Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.

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Cold plasma treated thyme essential oil/silk fibroin nanofibers against Salmonella Typhimurium in poultry meat

Food Packaging and Shelf Life ◽

10.1016/j.fpsl.2019.100337 ◽

2019 ◽

Vol 21 ◽

pp. 100337 ◽

Cited By ~ 16

Author(s):

Lin Lin ◽

Xue Liao ◽

Haiying Cui

Keyword(s):

Essential Oil ◽

Salmonella Typhimurium ◽

Silk Fibroin ◽

Cold Plasma ◽

Poultry Meat ◽

Thyme Essential Oil ◽

Silk Fibroin Nanofibers

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Silk Fibroin Based Drug Delivery Applications: Promises and Challenges

Current Drug Targets ◽

10.2174/1389450119666171227205525 ◽

2018 ◽

Vol 19 (10) ◽

pp. 1177-1190 ◽

Cited By ~ 12

Author(s):

Shahid Ud Din Wani ◽

Gangadharappa Hosahalli Veerabhadrappa

Keyword(s):

Drug Delivery ◽

Silk Fibroin ◽

Drug Delivery Applications

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Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy

Nanomaterials ◽

10.3390/nano9040656 ◽

2019 ◽

Vol 9 (4) ◽

pp. 656 ◽

Cited By ~ 27

Author(s):

Rafael Contreras-Cáceres ◽

Laura Cabeza ◽

Gloria Perazzoli ◽

Amelia Díaz ◽

Juan Manuel López-Romero ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Electrospun Nanofibers ◽

Poly Lactic Acid ◽

Colloidal Nanoparticles ◽

Stimuli Responsive ◽

Cancer Treatments ◽

Polymeric Nanofibers ◽

Drug Delivery Applications ◽

New Strategies

Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.

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Preparation, characterization and antimicrobial activity of chitosan microparticles with thyme essential oil

Hemijska industrija ◽

10.2298/hemind140415048p ◽

2014 ◽

Vol 68 (6) ◽

pp. 721-729 ◽

Cited By ~ 4

Author(s):

Danijela Pecarski ◽

Zorica Knezevic-Jugovic ◽

Suzana Dimitrijevic-Brankovic ◽

Katarina Mihajilovski ◽

Slobodan Jankovic

Keyword(s):

Drug Delivery ◽

Antimicrobial Activity ◽

Particle Size ◽

Essential Oil ◽

Essential Oils ◽

Drug Delivery System ◽

Delivery System ◽

Thyme Oil ◽

Chitosan Microparticles ◽

Thyme Essential Oil

Considering the therapeutic effects of formulations with violate essential oils, development of an available drug delivery system is of great interest, especially assuming the fact that using essential oils as antimicrobial agents is a rather expanded in antimicrobial therapy nowadays. In this work, chitosan microparticles with encapsulated thyme essential oil were prepared by the emulsion cross-linking method. The effect of thyme oil and glutaraldehyde initial concentrations on particle size, morphology, and particle size distribution was investigated. In addition, the influence of these parameters on the encapsulation of thyme oil in chitosan microparticles, concerning thyme oil loadings and encapsulation efficiency was also tested. The particles showed a spherical shape with an average diameter from 4.71?1.42 to 13.65?4.34 m, depending on the concentration of the essential oil and glutaraldehyde that were used. The diameter of microparticles appeared to increase with increasing the thyme essential oil concentration, and decreased with the increase of glutaraldehyde concentration. It was shown that the concentration of glutaraldehyde did not affect the degree of encapsulation, but the increase in the initial concentration of thyme oil increased the degree of encapsulation of this essential oil in chitosan microparticles. All particles containing thyme essential oil, as well as essential oil of thyme itself showed significant antimicrobial activity against Staphylococcus aureus ATCC 25923, Esherichia coli ATCC 25922, Candida albicans ATCC 24433, Enterococcus faecalis ATCC 25929. This study showed a great potential of the use of thyme essential oil as an antimicrobial agent, especially when encapsulated in a drug delivery system with controlled release of the active antimicrobial component.

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Functionalization Techniques for Electrospun Nanofibers for Drug Delivery Applications: A Review

Usak University Journal of Material Sciences ◽

10.12748/uujms.201429447 ◽

2014 ◽

Vol 3 (2) ◽

pp. 180-180

Author(s):

Ramazan Erdem ◽

Erhan Sancak

Keyword(s):

Drug Delivery ◽

Electrospun Nanofibers ◽

Drug Delivery Applications

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Release study and inhibitory activity of thyme essential oil-loaded chitosan nanoparticles and nanocapsules against foodborne bacteria

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2017.05.063 ◽

2017 ◽

Vol 103 ◽

pp. 409-414 ◽

Cited By ~ 42

Author(s):

M. Sotelo-Boyás ◽

Z. Correa-Pacheco ◽

S. Bautista-Baños ◽

Y. Gómez y Gómez

Keyword(s):

Essential Oil ◽

Inhibitory Activity ◽

Chitosan Nanoparticles ◽

Foodborne Bacteria ◽

Thyme Essential Oil ◽

Release Study

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Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications

Pharmaceutics ◽

10.3390/pharmaceutics11010006 ◽

2018 ◽

Vol 11 (1) ◽

pp. 6 ◽

Cited By ~ 35

Author(s):

Fuat Topuz ◽

Tamer Uyar

Keyword(s):

Drug Delivery ◽

Water Solubility ◽

Drug Carrier ◽

Drug Loading ◽

Electrospun Nanofibers ◽

High Specific Surface Area ◽

Drug Molecules ◽

Drug Delivery Applications ◽

The Stability ◽

Functional Nanofibers

Electrospun nanofibers have sparked tremendous attention in drug delivery since they can offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun nanofibers to greatly expand their drug loading capacity or to provide the sustained release of the embedded drug molecules. In this regard, cyclodextrins (CyD) are considered as ideal drug carrier molecules as they are natural, edible, and biocompatible compounds with a truncated cone-shape with a relatively hydrophobic cavity interior for complexation with hydrophobic drugs and a hydrophilic exterior to increase the water-solubility of drugs. Further, the formation of CyD-drug inclusion complexes can protect drug molecules from physiological degradation, or elimination and thus increases the stability and bioavailability of drugs, of which the release takes place with time, accompanied by fiber degradation. In this review, we summarize studies related to CyD-functional electrospun nanofibers for drug delivery applications. The review begins with an introductory description of electrospinning; the structure, properties, and toxicology of CyD; and CyD-drug complexation. Thereafter, the release of various drug molecules from CyD-functional electrospun nanofibers is provided in subsequent sections. The review concludes with a summary and outlook on material strategies.

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