scholarly journals Azacitidine Omega-3 Self-Assemblies: Synthesis, Characterization, and Potent Applications for Myelodysplastic Syndromes

2021 ◽  
Vol 14 (12) ◽  
pp. 1317
Author(s):  
Milad Baroud ◽  
Elise Lepeltier ◽  
Yolla El-Makhour ◽  
Nolwenn Lautram ◽  
Jerome Bejaud ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Myelodysplastic Syndromes ◽  
Self Assembly ◽  
The Elderly ◽  
Human Cell Line ◽  
Acid Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Multilamellar Vesicle ◽  
Stable Arrangement

5-Azacitidine, a cytidine analogue used as a hypomethylating agent, is one of the main drugs for the treatment of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) in the elderly. However, after administration, it exhibits several limitations, including restricted diffusion and cellular internalization due to its hydrophilicity, and a rapid enzymatic degradation by adenosine deaminase. The aim of this study was to improve the drug cell diffusion and protect it from metabolic degradation via the synthesis of amphiphilic prodrugs and their potential self-assembly. Azacitidine was conjugated to two different omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The carboxylic acid group of the omega-3 fatty acids was effectively conjugated to the amine group of the azacitidine base, yielding two amphiphilic prodrugs. Nanoprecipitation of the obtained prodrugs was performed and self-assemblies were successfully obtained for both prodrugs, with a mean diameter of 190 nm, a polydispersity index below 0.2 and a positive zeta potential. The formation of self-assemblies was confirmed using pyrene as a fluorescent dye, and the critical aggregation concentrations were determined: 400 µM for AzaEPA and 688 µM for AzaDHA. Additionally, the stability of the obtained self-assemblies was studied and after 5 days their final stable arrangement was reached. Additionally, cryo-TEM revealed that the self-assemblies attain a multilamellar vesicle supramolecular structure. Moreover, the obtained self-assemblies presented promising cytotoxicity on a leukemia human cell line, having a low IC50 value, comparable to that of free azacitidine.

scholarly journals Effects of exergame training combined with omega-3 fatty acids on the elderly brain: a randomized double-blind placebo-controlled trial

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Alexandra Schättin ◽  
Corinne Baier ◽  
Domenique Mai ◽  
Verena Klamroth-Marganska ◽  
Isabelle Herter-Aeberli ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Controlled Trial ◽  
The Elderly ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Omega 3 fatty acids in the elderly

2012 ◽  
Vol 107 (S2) ◽  
pp. S137-S151 ◽  
Author(s):  
Natalia Úbeda ◽  
María Achón ◽  
Gregorio Varela-Moreiras
Keyword(s):  
Quality Of Life ◽  
Fatty Acids ◽  
The Elderly ◽  
Normal Aging ◽  
Population Ageing ◽  
Sufficient Evidence ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pathological Conditions

Population ageing affects the entire world population. Also at world level one can observe a sharp increase in the proportion of older people. The challenge posed by population ageing translates into ensuring that the extra years of life will be as good as possible, free from high-cost dependency. Omega-3 fatty acids are now generally recognized as potential key nutrients to prevent the pathological conditions associated to the aging process. Ageing physiological process, its association with quality of life and the impact of omega-3 fatty acids intake and/or status is the focus of the present review. This report deals with the effects of omega-3 fatty acids on normal aging of older adults ( ≥  65 years) mainly on the effects such as nutritional status itself, cognition, bone health, muscle tonus, and general health status. The preliminary broad search of the literature on the effects of omega-3 fatty acids on normal aging yielded 685 citations. Forty two full text papers were checked for inclusion and thirty six studies were finally included in this review. It may be concluded that paradoxically even though the elderly population is the largest one, the number of studies and the methodology employed clearly lacks of sufficient evidence to establish definite conclusions on the effects of omega-3 fatty acids on aging metabolism without pathological conditions and on quality of life.

scholarly journals The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly

2018 ◽  
Vol 16 (3) ◽  
pp. 308-326 ◽  
Author(s):  
Stefano Farioli-Vecchioli ◽  
Stefano Sacchetti ◽  
Nicolis V. di Robilant ◽  
Debora Cutuli
Keyword(s):  
Fatty Acids ◽  
Physical Exercise ◽  
The Elderly ◽  
Depressive Illness ◽  
Omega 3 Fatty Acids ◽  
Omega 3

The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study

2011 ◽  
Vol 261 (8) ◽  
pp. 539-549 ◽  
Author(s):  
Yaser Tajalizadekhoob ◽  
Farshad Sharifi ◽  
Hossein Fakhrzadeh ◽  
Mojde Mirarefin ◽  
Maryam Ghaderpanahi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Low Dose ◽  
The Elderly ◽  
Controlled Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Moderate Depression

scholarly journals Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3739
Author(s):  
Ya-Hui Huang ◽  
Wan-Chun Chiu ◽  
Yuan-Pin Hsu ◽  
Yen-Li Lo ◽  
Yuan-Hung Wang
Keyword(s):  
Fatty Acids ◽  
Muscle Mass ◽  
Walking Speed ◽  
Meta Analysis ◽  
Mass Gain ◽  
The Elderly ◽  
Cochrane Library ◽  
Omega 3 Fatty Acids ◽  
Omega 3

There is increasing evidence showing the role of fatty acids and their derived lipid intermediates in the regulation of skeletal muscle mass synthesis and function. However, the role of omega-3 fatty acids remains unclear. Therefore, we conducted a meta-analysis to evaluate the potential effects of omega-3 fatty acids on sarcopenia-related performances among the elderly. Eligible literature and reports of randomized controlled trials were comprehensively searched from the PubMed, Cochrane Library, ClinicalTrials.gov, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases until July 2018. A total of 10 articles were available for the meta-analysis. There were minor benefits for muscle mass gain (0.33 kg; 95% CI: 0.05, 0.62) and timed up and go performance (−0.30 s; 95% CI: −0.43, −0.17). Subgroup analyses regarding muscle mass and walk speed indicated that omega-3 fatty acid supplements at more than 2 g/day may contribute to muscle mass gain (0.67 kg; 95% CI: 0.16, 1.18) and improve walking speed, especially for those receiving more than 6 months of intervention (1.78 m/sec; 95% CI: 1.38, 2.17). Our findings provide some insight into the effects of omega-3 fatty acids on muscle mass, especially for those taking supplements at more than 2 g/day. We also observed that a long period of omega-3 fatty acids supplementation may improve walking speed.

Cheese fortification using saturated monoglyceride self-assembly structures as carrier of omega-3 fatty acids

2015 ◽  
Vol 50 (9) ◽  
pp. 2129-2134 ◽  
Author(s):  
Sonia Calligaris ◽  
Alexandra Ignat ◽  
Marialuisa Biasutti ◽  
Nadia Innocente ◽  
Maria Cristina Nicoli
Keyword(s):  
Fatty Acids ◽  
Self Assembly ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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