Biodegradable Bone Cement Using Calcium Phosphate Glass

2006 ◽  
Vol 309-311 ◽  
pp. 861-864 ◽  
Author(s):  
Byung Hyun Lee ◽  
Min Chul Kim ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Dissolution Rate ◽  
Phosphate Glass ◽  
Body Fluid ◽  
Setting Time ◽  
Ageing Test ◽  
Dynamic Assay

In preliminary ageing test, the cement using only calcium phosphate glass as power phase cracked with 1 day in simulated body fluid because of high dissolution rate of the cement. We added 30 wt% of either β-TCP or HA to 70 wt% calcium phosphate glass as powder phase to control the dissolution rate of the cement and performed in vitro ageing test in simulated body fluid by dynamic protocol as well as static protocol to confirm the possibility of controlling. Adding either β-TCP or HA to the cement increases the setting time and decreases the compressive strength. In dynamic assay, the pH of extract is maintained over 7. However, pH decreased to around 5 in static assay. Therefore, weight loss by static protocol continuously increased for 14 days, while weight loss by dynamic protocol almost saturated. In XRD patterns of ageing cements, CaO peaks appeared. CaO peak was maximized most lately in dynamic assay of the cement adding HA and within 7 days, the cement adding HA showed higher weight loss. It is indicated that CaO formed in surface of the cement hinder the dissolution of the cement. In addition, compressive strength increased when the CaO peak was maximized.

Behaviour of Calcium Alkali Orthophosphate Cements under Simulated Implantation Conditions

2008 ◽  
Vol 396-398 ◽  
pp. 213-216 ◽  
Author(s):  
Daniela Jörn ◽  
Renate Gildenhaar ◽  
Georg Berger ◽  
Michael Stiller ◽  
Christine Knabe
Keyword(s):  
Compressive Strength ◽  
Simulated Body Fluid ◽  
Clinical Application ◽  
Body Fluid ◽  
Setting Time ◽  
Great Decrease ◽  
Final Setting Time ◽  
Laboratory Conditions ◽  
Setting Times

The setting behaviour, the compressive strength and the porosity of four calcium alkali orthophosphate cements were examined under laboratory conditions (dry) and under conditions similar to those during clinical application (37°C, contact with body fluid). The results showed an increase of the setting times when specimens were covered with simulated body fluid. Especially, the final setting time (FHZ) was significantly higher for three of the four cements. Furthermore, when specimens were stored in SBF for 16h, an extensive decrease of the compressive strength was noted. The porosity was more than twice as high after 16h in SBF and this may be the cause for the great decrease of the compressive strength.

Preliminary Investigation of Bone Cement Using Calcium Phosphate Glass

2005 ◽  
Vol 284-286 ◽  
pp. 109-112 ◽  
Author(s):  
Byung Hyun Lee ◽  
Min Chul Kim ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Phosphate Glass ◽  
Setting Time ◽  
Preliminary Investigation ◽  
Distilled Water ◽  
Liquid Ratio ◽  
Ft Ir ◽  
Kinetics Of Dissolution ◽  
Kinetics Of

The mixed pastes of binary calcium phosphate glass with Ca/P ratio of 0.6 and distilled water were set after about 4 hr, while never set when calcium phosphate glass with Ca/P lower than 0.5. Their compressive strength was ranged from 16.0 to 23.3 MPa. When Na2HPO4 solution was used instead of distilled water as liquid phase, the setting time became drastically much shorter. As the mole concentration of Na2HPO4 solution increased from 0.25 M to 2 M, setting time was shortened to 35 min from almost 3 hr, but compressive strength decreased from 28.8 MPa to 13.2 MPa. At constant mole concentration, as the mass ratio of a powder to liquid ratio increased, setting time was shortened and maximum compressive strength was measured when a powder/liquid ratio was 2.5. However, no crystallized phases were detected either during setting or after complete setting. The XRD , FT-IR and SEM examinations indicated that calcium phosphate glass dissolved and then glass phase precipitated again. We concluded, therefore, that Na2HPO4 just affected the kinetics of dissolution and precipitation of CPG. The mechanism of hardening has yet to be studied.

