scholarly journals Analysis of Boswellic Acid Contents and Related Pharmacological Activities of Frankincense-Based Remedies That Modulate Inflammation

2021 ◽  
Vol 14 (7) ◽  
pp. 660
Author(s):  
Friedemann Börner ◽  
Markus Werner ◽  
Johannes Ertelt ◽  
Jürgen Meins ◽  
Mona Abdel-Tawab ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Human Neutrophils ◽  
Boswellic Acid ◽  
Blood Monocytes ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Bioactive Ingredients ◽  
Ancient Times ◽  
Anti Inflammatory ◽  
Work Up

Extracts of frankincense, the gum resin of Boswellia species, have been extensively used in traditional folk medicine since ancient times and are still of great interest as promising anti-inflammatory remedies in Western countries. Despite their common therapeutic use and the intensive pharmacological research including studies on active ingredients, modes of action, bioavailability, pharmacokinetics, and clinical efficacy, frankincense preparations are available as nutraceuticals but have not yet approved as a drug on the market. A major issue of commercially available frankincense nutraceuticals is the striking differences in their composition and quality, especially related to the content of boswellic acids (BAs) as active ingredients, mainly due to the use of material from divergent Boswellia species but also because of different work-up and extraction procedures. Here, we assessed three frequently used frankincense-based preparations for their BA content and the interference with prominent pro-inflammatory actions and targets that have been proposed, that is, 5-lipoxygenase and leukotriene formation in human neutrophils, microsomal prostaglandin E2 synthase-1, and inflammatory cytokine secretion in human blood monocytes. Our data reveal striking differences in the pharmacological efficiencies of these preparations in inflammation-related bioassays which obviously correlate with the amounts of BAs they contain. In summary, high-quality frankincense extracts display powerful anti-inflammatory effectiveness against multiple targets which can be traced back to BAs as bioactive ingredients.

Oxy+ (arthrospira) and its medicinal importance: an appraisal

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Md Anzar Alam ◽  
Mohd Aleemuddin Quamri ◽  
Muzafar Din Ahmad Bhat ◽  
Siddiqui Aafreen ◽  
Ghulamuddin Sofi
Keyword(s):  
Linoleic Acid ◽  
Dietary Supplement ◽  
Autoimmune Disorders ◽  
Natural Source ◽  
Sulfated Polysaccharides ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Obesity Hypertension

AbstractOxy+ is a natural source of arthrospira found in nature, used as a dietary supplement and manufactured in Aruba for lifefactors. Arthrospira contains good quality of proteins, sulfated polysaccharides, γ-linoleic acid, along with an array of carotene and phytopigments, vitamins, and minerals which are reported to be antioxidant, immunomodulator, antihyperglycemic, antidyslipidemic, cardioprotective, hepatoprotective, antiviral, anticancerous, antihypertensive, anti-inflammatory, analgesic, neuroprotective and renoprotective activities. Several studies have shown arthrospira, and active ingredients of it revealed various pharmacological activities. It can be used for the management of various ailments such as diabetes, dyslipidemia, obesity, hypertension, cancer, arthritis, osteoarthritis, autoimmune disorders, etc. This review attempts to explore the hidden benefits of Oxy+ (arthrospira).

scholarly journals Anti-inflammatory and Anti-oxidative Activities of Polyacetylene from Dendropanax dentiger

2014 ◽  
Vol 9 (11) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Shih-Chang Chien ◽  
Yen-Hsueh Tseng ◽  
Wei-Ning Hsu ◽  
Fang-Hua Chu ◽  
Shang-Tzen Chang ◽  
...  
Keyword(s):  
Folk Medicine ◽  
No Production ◽  
Raw 264.7 ◽  
Dependent Manner ◽  
Antioxidant Gene ◽  
Mrna And Protein Expression ◽  
Ancient Times ◽  
Anti Inflammatory ◽  
Chemoprevention Agent ◽  
Dose Dependent

