Emulsion electrospun polylactic acid/Apocynum venetum nanocellulose nanofiber membranes with controlled sea buckthorn extract release as a drug delivery system

Prolonging the duration of drug action and reducing toxicity play a vital role in wound administration as they reduce the chance of infection and decrease complications and cost. This study reports the natural antioxidant procyanidins extracted from sea buckthorn (SBT) and laboratory-manufactured Apocynum venetum cellulose nanofiber as core drugs. The sustained-release nanofiber membrane was prepared by electrospinning on polylactic acid/polyvinyl pyrrolidone nanofibers. High-performance liquid chromatography-mass spectrometry was used to identify the phenolic compounds in SBT extracts and confirmed the presence of procyanidins with a content of 0.0345 mg/g. The nanofiber membrane was characterized through transmission electron microscopy, encapsulation efficiency, in vitro drug-release study and antioxidant assay. The results indicated that the extracted procyanidins were successfully encapsulated in the core–sheath structure nanofibers, and the encapsulation efficiency of nanofiber membranes reached 83.84%. In vitro measurements of the delivery showed this core–sheath structure could significantly alleviate the drug burst release, which is followed by a linear and smooth release within 30 hours. Further tests showed that the removal efficiency of 2,2-diphenyl-1-picrylhydrazyl reached 88.62%, indicating that the membranes had high antioxidant activity. This work implies that the combination of Apocynum venetum nanocellulose and emulsion electrospun fibers has promising potential applications in tissue engineering or drug delivery.

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Preparation of poly(lactic acid)/graphene oxide nanofiber membranes with different structures by electrospinning for drug delivery

RSC Advances ◽

10.1039/c8ra01565a ◽

2018 ◽

Vol 8 (30) ◽

pp. 16619-16625 ◽

Cited By ~ 15

Author(s):

Zhou Mao ◽

Jialiang Li ◽

Wenjie Huang ◽

Hao Jiang ◽

Bhahat Lawlley Zimba ◽

...

Keyword(s):

Mechanical Properties ◽

Drug Delivery ◽

Graphene Oxide ◽

Lactic Acid ◽

Poly Lactic Acid ◽

Burst Release ◽

Nanofiber Membrane ◽

Initial Burst ◽

Nanofiber Membranes ◽

Sheath Structure

PLA/GO nanofiber membrane with the co-axial structure exhibited the improved mechanical properties, which is also beneficial to separately loading different drugs in core-/sheath-structure and suppressing the initial burst release of drugs.

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Applicability of Gum Karaya in the Preparation and in Vitro Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

Journal of Scientific Research ◽

10.3329/jsr.v7i1-2.21182 ◽

2015 ◽

Vol 7 (1-2) ◽

pp. 65-74

Author(s):

K. Latha ◽

V. V. Srikanth ◽

S. A. Sunil ◽

N. R. Srinivasa ◽

M. U. Uhumwangho ◽

...

Keyword(s):

Drug Delivery ◽

Tensile Strength ◽

Drug Delivery System ◽

Delivery System ◽

Lag Time ◽

Losartan Potassium ◽

In Vitro Dissolution ◽

Burst Release ◽

Gum Karaya

The objective of this investigation is to study the applicability of gum karaya, the natural gum for the preparation and in vitro evaluation of losartan potassium, as Chronotherapeutic Drug Delivery System (ChDDS). The compression-coated timed-release tablets (CCT) containing losartan potassium in the core tablet were prepared by dry coating technique with different ratios of gum karaya as the outer coat. The parameters investigated were tensile strength, friability, in vitro dissolution studies and drug concentration. The optimized formulation was further characterized by powder XRD and FTIR to investigate interactions and no interactions observed. The tensile strength and friability of all the CCT were between 1.06-1.23 MN/m2 and < 0.3% respectively. All the CCT showed a clear lag time before a burst release of drug. However, the lag time of drug release increased as the amount of gum karaya in the outer layer increased. For instance, the lag time of LGK1, LGK2, LGK3, LGK4, LGK5, LGK6 and LGK7 were 16, 10.5, 5.5, 3, 2, 1.5 and 0.5 hrs respectively. The drug content of all the CCT was >98%. Formulation LGK3 was taken as an optimized formulation which can be exploited to achieve ChDDS of losartan potassium for the treatment of hypertension.