Processing Effect on the Compressive Strength and Bioactivity of Ti-Based Composites Produced with TiH2 and Calcium Phosphate

2014 ◽  
Vol 906 ◽  
pp. 45-50
Author(s):  
Enori Gemelli ◽  
Fabio Nery ◽  
Nelson Heriberto Almeida Camargo ◽  
Vinicius André Rodrigues Henriques ◽  
Daiara Floriano da Silva
Keyword(s):  
Compressive Strength ◽  
Powder Metallurgy ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Simulated Body Fluid Solution ◽  
Fluid Solution ◽  
Processing Effect ◽  
Crystal Phases

Titanium-based composites with bioactive phases were produced with TiH2and 10% in volume of calcium phosphate. The mixtures were prepared either by conventional powder metallurgy processing or by ultrasound, dried in a rotary evaporator, pressed at 600 MPa and vacuum-sintered at 1200 °C for 2 hours. Crystal phases of the as-fabricated composites are found to be α-Ti, CaTiO3and TixPyphase (s). The TixPyand CaTiO3phases resulted from the reaction between titanium and tricalcium phosphate at about 1130 °C. Calcium phosphate was better dispersed by ultrasound leading to a higher compressive strength of the composite and a more uniform Ca-P deposition in simulated body fluid solution.

Microstructure and properties of polyhydroxybutyrate-calcium phosphate cement composites

2011 ◽  
Vol 65 (5) ◽  
Author(s):  
Ľubomír Medvecký ◽  
Radoslava Štulajterová ◽  
Sergey Kutsev
Keyword(s):  
Tensile Strength ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Setting Time ◽  
Cement Composites ◽  
Mechanical Mixing ◽  
Soaking Time ◽  
Composite Mixture ◽  
Diametral Tensile Strength

AbstractThe biopolymer (polyhydroxybutyrate) microparticles-calcium phosphate composites were prepared by mechanical mixing of the basic composite components with the addition of hardening liquid after ethanol-composite mixture suspension moulding. The composite microstructures were more compact than the pure cement samples as confirmed by the lower values of specific areas and mesopore volumes. Both the specific areas and mesopore volumes decreased with soaking time in a simulated body fluid. The low polyhydroxybutyrate degradation in composites was found after soaking in simulated body fluid, which was terminated after one week. The formation of a dense apatite layer bonded directly to the surface of polyhydroxybutyrate microparticles was observed. The highest diametral tensile strength (13 MPa) and compressive strength (95 MPa) values of up to 50 % higher than in pure cement were measured in samples with 10 % of polyhydroxybutyrate. The addition of polyhydroxybutyrate microparticles had no effect on the setting time.

Effect of Other Oxides on Solubility and Bioactivity in Calcium Phosphate Glasses

2005 ◽  
Vol 284-286 ◽  
pp. 513-516 ◽  
Author(s):  
Min Chul Kim ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
Chong Kwan Kim ◽  
...  
Keyword(s):  
Weight Loss ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Potassium Acetate ◽  
Phosphate Glasses ◽  
Molar Ratio ◽  
Distilled Water ◽  
Ion Release ◽  
Buffer Solution

The development of phosphate glasses for use in orthopaedic implants has attracted much interest because their chemical and physical properties make them suitable for use as bone-bonding materials. We prepared various compositions of CaO-P2O5-MO or CaO-P2O5-M2O (M: K, Li, Na, Mg, Zn) glasses to measure ion release, solubility and bioactivity. The compositions with (Ca,M)/P molar ratio 0.6 were fixed P2O5 mol% content at 45.45 mol%, and varying MO or M2O mol% at 10, 20 and 30 mol%. Ca2+ ion release properties were investigated in 0.1M potassium acetate with pH 6 at 37oC by immersing 50 mg of powder into 100 ml of acidic buffer solution. The highest and lowest extent of released Ca2+ ion was observed for composition with 10 mol% of K2O and 30 mol% of MgO, respectively. The weight loss in distilled water at 37oC was measured. Solubility increased with decreasing CaO content, but decreased with increasing MgO content. Bioactivity in the simulated body fluid at 37oC was measured.

