scholarly journals Role of Citicoline in the Management of Traumatic Brain Injury

2021 ◽  
Vol 14 (5) ◽  
pp. 410
Author(s):  
Julio J. Secades
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Brain Ischemia ◽  
Potential Role ◽  
Short Review ◽  
Excellent Safety Profile ◽  
Almost All ◽  
Recovery Of Consciousness

Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improvements in the treatment of TBI, neuroprotection is one of the upcoming improvements. Citicoline has been used in the management of brain ischemia related disorders, such as TBI. Citicoline has biochemical, pharmacological, and pharmacokinetic characteristics that make it a potentially useful neuroprotective drug for the management of TBI. A short review of these characteristics is included in this paper. Moreover, a narrative review of almost all the published or communicated studies performed with this drug in the management of patients with head injury is included. Based on the results obtained in these clinical studies, it is possible to conclude that citicoline is able to accelerate the recovery of consciousness and to improve the outcome of this kind of patient, with an excellent safety profile. Thus, citicoline could have a potential role in the management of TBI.

scholarly journals Role of Citicoline in the Management of Traumatic Brain Injury

2021 ◽  
Author(s):  
Julio J Secades
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Brain Ischemia ◽  
Potential Role ◽  
Short Review ◽  
Excellent Safety Profile ◽  
Almost All ◽  
Recovery Of Consciousness

Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improvements on the treatment of TBI, neuroprotection is one of the upcoming improvements. Citicoline has been used in the management of brain ischemia related disorders, such as TBI. Citicoline has biochemical, pharmacological, and pharmacokinetic characteristics that make it a potentially useful neuroprotective drug for the management of TBI. A short review of these characteristics is included in this paper. Also, a narrative review of almost all the published or communicated studies performed with this drug in the management of patients with head injury is included. Based on the results obtained in these clinical studies, it is possible to conclude that citicoline was able to accelerate recovery of consciousness and to improve the outcome of this kind of patients, with an excellent safety profile. Thus, citicoline could have a potential role in the management of TBI.

scholarly journals Creatine Supplementation and Brain Health

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 586 ◽  
Author(s):  
Hamilton Roschel ◽  
Bruno Gualano ◽  
Sergej M. Ostojic ◽  
Eric S. Rawson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Function ◽  
Cognitive Processing ◽  
Brain Function ◽  
Creatine Supplementation ◽  
Short Review ◽  
Future Research ◽  
Brain Health

There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.

The potential role of renin-angiotensin system in mild traumatic brain injury

2022 ◽  
Author(s):  
João Luís Vieira Monteiro de Barros ◽  
Maíra Glória Cardoso ◽  
Caroline Amaral Machado ◽  
Érica Leandro Marciano Vieira ◽  
Rodrigo Moreira Faleiro ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Potential Role ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Complications of head injury

2019 ◽  
pp. 521-530
Author(s):  
Fardad T. Afshari ◽  
Antonio Belli ◽  
Peter C Whitfield
Keyword(s):  
Traumatic Brain Injury ◽  
Young Adults ◽  
Brain Injury ◽  
Head Injury ◽  
Older People ◽  
Late Phase ◽  
Late Complications ◽  
Neuronal Tissue

Traumatic brain injury is a potentially devastating condition that affects many young adults and is increasingly seen in older people. In addition to initial insult to the neuronal tissue at the time injury, patients with traumatic brain injury may suffer from many physical and psychological complications. These complications further protract the path of recovery and pose challenges in treatment of this group of patients. In this chapter we aim to discuss early and late phase complications following traumatic brain injury and summarize the role of neurorehabilitation in the care of patients with head injury, with the understanding that classification by timing is an inexact science and there is considerable overlap between early and late complications.

Neuropsychiatric Sequelae of Stroke and Traumatic Brain Injury: The Role of Psychostimulants

1995 ◽  
Vol 25 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Marilyn F. Kraus
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Case Studies ◽  
Current Literature ◽  
Treatment Choice ◽  
Clinical Usefulness ◽  
Cognitive Symptoms ◽  
General Review

Objective: The primary purpose of this article is to review certain neuropsychiatric sequelae of stroke and traumatic brain injury (TBI), and the role of the psychostimulants methylphenidate (MPD) and dextroamphetamine (DAMP) in their treatment. Method: A general review of the topic is presented. Controlled and uncontrolled studies involving the use of the psychostimulants are discussed. These consist of 11 studies listed with Medline 2000 that deal specifically with stroke or head injury, with the oldest study reviewed dating back to 1984. Studies concerning the use of psychostimulants in the medically or neurologically ill are reviewed to the extent that they are pertinent. Results: The current literature consists primarily of uncontrolled case studies. However, these are reviewed and found to suggest a role for the use of the psychostimulants, which is discussed. Conclusions: In general, these drugs appear to be a reasonable treatment choice for certain types of mood, behavior, and cognitive symptoms following brain injury. However, it is noted that larger scale controlled studies are needed to adequately assess the clinical usefulness of these drugs.

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