scholarly journals Polymorphisms Contributing to Calcium Status: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2488
Author(s):  
Katharina da Silva Lopes ◽  
Sarah Krull Abe
Keyword(s):  
Systematic Review ◽  
Calcium Homeostasis ◽  
Nucleotide Polymorphisms ◽  
Study Quality ◽  
Dietary Recommendations ◽  
Vdr Gene ◽  
Cross Sectional ◽  
Casr Gene ◽  
Calcium Sensing ◽  
Calcium Status

This systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in genes related to calcium metabolism were considered. Two reviewers independently screened references, extracted relevant data and assessed study quality using the Q-Genie tool. Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) in relation to calcium status were identified. Almost half of the included studies were of good study quality according to the Q-Genie tool. Seventeen studies were cross-sectional, 14 case-control, seven association and three were Mendelian randomization studies. Included studies were conducted in over 18 countries. Participants were mainly adults, while six studies included children and adolescents. Ethnicity was described in 31 studies and half of these included Caucasian participants. Twenty-six independent studies examined the association between calcium and polymorphism in the calcium-sensing receptor (CASR) gene. Five studies assessed the association between polymorphisms of the Vitamin D receptor (VDR) gene and changes in calcium levels or renal excretion. The remaining ten studies investigated calcium homeostasis and other gene polymorphisms such as the CYP24A1 SNP or CLDN14. This study identified several CASR, VDR and other gene SNPs associated with calcium status. However, to provide evidence to guide dietary recommendations, further research is needed to explore the association between common polymorphisms and calcium requirements.

scholarly journals Vitamin D and its pathway genes in myopia: systematic review and meta-analysis

2018 ◽  
Vol 103 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Shu Min Tang ◽  
Tiffany Lau ◽  
Shi Song Rong ◽  
Seyhan Yazar ◽  
Li Jia Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Meta Analysis ◽  
Nucleotide Polymorphisms ◽  
Vdr Gene ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Standard Mean Difference ◽  
Increased Risk ◽  
Full Analysis

ObjectiveTo conduct a systematic review and meta-analysis of the association of blood vitamin D (25-hydroxyvitamin D, 25(OH)D) concentration and vitamin D pathway genes with myopia.MethodsWe searched the MEDLINE and EMBASE databases for studies published up to 29 January 2018. Cross-sectional or cohort studies which evaluated the blood 25(OH)D concentration, blood 25(OH)D3 concentration or vitamin D pathway genes, in relation to risk of myopia or refractive errors were included. Standard mean difference (SMD) of blood 25(OH)D concentrations between the myopia and non-myopia groups was calculated. The associations of blood 25(OH)D concentrations and polymorphisms in vitamin D pathway genes with myopia using summary ORs were evaluated.ResultsWe summarised seven studies involving 25 008 individuals in the meta-analysis. The myopia group had lower 25(OH)D concentration than the non-myopia group (SMD=−0.27 nmol/L, p=0.001). In the full analysis, the risk of myopia was inversely associated with blood 25(OH)D concentration after adjusting for sunlight exposure or time spent outdoors (adjusted odds ratio (AOR)=0.92 per 10 nmol/L, p<0.0001). However, the association was not statistically significant for the <18 years subgroup (AOR=0.91 per 10 nmol/L, p=0.13) and was significant only for 25(OH)D3 (likely to be mainly sunlight derived), but not total 25(OH)D (AOR=0.93 per 10 nmol/L, p=0.00007; AOR=0.91 per 10 nmol/L, p=0.15). We analysed four single nucleotide polymorphisms in the VDR gene from two studies; there was no significant association with myopia.ConclusionsLower 25(OH)D is associated with increased risk of myopia; the lack of a genetic association suggests that 25(OH)D level may be acting as a proxy for time outdoors.

scholarly journals Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Besut Daryanto ◽  
Basuki Bambang Purnomo ◽  
Atma Gunawan ◽  
Fredo Tamara ◽  
Saga Aditya Hutama ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Group Analysis ◽  
Asian Population ◽  
Nucleotide Polymorphisms ◽  
Calcium Sensing Receptor ◽  
Casr Gene ◽  
Calcium Sensing