Self-Setting Biphase Porous Calcium Phosphate Cement

2007 ◽  
Vol 336-338 ◽  
pp. 1615-1617
Author(s):  
Jian Pan ◽  
Jie Mo Tian ◽  
Li Min Dong ◽  
Chen Wang ◽  
Qing Feng Zan
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Body Fluid ◽  
Setting Time ◽  
Xrd Analysis ◽  
Weight Percent ◽  
Sem Observation

This work has achieved a novel self-setting biphase porous calcium phosphate cement (CPC). This biphase porous CPC is mainly formed by α-tricalcium phosphate (α-TCP) and β-tricalcium phosphate (β-TCP). The influence of the weight percent (wt%) of β-TCP of the powder was studied. The setting time is mainly 10-30min, and increasing with the weight percent of β-TCP. Powder ray diffraction (XRD) analysis showed that most α-TCP have turned to low-crystallinized HA after immersed in Simulated Body Fluid (SBF) of 37°C for 7 days. SEM observation showed that the resultants are mainly formed with micropores and microcrystallites, and more micropores turned out in cements with more β-TCP after immersed in SBF for 8 weeks.

IN-VITRO BEHAVIOUR OF BIPHASIC CALCIUM PHOSPHATE WITH DIFFERENT RATIO OF SILICA CONTENT IN SIMULATED BODY FLUID

2015 ◽  
Vol 23 (1) ◽  
pp. 1-14
Author(s):  
Sudirman Sahid ◽  
◽  
Nor Shahida Kader Bashah ◽  
Salina Sabudin ◽  
◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Biphasic Calcium Phosphate ◽  
Silica Content

Primary Study of an Injectable In Situ Composite of Collagen/Calcium Phosphate Porous Scaffold for Bone Substitute

2006 ◽  
Vol 309-311 ◽  
pp. 857-860 ◽  
Author(s):  
Q. Yao ◽  
Dong Xiao Li ◽  
K.W. Liu ◽  
Bo Zhang ◽  
H. Li ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Ph Value ◽  
Porous Scaffold ◽  
Setting Time ◽  
Primary Study ◽  
In Situ Composite ◽  
Setting Process ◽  
Main Material

This study was to develop an injectable biocompatible and porous calcium phosphate collagen composite cement scaffold by in situ setting. TTCP was prepared as main material of the CPC powder, and the collagen solution was added into the phosphoric acid directly to form the liquid phase. The injectable time (tI), setting time (tS) and setting temperature (TS), along with the PH value were recorded during the setting process. The compressive strength, morphology and porosity were tested. With the increase of collagen, this novel CPC get a tI of 5mins to 8mins, tS of 20mins to 30mins, compressive strength from 1.5MPa to 4MPa, and the porosity from 40% to 60%. This study gave a possibility to form a porous scaffold of collagen/CPC composite with the nature of injectability and setting in situ.

The pH-Dependent Properties of the Biphasic Calcium Phosphate for Bone Cements

2014 ◽  
Vol 21 ◽  
pp. 3-16 ◽  
Author(s):  
Nuan La Ong Srakaew ◽  
Sirirat Tubsungnoen Rattanachan
Keyword(s):  
Compressive Strength ◽  
Liquid Phase ◽  
Calcium Phosphate ◽  
Phase Analysis ◽  
Calcium Phosphate Cement ◽  
Biphasic Calcium Phosphate ◽  
Setting Time ◽  
Bone Cements ◽  
Apatite Formation ◽  
Apatite Cement

Self-setting calcium phosphate cement (CPC) has been used in bone repair and substitution due to their excellent biocompatibility, bioactive as well as simplicity of preparation and use. The inherent brittleness and slow degradation are the major disadvantages for the use of calcium phosphate cements. To improve the degradation for the traditional CPC, the apatite cement formula incorporated with β-tricalcium phosphate (β-TCP) with varying concentration were studied and the effect of the pH value of liquid phase on the properties of this new calcium phosphate cement formula was evaluated. The apatite cements containing β-TCP for 10 and 40 wt.% were mixed into the aqueous solution with different pH values and then aging in absolute humidity at 37°C for 7 days. The setting time and phase analysis of the biphasic calcium phosphate were determined as compared to the apatite cement. For proper medical application, the compressive strength, the phase analysis and the degradation of the CPC samples at pH 7.0 and 7.4 were evaluated after soaking in the simulated body fluid (SBF) at 37°C for 7 days. The results indicated that the properties of the samples such as the setting time, the compressive strength related to the phase analysis of the set cements. The high degradation of the CPC was found in the cement with increasing β-TCP addition due to the phase after setting. Apatite formation with oriented plate-like morphology was also found to be denser on the surface of the biphasic bone cements after soaking in SBF for 7 days. The obtained results indicated that the cement containing β-TCP mixed with the liquid phase at pH 7.4 could be considered as a highly biodegradable and bioactive bone cement, as compared to the traditional CPC.

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