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An Antimicrobial Peptide-Loaded Chitosan/Polyethylene Oxide Nanofibrous Membrane Fabricated by Electrospinning Technology

Frontiers in Materials ◽

10.3389/fmats.2021.650223 ◽

2021 ◽

Vol 8 ◽

Author(s):

Ling Yu ◽

Shubin Dou ◽

Jinghan Ma ◽

Qiang Gong ◽

Mogen Zhang ◽

...

Keyword(s):

Wound Healing ◽

Polyethylene Oxide ◽

Total Concentration ◽

Average Diameter ◽

Nanofiber Membrane ◽

New Class ◽

Intensity Changes ◽

Good Biocompatibility ◽

Nanofiber Membranes

Antimicrobial peptides (AMPs) are a new class of promising antibacterial agents. We prepared electrospinning chitosan (CS)-polyethylene oxide (PEO) nanofiber membranes containing different concentrations of an antibacterial peptide NP10. The average diameter of nanofibers increased with the total concentration of NP10. The FTIR shows that all the peaks of CS-PEO nanofiber membranes with different concentrations of NP10 were almost the same as those of pure CS-PEO nanofiber membranes, and only the peak intensity changes. Adding NP10 can improve the thermal stability of CS-PEO nanofiber membranes. In the in vitro release experiment, NP10 was released from the CS-PEO-0.5%NP10 nanofiber membrane in a burst first and then slowly and continuously. Simultaneously, the CS-PEO-NP10 nanofiber membrane had good antibacterial activity against Escherichia coli and Staphylococcus aureus and good biocompatibility. In animal wound healing experiments, CS-PEO-0.5%NP10 nanofiber membrane had advantages over gauze and CS-PEO nanofiber membrane in wound healing. These properties may provide a choice for the clinical application of AMPs and treatment of wound infections.

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Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

Pharmaceutics ◽

10.3390/pharmaceutics11070305 ◽

2019 ◽

Vol 11 (7) ◽

pp. 305 ◽

Cited By ~ 49

Author(s):

Bishweshwar Pant ◽

Mira Park ◽

Soo-Jin Park

Keyword(s):

Drug Delivery ◽

Electrospun Nanofibers ◽

Coaxial Electrospinning ◽

Burst Release ◽

High Porosity ◽

Nanofiber Membrane ◽

Initial Burst ◽

Initial Burst Release ◽

Small Pore ◽

Drug Delivery Applications

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.

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Dual-Drug-Loaded Silk Fibroin/PLGA Scaffolds for Potential Bone Regeneration Applications

Journal of Nanomaterials ◽

10.1155/2019/8050413 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 4

Author(s):

Jihang Yao ◽

Yilong Wang ◽

Wendi Ma ◽

Wenying Dong ◽

Mei Zhang ◽

...

Keyword(s):

Drug Release ◽

Sustained Release ◽

Bone Regeneration ◽

Silk Fibroin ◽

Bone Morphogenetic Protein 2 ◽

Burst Release ◽

Nanofiber Membrane ◽

Differentiation Potential ◽

Dual Drug

Developing scaffold materials with excellent biocompatibility, mechanical properties, and controlled drug release properties is vital to tissue engineering. In this study, we fabricated silk fibroin (SF)/poly(lactide-co-glycolide) (PLGA) nanofiber scaffolds containing recombinant human bone morphogenetic protein 2 (rhBMP2) and dexamethasone (DXM) via coaxial electrospinning, which were used in in vitro bone formation with rat bone marrow mesenchymal stem cells (rBMSCs). An in vitro drug release study was adopted to evaluate the sustained release potential of the core-shell structured nanofibers. Furthermore, we detected the potential of the SF/PLGA nanofiber membrane in vitro. In vitro studies showed that rhBMP2 still remained active on the nanofiber membrane. In addition, the dual-drug-loaded nanofiber membrane showed an early burst release of DXM and late sustained release of rhBMP2. rhBMP2 and DXM exhibited strong osteogenic differentiation potential when they acted on rBMSCs. Therefore, the SF/PLGA nanofiber membrane loaded with rhBMP2 and DXM has great potential for the enhancement of bone regeneration.

