Bacteria Patterns on Tonsillar Surface and Tonsillar Core Tissue among Patients Scheduled for Tonsillectomy at Bugando Medical Centre, Mwanza, Tanzania

Background: Tonsillitis is an inflammation of the tonsils due to either viruses or bacteria. Here, we report the bacteria patterns on the tonsillar surface and tonsillar core tissue among patients scheduled for tonsillectomy at Bugando Medical Centre (BMC), Mwanza Tanzania. Methods: The study included 120 patients planned for tonsillectomy between April and July 2019. Swab samples from tonsillar surface pre-tonsillectomy and core post-tonsillectomy were collected. Culture was performed following the microbiology laboratory standard operating procedures. Data analysis was completed using STATA version 13, as per the study objectives. Results: The slight majority of participants were males (73; 60.83%) with median age of 6 years (interquartile range 4–11). The proportion of positive culture growth was higher on the surface than in core swab samples: 65 (54.2%) vs. 42 (35.0%), p = 0.003. The commonest bacterial pathogen detected from the surface and core were S. aureus in 29 (40.3%) and 22 (51.2%) participants, followed by S. pyogenes in 17 (23.6%) and 11 (25.6%), respectively. Methicillin-resistant Staphylococcus aureus (MRSA) was observed in 20/51 (39%) of isolates. Streptococcus pyogenes resistance to macrolides ranged from 8.3% for core isolates to 35.3% for surface isolates. Features suggestive of tonsillitis on histology were reported in 83 (73.5%) samples. Conclusion: More than two-thirds of patients undergoing tonsillectomy had a positive culture for possible bacterial pathogens. Staphylococcus aureus and Streptococcus pyogenes were the predominant bacteria detected with more than one third of Staphylococcus aureus being MRSA. More studies to investigate the treatment outcome of these patients are highly recommended.

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Bacteria Patterns on Tonsillar Surface and Tonsillar Core Tissue among Patients Scheduled for Tonsillectomy at Bugando Medical Centre

10.21203/rs.3.rs-640239/v1 ◽

2021 ◽

Author(s):

Gustave Buname ◽

Gapto Kiwale ◽

Vitus Silago ◽

Martha F Mushi ◽

Stephen E Mshana

Keyword(s):

Bacterial Pathogen ◽

Positive Culture ◽

Medical Centre ◽

Microbiology Laboratory ◽

Bugando Medical ◽

Positive Growth ◽

Standard Operating ◽

Core Tissue ◽

Bugando Medical Centre ◽

Culture Positive

Abstract Background: Tonsillitis is an inflammation of tonsils due to either viruses or bacteria. Here we report the bacteria patterns on tonsillar surface and tonsillar core tissue among patients scheduled for tonsillectomy at Bugando Medical Centre (BMC), Mwanza Tanzania.Methods: The study included 120 patients planned for tonsillectomy between April and July 2019. Swab samples from tonsilar surface pre-tonsillectomy and core post-tonsillectomy were collected. Culture was performed following the microbiology laboratory standard operating procedures. Data analysis was done using STATA version 13 as per study objectives.Results: The slightly majority of participants were males 73 (60.83%) with median age of 6 [IQR 4-11] years. The proportion of culture positive growth was high on surface than in core swab samples 65(54.2%) vs 42(35.0%), p=0.003. The commonest bacterial pathogen detected from the surface and core were S. aureus 29(40.3%) and 22(51.2%), followed by S. pyogenes, 17(23.6%) and 11(25.6%), respectively. Features suggestive of tonsillitis on histology were reported in 83 (73.5%) of samples. Conclusion: More than two-third of patients undergoing tonsillectomy had positive culture of possible bacterial pathogens. Streptococcus pyogenes and Staphylococcus aureus were the predominant bacteria detected. More studies to investigate the treatment outcome of these patients are highly recommended.

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Prevalence of clindamycin inducible resistance among methicillin-resistant Staphylococcus aureus at Bugando Medical Centre, Mwanza, Tanzania

Tanzania Journal of Health Research ◽

10.4314/thrb.v11i2.45197 ◽

2009 ◽

Vol 11 (2) ◽

Cited By ~ 8

Author(s):

SE Mshana ◽

E Kamugisha ◽

M Miramb ◽

P Chalya ◽

P Rambau ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Medical Centre ◽

Methicillin Resistant ◽

Inducible Resistance ◽

Bugando Medical ◽

Bugando Medical Centre

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Predominance of methicillin resistant Staphylococcus aureus -ST88 and new ST1797 causing wound infection and abscesses

The Journal of Infection in Developing Countries ◽

10.3855/jidc.2093 ◽

2012 ◽

Vol 6 (08) ◽

pp. 620-625 ◽

Cited By ~ 22

Author(s):

Nyambura Moremi ◽

Stephen E Mshana ◽

Erasmus Kamugisha ◽

Johannes Kataraihya ◽

Dennis Tappe ◽

...