Abstract Backgrounds In the last two decades, studies have been widely carried out to assess the association between single-nucleotide polymorphisms (SNPs) of calcium-sensing receptor (CaSR) gene in exon 7 and the risk of urolithiasis. However, inconsistency across the studies was reported. Therefore, our current study aimed to perform a meta-analysis concerning the association between the risk of urolithiasis and the gene polymorphisms of CaSR R990G, CaSR A986S, and CaSR Q1011E. Methods Published papers from PubMed, Embase, Cohcrane, and Web of science were included for the study, and they were analyzed using fixed or random effect model. Results A total of 11 papers consisting of eight papers evaluating CaSR R990G, nine papers evaluating CaSR A986S, and five papers evaluating CaSR Q1011E were included in our analysis. Our pooled calculation found that protective effect against urolithiasis was observed in R allele and RR genotype of CaSR R990G and A allele and AA genotype of CaSR A986S. Conversely, increased susceptibility to urolithiasis was found in G allele and RG genotype of CaSR R990G and S allele of CaSR A986S. Interestingly, our findings in sub-group analysis confirmed that the correlation between CaSR R990G and urolithiasis was found in Caucasian population. Meanwhile, in Asian population, the association was observed in CaSR A986S. Conclusions CaSR R990G and CaSR A986S, but not CaSR Q1011E, are associated with the risk of urolithiasis.

scholarly journals Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism

2011 ◽  
Vol 164 (3) ◽  
pp. 421-427 ◽  
Author(s):  
Giuseppe Vezzoli ◽  
Alfredo Scillitani ◽  
Sabrina Corbetta ◽  
Annalisa Terranegra ◽  
Elena Dogliotti ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Regulatory Region ◽  
Ionized Calcium ◽  
Nucleotide Polymorphisms ◽  
Calcium Sensing Receptor ◽  
Single Nucleotide ◽  
Casr Gene ◽  
Calcium Sensing ◽  
Serum Ionized Calcium ◽  
A Minor

Background and objectiveSingle nucleotide polymorphisms (SNPs) of the calcium-sensing receptor (CASR) gene at the regulatory region were associated with idiopathic calcium nephrolithiasis. To confirm their association with nephrolithiasis, we tested patients with primary hyperparathyroidism (PHPT).DesignA genotype–phenotype association study.MethodsIn all, 332 PHPT patients and 453 healthy controls were genotyped for the rs7652589 (G>A) and rs1501899 (G>A) SNPs sited in the noncoding regulatory region of the CASR gene. Allele, haplotype, and diplotype distribution were compared between PHPT patients and controls, and in stone forming and stone-free PHPT patients.ResultsThe allele frequency at rs7652589 and rs1501899 SNPs was similar in PHPT patients and controls. The A minor alleles at these two SNPs were more frequent in stone forming (n=157) than in stone-free (n=175) PHPT patients (rs7652589: 36.9 vs 27.1%, P=0.007; rs1501899: 37.1 vs 26.4%, P=0.003). Accordingly, homozygous or heterozygous PHPT patients for the AA haplotype (n=174, AA/AA or AA/GG diplotype) had an increased stone risk (odds ratio 1.83, 95% confidence interval 1.2–2.9, P=0.008). Furthermore, these PHPT patients had higher serum concentrations of ionized calcium and parathyroid hormone (1.50±0.015 mmol/l and 183±12.2 pg/ml) than patients with the GG/GG diplotype (n=145, 1.47±0.011 mmol/l (P=0.04) and 150±11.4 pg/ml (P=0.049)). Using a logistic regression model, the increase in stone risk in PHPT patients was predicted by AA/AA or AA/GG diplotype, the highest tertile of serum ionized calcium values and the lowest tertile of age.ConclusionsPolymorphisms located in the regulatory region of the CASR gene may increase susceptibility of the PHPT patients to kidney stone production.

scholarly journals A Systematic Review of the Evidence on Inflammation in Depressive Illness and Symptoms, in Chronic and End Stage Kidney Disease

2021 ◽  
Author(s):  
Simone Jayakumar ◽  
Stacey Jennings ◽  
Kristoffer Halvorsrud ◽  
Christophe Clesse ◽  
Livia Araujo de Carvalho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Kidney Disease ◽  
Physical Health ◽  
Inflammatory Markers ◽  
Depressive Illness ◽  
Significant Heterogeneity ◽  
Study Quality ◽  
Cross Sectional ◽  
Meta Analyses ◽  
End Stage

