to a concentration of 4% w/v. The MET polymer is a non-irritant ocular penetration enhancer that may be used to deliver hydrophobic drugs in optically clear topical ocular formulations.

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