scholarly journals Rhus chinensis Mill. Fruits Ameliorate Hepatic Glycolipid Metabolism Disorder in Rats Induced by High Fat/High Sugar Diet

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4480
Author(s):  
Zihuan Wu ◽  
Qingqing Ma ◽  
Shengbao Cai ◽  
Yilin Sun ◽  
Yuanyue Zhang ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Metabolic Disorders ◽  
Ethanol Extract ◽  
Key Factors ◽  
High Fat ◽  
Glycolipid Metabolism ◽  
High Sugar ◽  
Metabolism Disorder ◽  
Rhus Chinensis ◽  
Underlying Mechanisms

Hepatic glycolipid metabolism disorder is considered as one of the key factors in the pathogenesis of many chronic diseases. The objective of this study was to investigate the protective effect and underlying mechanisms of Rhus chinensis Mill. fruits against hepatic glycolipid metabolic disorders in rats induced by a high fat/high sugar diet. Results showed that ethanol extract, especially at a dose of 600 mg/kg b.w., could effectively ameliorate glycolipid metabolic disorders in rats. The biochemical indexes, including CAT, GSH and HOMA-IR, were significantly improved by the administration of ethanol extract. Immunohistochemistry and Western blot analysis revealed that ethanol extract up-regulated the expression levels of PI3K/AKT, PPAR-α, and the phosphorylation of IRS1 and AMPK proteins, and down-regulated the expressions of SREBP-1 and FAS proteins in the liver, which are closely related to hepatic glycolipid metabolism. Those findings suggested that R. chinensis Mill. fruits could be developed as functional foods and/or nutraceuticals for preventing or controlling some chronic diseases related to hepatic glycolipid metabolism disorder.

scholarly journals Kaempferide Improves Glycolipid Metabolism Disorder by Activating PPARγ in High-Fat-Diet-Fed Mice

2020 ◽  
Author(s):  
Qingfu Zeng ◽  
Heng Tang ◽  
Ting Tang ◽  
Peng Pu
Keyword(s):  
Signaling Pathway ◽  
High Fat Diet ◽  
Metabolic Diseases ◽  
Serum Insulin ◽  
High Fat ◽  
Glycolipid Metabolism ◽  
Metabolism Disorder ◽  
Pparγ Agonist ◽  
Underlying Mechanisms

Abstract Background: Kaempferide (Ka, 3,5,7-trihydroxy-4′-methoxyflavone), an active ingredient of Tagetes erecta L has been demonstrated to possess many pharmacological effects, including antioxidant, anti-inflammation, anticancer and antihypertension in previous study. However, there is no evidence of Ka on metabolic disorder in former studies. This study investigated the effects of Ka on glycolipid metabolism and explored the underlying mechanisms of action in vivo and vitro. Methods: High-fat diet (HFD) was used to induce the model of glycolipid metabolism disorder in mice.The hypolipidemic and hypoglycemic effect was detected by several indicators, like blood sample analysis blood glucose, serum insulin, HOMA index and intraperitoneal glucose tolerance tests (IPGTT). The signaling pathways of lipid metabolism (PPARγ/LXRα/ABCA1) and glucose metabolism (PPARγ/PI3K/AKT) were evaluated using Real-Time PCR and Western blot. The primary culture of hepatocytes was prepared to confirm the target of Ka by co-culturing with PPARγ agonist or inhibitor.Results: Administration of Ka at a dose of 10mg/kg for 16 weeks effectively attenuated obesity, hyperlipidemia, hyperglycemia and insulin resistance in HFD mice. Further studies revealed the hypolipidemic and hypoglycemic effects of Ka depended on the activation of PPARγ/LXRα/ABCA1 pathway and PPARγ/PI3K/AKT pathway, respectively. The primary hepatocyte test, co-cultured with PPARγ agonists or inhibitors, further confirmed the above signaling pathway and key protein. Conclusion: Ka played an important role in improving glycolipid metabolism disorder, which were causally associated with weight loss. The underlying mechanisms might are associated with the activation of PPARγ and its downstream signaling pathway. Our study helped to understand the pharmacological actions of Ka, and provides theoretical basis for Ka in the effective treatment of obesity, diabetes and other metabolic diseases.