BackgroundDepressive illness and symptoms are known to be common in physical health problems and are present in at least a third of people with chronic kidney disease and end stage renalfailure (CKD/ESKD). Depressive illness and symptoms in CKD/ESKD complicates care, is associated with a shorter life expectancy, and may arise in response to inflammation.MethodsWe undertook a systematic review of studies including measures of depression and inflammatory markers in CKD/ESKD. The protocol was pre-registered with PROSPERO: CRD42019141305. Data base searches were completed in 2019 and repeated in May 2020. We assessed study quality, and undertook a narrative synthesis as well as meta-analyses of cross-sectional and longitudinal studies, examining associations between depressive states and inflammatory markers.ResultsThere was significant heterogeneity in study quality, comorbidities, samples, depression measures, and study design, as well as in the specific measured inflammatory markers.Overall, there is some evidence for associations of IL6 and CRP with depressive illness and symptoms, with inconclusive or contradictory evidence for other inflammatory markers. There were few intervention studies. Studies of samples with physical comorbidity and higher rated quality were more likely to show positive associations. There were few longitudinal studies.ConclusionsThere is some evidence of inflammation being an important correlate of depressive illness and symptoms in the presence of physical health comorbidities. Better research designs areneeded including a range of inflammatory markers.

scholarly journals Frequency of Food Shopping and Fruit and Vegetable Consumption: A Systematic Review

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 219-219
Author(s):  
Amanda Kopetsky ◽  
Samantha Rex ◽  
Sarah Katz ◽  
Shannon Robson
Keyword(s):  
Systematic Review ◽  
The United States ◽  
Grocery Store ◽  
Cochrane Library ◽  
Outcome Variable ◽  
Study Quality ◽  
Fruit And Vegetable ◽  
Cross Sectional ◽  
Food Shopping ◽  
The Relationship

Abstract Objectives To examine the relationship between frequency of food shopping and fruit and vegetable (FV) intake in adults. Methods A systematic review, guided by the Cochrane handbook, was conducted across four online databases: PudMed, CINAHL, Web of Science and the Cochrane Library. Studies were included if published in a peer reviewed journal through March 2019, included adults (³ 18 years of age), and were conducted in the United States. Any study using a cross-sectional, longitudinal cohort, or randomized study design that examined the relationship between the exposure variable of frequency of food shopping (defined as purchasing foods at a grocery store, farmer's market, corner store, convenience store, specialty store, mobile produce van) and outcome variable, FV intake was selected. Study quality was reviewed using the Quality Control Checklist. Due to heterogeneity across study designs and variable measurement, the systematic review findings were qualitatively summarized. Results A total of 1021 records were reviewed after 488 duplicates were removed and 69 were selected for full review. Twenty met inclusion criteria and were included in the systematic review. The majority of studies (75%) found evidence of a positive association between the frequency of food shopping and FV intake, such that as frequency increased so did FV intake. The majority of studies received a neutral rating for study quality as most studies (85%) had a cross-sectional or longitudinal design and lacked a consistent definition of frequency of food shopping. FV intake was assessed using self-report measures with only one study using 24-hour recalls. Conclusions There is evidence to show a positive relationship between frequency of food shopping and increased FV intake. More frequent shopping may be an important strategy to incorporate as part of nutrition education, especially within food assistance programs as it may promote FV intake. Given food shopping frequency was broadly defined across food store types that were variable, future research should consider examining if store type influences FV intake. Funding Sources None.

scholarly journals Determinants of Healthcare Use Based on the Andersen Model: A Systematic Review of Longitudinal Studies

Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1354
Author(s):  
André Hajek ◽  
Benedikt Kretzler ◽  
Hans-Helmut König
Keyword(s):  
Systematic Review ◽  
Longitudinal Studies ◽  
Observational Studies ◽  
Study Quality ◽  
Healthcare Use ◽  
Cross Sectional ◽  
Hand Search ◽  
Andersen Model ◽  
Longitudinal Association ◽  
Longitudinal Observational Studies

