scholarly journals Associations of Food and Nutrient Intake with Serum Hepcidin and the Risk of Gestational Iron-Deficiency Anemia among Pregnant Women: A Population-Based Study

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3501
Author(s):  
Noor Rohmah Mayasari ◽  
Chyi-Huey Bai ◽  
Tzu-Yu Hu ◽  
Jane C.-J. Chao ◽  
Yi Chun Chen ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Nutrient Intake ◽  
Vegetable Consumption ◽  
Iron Status ◽  
Leafy Vegetables ◽  
Deficiency Anemia ◽  
Serum Hepcidin ◽  
Food And Nutrient Intake

Hepcidin is a regulator of iron metabolism. Diet affects the body’s iron status, but how it influences hepcidin concentrations and the risk of gestational iron-deficiency anemia (IDA) remains unclear. We investigated relationships of food and nutrient intake with serum hepcidin levels in relation to the iron status at a population scale. A retrospective cross-sectional study was conducted based on data obtained from the Nationwide Nutrition and Health Survey in pregnant women, Taiwan (2017~2020). In total, 1430 pregnant women aged 20~45 years with a singleton pregnancy were included. Data from blood biochemistry, 24-h dietary recall, and a food frequency questionnaire were collected during a prenatal checkup. Adjusted multivariate linear and logistic regression analyses were employed to measure the beta coefficient (ß) and 95% confidence interval (CI) of serum hepcidin and the odds ratio (OR) of IDA. In IDA women, serum hepcidin levels were positively correlated with the intake frequency of Chinese dim sum and related foods (β = 0.037 (95% CI = 0.015~0.058), p = 0.001) and dark leafy vegetables (β = 0.013 (0.001~0.025), p = 0.040), but they were negatively correlated with noodles and related products (β = −0.022 (−0.043~−0.001), p = 0.038). An adjusted multivariate logistic regression analysis showed that dietary protein [OR: 0.990 (0.981~1.000), p = 0.041], total fiber [OR: 0.975 (0.953~0.998), p = 0.031], and rice/rice porridge [OR: 1.007 (1.00~1.014), p = 0.041] predicted gestational IDA. Total carbohydrates [OR: 1.003 (1.000~1.006), p = 0.036], proteins [OR: 0.992 (0.985~0.999), p = 0.028], gourds/shoots/root vegetables [OR: 1.007 (0.092~1.010), p = 0.005], and to a lesser extent, savory and sweet glutinous rice products [OR: 0.069 (0.937~1.002), p = 0.067] and dark leafy vegetables [OR: 1.005 (0.999~1.011), p = 0.088] predicted IDA. The risk of IDA due to vegetable consumption decreased with an increasing vitamin C intake (p for trend = 0.024). Carbohydrates and vegetables may affect the gestational iron status through influencing hepcidin levels. Vitamin C may lower the risk of gestational IDA due to high vegetable consumption.

Impact of the WIC Program on the Iron Status of Infants

PEDIATRICS ◽  
1985 ◽  
Vol 75 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Virginia Miller ◽  
Sheldon Swaney ◽  
Amos Deinard
Keyword(s):  
Socioeconomic Status ◽  
Iron Deficiency ◽  
Nutritional Status ◽  
Pregnant Women ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Wic Program ◽  
Lactating Women ◽  
Supplemental Food ◽  
Women And Children

The WIC Program (Special Supplemental Food Program for Women, Infants and Children) was initiated in the early 1970s to improve the nutritional status of pregnant women, lactating women, and children from birth to 5 years of age who were at risk for nutritionally related health problems. Better hematologic status of a group of preschool-aged infants who were enrolled in the WIC Program from birth, as compared with another group of similar age and socioeconomic status from the pre-WIC Program era, suggests that participation in the WIC Program will help limit the development of iron depletion or iron deficiency anemia in young children, an important consideration in view of the deleterious hematologic and nonhematologic effects that have been attributed to those conditions.

scholarly journals IRON DEFICIENCY ANEMIA:

