scholarly journals Hybrid Nanoparticles of Poly (Methyl Methacrylate) and Antimicrobial Quaternary Ammonium Surfactants

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 340 ◽  
Author(s):  
Beatriz Ideriha Mathiazzi ◽  
Ana Maria Carmona-Ribeiro
Keyword(s):  
Methyl Methacrylate ◽  
Quaternary Ammonium ◽  
Antimicrobial Properties ◽  
Bioactive Molecules ◽  
Hybrid Nanoparticles ◽  
Ammonium Bromide ◽  
Poly Methyl Methacrylate ◽  
Dimethyl Ammonium ◽  
Cetyl Trimethyl Ammonium ◽  
Quaternary Ammonium Surfactants

Quaternary ammonium surfactants (QACs) are microbicides, whereas poly (acrylates) are biocompatible polymers. Here, the physical and antimicrobial properties of two QACs, cetyl trimethyl ammonium bromide (CTAB) or dioctadecyl dimethyl ammonium bromide (DODAB) in poly (methyl methacrylate) (PMMA) nanoparticles (NPs) are compared to those of QACs alone. Methyl methacrylate (MMA) polymerization using DODAB or CTAB as emulsifiers and initiator azobisisobutyronitrile (AIBN) yielded cationic, nanometric, homodisperse, and stable NPs. NPs’ physical and antimicrobial properties were assessed from dynamic light scattering (DLS), scanning electron microscopy, and viability curves of Escherichia coli, Staphylococcus aureus, or Candida albicans determined as log(colony-forming unities counting) over a range of [QACs]. NPs were spherical and homodisperse but activity for free QACs was higher than those for QACs in NPs. Inhibition halos against bacteria and yeast were observed only for free or incorporated CTAB in NPs because PMMA/CTAB NPs controlled the CTAB release. DODAB displayed fungicidal activity against C. albicans since DODAB bilayer disks could penetrate the outer glycoproteins fungus layer. The physical properties and stability of the cationic NPs highlighted their potential to combine with other bioactive molecules for further applications in drug and vaccine delivery.

scholarly journals Cationic and Biocompatible Polymer/Lipid Nanoparticles as Immunoadjuvants

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1859
Author(s):  
Yunys Pérez-Betancourt ◽  
Péricles Marques Araujo ◽  
Bianca de Carvalho Lins Fernandes Távora ◽  
Daniele Rodrigues Pereira ◽  
Eliana Lima Faquim-Mauro ◽  
...  
Keyword(s):  
Immune Responses ◽  
Methyl Methacrylate ◽  
Cationic Lipid ◽  
Lipid Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Ammonium Bromide ◽  
The Novel ◽  
Biocompatible Polymer ◽  
Dimethyl Ammonium ◽  
Oppositely Charged

Nanostructures have been of paramount importance for developing immunoadjuvants. They must be cationic and non-cytotoxic, easily assembling with usually oppositely charged antigens such as proteins, haptens or nucleic acids for use in vaccines. We obtained optimal hybrid nanoparticles (NPs) from the biocompatible polymer poly(methyl methacrylate) (PMMA) and the cationic lipid dioctadecyl dimethyl ammonium bromide (DODAB) by emulsion polymerization of methyl methacrylate (MMA) in the presence of DODAB. NPs adsorbed ovalbumin (OVA) as a model antigen and we determined their adjuvant properties. Interestingly, they elicited high double immune responses of the cellular and humoral types overcoming the poor biocompatibility of DODAB-based adjuvants of the bilayer type. The results suggested that the novel adjuvant would be possibly of use in a variety of vaccines.

Antimicrobial Particles from Emulsion Polymerization of Methyl Methacrylate in the Presence of Quaternary Ammonium Surfactants

Langmuir ◽  
2013 ◽  
Vol 29 (31) ◽  
pp. 9677-9684 ◽  
Author(s):  
Alliny F. Naves ◽  
Renata R. Palombo ◽  
Letícia D. M. Carrasco ◽  
Ana M. Carmona-Ribeiro
Keyword(s):  
Methyl Methacrylate ◽  
Emulsion Polymerization ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Surfactants

Surface Modification for Cotton Fiber and its Antimicrobial Characteristics

2011 ◽  
Vol 311-313 ◽  
pp. 2067-2070
Author(s):  
Fei Zhou ◽  
Jing Zheng
Keyword(s):  
Cotton Fiber ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Compound ◽  
Hydroxyl Group ◽  
Ammonium Bromide ◽  
Ammonium Compound ◽  
Gram Positive Bacteria ◽  
Wide Range ◽  
Dimethyl Ammonium ◽  
Ammonium Compounds

Quaternary ammonium compounds, Couple, Cotton fiber, Antibacterial activity. Abstract. a gemini-type quaternary ammonium compound with a hydroxyl group in their spacer chain, 4,5-bis(dodecyl dimethyl ammonium bromide)-1-pentanol (called as DAP12), was immobilized on the surface of cotton fiber by using a silane coupler, tetraethoxysilane and a novel antibacterial cotton fiber (called as CF12) was prepared. Antibacterial characteristics of CF12 were investigated comparatively with [3-(trimethoxysilyl) propyl] octadecyldimethylammonium chloride(TPOAC), a mono-type quaternary ammonium salt. CF12 had excellent antibacterial characteristics in the wide range of environmental pH and temperature, which is not weakened even if 30 times repetitive use. The experimental results indicated also that CF12 has higher antimicrobial activity than TPOAC immobilized on the surface of cotton fiber against a broad range of microorganisms, and average inhibition ratio against 15 strains of gram-negative, gram-positive bacteria and yeasts is 99.0% at 30 °C and pH 6.0.

