scholarly journals The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2576
Author(s):  
Shamsi Ebrahimi ◽  
Coswald Stephen Sipaut
Keyword(s):  
Compressive Strength ◽  
Liquid Phase ◽  
Body Fluid ◽  
Setting Time ◽  
Nucleation And Growth ◽  
Apatite Layer ◽  
Hydrogen Phosphate ◽  
Sodium Hydrogen Phosphate ◽  
Sodium Hydrogen ◽  
Sbf Solution

Composite scaffolds of hydroxyapatite (HAp) nanoparticles and bioactive glass (BG) have been applied as appropriate materials for bone tissue engineering. In this study, hydroxyapatite/bioglass cement in different ratios was successfully fabricated. To prepare HAp and HAp/BG cement, synthesized HAp and HAp/BG powder were mixed in several ratios, using different concentrations of sodium hydrogen phosphate (SP) and water as the liquid phase. The liquid to powder ratio used was 0.4 mL/g. The results showed that setting time increased with BG content in the composite. The results also showed that with the addition of bioglass to the HAp structure, the density decreased and the porosity increased. It was also found that after immersion in simulated body fluid (SBF) solution, the compressive strength of the HAp and HAp/BG cements increased with BG concentration up to 30 wt.%. SEM results showed the formation of an apatite layer in all selected samples after immersion in SBF solution. At 30 wt.% BG, greater nucleation and growth of the apatite layer were observed, resulting in higher bioactivity than pure HAp and HAp/BG in other ratios.

Chitosan-Crystallized Apatite Composites for Bone Cements: Mechanical Strength and Setting Behavior

2007 ◽  
Vol 330-332 ◽  
pp. 839-842
Author(s):  
Sirirat T. Rattanachan ◽  
Charussri Lorpayoon ◽  
Piyanan Bunpayun
Keyword(s):  
Mechanical Strength ◽  
Setting Time ◽  
Xrd Analysis ◽  
Bone Cements ◽  
Hydrogen Phosphate ◽  
Sodium Hydrogen Phosphate ◽  
Normal Bone ◽  
Calcium Phosphate Cements ◽  
Sodium Hydrogen ◽  
Normal Calcium

Crystallized apatite behaved to plaster of Paris was prepared by the chemical method. Apatite powder was mixed with chitosan. In this study, it was also studied the effect of HA seed and sodium hydrogen phosphate as an additive on their mechanical strength, compared with the normal calcium phosphate cements. Setting time of paste cements was determined using Gillmore method. Phases of cement obtained from a crushed cylinder were analyzed using XRD analysis. From the results, chitosan was effective both in increasing mechanical properties and accelerating hardening of the normal bone cements. Nevertheless, the compressive strength of chitosan-crystallized apatite composites was not significantly improved as compared to the controlled one. In addition, it was found that the mechanical strength of the cements decreased when increasing the concentration of HA seed and an additive.

scholarly journals Growth and characterization of di-sodium hydrogen phosphate

2002 ◽  
Vol 244 (2) ◽  
pp. 194-199 ◽  
Author(s):  
M Gunasekaran ◽  
N Vijayan ◽  
R Ramesh Babu ◽  
R Gopalakrishnan ◽  
P Ramasamy ◽  
...  
Keyword(s):  
Hydrogen Phosphate ◽  
Sodium Hydrogen Phosphate ◽  
Sodium Hydrogen

The pH-Dependent Properties of the Biphasic Calcium Phosphate for Bone Cements

2014 ◽  
Vol 21 ◽  
pp. 3-16 ◽  
Author(s):  
Nuan La Ong Srakaew ◽  
Sirirat Tubsungnoen Rattanachan
Keyword(s):  
Compressive Strength ◽  
Liquid Phase ◽  
Calcium Phosphate ◽  
Phase Analysis ◽  
Calcium Phosphate Cement ◽  
Biphasic Calcium Phosphate ◽  
Setting Time ◽  
Bone Cements ◽  
Apatite Formation ◽  
Apatite Cement

