scholarly journals Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 305 ◽  
Author(s):  
Bishweshwar Pant ◽  
Mira Park ◽  
Soo-Jin Park
Keyword(s):  
Drug Delivery ◽  
Electrospun Nanofibers ◽  
Coaxial Electrospinning ◽  
Burst Release ◽  
High Porosity ◽  
Nanofiber Membrane ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Small Pore ◽  
Drug Delivery Applications

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.

scholarly journals Preparation of poly(lactic acid)/graphene oxide nanofiber membranes with different structures by electrospinning for drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16619-16625 ◽  
Author(s):  
Zhou Mao ◽  
Jialiang Li ◽  
Wenjie Huang ◽  
Hao Jiang ◽  
Bhahat Lawlley Zimba ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Graphene Oxide ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
Burst Release ◽  
Nanofiber Membrane ◽  
Initial Burst ◽  
Nanofiber Membranes ◽  
Sheath Structure

PLA/GO nanofiber membrane with the co-axial structure exhibited the improved mechanical properties, which is also beneficial to separately loading different drugs in core-/sheath-structure and suppressing the initial burst release of drugs.

The effect of crosslinking agent on sustained release of bFGF–collagen microspheres

RSC Advances ◽  
2015 ◽  
Vol 5 (44) ◽  
pp. 34511-34516 ◽  
Author(s):  
Ting Liu ◽  
Nianhua Dan ◽  
Weihua Dan
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Crosslinking Agent ◽  
Delivery Systems ◽  
Burst Release ◽  
Initial Burst ◽  
Initial Burst Release

Initial burst release and loss of bioactivity of drugs are the shortcomings of drug delivery systems (DDSs) used for in vivo treatment.

SUSTAINED RELEASE OF INSULIN FROM POLOXAMER GELS INTERPENETRATED BY POLYION COMPLEXATION OF CHITOSAN-HYALURONIC ACID NETWORK

2010 ◽  
Vol 22 (06) ◽  
pp. 475-480
Author(s):  
Ming-Chia Yang ◽  
Jiun-Sheng Yang ◽  
Yi-You Huang ◽  
Ming-Jium Shieh ◽  
Tze-Wen Chung
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Sustained Release ◽  
Insulin Release ◽  
Burst Release ◽  
Protein Drug ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Protein Drug Delivery

This study investigates in vitro the protein drug delivery characteristics of new thermal sensitive gels, poloxamer (P)–chitosan (CS)/hyaluronic acid (HA) gels (P–CS/HA), in which a CS solution is interacting with various concentrations of HA that interpenetrates P gels. The polyion complexation occurs between CS and HA that can protect drugs from proteolysis. The results indicate that the swelling ratios of all P–CS/HA gels are markedly superior to those of nonswelling P and P–CS gels. For example, P–CS/HA (0.5% (w/w)) gels have swelling ratios of 48.3 ± 2.7% (w/w), which are maintained for approximately 0.5 h in water at 37°C. In vitro releases of insulin from P–CS/HA (0.5% (w/w)) gels had significantly lowered initial burst release (P < 0.01) and lasted much longer than those from gels without a CS network. The duration of insulin release was in a significantly sustained manner for up to 3.5 h, which was about two times or longer than the period of delivery using P or P–CS gels.

Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study

2018 ◽  
Vol 106 (4) ◽  
pp. 1092-1103 ◽  
Author(s):  
Masoud Dadras Chomachayi ◽  
Atefeh Solouk ◽  
Somaye Akbari ◽  
Davoud Sadeghi ◽  
Fereshteh Mirahmadi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Silk Fibroin ◽  
Electrospun Nanofibers ◽  
Thyme Essential Oil ◽  
Release Study ◽  
Drug Delivery Applications

scholarly journals PLGA Microspheres of hGH of Preserved Native State Prepared Using a Self-Regulated Process