2012 ◽  
Vol 19 (02) ◽  
pp. 155-158
Author(s):  
SAEED SIDDIQUI ◽  
ATIF SITWAT HAYAT ◽  
M. KHALID SIDDIQUI ◽  
Naila Atif ◽  
Hamayun Shah
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
High Altitude ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Child Bearing ◽  
Age Range

Objectives: To estimate the frequency of iron deficiency anemia in a sample of population of pregnant women residingpermanently at high altitude of ≥5000 feet in different areas of district Abbottabad. Study Design: Cross sectional Study. Place & duration ofStudy: Northern Institute of Medical Sciences Abbottabad: From 17 August 2009 to 15 June 2010. Subjects and Methods: This study wascarried out on hundred pregnant women residing permanently at an altitude of ≥5000 feet above sea level in district Abbottabad. The agerange was fixed to 15-45 (child bearing age ) years. Suspected study participants having anemia were tested for iron status by serum ferritintest. Pregnant women having both anemia and iron deficiency were labeled as patients of Iron deficiency anemia. Results: The age range was15-41 years with a mean of + / - SD of 28.13 + / - 6.61. All women were of low and middle socioeconomic class with 74 % illiteracy. 60 % of womenhad birth spacing of two or less than two years. 64 % of pregnant women had three children. Anemia was detected in 74 % (X2 =9.42 p > 0.05),iron deficiency in 66 % (X2 = 14.76 p <0.01) and iron deficiency anemia in 60 % (X2 = 13.56 p < 0.01). Conclusions: High altitude residentpregnant women remain at high risk of developing iron deficiency anemia because of illiteracy, poverty and ignorance. With adequate nutritionand health education the problem can be addressed effectively.

scholarly journals Oral Iron Prophylaxis in Pregnancy: Not Too Little and Not Too Much!

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Nils Milman
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Cognitive Abilities ◽  
Ferrous Iron ◽  
Iron Status ◽  
Fetal Brain ◽  
Developed Countries ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Iron Deficient

An adequate supply of iron is essential for normal development of the fetus and newborn child. Iron deficiency and iron deficiency anemia (IDA) during pregnancy increase the risk of preterm birth and low birth weight. Iron is important for development of the fetal brain and cognitive abilities of the newborn. Children born to iron-deficient mothers will start their lives suffering from iron deficiency or even IDA. Oral iron prophylaxis to pregnant women improves iron status and prevents development of IDA. The Danish National Board of Health has since 1992 recommended prophylactic oral iron supplements to all pregnant women and the currently advocated dose is 40–50 mg ferrous iron taken between meals from 10 weeks gestation to delivery. However, 30–40 mg ferrous iron is probably an adequate dose in most affluent societies. In developed countries, individual iron prophylaxis guided by iron status (serum ferritin) has physiological advantages compared to general iron prophylaxis. In contrast, in most developing countries, general iron prophylaxis is indicated, and higher doses of oral iron, for example, 60 mg ferrous iron or even more should be recommended, according to the present iron status situation in the specific populations of women of fertile age and pregnant women.

scholarly journals Effect of Emblica Officinalis (amloki) on iron status in pregnant women with iron deficiency anaemia

2019 ◽  
Vol 14 (1) ◽  
pp. 1-6
Author(s):  
Tahmina Akter ◽  
Qazi Shamima Akhter
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Iron ◽  
Iron Supplementation ◽  
Binding Capacity ◽  
Iron Status ◽  
Ferritin Level ◽  
Deficiency Anemia ◽  
Iron Level ◽  
Emblica Officinalis

