The Effects of a 6-Month High Dose Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins Supplementation on Cognitive Function and Functional Capacity in Older Adults with Mild Cognitive Impairment

The aim of the present study was to examine the effects of a high-dose omega-3 and omega-6 fatty acids supplementation, in combination with antioxidant vitamins, on cognitive function and functional capacity of older adults with mild cognitive impairment (MCI), over a 6-month period in a randomized, double-blind, placebo-controlled trial. Forty-six older adults with MCI (age: 78.8 ± 7.3 years) were randomized 1:1 to receive either a 20 mL dose of a formula containing a mixture of omega-3 (810 mg Eicosapentaenoic acid and 4140 mg Docosahexaenoic acid) and omega-6 fatty acids (1800 mg gamma-Linolenic acid and 3150 mg Linoleic acid) (1:1 w/w), with 0.6 mg vitamin A, vitamin E (22 mg) plus pure γ-tocopherol (760 mg), or 20 mL placebo containing olive oil. Participants completed assessments of cognitive function, functional capacity, body composition and various aspects of quality of life at baseline and following three and six months of supplementation. Thirty-six participants completed the study (eighteen from each group). A significant interaction between supplementation and time was found on cognitive function (Addenbrooke’s Cognitive Examination -Revised (ACE-R), Mini-Mental State Examination (MMSE) and Stroop Color and Word Test (STROOP) color test; p < 0.001, p = 0.011 and p = 0.037, respectively), functional capacity (6-min walk test and sit-to-stand-60; p = 0.028 and p = 0.032, respectively), fatigue (p < 0.001), physical health (p = 0.007), and daily sleepiness (p = 0.007)—showing a favorable improvement for the participants receiving the supplement. The results indicate that this nutritional modality could be promising for reducing cognitive and functional decline in the elderly with MCI.

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The Effects of a 6-Month Omega Fatty Acid and Antioxidant Vitamin Supplementation on Functional Capacity and Cognitive Function in Older Adults with Cognitive Impairment

Proceedings ◽

10.3390/proceedings2019025036 ◽

2019 ◽

Vol 25 (1) ◽

pp. 36

Author(s):

Stavrinou ◽

Andreou ◽

Aphamis ◽

Ioannou ◽

Pantzaris ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Fatty Acid ◽

Cognitive Function ◽

Functional Capacity ◽

Vitamin Supplementation ◽

Antioxidant Vitamin ◽

High Dose ◽

Omega 3 ◽

Omega Fatty Acid

Aim: Aging is associated with declines in functional capacity and cognitive function. The aim of the present study was to examine, for the first time, the effects of a high-dose omega-3 and omega-6 fatty acid supplementation, in combination with antioxidant vitamins, on functional capacity and cognitive function in older adults with cognitive impairment, over a 6-month period in a randomized, double-blind, placebo-controlled design. Material & Method: Thirty-six older adults with cognitive impairment (aged 79.3 ± 7.6 yrs, 22 females) were randomized to receive either a formula containing a mixture of omega-3 and omega-6 fatty acids with antioxidant vitamins or placebo for six months. Participants completed assessments of functional capacity, cognitive function, and various aspects of quality of life at baseline and following three and six months of supplementation. Functional capacity was evaluated using two sit-to-stand tests (STS-5, STS-60), the timed-up-and-go test (TUG), the 6-min walk test (6MWT), and the handgrip strength test. Cognitive function was evaluated through the Addenbrooke’s Cognitive Examination Revised (ACE-R) and the Mini Mental State Examination (MMSE), whilst health-related quality of life, sleep quality, daily sleepiness, and fatigue were assessed by specific questionnaires. A linear mixed model with a random effect for participant was used to evaluate differences in the dependent variables between the supplementation and placebo groups throughout time, whilst it was adjusted for age and education of the participants. Results: A significant interaction between supplementation and time was found on functional capacity (6MWT and STS-60; p = 0.028 and p = 0.032, respectively), cognitive function (ACER and MMSE; p < 0.001 and p = 0.011, respectively), fatigue (p < 0.001), physical health component (p = 0.007), and daily sleepiness (p = 0.007), showing a favorable improvement for the participants receiving the nutritional supplement. Conclusions: The results of the present study showed that high-dose omega fatty acid and antioxidant vitamin supplementation improves functional capacity and cognitive function in older adults with cognitive impairment. Thus, this novel approach appears promising for reducing cognitive decline and frailty in the elderly.