Dendropanax dentiger has been used as a folk medicine since ancient times. In our current study, we observed that D. dentiger exhibited a significant anti-inflammatory activity, which could efficiently inhibit nitric oxide (NO) production in the lipopolysaccharide (LPS)-induced macrophage inflammation assay. (9 Z,16 S)-16-Hydroxy-9,17-octadecadiene-12,14-diynoic acid (HODA) was isolated from the leaves of D. dentiger following a bioactivity guided fractionation protocol. Our data indicated that HODA significantly inhibited the NO production in LPS-induced RAW 264.7 murine macrophage cells (IC50 = 4.28 μM). Consistent with these observations, the mRNA and protein expression levels of iNOS were also inhibited by HODA in a dose-dependent manner. HODA also reduced the translocation of NF-κB into nuclear fractions. Meanwhile, HODA enhanced Nrf-2 activation and its downstream antioxidant gene HO-1. We concluded that HODA possessed significant anti-inflammatory and anti-oxidative activity; the compound may have a potential for development as a chemoprevention agent.

scholarly journals Ethanobotanical, phytochemical and pharmacological properties of Zizyphus nummularia (Burm. F.): A Review

2018 ◽  
Vol 10 (3) ◽  
pp. 137
Author(s):  
Babita Aggarwal ◽  
Pankaj Sharma ◽  
HS Lamba
Keyword(s):  
Mental Retardation ◽  
Folk Medicine ◽  
Present Review ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Anti Inflammatory

<p><em>Zizyphus nummularia</em> (Burm. F.), Family: Rhamnaceae, is widely distributed in dry regions of India. It is a bushy weed used as folk medicine. The plant is valued for its nutritional edible fruits. Traditionally, it is used in mental retardation, fever, diarrhea, dysentery. The plant has been evaluated for various pharmacological activities such as anti-inflammatory, anthelmintic, antibacterial, antifertility activity. Present review discusses phytochemistry and pharmacological aspects of the drug.</p>

scholarly journals Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1880
Author(s):  
Caterina Vicidomini ◽  
Valentina Roviello ◽  
Giovanni N. Roviello
Keyword(s):  
Potential Role ◽  
Folk Medicine ◽  
Drug Repurposing ◽  
Syzygium Aromaticum ◽  
Traditional Medicines ◽  
Antithrombotic Effects ◽  
Ancient Times ◽  
Anti Inflammatory ◽  
Problem Drug

The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2 infection is enormously affecting the worldwide health and economy. In the wait for an effective global immunization, the development of a specific therapeutic protocol to treat COVID-19 patients is clearly necessary as a short-term solution of the problem. Drug repurposing and herbal medicine represent two of the most explored strategies for an anti-COVID-19 drug discovery. Clove (Syzygium aromaticum L.) is a well-known culinary spice that has been used for centuries in folk medicine in many disorders. Interestingly, traditional medicines have used clove since ancient times to treat respiratory ailments, whilst clove ingredients show antiviral and anti-inflammatory properties. Other interesting features are the clove antithrombotic, immunostimulatory, and antibacterial effects. Thus, in this review, we discuss the potential role of clove in the frame of anti-COVID-19 therapy, focusing on the antiviral, anti-inflammatory, and antithrombotic effects of clove and its molecular constituents described in the scientific literature.

scholarly journals Phytomedicine - A Holistic Approach in Dentistry

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Rita Zarina ◽  
Jaini. J. L ◽  
Ektah Khosla
Keyword(s):  
Medicinal Plant ◽  
Folk Medicine ◽  
Holistic Approach ◽  
Herbal Products ◽  
Antibiotic Overuse ◽  
Ancient Times ◽  
Anti Inflammatory ◽  
Sedative Agents ◽  
Microbiological Properties

