scholarly journals Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 878
Author(s):  
Jae Yeun Lee ◽  
Joon Mo Kim ◽  
Kyoung Yong Lee ◽  
Bokyung Kim ◽  
Mi Yeon Lee ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Dietary Intake ◽  
Large Scale ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Multivariate Logistic Regression Analysis ◽  
Open Angle ◽  
Cross Sectional Survey ◽  
Increased Risk ◽  
Calcium Phosphorus

To investigate the association between nutrient intake and primary open angle glaucoma (POAG) in Koreans, a population-based, cross-sectional survey, the Korean National Health and Nutrition Examination Survey, was analyzed. Glaucoma diagnosis was based on criteria established by the International Society of Geographic and Epidemiologic Ophthalmology. Multivariate regression analysis was used to assess the correlation between dietary intake and the prevalence of POAG in all enrolled subjects. In the low Body mass index(BMI) group (BMI <18.5), females with POAG had significantly lower intakes of energy, protein, fat, carbohydrate, ash, calcium, phosphorus, sodium, potassium, vitamin A, B-carotene, thiamin, riboflavin, and vitamin C than their non-glaucoma counterparts, based on a multivariate logistic regression analysis (all p < 0.05). In females with a medium BMI (18.5 ≤ BMI < 23), POAG showed a significant association with lower food intake, energy, protein, calcium, phosphorus, potassium, thiamin and niacin. (all p < 0.05). Lower protein thiamine intake in medium BMI males was related to POAG. Low dietary intake of several nutrients showed an association with glaucoma in low BMI female subjects. An insufficient intake of certain nutrients may be associated with an increased risk of glaucoma in Koreans. Further large-scale cohort studies are needed to determine how specific nutrients alter the risk of glaucoma.

Primary Open-angle Glaucoma and Increased Risk of Chronic Kidney Disease

2019 ◽  
Vol 28 (12) ◽  
pp. 1067-1073
Author(s):  
Sang Jun Park ◽  
Seong Jun Byun ◽  
Jae Yoon Park ◽  
Martha Kim
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Increased Risk

Optic disc haemorrhage and primary open-angle glaucoma: a clinical review

2020 ◽  
pp. bjophthalmol-2019-314583 ◽  
Author(s):  
Uma Jasty ◽  
Alon Harris ◽  
Brent Siesky ◽  
Lucas W Rowe ◽  
Alice C Verticchio Vercellin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Treatment Strategies ◽  
Significant Risk ◽  
Female Gender ◽  
Open Angle ◽  
Increased Risk ◽  
Disc Haemorrhage

Studies have confirmed that optic disc haemorrhage (ODH) is a significant risk factor for the development and progression of primary open-angle glaucoma (POAG). Various populations have differing risk factors for developing POAG. As such, a literature review was conducted examining seven studies published in India, China, Japan, Australia, Korea and the USA. The goal of this review was to better identify ODH risk factors and their relationship to development and progression of POAG. Ultimately, patients with ODH have a greater risk for developing POAG across all populations analysed in this review. However, some populations demonstrated additional risk factors for ODH, such as increasing age and female gender. Paradoxically, data from several studies show that people of African descent have a reduced risk of ODH despite having increased risk of open-angle glaucoma than their Caucasian counterparts. By parsing out the complex relations between ODH and open-angle glaucoma stratified by age, gender and race, we may gain a broader understanding of glaucoma pathogenesis and derive individualised treatment strategies.

Capabilities of modern statistical methods of regression analysis in the prediction of primary open angle glaucoma

2018 ◽  
Vol 16 (5) ◽  
pp. 168-172
Author(s):  
O. N. Levanova ◽  
◽  
V. G. Likhvantseva ◽  
V. A. Sokolov ◽  
T. E. Borisenko ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Statistical Methods ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

scholarly journals PROGNOSIS OF POSTOPERATIVE PROGRESSION OF GLAUCOMA OPTIC NEUROPATHY AT PRIMARY OPEN-ANGLE GLAUCOMA

2020 ◽  
pp. 60-68
Author(s):  
Anton Serdiuk
Keyword(s):  
Regression Analysis ◽  
Optic Neuropathy ◽  
Fas Ligand ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Soluble Form ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Open Angle

