scholarly journals Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2000
Author(s):  
Francesco Mainini ◽  
Arianna Bonizzi ◽  
Marta Sevieri ◽  
Leopoldo Sitia ◽  
Marta Truffi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transferrin Receptor ◽  
Genetic Manipulation ◽  
Loading Capacity ◽  
Vast Array ◽  
Transferrin Receptor 1 ◽  
Novel Variants

Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In particular, ferritin nanocages (FNs) have been employed for the delivery of a vast array of molecules, ranging from chemotherapeutics to imaging agents, among others. One of the main favorable characteristics of FNs is their intrinsic targeting efficiency toward the Transferrin Receptor 1, which is overexpressed in many tumors. Furthermore, genetic manipulation can be employed to introduce novel variants that are able to improve the loading capacity, targeting capabilities and bio-availability of this versatile drug delivery system. In this review, we discuss the main characteristics of FN and the most recent applications of this promising nanotechnology in the field of oncology with a particular emphasis on the imaging and treatment of solid tumors.

scholarly journals In Vitro Cytotoxicity and Antitumor Activity of Dual-Targeting Drug Delivery System Based on Modified Magnetic Carbon by Folate

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Jinglei Du ◽  
Qiang Li ◽  
Lin Chen ◽  
Shicai Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hela Cells ◽  
Folate Receptor ◽  
Drug Loading ◽  
Magnetic Characteristics ◽  
Loading Capacity ◽  
Dual Targeting

A dual-targeting drug delivery system (DTDDS) with magnetic targeting and active targeting was obtained to improve the targeting and drug-loading capacity of magnetic drug nanocarriers. An ultraviolet-visible spectrophotometer and flow cytometry were used to investigate the drug-loading and release capacity, cytotoxicity, and inhibition of tumor cell proliferation, separately. Results show that DTDDS has obvious magnetic characteristics, on which the modification amount of folic acid is 64.82 mg g-1. Doxorubicin was taken as a template drug to evaluate its drug-loading capacity, which was as high as 577.12 mg g-1. Good biocompatibility and low cytotoxicity of DTDDS were further confirmed. Moreover, DTDDS can target the folate receptor on the surface of HeLa cells and deliver doxorubicin into HeLa cells, thereby increasing the proliferation inhibition for cancer cells. Therefore, this new dual-targeting drug delivery system shows potential in significantly reducing the toxic side effects of chemotherapy and improving chemotherapy efficiency.

scholarly journals Modelling of combination therapy using implantable anticancer drug delivery with thermal ablation in solid tumor

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Muneer Al-Zu’bi ◽  
Ananda Mohan
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Solid Tumors ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Solid Tumor ◽  
Thermal Ablation ◽  
Intracellular Concentration ◽  
Design Parameters

Abstract Local implantable drug delivery system (IDDS) can be used as an effective adjunctive therapy for solid tumor following thermal ablation for destroying the residual cancer cells and preventing the tumor recurrence. In this paper, we develop comprehensive mathematical pharmacokinetic/pharmacodynamic (PK/PD) models for combination therapy using implantable drug delivery system following thermal ablation inside solid tumors with the help of molecular communication paradigm. In this model, doxorubicin (DOX)-loaded implant (act as a transmitter) is assumed to be inserted inside solid tumor (acts as a channel) after thermal ablation. Using this model, we can predict the extracellular and intracellular concentration of both free and bound drugs. Also, Impact of the anticancer drug on both cancer and normal cells is evaluated using a pharmacodynamic (PD) model that depends on both the spatiotemporal intracellular concentration as well as characteristics of anticancer drug and cells. Accuracy and validity of the proposed drug transport model is verified with published experimental data in the literature. The results show that this combination therapy results in high therapeutic efficacy with negligible toxicity effect on the normal tissue. The proposed model can help in optimize development of this combination treatment for solid tumors, particularly, the design parameters of the implant.

scholarly journals Preparation and Evaluation of Smart Nanocarrier Systems for Drug Delivery Using Magnetic Nanoparticle and Avidin-Iminobiotin System

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Shuguo Sun ◽  
Beiping Li ◽  
Tao Yang ◽  
Meihu Ma ◽  
Qinlu Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
High Performance ◽  
Physicochemical Characterization ◽  
Reversed Phase ◽  
Loading Capacity ◽  
Controllable Release ◽  
The Stability ◽  
Affinity Interaction

Therapeutic efficacy and the regulation of drug release can be improved by using selective targeting drug delivery systems. In this paper, we have demonstrated avidin-immobilized magnetic nanoparticles (AMNPs) as a novel targeted drug delivery system to deliver iminobiotinylated daunomycin (IDAU). TEM, XRD, VSM, and FTIR were employed for the physicochemical characterization of the drug-loaded MNPs. The binding of IDAU had little effect on sizes of AMNPs (~35 nm), but the stability and dispersibility of the nanoparticles were improved. The study also found that the loading capacity and efficiency of nanoparticles were mainly dependent on affinity interaction between IDAU and AMNPs. The optimal loading capacity and efficiency of MNPs for IDAU were 0.408 ± 0.012 mg/g and 94.18 ± 2.64% according to the reversed-phase high-performance liquid chromatography (RP-HPLC) data, respectively. Under the conditions of pH 6.8 and 1 mmol/L of biotin, the drug-loaded MNPs released rapidly at beginning and then maintained at a certain controllable release level. The effect of IDAU on DLKP proliferation was tested, and the results showed that IC50 was (1.60 ± 0.05) × 10−3 mg/mL. Our findings indicated that AMNPs hold tremendous potential as an effective drug delivery system.

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