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Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery

BioMed Research International ◽

10.1155/2017/3564060 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 7

Author(s):

Ting-Ting Yang ◽

Yuan-Zheng Cheng ◽

Meng Qin ◽

Yong-Hong Wang ◽

Hong-Li Yu ◽

...

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Delivery System ◽

Drug Loading ◽

Great Promise ◽

Burst Release ◽

Bletilla Striata ◽

Vaginal Drug Delivery ◽

Thermosensitive Hydrogels

Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL). The physicochemical properties of the optimal MS (MS F) were characterized. Depending on the gelation temperature and gelating time, the optimal CTS-sodium alginate- (SA-) α,β-glycerophosphate (GP) (CTS-SA-GP) hydrogel was obtained. Observed by scanning electron microscope (SEM), TFV/BSP/CTS MS were successfully encapsulated in CTS-SA-GP. In vitro releasing demonstrated that MS F-CTS-SA-GP retained desirable in vitro sustained-release characteristics as a vaginal delivery system. Bioadhesion measurement showed that MS-CTS-SA-GP exhibited the highest mucoadhesive strength. Collectively, MS-CTS-SA-GP holds great promise for topical applications as a sustained-release vaginal drug delivery system.

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Sucrose Acetate Isobutyrate as an In situ Forming Implant for Sustained Release of Local Anesthetics

Current Drug Delivery ◽

10.2174/1567201816666181119112952 ◽

2019 ◽

Vol 16 (4) ◽

pp. 331-340

Author(s):

Hanmei Li ◽

Yuling Xu ◽

Yuna Tong ◽

Yin Dan ◽

Tingting Zhou ◽

...

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Local Anesthetics ◽

Subcutaneous Injection ◽

In Vitro Release ◽

Pharmacokinetic Analysis ◽

Burst Release

Objective: In this study, an injectable Sucrose Acetate Isobutyrate (SAIB) drug delivery system (SADS) was designed and fabricated for the sustained release of Ropivacaine (RP) to prolong the duration of local anesthesia. Methods: By mixing SAIB, RP, and N-methyl-2-pyrrolidone, the SADS was prepared in a sol state with low viscosity before injection. After subcutaneous injection, the pre-gel solution underwent gelation in situ to form a drug-released depot. Result: The in vitro release profiles and in vivo pharmacokinetic analysis indicated that RP-SADS had suitable controlled release properties. Particularly, the RP-SADS significantly reduced the initial burst release after subcutaneous injection in rats. Conclusion: In a pharmacodynamic analysis of rats, the duration of nerve blockade was prolonged by over 3-fold for the RP-SADS formulation compared to RP solution. Additionally, RP-SADS showed good biocompatibility in vitro and in vivo. Thus, the SADS-based depot technology is a safe drug delivery strategy for the sustained release of local anesthetics with long-term analgesia effects.

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Development and Characterization of Olanzapine Loaded Poly(lactide-co-glycolide) Microspheres for Depot Injection: In vitro and In vivo Release Profiles

Current Drug Delivery ◽

10.2174/1567201816666181227105930 ◽

2019 ◽

Vol 16 (4) ◽

pp. 375-383 ◽

Cited By ~ 3

Author(s):

Fahad Pervaiz ◽

Mahmood Ahmad ◽

Lihong Li ◽

Ghulam Murtaza

Keyword(s):

