scholarly journals An Integrated Health-System Specialty Pharmacy Model for Coordinating Transitions of Care: Specialty Medication Challenges and Specialty Pharmacist Opportunities

Pharmacy ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 163
Author(s):  
Autumn D. Zuckerman ◽  
Alicia Carver ◽  
Katrina Cooper ◽  
Brandon Markley ◽  
Amy Mitchell ◽  
...  
Keyword(s):  
Best Practices ◽  
Health System ◽  
Vital Role ◽  
Transitions Of Care ◽  
Case Examples ◽  
Specialty Pharmacy ◽  
Specialty Medication ◽  
Insight Into ◽  
Shed Light

Adherence and persistence to specialty medications are necessary to achieve successful outcomes of costly therapies. The increasing use of specialty medications has exposed several unique barriers to certain specialty treatments’ continuation. Integrated specialty pharmacy teams facilitate transitions in sites of care, between different provider types, among prescribed specialty medications, and during financial coverage changes. We review obstacles encountered within these types of transitions and the role of the specialty pharmacist in overcoming these obstacles. Case examples for each type of specialty transition provide insight into the unique complexities faced by patients, and shed light on pharmacists’ vital role in patient care. This insightful and real-world experience is needed to facilitate best practices in specialty care, particularly in the growing number of health-system specialty pharmacies.

The Ubiquitous Role of Mobile Phones in Value Co-Creation Through Social Media Marketing

2021 ◽  
pp. 2166-2180
Author(s):  
Syed Far Abid Hossain ◽  
Xu Shan ◽  
Abdul Qadeer
Keyword(s):  
Social Media ◽  
Data Collection ◽  
Mobile Phones ◽  
Random Sampling ◽  
Vital Role ◽  
Social Media Marketing ◽  
Primary Data ◽  
Use Of Social Media ◽  
Shed Light

The purpose of this paper is to ascertain the contemporary role of mobile phones in value co-creation through social media marketing. How mobile phones, in particular, smartphones with the help of numerous social media generate value co-creation, is the key objective of this study. A random sampling method was used to conduct a survey in different universities in China to identify the role of mobile phones in value co-creation. Findings from primary data collection indicated that mobile phones play a vital role in value co-creation because of the extensive use of social media. If value co-creation through social media marketing develops with the help of producers, suppliers and other intermediaries with the necessary technology and trust, the society, as well as customers, may enjoy a unique way of shopping. Future studies with mixed methodology and respondents who use different social media as a tool to generate value co-creation may shed light on the undiscovered phenomenon of social media marketing in the context of the mobile phone.

scholarly journals Cryo-EM structure of native human thyroglobulin

2021 ◽  
Author(s):  
Ricardo Adaixo ◽  
Eva M. Steiner ◽  
Ricardo D. Righetto ◽  
Alexander Schmidt ◽  
Henning Stahlberg ◽  
...  
Keyword(s):  
Secretory Pathway ◽  
3D Structure ◽  
Vital Role ◽  
Hormone Synthesis ◽  
Cryo Electron Microscopy ◽  
Glycosylation Sites ◽  
Regulation Of Metabolism ◽  
Fundamental Understanding ◽  
Insight Into

The thyroglobulin (Tg) protein is essential to thyroid hormone synthesis, playing a vital role in the regulation of metabolism, development and growth. Its structure is conserved among vertebrates. Tg is delivered through the secretory pathway of the thyroid follicular unit to the central colloid depository, where it is iodinated at specific tyrosine sites to form mono- or diiodotyrosine, which combine to produce triiodothyronine (T3) and thyroxine (T4), respectively. Synthesis of these hormones depends on the precise 3D structure of Tg, which has remained unknown despite decades of research. Here, we present the cryo-electron microscopy structure of human thyroglobulin (hTg) to a global resolution of 3.2 Å. The structure provides detailed information on the location of the hTg hormonogenic sites and reveals the position as well as the role of many of its glycosylation sites. Our results offer structural insight into thyroid hormonogenesis and provide a fundamental understanding of clinically relevant hTg mutations, which can improve treatment of thyroid diseases.

scholarly journals Culture and ELT: Cambodian teachers' perception and practice of textbook adaptation to realize intercultural awareness

2020 ◽  
Vol 9 (1) ◽  
pp. 65-74
Author(s):  
Davut Nhem
Keyword(s):  
Vital Role ◽  
Cultural Integration ◽  
Phnom Penh ◽  
Teaching Culture ◽  
Language And Culture ◽  
Intercultural Awareness ◽  
Individual Interviews ◽  
Efl Teachers ◽  
Shed Light