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 683
Author(s):  
Jebun Nessa Diana ◽  
Ying Tao ◽  
Qiran Du ◽  
Meng Wang ◽  
Chinta Uday Kumar ◽  
...  
Keyword(s):  
Osmotic Pressure ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
High Dose ◽  
Burst Release ◽  
Polymeric Microspheres ◽  
Aqueous Emulsion ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Physical Chemical

The challenges of formulating recombinant human growth hormone (rhGH) into sustained-release polymeric microspheres include two mutual causal factors, protein denaturing by the formulation process and severe initial burst release related with relative high dose. The stabilizers to protect the proteins must not evoke osmotic pressure inside the microspheres, and the contact of the protein with the interface between water and organic solution of the polymer must be minimized. To meet these criteria, rhGH was pre-formulated into polysaccharide particles via an aqueous–aqueous emulsion in the present study, followed by encapsulating the particles into microspheres through a self-regulated process to minimize the contact of the protein with the water–oil interface. Polysaccharides as the protein stabilizer did not evoke osmotic pressure as small sugar stabilizers, the cause of severe initial burst release. Reduced initial burst enabled reduced protein loading to 9% (from 22% of the once commercialized Nutropin depot), which in turn reduced the dosage form index from 80 to 8.7 and eased the initial burst. A series of physical chemical characterizations as well as biologic and pharmacokinetic assays confirmed that the present method is practically feasible for preparing microspheres of proteins.

Emulsion electrospun polylactic acid/Apocynum venetum nanocellulose nanofiber membranes with controlled sea buckthorn extract release as a drug delivery system

2020 ◽  
pp. 004051752097017
Author(s):  
Lu Wang ◽  
Chenmeizi Wang ◽  
Ling Wang ◽  
Qingle Zhang ◽  
Ying Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polylactic Acid ◽  
Encapsulation Efficiency ◽  
Sea Buckthorn ◽  
Burst Release ◽  
Nanofiber Membrane ◽  
Apocynum Venetum ◽  
Nanofiber Membranes ◽  
Sheath Structure

Prolonging the duration of drug action and reducing toxicity play a vital role in wound administration as they reduce the chance of infection and decrease complications and cost. This study reports the natural antioxidant procyanidins extracted from sea buckthorn (SBT) and laboratory-manufactured Apocynum venetum cellulose nanofiber as core drugs. The sustained-release nanofiber membrane was prepared by electrospinning on polylactic acid/polyvinyl pyrrolidone nanofibers. High-performance liquid chromatography-mass spectrometry was used to identify the phenolic compounds in SBT extracts and confirmed the presence of procyanidins with a content of 0.0345 mg/g. The nanofiber membrane was characterized through transmission electron microscopy, encapsulation efficiency, in vitro drug-release study and antioxidant assay. The results indicated that the extracted procyanidins were successfully encapsulated in the core–sheath structure nanofibers, and the encapsulation efficiency of nanofiber membranes reached 83.84%. In vitro measurements of the delivery showed this core–sheath structure could significantly alleviate the drug burst release, which is followed by a linear and smooth release within 30 hours. Further tests showed that the removal efficiency of 2,2-diphenyl-1-picrylhydrazyl reached 88.62%, indicating that the membranes had high antioxidant activity. This work implies that the combination of Apocynum venetum nanocellulose and emulsion electrospun fibers has promising potential applications in tissue engineering or drug delivery.

scholarly journals Effect of Self-healing Encapsulation on the Initial Burst Release from PLGA Microspheres Containing a Long-Acting Prostacyclin Agonist, ONO-1301

2017 ◽  
Vol 65 (7) ◽  
pp. 653-659 ◽  
Author(s):  
Mai Hazekawa ◽  
Honami Kojima ◽  
Tamami Haraguchi ◽  
Miyako Yoshida ◽  
Takahiro Uchida
Keyword(s):  
Burst Release ◽  
Self Healing ◽  
Plga Microspheres ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Long Acting
Sign in / Sign up

Export Citation Format

Share Document