scholarly journals Addition of Regular Insulin to Ternary Parenteral Nutrition: A Stability Study

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 458
Author(s):  
Heloise Henry ◽  
Damien Lannoy ◽  
Patrice Maboudou ◽  
David Seguy ◽  
Thierry Dine ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Ethylene Vinyl Acetate ◽  
Regular Insulin ◽  
Stability Study ◽  
Analysis Of Covariance ◽  
Insulin Concentration ◽  
The Stability ◽  
Ph Level ◽  
Insulin Stability ◽  
Stability Results

Background: Parenteral nutrition (PN) is a complex medium in which added insulin can become unstable. The aim of this study is, therefore, to evaluate the stability of insulin in PN and to identify influencing factors. Methods: A total of 20 IU/L of regular insulin was added to PN in either glass or Ethylene Vinyl Acetate (EVA) containers. A 24 h stability study was performed via an electrochemiluminescence immunoassay in different media: A ternary PN admixture, separate compartments of the PN bag and a binary admixture. This study was repeated in the absence of zinc, with the addition of serum albumin or tween and with pH adjustment (3.6 or 6.3). Insulin concentration at t time was expressed as a percentage of the initial insulin concentration. Analysis of covariance (ANCOVA) was applied to determine the factors that influence insulin stability. Results: In all PN admixtures, the insulin concentration ratio decreased, stabilising at a 60% and then plateauing after 6 h. At pH 3.6, the ratio was above 90%, while at pH 6.3 it decreased, except in the amino acid solution. ANCOVA (r2 = 0.68, p = 0.01) identified dextrose and pH as significant factors influencing insulin stability. Conclusion: A low pH level seems to stabilise insulin in PN admixtures. The influence of dextrose content suggests that insulin glycation may influence stability.

scholarly journals Experimental Stability Study on Herringbone-Microgrooved Journal Bearing in an Impeller-Spindle

2012 ◽  
Vol 28 (1) ◽  
pp. 123-133 ◽  
Author(s):  
B.-H. Chang ◽  
P.-H. Chen ◽  
D.-S. Lee
Keyword(s):  
Static Load ◽  
Journal Bearing ◽  
Stability Study ◽  
Experimental Device ◽  
Eccentricity Ratio ◽  
Tablet Pcs ◽  
Damping Coefficients ◽  
The Stability ◽  
Stiffness And Damping ◽  
Stability Results

ABSTRACTThe reliability of the impeller-spindle with respect to the effects of abnormal vibrations and noises is relative to the whirl rotation in notebook (NB) computers, all-in-one (AIO) desktop systems, and tablet PCs. This study experimentally investigates the stability of a herringbone-microgrooved journal bearing in an impeller-spindle under static radial forces.The experimental device operated at 2700, 3600, 4200, and 4900rpm, with a static load ranging from 0.4, 0.8, and 1.6N. The experiment obtained the stiffness and damping coefficients, and the study involved analyzing the stability. Results show that the dimensionless threshold speed of rotation decreased as the Sommerfeld number increased. The proposed impeller-spindle is stable when the Sommerfeld number is less than 59, indicating that the impeller-spindle should not operate at an eccentricity ratio below 0.18.

Epitaxial Growth in Dislocation-Free Strained Alloy Films

2002 ◽  
Vol 715 ◽  
Author(s):  
Zhi-Feng Huang ◽  
Rashmi C. Desai
Keyword(s):  
Deposition Rate ◽  
Elastic Moduli ◽  
Composition Dependence ◽  
Critical Thickness ◽  
Lattice Misfit ◽  
Misfit Strain ◽  
Joint Stability ◽  
Alloy Films ◽  
The Stability ◽  
Stability Results