Currently, it is recognized that language and culture go hand in hand, which means that when we teach a language, we also teach the culture of that language or other languages that appear in the textbooks being used. This wide recognition of the vital role of culture in the second language teaching has presented challenges for EFL teachers in various contexts. This article reports a qualitative study on three Cambodian teachers of English at one school in Phnom Penh. The study aims to investigate EFL teachers’ views and practices of textbook adaptation, as well as how they adapt textbooks to help students develop intercultural awareness in the ELT. To achieve these objectives, the qualitative data obtained from individual interviews, classroom observations, and teaching materials were engaged to shed light on the backdrop of the textbook adaptation and cultural integration in the ELT classroom. The findings in this study reveal an inconsistency between teachers’ views and practices about the textbook adaptation and the teachers’ limited capacity of interculturality-stimulated scholarship that is inherently tied to the development of cultural activities in the ELT classroom. This study suggests teacher training on the textbook adaptation and teaching culture should be provided to the teachers in the context and beyond.

scholarly journals Cryo-EM structure of native human thyroglobulin

2021 ◽  
Author(s):  
Ricardo Adaixo ◽  
Eva Steiner ◽  
Ricardo Righetto ◽  
Alexander Schmidt ◽  
Henning Stahlberg ◽  
...  
Keyword(s):  
Secretory Pathway ◽  
3D Structure ◽  
Vital Role ◽  
Hormone Synthesis ◽  
Cryo Electron Microscopy ◽  
Glycosylation Sites ◽  
Regulation Of Metabolism ◽  
Fundamental Understanding ◽  
Insight Into

Abstract The thyroglobulin (Tg) protein is essential to thyroid hormone synthesis, playing a vital role in the regulation of metabolism, development and growth. Its structure is conserved among vertebrates. Tg is delivered through the secretory pathway of the thyroid follicular unit to the central colloid depository, where it is iodinated at specific tyrosine sites to form mono- or diiodotyrosine, which combine to produce triiodothyronine (T3) and thyroxine (T4), respectively. Synthesis of these hormones depends on the precise 3D structure of Tg, which has remained unknown despite decades of research. Here, we present the cryo-electron microscopy structure of human thyroglobulin (hTg) to a global resolution of 3.2 Å. The structure provides detailed information on the location of the hTg hormonogenic sites and reveals the position as well as the role of many of its glycosylation sites. Our results offer structural insight into thyroid hormonogenesis and provide a fundamental understanding of clinically relevant hTg mutations, which can improve treatment of thyroid diseases.

scholarly journals A partial defense of clinical equipoise

2019 ◽  
Vol 15 (2) ◽  
pp. 1-17
Author(s):  
Scott D Gelfand
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Clinical Equipoise ◽  
Best Interest ◽  
Fourth Section ◽  
Insight Into ◽  
Shed Light

In this essay, I suggest that a slightly modified version of Freedman’s formulation of the clinical equipoise requirement is justified. I begin this essay with a brief discussion of the equipoise requirement. In the second and third sections, I discuss several objections to the clinical equipoise requirement as well as two attempts to justify the equipoise requirement. In the fourth section, in order to gain some insight into what it means to say that a physician has an obligation to act in the best interest of her patient, I examine a similar obligation, namely, a parent’s obligation to act in her child’s best interest. I claim that there are several uncontroversial exceptions to this obligation, and these exceptions arise when a parent occupies a role more complex than the role of parent simpliciter. In the fifth section, I explore whether the exceptions to a parent’s obligation to act in her child’s best interest may shed light on some exceptions to a physician–researcher’s obligation to act in the best interest of her patient. These exceptions, I suggest, arise when a physician occupies a role more complex than physician simpliciter, and they ground a permission to conduct randomized clinical trials, even if doing so is not in the best interest of a physician–researcher’s patients. I furthermore claim that these exceptions provide justification for a modified formulation of the clinical equipoise requirement.

Assertion, Negotiation and Subjugation of Identity: Understanding the Tamil-Malayali Conflict in Munnar

2019 ◽  
Vol 10 (2) ◽  
pp. 167-182
Author(s):  
Shyam Hari P.
Keyword(s):  
Social Interaction ◽  
Social Identity ◽  
Critical Role ◽  
Vital Role ◽  
Social Identities ◽  
Dynamic Nature ◽  
Major Objective ◽  
Heterogeneous Societies ◽  
Insight Into

Social identities play a critical role in the various phases of conflict. Existing literature often examines the role of social identity of groups in inducing conflict in heterogeneous societies. This article puts forward the view that the role of identity is not limited in terms of inducing conflict, but it also plays a vital role in influencing the dynamics of conflict. Based on this conceptual framework, the article outlines the conflict dynamics observable in the Kannan Devan Hills village in Kerala, where several factors, over the course of time in the last century, have led to the perception of conflict between the Tamils and the Malayalis. As a major objective, the article identifies the issues and processes of social interaction between the two groups that necessarily influence the nature of the conflict. The article identifies that the conflict between the two communities, though mostly latent, can be seen through three important aspects: assertion, negotiation and subjugation of identities. Through assertion of identity, the conflict is perceived over ethnic lines, whereas the process of negotiation and subjugation of identity constantly undermines the ethnic nature of conflict to specific grievances, thus giving insight into the dynamic nature of the conflict.

