scholarly journals Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy

Nutrients ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 672 ◽  
Author(s):  
Rosita Aitoro ◽  
Lorella Paparo ◽  
Antonio Amoroso ◽  
Margherita Di Costanzo ◽  
Linda Cosenza ◽  
...  
Keyword(s):  
Food Allergy ◽  
Gut Microbiota ◽  
Therapeutic Intervention

scholarly journals A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1682
Author(s):  
Ewa Łoś-Rycharska ◽  
Marcin Gołębiewski ◽  
Marcin Sikora ◽  
Tomasz Grzybowski ◽  
Marta Gorzkiewicz ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Gut Microbiota ◽  
Bacterial Species ◽  
Rrna Gene ◽  
Healthy Children ◽  
Skin Microbiota ◽  
Fecal Samples ◽  
Healthy Infants ◽  
Α Diversity

The gut microbiota in patients with food allergy, and the skin microbiota in atopic dermatitis patients differ from those of healthy people. We hypothesize that relationships may exist between gut and skin microbiota in patients with allergies. The aim of this study was to determine the possible relationship between gut and skin microbiota in patients with allergies, hence simultaneous analysis of the two compartments of microbiota was performed in infants with and without allergic symptoms. Fifty-nine infants with food allergy and/or atopic dermatitis and 28 healthy children were enrolled in the study. The skin and gut microbiota were evaluated using 16S rRNA gene amplicon sequencing. No significant differences in the α-diversity of dermal or fecal microbiota were observed between allergic and non-allergic infants; however, a significant relationship was found between bacterial community structure and allergy phenotypes, especially in the fecal samples. Certain clinical conditions were associated with characteristic bacterial taxa in the skin and gut microbiota. Positive correlations were found between skin and fecal samples in the abundance of Gemella among allergic infants, and Lactobacillus and Bacteroides among healthy infants. Although infants with allergies and healthy infants demonstrate microbiota with similar α-diversity, some differences in β-diversity and bacterial species abundance can be seen, which may depend on the phenotype of the allergy. For some organisms, their abundance in skin and feces samples may be correlated, and these correlations might serve as indicators of the host’s allergic state.

scholarly journals Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile–Young Adult Rats

2019 ◽  
Vol 7 (10) ◽  
pp. 463 ◽  
Author(s):  
Tulyeu ◽  
Kumagai ◽  
Jimbo ◽  
Watanabe ◽  
Yokoyama ◽  
...  
Keyword(s):  
Food Allergy ◽  
Young Adult ◽  
Gut Microbiota ◽  
Tight Junction ◽  
Intestinal Permeability ◽  
Lactobacillus Reuteri ◽  
Intestinal Barrier ◽  
Mucosal Inflammation ◽  
Adult Rats ◽  
Epithelial Barrier Function

Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the contribution of intestinal microbiota. Juvenile–young adult rats were sensitized with ovalbumin and treated with antibiotics or probiotics (Clostridium butyricum and Lactobacillus reuteri), respectively. The serum ovalbumin-IgE levels, intestinal permeability, histopathological features, tight junction (TJ)-associated proteins, Th2 cytokines, and gut microbiota in feces were analyzed in each group. Sensitized rats showed an increase in ovalbumin-IgE levels and intestinal permeability with gut mucosal inflammation, whereas rats that received probiotics were only mildly affected. Rats given ovalbumin, but not those given probiotics, showed a reduction in both TJ-related protein expression and localization. Th2 cytokine levels were increased in the sensitized rats, but not in those given probiotics. TJs in rats treated with ovalbumin and antibiotics were disrupted, but those in rats administered probiotics were undamaged. Clostridiaceae were increased in the probiotics groups, especially Alkaliphilus, relative to the ovalbumin-sensitized group. Gut microbiota appears to play a role in regulating epithelial barrier function, and probiotics may help to prevent food sensitization through the up-regulation of TJ proteins.