AbstractThe morphological and compositional instabilities in the heteroepitaxial strained alloy films have attracted intense interest from both experimentalists and theorists. To understand the mechanisms and properties for the generation of instabilities, we have developed a nonequilibrium, continuum model for the dislocation-free and coherent film systems. The early evolution processes of surface pro.les for both growing and postdeposition (non-growing) thin alloy films are studied through a linear stability analysis. We consider the coupling between top surface of the film and the underlying bulk, as well as the combination and interplay of different elastic effects. These e.ects are caused by filmsubstrate lattice misfit, composition dependence of film lattice constant (compositional stress), and composition dependence of both Young's and shear elastic moduli. The interplay of these factors as well as the growth temperature and deposition rate leads to rich and complicated stability results. For both the growing.lm and non-growing alloy free surface, we determine the stability conditions and diagrams for the system. These show the joint stability or instability for film morphology and compositional pro.les, as well as the asymmetry between tensile and compressive layers. The kinetic critical thickness for the onset of instability during.lm growth is also calculated, and its scaling behavior with respect to misfit strain and deposition rate determined. Our results have implications for real alloy growth systems such as SiGe and InGaAs, which agree with qualitative trends seen in recent experimental observations.

scholarly journals Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 549
Author(s):  
Szymon Tomczak ◽  
Aleksandra Gostyńska ◽  
Malwina Nadolna ◽  
Karolina Reisner ◽  
Marta Orlando ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Treatment Failure ◽  
Medical Errors ◽  
Stability Test ◽  
Intravenous Drug ◽  
Common Cause ◽  
Life Threatening ◽  
Degradation Studies ◽  
The Stability ◽  
Infusion Fluids

Intravenous drug incompatibilities are a common cause of medical errors, contributing to ineffective therapy and even life-threatening events. The co-administration of drugs must always be supported by studies confirming compatibility and thus guarantee the therapy’s safety. Particular attention should be paid to the possible incompatibilities or degradation of intravenous cephalosporins in different infusion regimens since the administration of drugs with inadequate quality may cause treatment failure. Therefore, an appropriate stability test should be performed. The study aimed to present various aspects of the stability and compatibility of five cephalosporins: cefepime (CFE), cefuroxime (CFU), ceftriaxone (CFX), ceftazidime (CFZ), and cefazoline (CFL). The degradation studies in parenteral infusion fluids and PN admixtures were conducted for CFE and CFU. The interactions between CFX or CFZ and PN admixtures, as well as the compatibility of CFL with five commercial parenteral nutrition (PN) admixtures, were investigated. The content of CFX and CFZ in PN admixture after 24 h was >90%. CFL administered simultaneously with PN admixture by the same infusion set using Y-site was compatible only with Nutriflex Lipid Special. CFE and CFU were stable in all tested infusion fluids for a minimum of 48 h and decomposed in PN admixtures during storage.

scholarly journals Analysis of dengue model with fractal-fractional Caputo–Fabrizio operator

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Fatmawati ◽  
Muhammad Altaf Khan ◽  
Cicik Alfiniyah ◽  
Ebraheem Alzahrani
Keyword(s):  
Statistical Data ◽  
Dengue Infection ◽  
Fractional Operator ◽  
Novel Approach ◽  
Reduction Number ◽  
Best Fitting ◽  
The Stability ◽  
Parameter Values ◽  
Graphical Illustration ◽  
Stability Results

AbstractIn this work, we study the dengue dynamics with fractal-factional Caputo–Fabrizio operator. We employ real statistical data of dengue infection cases of East Java, Indonesia, from 2018 and parameterize the dengue model. The estimated basic reduction number for this dataset is $\mathcal{R}_{0}\approx2.2020$ R 0 ≈ 2.2020 . We briefly show the stability results of the model for the case when the basic reproduction number is $\mathcal{R}_{0} <1$ R 0 < 1 . We apply the fractal-fractional operator in the framework of Caputo–Fabrizio to the model and present its numerical solution by using a novel approach. The parameter values estimated for the model are used to compare with fractal-fractional operator, and we suggest that the fractal-fractional operator provides the best fitting for real cases of dengue infection when varying the values of both operators’ orders. We suggest some more graphical illustration for the model variables with various orders of fractal and fractional.

