scholarly journals Overview of Phase-Change Electrical Probe Memory

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 772 ◽  
Author(s):  
Lei Wang ◽  
Wang Ren ◽  
Jing Wen ◽  
Bangshu Xiong
Keyword(s):  
Phase Transformation ◽  
Kinetic Model ◽  
Phase Change ◽  
State Of The Art ◽  
The State ◽  
Design Rule ◽  
Next Generation ◽  
Future Prospects ◽  
Storage Devices ◽  
Electrical Probe

Phase-change electrical probe memory has recently attained considerable attention owing to its profound potential for next-generation mass and archival storage devices. To encourage more talented researchers to enter this field and thereby advance this technology, this paper first introduces approaches to induce the phase transformation of chalcogenide alloy by probe tip, considered as the root of phase-change electrical probe memory. Subsequently the design rule of an optimized architecture of phase-change electrical probe memory is proposed based on a previously developed electrothermal and phase kinetic model, followed by a summary of the state-of-the-art phase-change electrical probe memory and an outlook for its future prospects.

Next-generation textiles: from embedded supercapacitors to lithium ion batteries

2016 ◽  
Vol 4 (43) ◽  
pp. 16771-16800 ◽  
Author(s):  
Umair Gulzar ◽  
Subrahmanyam Goriparti ◽  
Ermanno Miele ◽  
Tao Li ◽  
Giulia Maidecchi ◽  
...  
Keyword(s):  
Energy Storage ◽  
Lithium Ion Batteries ◽  
State Of The Art ◽  
Lithium Ion ◽  
The State ◽  
Next Generation ◽  
Energy Storage Devices ◽  
Storage Devices

In this work we have reviewed the state of the art of energy storage devices for textile applications.

RNA Interference Therapeutics and Human Diseases

2019 ◽  
pp. 69-83
Author(s):  
Dolly Sharma ◽  
Shailendra Singh ◽  
Trilok Chand
Keyword(s):  
Gene Expression ◽  
Protein Synthesis ◽  
Rna Interference ◽  
State Of The Art ◽  
The State ◽  
Human Diseases ◽  
Future Prospects ◽  
The Future ◽  
Rnai Therapeutics ◽  
Interference Rna

Defective protein synthesis leads to diseases. If protein synthesis can be controlled, disease causing molecules can be tailored in some way. This is the perception behind RNA interference. RNA interference (RNAi) therapeutics is branch of medicine which deals with the treatment of diseases while controlling the gene expression at RNA level. The motive of this chapter is to discover the state-of-the-art of RNAi therapeutics, to explore various techniques used by RNAi therapeutics to fight from diseases, and discuss the future prospects of it.

Future Prospects of Superconducting RF for Accelerator Applications

2019 ◽  
Vol 10 (01) ◽  
pp. 125-156 ◽  
Author(s):  
Hasan Padamsee
Keyword(s):  
State Of The Art ◽  
The State ◽  
Future Prospects ◽  
Superconducting Rf ◽  
High Beta ◽  
Future Plans

Part I of this article provides a status update on the ongoing projects for both high-beta and low-beta applications. Some of these projects are already under production, others are perfecting prototypes and future plans. We first cover the funded projects and continue with the planned projects. The update naturally captures the state-of-the-art for superconducting RF (SRF) performance for applications in progress. Part II goes on to present a vision for future prospects for performance progress in the field, along with some advice about the likely fruitful R&D paths to follow. In general, the R&D paths chosen for discussion will benefit most SRF-based accelerators.

Photocatalytic fixation of nitrogen to ammonia: state-of-the-art advancements and future prospects

2018 ◽  
Vol 5 (1) ◽  
pp. 9-27 ◽  
Author(s):  
Xingzhu Chen ◽  
Neng Li ◽  
Zhouzhou Kong ◽  
Wee-Jun Ong ◽  
Xiujian Zhao
Keyword(s):  
Photocatalytic Activity ◽  
Chemical Composition ◽  
State Of The Art ◽  
The State ◽  
Photocatalytic Reduction ◽  
Future Prospects ◽  
Modification Of Catalysts

The state-of-the-art developments in the photocatalytic reduction of N2 to NH3 are presented by classifying the photocatalysts based on chemical composition. Additionally, the correlation between the modification of catalysts and their photocatalytic activity is highlighted.

scholarly journals The State of the Art and the Future Prospects on Long-Span Concrete Arch Bridges

2001 ◽  
Vol 39 (3) ◽  
pp. 12-20 ◽  
Author(s):  
T. Mori ◽  
T. Yamamoto ◽  
N. Tamehiro ◽  
J. Niwa
Keyword(s):  
State Of The Art ◽  
The State ◽  
Future Prospects ◽  
Long Span ◽  
The Future ◽  
Arch Bridges

scholarly journals Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Yannick Van Herck ◽  
Asier Antoranz ◽  
Madhavi Dipak Andhari ◽  
Giorgia Milli ◽  
Oliver Bechter ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Single Cell ◽  
State Of The Art ◽  
Deep Understanding ◽  
Response Rates ◽  
The State ◽  
Patient Specific ◽  
Specific Cell ◽  
Next Generation ◽  
Single Cell Profiling

The state-of-the-art for melanoma treatment has recently witnessed an enormous revolution, evolving from a chemotherapeutic, “one-drug-for-all” approach, to a tailored molecular- and immunological-based approach with the potential to make personalized therapy a reality. Nevertheless, methods still have to improve a lot before these can reliably characterize all the tumoral features that make each patient unique. While the clinical introduction of next-generation sequencing has made it possible to match mutational profiles to specific targeted therapies, improving response rates to immunotherapy will similarly require a deep understanding of the immune microenvironment and the specific contribution of each component in a patient-specific way. Recent advancements in artificial intelligence and single-cell profiling of resected tumor samples are paving the way for this challenging task. In this review, we provide an overview of the state-of-the-art in artificial intelligence and multiplexed immunohistochemistry in pathology, and how these bear the potential to improve diagnostics and therapy matching in melanoma. A major asset of in-situ single-cell profiling methods is that these preserve the spatial distribution of the cells in the tissue, allowing researchers to not only determine the cellular composition of the tumoral microenvironment, but also study tissue sociology, making inferences about specific cell-cell interactions and visualizing distinctive cellular architectures - all features that have an impact on anti-tumoral response rates. Despite the many advantages, the introduction of these approaches requires the digitization of tissue slides and the development of standardized analysis pipelines which pose substantial challenges that need to be addressed before these can enter clinical routine.

scholarly journals Next-Generation Gene Therapy for Parkinson’s Disease Using Engineered Viral Vectors

2021 ◽  
pp. 1-9
Author(s):  
Tomas Björklund ◽  
Marcus Davidsson
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Genome Editing ◽  
Viral Vectors ◽  
State Of The Art ◽  
The State ◽  
Next Generation ◽  
Suitable Vector

Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adeno associated viral (AAV) vector variants. They all have unique characteristics and abilities. This review summarizes the development and their potential in treating Parkinson’s disease (PD). Clinical trials in PD have shown over the last decade that AAV is a safe and suitable vector for gene therapy but that it also is a vehicle that can benefit significantly from improvement in specificity and potency. This review provides a concise collection of the state-of-the-art for synthetic capsids and their utility in PD. We also summarize what therapeutical strategies may become feasible with novel engineered vectors, including genome editing and neuronal rejuvenation.

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