scholarly journals Polysaccharide 3D Printing for Drug Delivery Applications

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 145
Author(s):  
Alexandra Zamboulis ◽  
Georgia Michailidou ◽  
Ioanna Koumentakou ◽  
Dimitrios N. Bikiaris
Keyword(s):  
Drug Delivery ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Large Family ◽  
Cellulose Derivatives ◽  
Natural Polymers ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Drug Delivery Applications

3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well as in the large choice of materials. It is a powerful tool in the field of personalized pharmaceutical treatment, particularly crucial for pediatric and geriatric patients. Polysaccharides are abundant and inexpensive natural polymers, that are already widely used in the food industry and as excipients in pharmaceutical and cosmetic formulations. Due to their intrinsic properties, such as biocompatibility, biodegradability, non-immunogenicity, etc., polysaccharides are largely investigated as matrices for drug delivery. Although an increasing number of interesting reviews on additive manufacturing and drug delivery are being published, there is a gap concerning the printing of polysaccharides. In this article, we will review recent advances in the 3D printing of polysaccharides focused on drug delivery applications. Among the large family of polysaccharides, the present review will particularly focus on cellulose and cellulose derivatives, chitosan and sodium alginate, printed by fused deposition modeling and extrusion-based printing.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Incorporation of fluorescent quantum dots for 3D printing and additive manufacturing applications

2018 ◽  
Vol 6 (28) ◽  
pp. 7584-7593 ◽  
Author(s):  
Cole D. Brubaker ◽  
Talitha M. Frecker ◽  
James R. McBride ◽  
Kemar R. Reid ◽  
G. Kane Jennings ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Quantum Dot ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Cadmium Sulfur Selenide ◽  
Functionalized Materials ◽  
Deposition Modeling ◽  
Manufacturing Applications

3D printing of cadmium sulfur selenide quantum dot functionalized materials compatible with fused deposition modeling type processes and applications.

scholarly journals Experience of implementation in educational process modern technologies of FDM 3D printing

2021 ◽  
pp. 55-59
Author(s):  
Petr Andrienko ◽  
Vladimir Vasilevskij ◽  
Ivan Vittsivskyi
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Current Transformer ◽  
Educational Process ◽  
Small Scale ◽  
Thermoplastic Material ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Modern Technologies

Fused Deposition Modeling is an additive manufacturing technology where a temperature-controlled head extrudes a thermoplastic material onto a build platform in a predetermined path. Standard, advanced thermoplastics and composites are used for printing. Among the areas of application for FDM printing, the main ones are rapid prototyping, as well as small-scale and batch production. The purpose of the work is the implementation of FDM 3D printing technology in the educational process of students in specialty 141 "Electroenergy, electrotechnics and electromechanics". The features of the technology of additive manufacturing of electrical apparatuses parts by the method of FDM printing have been investigated. Parts of four standard sizes were printed using ABS + and PLA plastics, namely, current transformer carcasses in the amount of 110 pieces and sensor bodies in the amount of 100 pieces. For printing, an FDM 3D printer was used built on the XZ Head Y Bed kinematic scheme with an open working chamber. The analysis of defects in finished products was carried out, which showed that the main defects are deviations of the actual dimensions and geometric shape of the finished products. Ways to prevent the occurrence of these defects are considered, namely, correcting the size of the model at the stage of preparing the model for printing, minimizing the filling density of the model, using brims in models, setting the optimal temperature of the working platform and simultaneously printing several products. The results of the study o features of the technology of additive manufacturing of electrical apparatuses parts by the method of FDM printing made it possible to develop a set of laboratory works for students of the specialty 141 "Electroenergy, electrotechnics and electromechanics".