The aim was to give an overview of longitudinal observational studies investigating the determinants of healthcare use explicitly using the Andersen model. To this end, three electronic databases (Medline, PsycINFO and CINAHL) were searched (and an additional hand search was performed). Longitudinal observational studies examining the determinants of healthcare use (outpatient physician services and hospital stays) based on the Andersen model were included, whereas disease-specific samples were excluded. Study quality was evaluated. The selection of studies, extraction of data and assessment of the studies were conducted by two reviewers. The following determinants of healthcare use were displayed based on the (extended) Andersen model: predisposing characteristics, enabling resources, need factors and psychosocial factors. In sum, n = 10 longitudinal studies have been included in our systematic review. The included studies particularly showed a longitudinal association between increased needs and higher healthcare use. Study quality was rather high. However, several studies did not conduct robustness checks or clarify the handling of missing data. In conclusion, this systematic review adds to our current understanding of the factors associated with healthcare use (mainly based on cross-sectional studies). It showed mixed evidence with regard to the association between predisposing characteristics, enabling resources and healthcare use longitudinally. In contrast, increased need factors (in particular, self-rated health and chronic conditions) were almost consistently associated with increased healthcare use. This knowledge may assist in managing healthcare use. Since most of the studies were conducted in North America or Europe, future longitudinal studies from other regions are urgently required.

scholarly journals Factors associated with vertebral fracture risk in patients with primary hyperparathyroidism

2014 ◽  
Vol 171 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Cristina Eller-Vainicher ◽  
Claudia Battista ◽  
Vito Guarnieri ◽  
Silvana Muscarella ◽  
Serena Palmieri ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Primary Hyperparathyroidism ◽  
Pcr Amplification ◽  
Mineral Density ◽  
Cross Sectional ◽  
Casr Gene ◽  
Calcium Sensing ◽  
Vertebral Fracture Risk ◽  
Sectional Analysis ◽  
Design And Methods

ObjectiveTo examine factors, in addition to bone mineral density (BMD), such as the common calcium-sensing receptor (CASR) gene polymorphisms, associated with vertebral fracture (VFx) risk in primary hyperparathyroidism (PHPT).Design and methodsA cross-sectional analysis of 266 Caucasian PHPT seen as outpatients. Serum calcium (sCa) phosphate metabolism parameters were measured. BMD was assessed by dual-energy X-ray absorptiometry (expressed as Z-score) at lumbar spine (Z-LS) and femoral neck, morphometric VFx by radiograph, and CASR A986S/R990G genotypes by PCR amplification and genomic DNA sequencing.ResultsFractured patients (n=100, 37.6%) had lower sCa (10.8±0.7 mg/dl) and Z-LS BMD (−1.0±1.44), higher age (61±10 years), and prevalence (51%) of ≥1 S alleles of the CASR A986S single-nucleotide polymorphism (SNP; AS/SS), than those not fractured (n=166, 11.2±1.0 mg/dl, −0.57±0.97, 58±13 years, and 38% AS/SS, respectively, P<0.05 for all comparisons). Logistic regression, with VFx as dependent variable, showed independent risks associated with increased age (OR 1.03, 95% CI 1.01–1.06, P=0.006), decreased sCa (OR 1.86, 95% CI 1.28–2.7, P=0.001), and Z-LS BMD (OR 1.4, 95% CI 1.12–1.7, P=0.002) and presence of AS/SS (OR 1.8, 95% CI 1.1–2.9, P=0.05). The presence of two out of three factors (age ≥58 years, sCa <10.8 and Z-LS BMD≤−1.0, and AS/SS genotype) gave an overall OR of 4.2 (95% CI 2.25–7.85, P<0.0001).ConclusionsIn PHPT, VFx is associated positively with age, negatively with sCa and spinal BMD, and presence of at least one copy of the CASR A986S SNP.

scholarly journals Industry funding of patient and health consumer organisations: systematic review with meta-analysis

BMJ ◽  
2020 ◽  
pp. l6925 ◽  
Author(s):  
Alice Fabbri ◽  
Lisa Parker ◽  
Cinzia Colombo ◽  
Paola Mosconi ◽  
Giussy Barbara ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Corporate Sponsorship ◽  
Study Quality ◽  
Industry Funding ◽  
Publication Type ◽  
Cross Sectional ◽  
Prevalence Estimates ◽  
Patient Groups ◽  
Corporate Funding