<div><p><em>Herbal products have been used since ancient times in folk medicine, involving both eastern and western medicinal traditions. Many plants with biological and anti-microbiological properties have been studied since there has been a relevant increase in the incidence of antibiotic overuse and misuse. In dentistry Phytomedicines has been used as anti-inflammatory, antibiotic, analgesic and sedative agents. This paper highlights certain medicinal plant which is used in dentistry as alternative and in holistic way.</em></p></div>

Oxy+ (arthrospira) and its medicinal importance: an appraisal

2020 ◽  
Vol 36 (4) ◽  
pp. 251-257
Author(s):  
Md Anzar Alam ◽  
Mohd Aleemuddin Quamri ◽  
Muzafar Din Ahmad Bhat ◽  
Siddiqui Aafreen ◽  
Ghulamuddin Sofi
Keyword(s):  
Linoleic Acid ◽  
Dietary Supplement ◽  
Autoimmune Disorders ◽  
Natural Source ◽  
Sulfated Polysaccharides ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Obesity Hypertension

Abstract Oxy+ is a natural source of arthrospira found in nature, used as a dietary supplement and manufactured in Aruba for lifefactors. Arthrospira contains good quality of proteins, sulfated polysaccharides, γ-linoleic acid, along with an array of carotene and phytopigments, vitamins, and minerals which are reported to be antioxidant, immunomodulator, antihyperglycemic, antidyslipidemic, cardioprotective, hepatoprotective, antiviral, anticancerous, antihypertensive, anti-inflammatory, analgesic, neuroprotective and renoprotective activities. Several studies have shown arthrospira, and active ingredients of it revealed various pharmacological activities. It can be used for the management of various ailments such as diabetes, dyslipidemia, obesity, hypertension, cancer, arthritis, osteoarthritis, autoimmune disorders, etc. This review attempts to explore the hidden benefits of Oxy+ (arthrospira).

scholarly journals Porophyllum Genus Compounds and Pharmacological Activities: A Review

2021 ◽  
Vol 89 (1) ◽  
pp. 7
Author(s):  
María José Vázquez-Atanacio ◽  
Mirandeli Bautista-Ávila ◽  
Claudia Velázquez-González ◽  
Araceli Castañeda-Ovando ◽  
Manasés González-Cortazar ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Current Knowledge ◽  
Folk Medicine ◽  
Western Hemisphere ◽  
Pharmacological Activities ◽  
New Class ◽  
Anti Inflammatory ◽  
Important Center

The genus Porophyllum (family Asteraceae) is native to the western hemisphere, growing in tropical and subtropical North and South America. Mexico is an important center of diversification of the genus. Plants belong of genus Porophyllum have been used in Mexican traditional medicine to treat kidney and intestinal diseases, parasitic, bacterial, and fungal infections and anti-inflammatory and anti-nociceptive activities. In this sense, several trials have been made on its chemical and in vitro and in vivo pharmacological activities. These studies were carried on the extracts and isolated compounds and support most of their reported uses in folk medicine as antifungal, antileishmanial, anti-inflammatory, anti-nociceptive and burn repair activities, and as a potential source of new class of insecticides. Bio guided phytochemical studies showed the isolation of thiophenes, terpenes and phenolics compounds, which could be responsible for the pharmacological activities. However, more pre-clinical assays that highlight the mechanisms of action of the compounds involved in pharmacological function are lacking. This review discusses the current knowledge of their chemistry, in vitro and in vivo pharmacological activities carried out on the plants belonging to the Porophyllum genus.

scholarly journals PHYTOCHEMICAL AND PHARMACOLOGICAL POTENTIAL OF ANNONA SPECIES: A REVIEW

2017 ◽  
Vol 10 (7) ◽  
pp. 68
Author(s):  
Amudha P ◽  
Vanitha Varadharaj
Keyword(s):  
Biological Activities ◽  
Folk Medicine ◽  
Pharmaceutical Preparations ◽  
Pharmacological Activities ◽  
Tropical Regions ◽  
Herbal Plants ◽  
Ancient Times ◽  
Pharmacological Potential ◽  
Ethnomedicinal Uses ◽  
Annona Reticulata