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The Effects of Specific Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins on Gait and Functional Capacity Parameters in Patients with Relapsing-Remitting Multiple Sclerosis

Nutrients ◽

10.3390/nu13103661 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3661

Author(s):

Panayiotis Aristotelous ◽

Manos Stefanakis ◽

Marios Pantzaris ◽

Constantinos S. Pattichis ◽

Philip C. Calder ◽

...

Keyword(s):

Multiple Sclerosis ◽

Fatty Acids ◽

Placebo Group ◽

Polyunsaturated Fatty Acids ◽

Functional Capacity ◽

Antioxidant Vitamins ◽

Omega 3 ◽

Gait Parameters ◽

Relapsing Remitting ◽

Omega 6

Patients with multiple sclerosis (MS) are characterized by, among other symptoms, impaired functional capacity and walking difficulties. Polyunsaturated fatty acids (PUFAs) have been found to improve MS patients’ clinical outcomes; however, their effect on other parameters associated with daily living activities need further investigation. The current study aimed to examine the effect of a 24-month supplementation with a cocktail dietary supplement formula, the NeuroaspisTM PLP10, containing specific omega-3 and omega-6 PUFAs and specific antioxidant vitamins on gait and functional capacity parameters of patients with MS. Fifty-one relapsing-remitting MS (RRMS) patients with low disability scores (age: 38.4 ± 7.1 years; 30 female) were randomized 1:1 to receive either a 20 mL daily dose of the dietary formula containing a mixture of omega-3 and omega-6 PUFAs (12,150 mg), vitamin A (0.6 mg), vitamin E (22 mg), and γ-tocopherol (760 mg), the OMEGA group (n = 27; age: 39 ± 8.3 years), or 20 mL placebo containing virgin olive oil, the placebo group (n = 24; age: 37.8 ± 5.3 years). The mean ± SD (standard deviation) Expanded Disability Status Scale (EDSS) score for the placebo group was 2.36 and for the OMEGA group 2.22. All enrolled patients in the study were on Interferon-b treatment. Spatiotemporal gait parameters and gait deviation index (GDI) were assessed using a motion capture system. Functional capacity was examined using various functional tests such as the six-minute walk test (6MWT), two sit-to-stand tests (STS-5 and STS-60), and the Timed Up and Go test (TUG). Isometric handgrip strength was assessed by a dynamometer. Leg strength was assessed using an isokinetic dynamometer. All assessments were performed at baseline and at 12 and 24 months of supplementation. A total of 36 patients completed the study (18 from each group). Six patients from the placebo group and 9 patients from the OMEGA group dropped out from the study or were lost to follow-up. The dietary supplement significantly improved the single support time and the step and stride time (p < 0.05), both spatiotemporal gait parameters. In addition, while GDI of the placebo group decreased by about 10% at 24 months, it increased by about 4% in the OMEGA group (p < 0.05). Moreover, performance in the STS-60 test improved in the OMEGA group (p < 0.05) and there was a tendency for improvement in the 6MWT and TUG tests. Long-term supplementation with high dosages of omega-3 and omega-6 PUFAs (compared to previous published clinical studies using PUFAs) and specific antioxidant vitamins improved some functional capacity and gait parameters in RRMS patients.

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Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults

Yearbook of Anesthesiology and Pain Management ◽

10.1016/s1073-5437(08)71001-5 ◽

2008 ◽

Vol 2008 ◽

pp. 273-274

Author(s):

M.F. Roizen

Keyword(s):

Older Adults ◽

Fatty Acids ◽

Depressive Symptoms ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Omega 6

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The Role of Daily Social Interactions in Detecting Mild Cognitive Impairment

Innovation in Aging ◽

10.1093/geroni/igaa057.2013 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 598-598

Author(s):

Ruixue Zhaoyang ◽

Stacey Scott ◽

Eric Cerino ◽

Martin Sliwinski

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Social Interactions ◽

Social Relationships ◽

Daily Basis ◽

Community Dwelling ◽

Normal Cognitive Function ◽

Social Markers

Abstract Social relationships play an important role in cognitive health and aging. However, it is unclear how older adult’s cognitive function affects their everyday social interactions, especially for those with mild cognitive impairment (MCI). This study examined whether older adults with intact cognition vs. MCI differed in their daily social interactions. Community-dwelling older adults from the Einstein Aging Study (N=244, 70-91 yrs) reported their social interactions five times daily for 14 consecutive days using smartphones. Compared to those with normal cognitive function, older adults with MCI reported less frequent positive social interactions (p=0.012) and in-person social activities (p=0.006) on a daily basis. These two groups, however, did not show significant differences in their social relationships assessed by a conventional global questionnaire. The results support that, relative to global social relationships, daily social interactions are more sensitive, ecologically valid social markers that can facilitate the early detection of MCI.

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