Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals
Keyword(s):
The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of 18F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [18F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [18F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.
1980 ◽
Vol 44
(02)
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pp. 081-086
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1964 ◽
Vol 12
(01)
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pp. 232-261
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1995 ◽
Vol 6
(3-6)
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pp. 251-260
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2019 ◽
Vol 26
(30)
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pp. 5609-5624
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