Bulk Density ◽

Encapsulation Efficiency ◽

In Vitro Release ◽

Infrared Spectrometry ◽

Burst Release ◽

In Vivo Release ◽

Depot Injection ◽

Vitro Release

Purpose: The purpose of this study was to develop a new PLGA based microsphere formulation aimed to release the olanzapine for the period of one month which will result in increased compliance. Methods: Microspheres loaded with olanzapine were prepared using oil in water emulsion and solvent evaporation technique. The microspheres were characterized by surface morphology, shape, size, bulk density, encapsulation efficiency, and Fourier transform infrared spectrometry. In vitro release studies were performed in phosphate buffer at 37°C and in vivo studies were conducted on male Sprague- Dawley rats. Results: The morphological results indicated that microspheres produced were having a smooth surface, spherical shape and the size in the range from 9.71 to 19.90 μm mean diameter. Encapsulation efficiency of olanzapine loaded microspheres was in the range of 78.53 to 96.12% and was affected by changing the ratio of lactic to glycolic acid in copolymer PLGA. The properties of PLGA and other formulation parameters had a significant impact on in vitro and in vivo release of drug from microspheres. In vitro release kinetics revealed that release of drug from microspheres is by both non-Fickian diffusion and erosion of PLGA polymer. In vivo data indicated an initial burst release and then sustained release depending on properties of PLGA, microsphere size, and bulk density. Conclusion: This study indicates that microsphere formulations developed with PLGA (75:25) and PLGA (85:15) have provided a sufficient steady release of drug for at least 30 days and can be potential candidates for 30-day depot injection drug delivery of olanzapine.

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Preparation and in vitro characterization of gellan based floating beads of acetohydroxamic acid for eradication of H. pylori

Acta Pharmaceutica ◽

10.2478/v10007-007-0033-5 ◽

2007 ◽

Vol 57 (4) ◽

pp. 413-427 ◽

Cited By ~ 41

Author(s):

Parauvathanahalli Rajinikanth ◽

Brahmeshwar mishra

Keyword(s):

Drug Release ◽

Encapsulation Efficiency ◽

Diffusion Mechanism ◽

Oral Dosage ◽

Acetohydroxamic Acid ◽

Burst Release ◽

Sustained Drug Release ◽

H Pylori

Preparation andin vitrocharacterization of gellan based floating beads of acetohydroxamic acid for eradication ofH. pyloriGellan based floating beads of acetohydroxamic acid (AHA) were prepared by the ionotropic gellation method to achieve controlled and sustained drug release for treatment ofHelicobacter pyloriinfection. The prepared beads were evaluated for diameter, surface morphology and encapsulation efficiency. Formulation parameters like concentrations of gellan, chitosan, calcium carbonate and the drug influenced thein vitrodrug release characteristics of beads. Drug and polymer interaction studies were carried out using differential scanning calorimetry. Chitosan coating increased encapsulation efficiency of the beads and reduced the initial burst release of the drug from the beads. Kinetic treatment of the drug release data revealed a matrix diffusion mechanism. Prepared floating beads showed good antimicrobial activity (in vitro H. pyloriculture) as potent urease inhibitors. In conclusion, an oral dosage form of floating gellan beads containing AHA may form a useful stomach site specific drug delivery system for the treatment ofH. pyloriinfection.

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Understanding the burst release phenomenon: toward designing effective nanoparticulate drug-delivery systems

Therapeutic Delivery ◽

10.4155/tde-2020-0099 ◽

2020 ◽

pp. 00-00

Author(s):

Sourav Bhattacharjee

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Mathematical Models ◽

Drug Delivery Systems ◽

Release Kinetics ◽

Burst Release ◽

Future Directions ◽

Short Period

Burst release of encapsulated drug with release of a significant fraction of payload into release medium within a short period, both in vitro and in vivo, remains a challenge for translation. Such unpredictable and uncontrolled release is often undesirable, especially from the perspective of developing sustained-release formulations. Moreover, a brisk release of the payload upsets optimal release kinetics. This account strives toward understanding burst release noticed in nanocarriers and investigates its causes. Various mathematical models to explain such untimely release were also examined, including their strengths and weaknesses. Finally, the account revisits current techniques of limiting burst release from nanocarriers and prioritizes future directions that harbor potential of fruitful translation by reducing such occurrences.

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