Background: Common clinical practice of prescribing Iron supplementation for Iron deficiency anemia (IDA) in pregnancy is associated with a number of side effects. Emblica officinalis (amloki) is a well known dietary supplement used by traditional practitioners to treat anemia. Objective: To evaluate the effects of oral supplementation of Emblica officinalis on iron status in pregnant women with IDA. Methods: This prospective interventional study was carried out in the Department of Physiology, Dhaka Medical College (DMC), Dhaka from July 2016 to June 2017 on 43 pregnant women aged 18 to 36 years between 13th to 20th weeks of gestation with IDA. They were recruited from the Out-patient department of Obstetrics and Gynaecology, DMC Hospital. Among them 24 were supplemented with amloki and iron (IAS) and 19 women received only iron supplementation (IS). Study variables were estimated at the baseline and after 45 days of supplementation. Serum iron, ferritin and Total iron binding capacity (TIBC) were estimated following standard laboratory methods. Data were expressed as mean ± SD. Paired and Unpaired Student’s t-test were used for statistical analysis. Results: Serum iron levels were significantly higher (p<0.001) and serum TIBC were significantly lower (p<0.001) in both groups after supplementation compared to their baseline value. But post supplementation serum ferritin level was significantly higher (p<0.01) only in IAS group compared to that of the baseline. Again, after intervention, serum iron level was significantly higher (p<0.05) and serum TIBC was significantly lower (p<0.01) in IAS group when compared with those of IS group. Conclusions: Data concluded that oral Emblica officinalis supplement along with iron was more effective than only iron supplementation to improve serum iron status in pregnant women with IDA. J Bangladesh Soc Physiol. 2019, June; 14(1): 1-6

Iron supplementation during pregnancy: what are the risks and benefits of current practices?

2007 ◽  
Vol 32 (2) ◽  
pp. 282-288 ◽  
Author(s):  
France M. Rioux ◽  
Caroline P. LeBlanc
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Current Knowledge ◽  
Iron Status ◽  
Gastrointestinal Symptoms ◽  
Deficiency Anemia ◽  
Dietary Reference Intake ◽  
Daily Dose

Iron-deficiency anemia is still prevalent among pregnant women living in industrialized countries such as Canada. To prevent this deficiency, iron supplements (30 mg/d) are routinely prescribed to Canadian pregnant women. Recently, dietary reference intakes for iron have increased from 18 and 23 mg/d during the second and third trimesters, respectively, to 27 mg/d throughout the pregnancy for all age groups. Whether this new recommendation implies an increase of iron dosage in supplements has not been answered. Are there any benefits or risks for the mother and her infant associated with iron supplementation during pregnancy? If iron supplementation is recommended, what should be the ideal dosage? This article reviews current knowledge on the potential negative or positive impact of iron supplementation during pregnancy on the outcomes of both infants and mothers. Based on the literature reviewed, a low daily dose of iron (30 mg elemental iron) during pregnancy improves women’s iron status and seems to protect their infants from iron-deficiency anemia. Several studies have also shown that a low daily dose of iron may improve birth weight even in non-anemic pregnant women. However, higher dosages are not recommended because of the potential negative effects on mineral absorption, oxidative pathways, and adverse gastrointestinal symptoms. To date, it is still not clear if health professionals should recommend routine or selective supplementation. However, neither routine nor selective iron supplementation during pregnancy is able to eliminate iron-deficiency anemia. Even though the dietary reference intake for iron during pregnancy has been recently increased, we do not recommend higher doses of iron in supplements designed for pregnant women.

scholarly journals Prognosis of iron deficiency anemia in pregnant women with different somatotypes

2021 ◽  
Vol 70 (2) ◽  
pp. 83-89
Author(s):  
Kristina G. Tomayeva ◽  
Sergey N. Gaidukov ◽  
Elena N. Komissarova ◽  
Leonid A. Kokoyev
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Hematological Parameters ◽  
Colorimetric Method ◽  
First Trimester ◽  
Study Groups ◽  
Deficiency Anemia ◽  
Serum Hepcidin