Finite Element Analysis of Additive Manufacturing Based on Fused Deposition Modeling: Distortions Prediction and Comparison With Experimental Data

2018 ◽  
Vol 141 (1) ◽  
Author(s):  
Alberto Cattenone ◽  
Simone Morganti ◽  
Gianluca Alaimo ◽  
Ferdinando Auricchio
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Step Size ◽  
Time Step ◽  
Time Step Size ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
The Impact ◽  
Functional Components

Additive manufacturing (or three-dimensional (3D) printing) is constantly growing as an innovative process for the production of complex-shape components. Among the seven recognized 3D printing technologies, fused deposition modeling (FDM) covers a very important role, not only for producing representative 3D models, but, mainly due to the development of innovative material like Peek and Ultem, also for realizing structurally functional components. However, being FDM a production process involving high thermal gradients, non-negligible deformations and residual stresses may affect the 3D printed component. In this work we focus on meso/macroscopic simulations of the FDM process using abaqus software. After describing in detail the methodological process, we investigate the impact of several parameters and modeling choices (e.g., mesh size, material model, time-step size) on simulation outcomes and we validate the obtained results with experimental measurements.

Additive Manufacturing as an Important Industry Player for the Next Decades

2019 ◽  
Vol 17 (16) ◽  
pp. 68-71
Author(s):  
Nastase-Dan Ciobota ◽  
Gheorghe Ion Gheorghe ◽  
Veronica Despa
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Rapid Prototyping ◽  
Full Advantage ◽  
Fused Deposition Modeling ◽  
Consumer Products ◽  
Motor Vehicles ◽  
Academic Institutions ◽  
Fused Deposition ◽  
Deposition Modeling

Abstract Additive Manufacturing (AM) concerns all classes of materials – polymers, metals, ceramics and glasses as well. For this reason, AM is in the focus of material scientists from all branches. Leaders of the industry realize that the possibilities of 3D printing are endless, and that these possibilities need ways and means to be taken full advantage of. Today, aerospace engineers are using the fused deposition modeling (FDM) method for rapid prototyping, part manufacturing, and tooling. They are followed by leaders and engineers from industry (industrial machines, motor vehicles, consumer products, medical/dental) but also from academic institutions and government/military.

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

scholarly journals Prototype for fit investigation

2021 ◽  
Vol 11 (1) ◽  
pp. 5-15
Author(s):  
Talal Alsardia ◽  
László Lovas ◽  
Péter Ficzere
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Physical Model ◽  
Fused Deposition Modeling ◽  
3 Dimensional ◽  
Promising Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
Deposition Modeling

Nowadays, additive manufacturing is a powerful tool and promising technology both for manufacturing and educational purposes. This work aims to present a case study of using 3 dimensional (3D) printing technology for fit investigations. It describes the creation of a physical model (prototype) by using the Fused Deposition Modeling (FDM) method. The prototype of two plates was made to perform an inspection how the prototype fits with other components.

scholarly journals Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 52 ◽  
Author(s):  
Nagi Reddy Dumpa ◽  
Suresh Bandari ◽  
Michael A. Repka
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Lag Time ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Pulsatile Drug Delivery ◽  
Hot Melt

This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method. Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC)-based filaments were fabricated using hot-melt extrusion technology and were utilized as feedstock material for printing shells in FDM 3D printing. The directly compressed theophylline tablet was used as the core. The tablet shell to form pulsatile floating dosage forms with different geometries (shell thickness: 0.8, 1.2, 1.6, and 2.0 mm; wall thickness: 0, 0.8, and 1.6 mm; and % infill density: 50, 75, and 100) were designed, printed, and evaluated. All core-shell tablets floated without any lag time and exhibited good floating behavior throughout the dissolution study. The lag time for the pulsatile release of the drug was 30 min to 6 h. The proportion of ethyl cellulose in the filament composition had a significant (p < 0.05) effect on the lag time. The formulation (2 mm shell thickness, 1.6 mm wall thickness, 100% infill density, 0.5% EC) with the desired lag time of 6 h was selected as an optimized formulation. Thus, FDM 3D printing is a potential technique for the development of complex customized drug delivery systems for personalized pharmacotherapy.

3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling

2021 ◽  
Vol 600 ◽  
pp. 120501
Author(s):  
Nagireddy Dumpa ◽  
Arun Butreddy ◽  
Honghe Wang ◽  
Neeraja Komanduri ◽  
Suresh Bandari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Hot Melt
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