Effect of polyaniline-coated carbon nanotube and nanosilver hybrid nanoparticles on the dielectric properties of poly(methyl methacrylate) nanocomposites

2018 ◽  
Vol 39 (S2) ◽  
pp. E1294-E1305 ◽  
Author(s):  
Satyabhama Sahu ◽  
Amrita Pritam Sahoo ◽  
Lipsa Shubhadarshinee ◽  
Ramakrishna D. S ◽  
Aruna Kumar Barick
Keyword(s):  
Carbon Nanotube ◽  
Dielectric Properties ◽  
Methyl Methacrylate ◽  
Hybrid Nanoparticles ◽  
Poly Methyl Methacrylate ◽  
Coated Carbon

Activity of Polyphenoloxidase in red Fuji Apples Promoted with Cationic Surfactant – Role of Surfactant Structure

2021 ◽  
Vol 58 (5) ◽  
pp. 383-393
Author(s):  
Maozhang Tian ◽  
Fan Zhang ◽  
Lu Wang ◽  
Xing Dong ◽  
Lifei Zhang ◽  
...  
Keyword(s):  
Gemini Surfactant ◽  
Cetyl Trimethyl Ammonium Bromide ◽  
Gemini Surfactants ◽  
Ammonium Bromide ◽  
Wide Range ◽  
Dimethyl Ammonium ◽  
Dodecyl Trimethyl Ammonium Bromide ◽  
Cetyl Trimethyl Ammonium ◽  
Menten Constant

Abstract In this study, we observed the activity of polyphenoloxidase (PPO) in red Fuji apples in the presence of single-chained surfactants (including cetyl trimethyl ammonium bromide (CTAB), and dodecyl trimethyl ammonium bromide (DTAB)) and gemini surfactants (pentamethylene-α,ω-bis(dodecyl dimethyl ammonium bromide), octamethylene-α,ω-bis(dodecyl dimethyl ammonium bromide, dodecamethylene-α,ω-bis(dodecyl dimethyl ammonium bromide), pentamethylene-α,ω-bis(cetyl dimethyl ammonium bromide), and octamethylene-α,ω-bis(cetyl dimethyl ammonium bromide)). It was found that all these surfactants enhanced the activity of PPO in a wide range of temperature at low content. When PPO was denatured by incubating at high temperature, the surfactants caused reactivation of PPO. Compared to the single-chained surfactants, the gemini surfactants increased PPO activity at a much lower concentration. Moreover, the single-chained surfactant and the gemini surfactant acted together to further increase PPO activity, and the synergistic effect reduced the amount of surfactant used. In addition, the Michaelis-Menten constant for PPO did not change in the presence of the surfactants, suggesting the active site should remain well with the surfactants.

Incorporation of poorly soluble drug Cefixime inside the micellar core of conventional and gemini surfactants

2022 ◽  
Author(s):  
Aparna D Saraf ◽  
shweta sharma ◽  
Shilpee Sachar
Keyword(s):  
Cetyl Trimethyl Ammonium Bromide ◽  
Gemini Surfactants ◽  
Ammonium Bromide ◽  
Antibiotic Drug ◽  
Dimethyl Ammonium ◽  
Poorly Soluble ◽  
Dodecyl Trimethyl Ammonium Bromide ◽  
Poorly Soluble Drug ◽  
Cetyl Trimethyl Ammonium ◽  
Micellar Core

This work reports the physicochemical behavior of antibiotic drug, cefixime (CEF) in presence of cetyl trimethyl ammonium bromide (CTAB), dodecyl trimethyl ammonium bromide (DTAB), dodecyl ethyl dimethyl ammonium bromide, (DDAB),...

Encapsulation of dodecyl trimethyl ammonium bromide-modified montmorillonite clay platelets in poly(methyl methacrylate-co-ethyl acrylate) particles

2017 ◽  
Vol 51 (29) ◽  
pp. 4053-4066 ◽  
Author(s):  
Jingshui Xu ◽  
Denglong Chen ◽  
Qinghua Chen ◽  
Zhong Zhang ◽  
Xionglong Hu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Methyl Methacrylate ◽  
Suspension Polymerization ◽  
Ethyl Acrylate ◽  
Sem Analysis ◽  
Ammonium Bromide ◽  
Transmission Electron Microscopy Analysis ◽  
Poly Methyl Methacrylate ◽  
Clay Platelets ◽  
Mmt Clay

Montmorillonite (MMT) clay platelets were successfully encapsulated in poly(methyl methacrylate- co-ethyl acrylate) [poly(MMA- co-EA)] matrix by an in situ suspension polymerization, and evaluated for their plugging behaviors in single-sand pack tube models. Swelling behaviors of the poly(MMA- co-EA)/MMT nanocomposites in various salinity water were also investigated. Results showed that the poly(MMA- co-EA)/MMT nanocomposites had a spherical morphology and their particle sizes mainly range from 10 to 120 µm by scanning electron microscopy (SEM) analysis. X-ray diffraction indicated that the existing of MMT layers in the polymer matrix was mainly in exfoliated form; this was consistent with transmission electron microscopy analysis. The thermal stability of poly(MMA- co-EA)/MMT nanocomposites were effectively improved after adding the MMT by thermogravimetric analysis. Furthermore, the selected nanocomposites containing MMT (1.0 wt%) provided an effective plugging in sand pack tubes of high permeability, and plugging rate was up to approximately 85.0%.

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