scholarly journals Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations

2021 ◽  
Vol 15 (1) ◽  
pp. 2
Author(s):  
Cristina Martín-Sabroso ◽  
Mario Alonso-González ◽  
Ana Fernández-Carballido ◽  
Juan Aparicio-Blanco ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Shelf Life ◽  
Stability Study ◽  
Eye Drops ◽  
Microbiological Analysis ◽  
Nitrogen Gas ◽  
Long Term Stability ◽  
Main Degradation Product ◽  
The Stability ◽  
Unstable Molecule

Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications. Cysteamine eye drop compounded formulations, commonly prepared by hospital pharmacy services, are meant to diminish the build-up of corneal cystine crystals. The objective of this work was to analyze whether the shelf life proposed for six formulations prepared following different protocols used in hospital pharmacies is adequate to guarantee the quality and efficacy of cysteamine eye drops. The long-term and in-use stabilities of these preparations were studied using different parameters: content of cysteamine and its main degradation product cystamine; appearance, color and odor; pH and viscosity; and microbiological analysis. The results obtained show that degradation of cysteamine was between 20% and 50% after one month of storage in the long-term stability study and between 35% and 60% in the in-use study. These data confirm that cysteamine is a very unstable molecule in aqueous solution, the presence of oxygen being the main degradation factor. Saturation with nitrogen gas of the solutions offers a means of reducing cysteamine degradation. Overall, all the formulae studied presented high instability at the end of their shelf life, suggesting that their clinical efficacy might be dramatically compromised.

scholarly journals FORMULATION, CHARACTERIZATION AND STABILITY STUDY OF FAST DISSOLVING THIN FILM CONTAINING ASTAXANTHIN NANOEMULSION USING HYDROXYPROPYLMETHYL CELLULOSE POLYMER

2021 ◽  
pp. 17-22
Author(s):  
LUSI NURDIANTI ◽  
IYAN SOPYAN ◽  
TAOFIK RUSDIANA
Keyword(s):  
Thin Film ◽  
Mechanical Characteristics ◽  
Storage Conditions ◽  
Stability Study ◽  
Matrix System ◽  
Stability Studies ◽  
Casting Method ◽  
Hydroxypropylmethyl Cellulose ◽  
The Stability ◽  
Physical And Mechanical Characteristics

Objective: The present study was conducted to formulate and characterize the thin film containing astaxanthin nanoemulsion (TF-ASN) using Hydroxypropylmethyl Cellulose (HPMC) polymer as a film matrix system. The stability studies in different storage conditions were also performed. Methods: Astaxanthin nanoemulsion (As-NE) was prepared by using self-nanoemulsifying method, followed by incorporation into the HPMC matrix system by solvent casting method to forming TF-ASN. Evaluation of TF-ASN was performed by physical and mechanical characterizations. Stability study was carried out in both of accelerated (temperature of 40±2 °C/75±5% RH) and non-accelerated (at ambient temperature) conditions. Assay of astaxanthin in individual TF-ASN was determined compared to pure astaxanthin. Results: TF-ASN had good physical and mechanical characteristics that suitable for intraoral administration. Conclusion: For the study of stability under different storage conditions, it was proven that nanoemulsion form was packed in a HPMC matrix could enhance the stability of the astaxanthin.

scholarly journals The stability study of a plane engine

2000 ◽  
Vol 27 (1) ◽  
pp. 35-44
Author(s):  
Rafał Kołodziej ◽  
Tomasz Nowicki
Keyword(s):  
Stability Study ◽  
The Stability

scholarly journals Physicochemical Properties and Stability of Microencapsulated Betacyanin Pigments from Red Dragon Fruit Peels and Flesh

2020 ◽  
pp. 141-148
Author(s):  
Rosalinda C Torres ◽  
Rowelain Mae G Yumang ◽  
Chelsea Kate F Jose ◽  
Danielle Camille P Canillo
Keyword(s):  
Moisture Content ◽  
Physicochemical Properties ◽  
Morphological Characterization ◽  
Stability Study ◽  
Natural Colorant ◽  
Hygroscopic Moisture ◽  
Dragon Fruit ◽  
The Stability ◽  
Spray Dried ◽  
Hylocereus Polyrhizus