Multigenerational effects of chronic maternal exposure to a high sugar/fat diet and physical training

2019 ◽  
Vol 11 (2) ◽  
pp. 159-167 ◽  
Author(s):  
Marcella Martins Terra ◽  
Tamiris Schaeffer Fontoura ◽  
Audryo Oliveira Nogueira ◽  
Jéssica Ferraz Lopes ◽  
Paulo Cézar de Freitas Mathias ◽  
...  
Keyword(s):  
Physical Training ◽  
Metabolic Disorders ◽  
Lactation Period ◽  
High Fat ◽  
Sedentary Control ◽  
High Sugar ◽  
Pregnancy And Lactation ◽  
Maternal Exercise ◽  
Diet Intake ◽  
Multigenerational Effects

AbstractPregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protective effect of physical exercise against possible metabolic changes in generations F1 and F2, whose mothers were subjected to a high-sugar/high-fat (HS/HF) diet. Wistar rats belonging to generation F0 were distributed into four groups (n = 10): sedentary control (CSed), exercised control (CExe), sedentary HS/HF diet (DHSed) and exercised HS/HF diet (DHExe). From 21 to 120 days of age, maintained during pregnancy and lactation period, CSed/CExe animals received standard feed and DHSed/DHExe animals a HS/HF diet. Animals from the CExe/DHExe underwent physical training from 21 to 120 days of age. Male and female F1 and F2 received a normocaloric feed and did not perform any physical training, categorized into four groups (n = 10) according to the maternal group to which they belonged to. An increase in body weight, adiposity and glucose, and a change in lipid profile in F0 were observed, while exercise reduced the biochemical parameters comparing DHSed with DHExe. Maternal exercise had an effect on future generations, reducing adiposity, glucose and triglyceride concentrations, and preventing deleterious effects on glucose tolerance. Maternal overeating increased health risks both for mother and offspring, demonstrating that an HS/HF diet intake promotes metabolic alterations in the offspring. Importantly, the physical training performed by F0 proved to be protective against such effects.

Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats

2018 ◽  
Vol 9 (6) ◽  
pp. 3419-3431 ◽  
Author(s):  
Wei-Ling Guo ◽  
Yu-Yang Pan ◽  
Lu Li ◽  
Tian-Tian Li ◽  
Bin Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Ganoderma Lucidum ◽  
Metabolic Disorders ◽  
Ethanol Extract ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition ◽  
Mrna Expression Levels

Ethanol extract from Ganoderma lucidum (GL95), enriched with triterpenoids, has the potential to ameliorate lipid metabolic disorders, in part through modulating specific gut microbiota and regulating the mRNA expression levels of the genes involved in lipid and cholesterol.

scholarly journals Kaempferide improves glycolipid metabolism disorder by activating PPARγ in high-fat-diet-fed mice

Life Sciences ◽  
2021 ◽  
Vol 270 ◽  
pp. 119133
Author(s):  
Heng Tang ◽  
Qingfu Zeng ◽  
Ting Tang ◽  
Yunjie Wei ◽  
Peng Pu
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Glycolipid Metabolism ◽  
Metabolism Disorder

The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet

2020 ◽  
Vol 11 (1) ◽  
pp. 799-812 ◽  
Author(s):  
Zihuan Wu ◽  
Yan Zhang ◽  
Xiarong Gong ◽  
Guiguang Cheng ◽  
Shibiao Pu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Preventive Effect ◽  
High Fat ◽  
Nonalcoholic Fatty Liver ◽  
Rhus Chinensis ◽  
Underlying Mechanisms

The objective of this study is to investigate the preventive effect of phenolic-rich extracts from Chinese sumac (Rhus chinensis Mill.) fruits against NAFLD in rats induced by a high-fat diet and to clarify the underlying mechanisms.

scholarly journals Eicosapentaenoic acid prevents high fat diet‐induced metabolic disorders: Genomic and metabolomic analyses of underlying mechanisms