BACKGROUND: Anemia during pregnancy, undiagnosed and untreated promptly, is the cause of various obstetric complications: spontaneous miscarriages, premature birth, placental insufficiency, obstetric bleeding, ante- and intrapartum fetal death. AIM: The aim of this study was to evaluate the incidence of iron deficiency anemia in pregnant women with different somatotypes and to develop a prognostic model for the pathology onset. MATERIALS AND METHODS: We examined 390 pregnant women. Somatometry was performed according to the method of R.N. Dorokhov in terms of pregnancy not exceeding 9-10 weeks. Of the examined pregnant women, 110 were of the macrosomatotype, 173 of the meso- and 107 of the microsomatotype. In a clinical blood test, the levels of hemoglobin and red blood cells were determined using well-known methods. Blood iron levels were evaluated by the colorimetric method with ferrozine using a Parma Iron Reagents Kit (Parma Diagnostics Ltd., Russia). Serum hepcidin levels were determined spectrophotometrically using ELISA methods. RESULTS: Iron deficiency anemia was most commonly detected in pregnant women of the macro- and microsomatotype, when compared to those of the mesosomatotype (p 0.05). There was no severe anemia in the study groups. The levels of hematological parameters (serum iron and serum hepcidin) were significantly higher in the group of pregnant women with latent anemia, compared to the study group without signs of anemia (p 0.05). In the second trimester, iron deficiency anemia occurred in the group of patients with latent anemia. Using multiple regression analysis, a formula was obtained for predicting the onset of iron deficiency anemia in pregnant women of different somatotypes. CONCLUSIONS: Hematological parameters (serum iron and serum hepcidin) should be attributed to markers of iron deficiency anemia and timely predict the onset of pathology. The mathematical formula obtained allows predicting with high accuracy the onset of iron deficiency anemia in pregnant women, taking into account the somatotype in the first trimester of pregnancy, and timely preventing the onset of pathology.

scholarly journals Association of Infant Feeding Practices with Iron Status and Hematologic Parametersin Thai Infants at 6 Months of Age

2021 ◽  
Author(s):  
Chayatat Ruangkit ◽  
Nawapat Prachakittikul ◽  
Nutthida Hemprachitchai ◽  
Oraporn Dumrongwongsiri ◽  
Sasivimon Soonsawad
Keyword(s):  
Logistic Regression ◽  
Iron Deficiency ◽  
Infant Feeding ◽  
Iron Supplementation ◽  
Complete Blood Count ◽  
Reference Group ◽  
Iron Status ◽  
Feeding Practices ◽  
Deficiency Anemia ◽  
Infant Feeding Practices

Abstract Background: An infant's iron intake in the first 6 months of life comes solely from milk intake. However, infants' feeding practices vary, and their association with infants' iron status and hematologic parameters has not been well studied. We aimed to evaluate how different infant feeding practices associate with iron status and hematologic parameters among 6-month-old Thai infants. Methods: In a retrospective chart review, we identified 403 infants who attended a well-baby clinic and received laboratory screening for anemia (complete blood count and serum ferritin) at 6-month visits. Infants were categorized into four groups according to feeding practices. Hematologic parameters and incidence of anemia (hemoglobin [Hb]<11 g/dL), iron deficiency (ID; ferritin<12 ng/mL), and iron deficiency anemia (IDA; Hb<11 g/dL and ferritin<12 ng/mL) were compared between groups. Univariate and multiple logistic regression models were used to identify IDA associated factors among 6-month-old infants. Results: In total, 105 infants were breastfed (BF), 78 were breastfed with iron supplementation (BI), 109 infants were mixed-fed (breast milk and formula) with or without iron supplementation starting at age 4 months (MF), and 111 infants were formula-fed (FF). The BF group had the highest incidence of anemia, ID, and IDA. Anemia was found in 38.1% of BF infants compared with 21.8% of BI, 19.3% of MF, and 16.2% of FF infants (p<0.001). ID was found in 28.6% of BF infants compared with 3.8% of BI, 3.7% of MF, and 0.9% of FF infants (p<0.001). IDA was found in 17.1% of BF infants compared with 2.6% of BI, 0.9% of MF, and 0.9% of FF infants (p<0.001). In multivariate logistic regression, higher weight gain during 0–6 months slightly increased the risk of IDA and higher birth weight slightly decreased this risk. BI, MF, and FF infants had 90.4%, 97.5%, and 96.9% decreased risk of IDA, respectively, with BF infants as a reference group. Conclusion: The incidence of anemia, ID, and IDA at age 6 months was higher in BF than FF or partially BF infants. However, iron supplements in BF infants starting at 4 months significantly reduced their ID and IDA incidence.

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