Altered Protein Expression of Cardiac CYP2J and Hepatic CYP2C, CYP4A, and CYP4F in a Mouse Model of Type II Diabetes—A Link in the Onset and Development of Cardiovascular Disease?

Cardiovascular disease is the most frequent cause of death in patient with diabetes. It is difficult to evaluate cardiovascular status of patients with diabetes because of complex symptomatology. NTproBNP, a split peptide from pro BNP molecule is a novel biomarker, released from cardiac myocytes in response to myocardial stretch, cardio vascular disease, endothelial dysfunction and heart failure. We aimed to test that is elevated NTproBNP levels associated with increased risk of cardiovascular disease in diabetes patients in comparison to matched control. Demographic, anthropometric measure, NT pro BNP, lipid profile, blood glucose were estimated and compared among angiographically proven cardiovascular disease patients with diabetes and healthy controls. Univariate and multivariate analysis were carried out to compare individual factor using t-Test, ANOVA and the inter group comparisons were done by using Bon ferroni Post Hoc test. Patients with type 2 diabetes were shown to have higher NTproBNP values (n=50, 1481.021±813.405) than control subjects (n=50, 23.562±23.395) (p <0.05). NTproBNP levels were independently related to diabetes after adjustment for age, sex, family history, smoking, obesity, blood pressure and lipid profile. Our data suggests that the secretion of NT pro BNP is increased in type II diabetes patients, suggesting association of diabetes and NTproBNP in cardio vascular disease with higher prevalence. Thus NTproBNP may serve as a screening tool to diagnose patients with type II diabetes with cardiovascular disease having complex symptomatology. Keyword: NTproBNP, Cardiovascular disease, Diabetes DOI:10.3329/jom.v11i1.4266 J Medicine 2010: 11: 33-38

Download Full-text

Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2020.119071 ◽

2020 ◽

Vol 577 ◽

pp. 119071

Author(s):

Zaizhi Gui ◽

Jinchang Zhu ◽

Song Ye ◽

Juan Ye ◽

Jiao Chen ◽

...

Keyword(s):

Glycemic Control ◽

Acute Toxicity ◽

Mouse Model ◽

Type Ii Diabetes ◽

Type Ii

Download Full-text

Low‐fat diet: case study of a cardiology patient

Nutrition & Food Science ◽

10.1108/00346651011029273 ◽

2010 ◽

Vol 40 (2) ◽

pp. 235-242 ◽

Cited By ~ 1

Author(s):

Tanefa A. Apekey ◽

Anne J.E. Morris ◽

Shamusi Fagbemi ◽

G.J. Griffiths

Keyword(s):

Cardiovascular Disease ◽

Pulse Rate ◽

Type Ii Diabetes ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Density Lipoprotein ◽

Type Ii ◽

Low Fat ◽

Content Type ◽

Low Fat Diet

PurposeHealthy diet and lifestyle have been shown to be important for obese patients in the management of diet‐related diseases especially in the improvement of cardiovascular disease risk indicators. The purpose of this paper is to determine the effects of a calorie‐restricted low‐fat diet on body weight, cardiovascular disease risk and liver function indicators in an obese, cardiology outpatient with type II diabetes.Design/methodology/approachA male, obese cardiology outpatient was assigned to a calorie‐restricted (6,694.4 kJ/d) low‐fat (not to exceed 20 per cent of total energy intake) diet for 12 weeks. His body mass index (BMI), blood pressure (BP), pulse rate, fasting glucose, total cholesterol, triglyceride, low‐density lipoprotein cholesterol, high‐density lipoprotein (HDL) cholesterol, alanine aminotranseferase, aspartate aminotranseferase (AST) concentration and TC/HDL ratio were measured prior to the start of the diet and during weeks four, eight and 12 of the diet.FindingsThe patient found it difficult making changes to his diet and only reduced his weight by 1 kg. He significantly reduced his serum triglyceride by about 20 per cent, TC/HDL ratio by 13 per cent and fasting blood glucose concentration by 31 per cent. However, there was no significant change in his BP, pulse rate, total and LDL cholesterol concentration. He also reduced his AST concentration by 20 per cent and alanine aminotranseferase (ALT) by 19 per cent.Originality/valueThis paper usefully shows how healthier food choices involving increased intake of fruits and vegetables and restricted intake of total and saturated fat reduced the risk of cardiovascular death in a male cardiology outpatient with type II diabetes.

Download Full-text