AbstractObjectiveTo investigate pharmaceutical or medical device industry funding of patient groups.DesignSystematic review with meta-analysis.Data sourcesOvid Medline, Embase, Web of Science, Scopus, and Google Scholar from inception to January 2018; reference lists of eligible studies and experts in the field.Eligibility criteria for selecting studiesObservational studies including cross sectional, cohort, case-control, interrupted time series, and before-after studies of patient groups reporting at least one of the following outcomes: prevalence of industry funding; proportion of industry funded patient groups that disclosed information about this funding; and association between industry funding and organisational positions on health and policy issues. Studies were included irrespective of language or publication type.Review methodsReviewers carried out duplicate independent data extraction and assessment of study quality. An amended version of the checklist for prevalence studies developed by the Joanna Briggs Institute was used to assess study quality. A DerSimonian-Laird estimate of single proportions with Freeman-Tukey arcsine transformation was used for meta-analyses of prevalence. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to assess the quality of the evidence for each outcome.Results26 cross sectional studies met the inclusion criteria. Of these, 15 studies estimated the prevalence of industry funding, which ranged from 20% (12/61) to 83% (86/104). Among patient organisations that received industry funding, 27% (175/642; 95% confidence interval 24% to 31%) disclosed this information on their websites. In submissions to consultations, two studies showed very different disclosure rates (0% and 91%), which appeared to reflect differences in the relevant government agency’s disclosure requirements. Prevalence estimates of organisational policies that govern corporate sponsorship ranged from 2% (2/125) to 64% (175/274). Four studies analysed the relationship between industry funding and organisational positions on a range of highly controversial issues. Industry funded groups generally supported sponsors’ interests.ConclusionIn general, industry funding of patient groups seems to be common, with prevalence estimates ranging from 20% to 83%. Few patient groups have policies that govern corporate sponsorship. Transparency about corporate funding is also inadequate. Among the few studies that examined associations between industry funding and organisational positions, industry funded groups tended to have positions favourable to the sponsor. Patient groups have an important role in advocacy, education, and research, therefore strategies are needed to prevent biases that could favour the interests of sponsors above those of the public.Systematic review registrationPROSPERO CRD42017079265.

scholarly journals Informal Caregiving, Loneliness and Social Isolation: A Systematic Review

2021 ◽  
Vol 18 (22) ◽  
pp. 12101
Author(s):  
André Hajek ◽  
Benedikt Kretzler ◽  
Hans-Helmut König
Keyword(s):  
Systematic Review ◽  
Social Isolation ◽  
Informal Care ◽  
Observational Studies ◽  
Informal Caregivers ◽  
Chronically Ill ◽  
Informal Caregiving ◽  
Study Quality ◽  
Cross Sectional ◽  
Cross Sectional Studies

Background: Several empirical studies have shown an association between informal caregiving for adults and loneliness or social isolation. Nevertheless, a systematic review is lacking synthesizing studies which have investigated these aforementioned associations. Therefore, our purpose was to give an overview of the existing evidence from observational studies. Materials and Methods: Three electronic databases (Medline, PsycINFO, CINAHL) were searched in June 2021. Observational studies investigating the association between informal caregiving for adults and loneliness or social isolation were included. In contrast, studies examining grandchild care or private care for chronically ill children were excluded. Data extractions covered study design, assessment of informal caregiving, loneliness and social isolation, the characteristics of the sample, the analytical approach and key findings. Study quality was assessed based on the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Each step (study selection, data extraction and evaluation of study quality) was conducted by two reviewers. Results: In sum, twelve studies were included in our review (seven cross-sectional studies and five longitudinal studies)—all included studies were either from North America or Europe. The studies mainly showed an association between providing informal care and higher loneliness levels. The overall study quality was fair to good. Conclusion: Our systematic review mainly identified associations between providing informal care and higher loneliness levels. This is of great importance in assisting informal caregivers in avoiding loneliness, since it is associated with subsequent morbidity and mortality. Moreover, high loneliness levels of informal caregivers may have adverse consequences for informal care recipients.

The association between dietary inflammatory index and risk of central obesity in adults: An updated systematic review and meta-analysis

2020 ◽  
Vol 90 (5-6) ◽  
pp. 535-552 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Central Obesity ◽  
Assessment Tool ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Obesity Indices

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.

Sign in / Sign up

Export Citation Format

Share Document