Bifidobacterium breve M‐16V alters the gut microbiota to alleviate OVA‐induced food allergy through IL‐33/ST2 signal pathway

2020 ◽  
Vol 235 (12) ◽  
pp. 9464-9473 ◽  
Author(s):  
Na Li ◽  
Yi Yu ◽  
Xuehua Chen ◽  
Shenshen Gao ◽  
Qingqing Zhang ◽  
...  
Keyword(s):  
Food Allergy ◽  
Gut Microbiota ◽  
Signal Pathway ◽  
Bifidobacterium Breve

scholarly journals Microbial signature in IgE-mediated food allergies

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Michael R. Goldberg ◽  
Hadar Mor ◽  
Dafna Magid Neriya ◽  
Faiga Magzal ◽  
Efrat Muller ◽  
...  
Keyword(s):  
Food Allergy ◽  
Gut Microbiota ◽  
Learning Algorithm ◽  
Area Under The Curve ◽  
Food Allergies ◽  
Rrna Gene ◽  
Microbiota Composition ◽  
Α Diversity ◽  
Ige Mediated ◽  
Gut Microbiota Composition

Abstract Background Multiple studies suggest a key role for gut microbiota in IgE-mediated food allergy (FA) development, but to date, none has studied it in the persistent state. Methods To characterize the gut microbiota composition and short-chain fatty acid (SCFAs) profiles associated with major food allergy groups, we recruited 233 patients with FA including milk (N = 66), sesame (N = 38), peanut (N = 71), and tree nuts (N = 58), and non-allergic controls (N = 58). DNA was isolated from fecal samples, and 16S rRNA gene sequences were analyzed. SCFAs in stool were analyzed from patients with a single allergy (N = 84) and controls (N = 31). Results The gut microbiota composition of allergic patients was significantly different compared to age-matched controls both in α-diversity and β-diversity. Distinct microbial signatures were noted for FA to different foods. Prevotella copri (P. copri) was the most overrepresented species in non-allergic controls. SCFAs levels were significantly higher in the non-allergic compared to the FA groups, whereas P. copri significantly correlated with all three SCFAs. We used these microbial differences to distinguish between FA patients and non-allergic healthy controls with an area under the curve of 0.90, and for the classification of FA patients according to their FA types using a supervised learning algorithm. Bacteroides and P. copri were identified as taxa potentially contributing to KEGG acetate-related pathways enriched in non-allergic compared to FA. In addition, overall pathway dissimilarities were found among different FAs. Conclusions Our results demonstrate a link between IgE-mediated FA and the composition and metabolic activity of the gut microbiota.

scholarly journals The gut microbiota, environmental factors, and links to the development of food allergy

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Khui Hung Lee ◽  
Yong Song ◽  
Weidong Wu ◽  
Kan Yu ◽  
Guicheng Zhang
Keyword(s):  
Food Allergy ◽  
Environmental Factors ◽  
Gut Microbiota

scholarly journals Distinctive Gut Microbiota Signature in Persistent IgE-mediated Food Allergy

2019 ◽  
Vol 143 (2) ◽  
pp. AB189
Author(s):  
Michael Goldberg ◽  
Hadar Gershon ◽  
Michael Appel ◽  
Liat Nachshon ◽  
Michael B. Levy ◽  
...  
Keyword(s):  
Food Allergy ◽  
Gut Microbiota ◽  
Ige Mediated

scholarly journals Gut Microbiota in a Rat Oral Sensitization Model: Effect of a Cocoa-Enriched Diet

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Mariona Camps-Bossacoma ◽  
Francisco J. Pérez-Cano ◽  
Àngels Franch ◽  
Margarida Castell
Keyword(s):  
Food Allergy ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Allergic Diseases ◽  
Faecal Microbiota ◽  
Lewis Rats ◽  
Specific Antibodies ◽  
Intestinal Iga

Increasing evidence is emerging suggesting a relation between dietary compounds, microbiota, and the susceptibility to allergic diseases, particularly food allergy. Cocoa, a source of antioxidant polyphenols, has shown effects on gut microbiota and the ability to promote tolerance in an oral sensitization model. Taking these facts into consideration, the aim of the present study was to establish the influence of an oral sensitization model, both alone and together with a cocoa-enriched diet, on gut microbiota. Lewis rats were orally sensitized and fed with either a standard or 10% cocoa diet. Faecal microbiota was analysed through metagenomics study. Intestinal IgA concentration was also determined. Oral sensitization produced few changes in intestinal microbiota, but in those rats fed a cocoa diet significant modifications appeared. Decreased bacteria from the Firmicutes and Proteobacteria phyla and a higher percentage of bacteria belonging to the Tenericutes and Cyanobacteria phyla were observed. In conclusion, a cocoa diet is able to modify the microbiota bacterial pattern in orally sensitized animals. As cocoa inhibits the synthesis of specific antibodies and also intestinal IgA, those changes in microbiota pattern, particularly those of the Proteobacteria phylum, might be partially responsible for the tolerogenic effect of cocoa.

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