Keyword(s):

Genetic Diversity ◽

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Medical Centre ◽

Clinical Isolates ◽

Methicillin Resistant ◽

Clinical Specimens ◽

Bugando Medical ◽

Mrsa Strains ◽

Bugando Medical Centre

Introduction: Although there has been a worldwide emergence and spread of methicillin-resistant Staphylococcus aureus (MRSA), little is known about the molecular epidemiology of MRSA in Tanzania. Methodology: In this study, we characterized MRSA strains isolated from clinical specimens at the Bugando Medical Centre, Tanzania, between January and December 2008. Of 160 S. aureus isolates from 600 clinical specimens, 24 (15%) were found to be MRSA. Besides molecular screening for the Panton Valentine leukocidin (PVL) genes by PCR, MRSA strains were further characterized by Multi-Locus Sequence Typing (MLST) and spa typing. Results: Despite considerable genetic diversity, the spa types t690 (29.1%) and t7231 (41.6%), as well as the sequence types (ST) 88 (54.2%) and 1797 (29.1%), were dominant among clinical isolates. The PVL genes were detected in 4 isolates; of these, 3 were found in ST 88 and one in ST1820. Resistance to erythromycin, clindamicin, gentamicin, tetracycline and co-trimoxazole was found in 45.8%, 62.5%, 41.6%, 45.8% and 50% of the strains, respectively. Conclusion: We present the first thorough typing of MRSA at a Tanzanian hospital. Despite considerable genetic diversity, ST88 was dominant among clinical isolates at the Bugando Medical Centre. Active and standardized surveillance of nosocomial MRSA infection should be conducted in the future to analyse the infection and transmission rates and implement effective control measures.

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Incidence and predictors of surgical site infections following caesarean sections at Bugando Medical Centre, Mwanza, Tanzania

Antimicrobial Resistance and Infection Control ◽

10.1186/2047-2994-3-25 ◽

2014 ◽

Vol 3 (1) ◽

pp. 25 ◽

Cited By ~ 44

Author(s):

Filbert J Mpogoro ◽

Stephen E Mshana ◽

Mariam M Mirambo ◽

Benson R Kidenya ◽

Balthazar Gumodoka ◽

...

Keyword(s):

Surgical Site Infections ◽

Medical Centre ◽

Bugando Medical ◽

Bugando Medical Centre

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Spectrum of maternal and perinatal outcomes among parturient women with preceding short inter-pregnancy interval at Bugando Medical Centre, Tanzania

Maternal Health Neonatology and Perinatology ◽

10.1186/s40748-014-0002-1 ◽

2015 ◽

Vol 1 (1) ◽

Cited By ~ 9

Author(s):

Athanase Lilungulu ◽

Dismas Matovelo ◽

Albert Kihunrwa ◽

Balthazar Gumodoka

Keyword(s):

Perinatal Outcomes ◽

Medical Centre ◽

Bugando Medical ◽

Bugando Medical Centre ◽

Inter Pregnancy Interval

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A Fibreoptic endoscopic study of upper gastrointestinal bleeding at Bugando Medical Centre in northwestern Tanzania: A retrospective review of 240 cases

BMC Research Notes ◽

10.1186/1756-0500-5-200 ◽

2012 ◽

Vol 5 (1) ◽

Cited By ~ 11

Author(s):

Hyasinta Jaka ◽

Mheta Koy ◽

Anthony Liwa ◽

Rodrick Kabangila ◽

Mariam Mirambo ◽

...

Keyword(s):

Gastrointestinal Bleeding ◽

Retrospective Review ◽

Upper Gastrointestinal Bleeding ◽

Medical Centre ◽

Bugando Medical ◽

Endoscopic Study ◽

Northwestern Tanzania ◽

Bugando Medical Centre ◽

Upper Gastrointestinal

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AWARENESS OF CHEMOTHERAPY SIDE EFFECTS AND ATTITUDE TOWARDS CHEMOTHERAPY USE AMONG CANCER PATIENTS ATTENDING ONCOLOGY CLINIC AT BUGANDO MEDICAL CENTRE, IN MWANZA, NORTHERN TANZANIA

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5.1900 ◽

2018 ◽

Vol 8 (5) ◽

pp. 448-454 ◽

Cited By ~ 1

Author(s):

Deogratias M Katabalo ◽

Raphael Matinde ◽

Stanley Mwita ◽

Karoli Marwa ◽

Nestory Masalu

Keyword(s):

Side Effects ◽

Cancer Cells ◽

Cancer Patients ◽

Cross Section ◽

Positive Attitude ◽

Medical Centre ◽

Bugando Medical ◽

Northern Tanzania ◽

Chemotherapy Side Effects ◽

Bugando Medical Centre

Background: Chemotherapy is the use of drugs to kill cancer cells. Because cancer cells generally grow and divide faster than normal cells, they are more susceptible to the action of these drugs. However, damage to healthy cells is unavoidable, and this damage accounts for the side effects linked to these drugs. Methodology: A cross section study was conducted at oncology department in Bugando Medical Centre. A sample of 216 people was recruited into the study. The data was collected by using the pre-constructed questionnaire. After data collection, the data was transferred into SPSS version 20 and analyzed. Results: The study found that 88 (40.7%) of the respondents were aware of the chemotherapy side effects whereby majority, 68 (77.3%) of these had been informed by the doctor. Most of the respondents, 197 (92.1%) had a positive attitude towards the use of chemotherapy. Conclusion: There is still poor awareness of the chemotherapy side effects among the cancer patients attending and receiving chemotherapy in oncology department at Bugando Medical Centre. However, most of the respondents had positive attitude towards the use of chemotherapy Keywords: Awareness, attitude, chemotherapy, side effects and Tanzania.

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