Dragon fruit (Hylocereus polyrhizus) is known for its purple-coloured peels and pulp, which can be attributed to the presence of betalains. In this study, the potential of red dragon fruit as a source of natural colorant was investigated. Betacyanins were extracted from red dragon fruit peels and flesh in 1:3 ratio with water. Microencapsulation by spray-drying was done by adding 5% and 10% (w/v) maltodextrin (DE 11.8) to peels and flesh extracts, respectively. The spray-dried colorant powders all obtained <10% moisture content, 5.261-6.409 g/100g hygroscopic moisture content, and 5.317-7.349(mg/100L) betacyanin content. Morphological characterization revealed spherical, agglomerated particles with visible cracks on the surface. The stability study conducted showed that pigment retention was lowest at 70°C and highest at 4°C. Keywords: Hylocereus polyrhizus; Red dragon fruit; Betacyanin; Microencapsulation; Physicochemical properties

scholarly journals A Fast and Validated HPLC Method for Simultaneous Determination of Dopamine, Dobutamine, Phentolamine, Furosemide, and Aminophylline in Infusion Samples and Injection Formulations

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Fuchao Chen ◽  
Baoxia Fang ◽  
Sicen Wang
Keyword(s):  
Mobile Phase ◽  
Dosage Form ◽  
Limit Of Detection ◽  
Hplc Method ◽  
Stability Study ◽  
Precision Data ◽  
Column Temperature ◽  
Ich Guidelines ◽  
Limit Of Quantitation ◽  
The Stability

A simple, fast, and validated HPLC method was developed for the simultaneous quantization of five cardiovascular agents: dopamine (DPM), dobutamine (DBM), phentolamine (PTM), furosemide (FSM), and aminophylline (APL) either in infusion samples or in an injection dosage form. The proposed method was achieved with a 150 mm × 4.6 mm, 5.0 μm C18 column, by using a simple linear gradient. Mobile phase A was buffer (50 mM KH2PO4) and mobile Phase B was acetonitrile at a flow rate of 1.0 mL/min. The column temperature was kept at 30°C, and the injection volume was 20 μL. All analytes were separated simultaneously at a retention time (tr) of 3.93, 5.84, 7.06, 8.76, and 9.67 min for DPM, DBM, PTM, FSM, and APL, respectively, with a total run time of less than 15.0 min. The proposed method was validated according to ICH guidelines with respect to accuracy, precision, linearity, limit of detection, limit of quantitation, and robustness. Linearity was obtained over a concentration range of 12.0–240.0, 12.0–240.0, 20.0–200.0, 6.0–240.0, and 10.0–200.0 μg/mL DPM, DBM, PTM, FSM, and APL, respectively. Interday and intraday accuracy and precision data were recorded in the acceptable limits. The new method has successfully been applied for quantification of all five drugs in their injection dosage form, infusion samples, and for evaluation of the stability of investigated drugs in mixtures for endovenous use. The results of the stability study showed that mixtures of DPM, DBM, PTM, FSM, and APL in 5% glucose or 0.9% sodium chloride injection were stable for 48 hours when stored in polypropylene syringes at 25°C.

scholarly journals Stability study of rock slope in fractured quartzite at right side of spillway, Middle Marsyangdi Hydroelectric Project, Nepal

2003 ◽  
Vol 28 ◽  
Author(s):  
Kaustubh Mani Nepal ◽  
Roger Olsson
Keyword(s):  
Rock Slope ◽  
Stability Study ◽  
Cut Slope ◽  
Stability Studies ◽  
Hydroelectric Project ◽  
The Stability ◽  
The Right ◽  
Cut Slopes

A 120 m long and 68 m high rock cut slope is designed at the right side of spillway of Middle Marsyangdi Hydroelectric Project. This paper describes the stability studies performed for the rock cut slopes in jointed quartzite for foundation of spillway.

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