Self-setting calcium phosphate cement (CPC) has been used in bone repair and substitution due to their excellent biocompatibility, bioactive as well as simplicity of preparation and use. The inherent brittleness and slow degradation are the major disadvantages for the use of calcium phosphate cements. To improve the degradation for the traditional CPC, the apatite cement formula incorporated with β-tricalcium phosphate (β-TCP) with varying concentration were studied and the effect of the pH value of liquid phase on the properties of this new calcium phosphate cement formula was evaluated. The apatite cements containing β-TCP for 10 and 40 wt.% were mixed into the aqueous solution with different pH values and then aging in absolute humidity at 37°C for 7 days. The setting time and phase analysis of the biphasic calcium phosphate were determined as compared to the apatite cement. For proper medical application, the compressive strength, the phase analysis and the degradation of the CPC samples at pH 7.0 and 7.4 were evaluated after soaking in the simulated body fluid (SBF) at 37°C for 7 days. The results indicated that the properties of the samples such as the setting time, the compressive strength related to the phase analysis of the set cements. The high degradation of the CPC was found in the cement with increasing β-TCP addition due to the phase after setting. Apatite formation with oriented plate-like morphology was also found to be denser on the surface of the biphasic bone cements after soaking in SBF for 7 days. The obtained results indicated that the cement containing β-TCP mixed with the liquid phase at pH 7.4 could be considered as a highly biodegradable and bioactive bone cement, as compared to the traditional CPC.

Behaviour of Calcium Alkali Orthophosphate Cements under Simulated Implantation Conditions

2008 ◽  
Vol 396-398 ◽  
pp. 213-216 ◽  
Author(s):  
Daniela Jörn ◽  
Renate Gildenhaar ◽  
Georg Berger ◽  
Michael Stiller ◽  
Christine Knabe
Keyword(s):  
Compressive Strength ◽  
Simulated Body Fluid ◽  
Clinical Application ◽  
Body Fluid ◽  
Setting Time ◽  
Great Decrease ◽  
Final Setting Time ◽  
Laboratory Conditions ◽  
Setting Times

The setting behaviour, the compressive strength and the porosity of four calcium alkali orthophosphate cements were examined under laboratory conditions (dry) and under conditions similar to those during clinical application (37°C, contact with body fluid). The results showed an increase of the setting times when specimens were covered with simulated body fluid. Especially, the final setting time (FHZ) was significantly higher for three of the four cements. Furthermore, when specimens were stored in SBF for 16h, an extensive decrease of the compressive strength was noted. The porosity was more than twice as high after 16h in SBF and this may be the cause for the great decrease of the compressive strength.

Biodegradable Bone Cement Using Calcium Phosphate Glass

2006 ◽  
Vol 309-311 ◽  
pp. 861-864 ◽  
Author(s):  
Byung Hyun Lee ◽  
Min Chul Kim ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Dissolution Rate ◽  
Phosphate Glass ◽  
Body Fluid ◽  
Setting Time ◽  
Ageing Test ◽  
Dynamic Assay

In preliminary ageing test, the cement using only calcium phosphate glass as power phase cracked with 1 day in simulated body fluid because of high dissolution rate of the cement. We added 30 wt% of either β-TCP or HA to 70 wt% calcium phosphate glass as powder phase to control the dissolution rate of the cement and performed in vitro ageing test in simulated body fluid by dynamic protocol as well as static protocol to confirm the possibility of controlling. Adding either β-TCP or HA to the cement increases the setting time and decreases the compressive strength. In dynamic assay, the pH of extract is maintained over 7. However, pH decreased to around 5 in static assay. Therefore, weight loss by static protocol continuously increased for 14 days, while weight loss by dynamic protocol almost saturated. In XRD patterns of ageing cements, CaO peaks appeared. CaO peak was maximized most lately in dynamic assay of the cement adding HA and within 7 days, the cement adding HA showed higher weight loss. It is indicated that CaO formed in surface of the cement hinder the dissolution of the cement. In addition, compressive strength increased when the CaO peak was maximized.

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