How Hard Is It To Red Team?

2006 ◽  
pp. 46-78
Author(s):  
Ang Yang ◽  
Hussein A. Abbass ◽  
Ruhul Sarker
Keyword(s):  
Fitness Function ◽  
Search Space ◽  
Strategic Decisions ◽  
Evolutionary Method ◽  
Forward Prediction ◽  
Expected Performance ◽  
Insight Into ◽  
Shed Light ◽  
Single Configuration

Red teaming is the process of studying a problem by anticipating adversary behaviors. When done in simulations, the behavior space is divided into two groups: one controlled by the red team, which represents the set of adversary behaviors or bad guys; the other controlled by the blue team, which represents the set of defenders or good guys. Through red teaming, analysts can learn about the future by forward prediction of scenarios. More recently, defense has been looking at evolutionary computation methods in red teaming. The fitness function in these systems is highly stochastic, where a single configuration can result in multiple outcomes. Operational, tactical and strategic decisions can be made based on the findings of the evolutionary method in use. Therefore, there is an urgent need to understand the nature of these problems and the role of the stochastic fitness to gain insight into the possible performance of different methods. This chapter presents a first attempt at characterizing the search space difficulties in red teaming to shed light on the expected performance of the evolutionary method in stochastic environments.

Sounding the Unheard River: Reflections on an Ecological Sound Art Praxis as a Response to Ecosystem Distress

2019 ◽  
Vol 49 (1) ◽  
pp. 151-170 ◽  
Author(s):  
Trish Morgan
Keyword(s):  
Sound Art ◽  
The Face ◽  
Multiple Audiences ◽  
The One ◽  
Insight Into ◽  
Shed Light

This article reflects on a body of academic and practice-based work in the contexts of praxis. It asserts that in the face of systemic issues pertaining to ecosystem crisis, multidisciplinary approaches are required, which also enable the agency of the researcher to continue their work in challenging circumstances. In reflecting on the work conducted, the article aims to offer an insight into multiple ways in which knowledge about ecosystem distress can be communicated to multiple audiences. Furthermore, in providing a reflexive account of an ecological sound art project titled The Miracle of the One Thing, the article aims to shed light on the role of practice-based approaches in communicating ecosystem distress. It implicitly offers an alternative to the ‘ocularcentrism’ of the visual turn. It questions the assumption that communication about ecosystem crisis is necessarily visual or written, and places the role of sonic practices to the fore.

scholarly journals Intrinsic flexibility of porous materials; theory, modelling and the flexibility window of the EMT zeolite framework

2015 ◽  
Vol 71 (6) ◽  
pp. 641-647 ◽  
Author(s):  
Rachel E. Fletcher ◽  
Stephen A. Wells ◽  
Ka Ming Leung ◽  
Peter P. Edwards ◽  
Asel Sartbaeva
Keyword(s):  
Real Space ◽  
Ionic Conductors ◽  
Static Properties ◽  
Zeolite Framework ◽  
Framework Materials ◽  
Collective Motions ◽  
The Cost ◽  
Insight Into ◽  
Shed Light

Framework materials have structures containing strongly bonded polyhedral groups of atoms connected through their vertices. Typically the energy cost for variations of the inter-polyhedral geometry is much less than the cost of distortions of the polyhedra themselves – as in the case of silicates, where the geometry of the SiO4 tetrahedral group is much more strongly constrained than the Si—O—Si bridging angle. As a result, framework materials frequently display intrinsic flexibility, and their dynamic and static properties are strongly influenced by low-energy collective motions of the polyhedra. Insight into these motions can be obtained in reciprocal space through the `rigid unit mode' (RUM) model, and in real-space through template-based geometric simulations. We briefly review the framework flexibility phenomena in energy-relevant materials, including ionic conductors, perovskites and zeolites. In particular we examine the `flexibility window' phenomenon in zeolites and present novel results on the flexibility window of the EMT framework, which shed light on the role of structure-directing agents. Our key finding is that the crown ether, despite its steric bulk, does not limit the geometric flexibility of the framework.

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