Herbal plants and phytogenic products have used for the treatment of various diseases from ancient times in the folklore medicine worldwide. Crude extracts from plants now play an important and valuable source for natural products that are used in the advancement of medicines against various diseases, for the improvement of pharmaceutical preparations and for novel bioscience research. One such plant genus is Annona, such as Annona muricata, Annona cherimola, Annona reticulata, Annona squamosa, and Annona senegalensis are some species widely cultivating in India and tropical regions of Asia for their edible fruits and medicinal values. These plants have been used for centuries as traditional folk medicine for the treatments of various diseases. The plants are considered to be a good source of vitamins, minerals, plant proteins, fibers, etc., as well as the plant is supposed to have many biological activities. This review describes the morphology and ecology of the plant, its ethnomedicinal uses, pharmacological activities, and phytoconstituents.

scholarly journals Antioxidant, Anti-inflammatory Activities and Polyphenol Profile of Rhamnus prinoides

2020 ◽  
Vol 13 (4) ◽  
pp. 55 ◽  
Author(s):  
Gui-Lin Chen ◽  
Fredrick Munyao Mutie ◽  
Yong-Bing Xu ◽  
Flora Didii Saleri ◽  
Guang-Wan Hu ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
No Production ◽  
Pharmacological Activities ◽  
Ic50 Value ◽  
Good Potential ◽  
Anti Inflammatory ◽  
Polyphenol Profile ◽  
First Time

Rhamnus prinoides L’Herit (R. prinoides) has long been widely consumed as folk medicine in Kenya and other Africa countries. Previous studies indicated that polyphenols were abundant in genus Rhamnus and exhibited outstanding antioxidant and anti-inflammatory activities. However, there are very few studies on such pharmacological activities and the polyphenol profile of this plant up to now. In the present study, the antioxidant activities of the crude R. prinoides extracts (CRE) and the semi-purified R. prinoides extracts (SPRE) of polyphenol enriched fractions were evaluated to show the strong radical scavenging effects against 1,1-diphenyl-2- picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) (0.510 ± 0.046 and 0.204 ± 0.005, mg/mL), and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) (0.596 ± 0.005 and 0.096 ± 0.004, mg/mL), respectively. Later, the SPRE with higher contents of polyphenols and flavonoids displayed obvious anti-inflammatory activities through reducing the NO production at the dosage of 11.11 − 100 μg/mL, and the COX-2 inhibitory activity with an IC50 value at 20.61 ± 0.13 μg/mL. Meanwhile, the HPLC-UV/ESI-MS/MS analysis of polyphenol profile of R. prinoides revealed that flavonoids and their glycosides were the major ingredients, and potentially responsible for its strong antioxidant and anti-inflammatory activities. For the first time, the present study comprehensively demonstrated the chemical profile of R. prinoides, as well as noteworthy antioxidant and anti-inflammatory activities, which confirmed that R. prinoides is a good natural source of polyphenols and flavonoids, and provided valuable information on this medicinal plant as folk medicine and with good potential for future healthcare practice.

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis

2019 ◽  
Vol 25 (6) ◽  
pp. 715-728 ◽  
Author(s):  
Hai-Yue Lan ◽  
Bin Zhao ◽  
Yu-Li Shen ◽  
Xiao-Qin Li ◽  
Su-Juan Wang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Southeast Asia ◽  
Clinical Application ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Momordica Cochinchinensis

Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benificial for health and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. More than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacological studies and clinical practice demonstrate that some chemical constituents of M. cochinchinensis possess wide pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammatory, etc. This paper reviews the phytochemistry, pharmacological activities, toxicity, and clinical application of M. cochinchinensis, aiming to bring new insights into further research and application of this ancient herb.

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