Search for new informative markers and methods of prognosis prediction glaucomatous optic neuropathy (GON) in primary open-angle glaucoma (POAG) is an urgent task. We have established efficiency surgical treatment of POAG, but the progression of GON is observed in 10–15 % patients. It is known that the main mechanism of GON is apoptotic death retinal ganglion cells, a marker of which is recognized as tumour necrosis factor-α (TNFα), Fas-ligand (FasL) and a soluble form of the Fas-receptor (sFas/APO-1). The aim of the study: to find out the possibility of using apoptosis factors (TNFα, FasL and sFas/APO-1) to predict postoperative progression of GON at POAG. Methods. 69 patients (69 eyes) with POAG stage I–III were examined, who underwent trabeculectomy with implantation of an Ex-Press shunt. In intraocular fluid (IOF) markers of apoptosis was determined by the method enzyme-linked immunosorbent assay. Repeated ophthalmological examination was performed in 1 year. The control group consisted of 25 patients who were operated on about phacoemulsification of cataracts. For statistical and regression analysis used software package GLZ (Statistica 10, StatSoft, Inc. USA) and module of analysis of operational characteristics of regression models – ROC-diagrams (MedCalc 18.9.1, MedCalc Software, Belgium). Results. Multivariate regression analysis showed that the progression of GON determine the content in IOF of TNFα and sFas/Apo-1 before surgery and intraocular pressure after three months. Based on these indicators, it is calculated satisfactory model of GON progression prediction with 95.4 % accuracy. One-factor logistic regression analysis proved the influence of the content of TNFα, FasL and sFas/Apo-1 for the presence or absence of progression of GON during the year after operations: direct dependence took place for TNFα and FasL and inverse – for sFas/Apo-1. The critical limits of the content in the IOF markers are calculated apoptosis, in which the progression of GON is unmistakably predicted during year after surgery. Conclusions. The obtained results prove the significant influence of the studied markers apoptosis on the progression of GON after surgery. Direct pathogenetic influence belongs to TNFα and FasL.

scholarly journals MYOC Gene Sequencing Analysis in Primary Open-Angle Glaucoma Patients from the Centre Region of Portugal

2020 ◽  
Vol 34 (13) ◽  
Author(s):  
Filipe Silva ◽  
Filipa Ferreira ◽  
Pedro Faria ◽  
Isa Sobral ◽  
Mariana Rodrigues ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Late Onset ◽  
Open Angle Glaucoma ◽  
Gene Mutations ◽  
Normal Tension Glaucoma ◽  
Sequencing Analysis ◽  
Open Angle ◽  
Sequence Variations ◽  
Increased Risk ◽  
Centre Region

Introduction: Primary open-angle glaucoma is the most frequent subtype of glaucoma. Relatives of primary open-angle glaucoma patients have an increased risk of developing the disease, suggesting a genetic predisposition to the disease. MYOC was the first primary open-angle glaucoma-causing gene identified. This study aimed to identify sequence variations in the MYOC gene that may be responsible for the phenotype in a group of primary open-angle glaucoma patients from the Centre Region of Portugal.Material and Methods: The three coding exons and the proximal splicing junctions of the MYOC gene were studied using a PCR sequencing approach in a group of 99 primary open-angle glaucoma patients.Results: The sequencing analysis enabled the identification of 20 variants, including four in the promoter region, seven in the introns and nine in exons one and three, of which four were missense variants.Discussion: Initially, all four missense sequence variations identified were considered candidates to glaucoma causing disease mutations. However, after literature review, only variant c.1334C>T (Ala445Val) remained as likely responsible for mild late-onset normal tension glaucoma.Conclusion: This is the first study performed in a group of primary open-angle glaucoma patients from the Centre Region of Portugal, contributing to the identification of one genetic variant in the MYOC gene and reinforcing the hypothesis that normal tension glaucoma could be also due to MYOC gene mutations.

scholarly journals The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hye Jin Chung ◽  
Hyung Bin Hwang ◽  
Na Young Lee
Keyword(s):  
Blood Pressure ◽  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Increased Risk ◽  
Low Blood Pressure ◽  
The Relationship

Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also been identified as risk factors and can lead to hypoperfusion of the optic nerve head and thus may play an important role in the pathogenesis and progression of POAG. The results of the present study suggest that both high and low blood pressure (BP) are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure (OPP) and subsequent ischemic injury. The relationship between IOP, OPP, and BP suggests that the relationship between BP and glaucoma progression is U-shaped.

scholarly journals Prevalence of glaucoma in first-degree relatives of patients with primary open-angle glaucoma and normal-tension glaucoma

2018 ◽  
Vol 16 (2) ◽  
pp. 95-100
Author(s):  
Preeti Gupta ◽  
Vijaya Pai. H.
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Risk Groups ◽  
Normal Tension Glaucoma ◽  
Open Angle ◽  
First Degree Relatives ◽  
Increased Risk ◽  
The Family ◽  
High Prevalence ◽  
History Of

Objective: To determine the prevalence of glaucoma in first-degree relatives of patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Methods: Observational study of first-degree relatives of patients with POAG and NTG who were screened for glaucoma. Results: A total of 66 first-degree relatives of patients with glaucoma (POAG/NTG) were included in the study. We found a prevalence rate of 16.6%: 13.6% were diagnosed to have the disease and 3% were newly detected to have glaucoma during the study. We found that although 66.7% of the subjects were aware of the family history of glaucoma, only 36.4% were aware that they were at increased risk of developing glaucoma. Conclusion: In our study, we found high prevalence of glaucoma in first-degree relatives of patients with glaucoma. This highlights the importance of selective screening of high-risk groups such as first-degree relatives of patients with POAG/NTG.

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