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Monique LeMieux ◽  
Nishan Kalupahana ◽  
Wenting Xin ◽  
Catthareeya Thanamool ◽  
Victor Voorhees ◽  
...  
Keyword(s):  
Eicosapentaenoic Acid ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Underlying Mechanisms

scholarly journals PO-042 Effect of 8 weeks aerobic combined with resistance exercise on hepatic glycolipid metabolism induced by high fat diet in mice

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Jing Xiao
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Liver Weight ◽  
Exercise Group ◽  
Diet Group ◽  
Normal Diet ◽  
High Fat ◽  
Glycolipid Metabolism ◽  
Metabolism Disorder ◽  
Glucose And Lipid Metabolism

Objective C57 mice were fed with high-fat diet. After the pathological features were detected, a group of C57 high-fat diet mice were randomly selected for eight weeks aerobic and anti-resistance exercise. To observe the effect of exercise on liver glucose and lipid metabolism in mice fed with high fat. To explore the effect of exercise on liver glucose and lipid metabolism disorder caused by high fat feeding, to provide the direction and evidence for the treatment and rehabilitation of fatty liver and other diseases caused by high fat diet. C57 mice were fed with high-fat diet. After the pathological features were detected, a group of C57 high-fat diet mice were randomly selected for eight weeks aerobic and anti-resistance exercise. To observe the effect of exercise on liver glucose and lipid metabolism in mice fed with high fat. To explore the effect of exercise on liver glucose and lipid metabolism disorder caused by high fat feeding, to provide the direction and evidence for the treatment and rehabilitation of fatty liver and other diseases caused by high fat diet. Methods 30 male C57 mice were 8 weeks old, with an average weight of 20.02 ±0.06 g. The purchased mice were randomly divided into C57 diet group (n = 10) and high-fat diet group (n = 20). A pathological model of hepatic glycolipid metabolism disorder was established by high-fat feed feeding. The success of the model was measured by calculating the area under the blood glucose curve. After modeling, the C57 mice were randomly divided into high fat group and high fat exercise group, with 10 mice in each group. The mice in high fat exercise group were trained 6 days a week for 8 weeks. At the end of the exercise, the three groups were uniformly selected. Results 1. Compared with the normal diet quiet group, there was a significant difference in the area under the blood glucose curve in the high-fat diet quiet group (p < 0. 01). Compared with the quiet high-fat diet group, there was a significant difference in the area under the blood glucose curve after intraperitoneal injection of glucose in the high-fat diet exercise group (p < 0. 05). After two weeks of high fat diet feeding, the body weight of the quiet group was significantly higher than that of the quiet group fed with normal diet (p < 0.05). After two weeks exercise training of high-fat mice, the body weight of high-fat exercise group was significantly lower than that of quiet high-fat mice (p < 0.05). Compared with the normal diet group, the liver weight and liver weight of the high-fat quiet group increased (p < 0 01), while the liver weight and liver / body weight of the high-fat exercise group were lower than those of the high-fat quiet group (p < 0 05). The liver AST (aspartate amino transferase) and ALT(Alanine transferase) in the High-fat diet quiet group were significantly higher than those in the normal diet quiet group (p < 0. 01). The ALT (alanine transferase) in high-fat diet exercise group was lower than that in quiet high-fat diet group (p < 0.05). Conclusions 16-week high-fat diet can establish a pathological model of hepatic glycolipid metabolism disorder. Hyper-insulinemia, hyper-lipidemia and other pathological phenomena will occur in mice. 8 weeks aerobic combined with anti-exercise intervention can improve hepatic glycolipid metabolism disorder and liver function.

2038-P: Rice Endosperm Protein Intake in Childhood Suppresses the Development of High-Fat Diet-Induced Metabolic Disorders and Kidney Disease during Adulthood in Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2038-P
Author(s):  
YUKI HIGUCHI ◽  
MICHIHIRO HOSOJIMA ◽  
HIDEYUKI KABASAWA ◽  
SHOJI KUWAHARA ◽  
RYOHEI KASEDA ◽  
...  
Keyword(s):  
Kidney Disease ◽  
High Fat Diet ◽  
Protein Intake ◽  
Metabolic Disorders ◽  
High Fat ◽  
Rice Endosperm ◽  
Endosperm Protein
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