scholarly journals Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 948
Author(s):  
Nicola Zerbinati ◽  
Sabrina Sommatis ◽  
Cristina Maccario ◽  
Maria Chiara Capillo ◽  
Giulia Grimaldi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Polyethylene Glycol ◽  
Biological Activities ◽  
Diglycidyl Ether ◽  
Dermal Filler ◽  
Cross Linking ◽  
Matrix Structure ◽  
Dermal Fillers ◽  
Rheological Characterization

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE family. Over the last few years, several studies have been performed to investigate the biocompatibility and biodegradability of these formulations, but little information is available regarding their matrix structure, rheological and physicochemical properties related to their cross-linking technologies, the HA content or the degree of cross-linking. (2) Methods: Seven different injectable HA hydrogels were subjected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed cross-linked dermal fillers showed a fibrous “spiderweb-like” matrix structure, with each medical device presenting different and peculiar rheological features. Except for HA non cross-linked hydrogel 18 mg/mL, all showed an elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literature works makes a preliminary characterization of these injectable medical devices possible.

scholarly journals Comparative Physicochemical Analysis among 1,4-Butanediol Diglycidyl Ether Cross-Linked Hyaluronic Acid Dermal Fillers

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 139
Author(s):  
Nicola Zerbinati ◽  
Sabrina Sommatis ◽  
Cristina Maccario ◽  
Maria Chiara Capillo ◽  
Giulia Grimaldi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Medical Devices ◽  
Physicochemical Analysis ◽  
Diglycidyl Ether ◽  
Dermal Filler ◽  
Cross Linking ◽  
Matrix Structure ◽  
Dermal Fillers ◽  
Aesthetic Medicine

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used in several chirurgical practices and in aesthetic medicine. HA filler stability can be enhanced through different cross-linking technologies; one of the most frequently cross-linker used is 1,4-butanediol diglycidyl ether (BDDE), also present in the HA-BDDE dermal filler family of the company Matex Lab S.p.A. (Brindisi, Italy). Our overview is focused on their characterization, drawing a correlation between matrix structure, rheological and physicochemical properties related to their cross-linking technologies. (2) Methods: Four different injectable HA hydrogels were characterized through optical microscopic examination and rheological behavior investigation. (3) Results: The cross-linked HA dermal fillers showed a fibrous “spiderweb-like” matrix structure and an elastic and solid-like profile. (4) Conclusions: The comparative analysis represents a preliminary characterization of these injectable medical devices in order to identify their best field of application.

scholarly journals Cetuximab associated dermal filler reaction

2019 ◽  
Vol 12 (8) ◽  
pp. e228882 ◽  
Author(s):  
Shivanshan Pathmanathan ◽  
Marcin Dzienis
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Radiation Therapy ◽  
Hyaluronic Acid ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Epidermal Growth ◽  
Receptor Inhibitor

A 52-year-old male patient with hyaluronic acid-based dermal fillers injected in his cheeks was diagnosed with glossotonsillary malignancy, and managed with concurrent cetuximab (epidermal growth factor receptor inhibitor) and radiation therapy. He developed significant inflammation around the dermal filler sites after first cycle of cetuximab which improved with dissolution of the dermal fillers with hyaluronidase. This suggests that cetuximab can lead to inflammation around the dermal filler sites, which can be treated with dissolution of the filler.

Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide cross-linking

Biomaterials ◽  
2002 ◽  
Vol 23 (4) ◽  
pp. 1205-1212 ◽  
Author(s):  
Si-Nae Park ◽  
Jong-Chul Park ◽  
Hea Ok Kim ◽  
Min Jung Song ◽  
Hwal Suh
Keyword(s):  
Hyaluronic Acid ◽  
Cross Linking

Polyacryloyl hydrazide based injectable & stimuli responsive hydrogels with tunable properties

2014 ◽  
Vol 2 (42) ◽  
pp. 7429-7439 ◽  
Author(s):  
Anuj Kumar ◽  
Sabindra K. Samal ◽  
Rupesh Dash ◽  
Umaprasana Ojha
Keyword(s):  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Diethyl Malonate ◽  
Synthesis And Characterization ◽  
Cross Linking ◽  
Stimuli Responsive ◽  
Polyethylene Glycol Diacrylate ◽  
Glycol Diacrylate ◽  
Responsive Hydrogels

The synthesis and characterization of a series of injectable and stimuli responsive hydrogels based on polyacryloyl hydrazide have been accomplished using dimethyl 2,2′-thiodiacetate, acrylic acid, diethyl malonate and polyethylene glycol diacrylate as cross-linkers through a chemical or dual cross-linking pathway.

Dermal filler migration complications following lip augmentation procedures

2020 ◽  
Vol 9 (7) ◽  
pp. 276-281
Author(s):  
Danielle Davy
Keyword(s):  
Hyaluronic Acid ◽  
Rare Complication ◽  
Post Treatment ◽  
The Body ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Short Term ◽  
Lip Augmentation ◽  
Permanent Fillers

Filler migration is a rare complication of dermal filler treatment. Although most research has found that more permanent fillers, such as silicone, are more likely to migrate due to their long-term presence in the body, there have also been reported cases of filler migration from short-term hyaluronic acid-based dermal fillers. As lip augmentation procedures are fast becoming one of the most frequently requested treatments in medical aesthetics, this article looks at the longevity of hyaluronic acid lip dermal fillers, while also aiming to assess the cause of dermal filler post-treatment migration and evaluating how to minimise its risk.

scholarly journals HA-based dermal filler: downstream process comparison, impurity quantitation by validated HPLC-MS analysis, and in vivo residence time study

2019 ◽  
Vol 17 (3) ◽  
pp. 228080001986707 ◽  
Author(s):  
Cristian Guarise ◽  
Carlo Barbera ◽  
Mauro Pavan ◽  
Susi Panfilo ◽  
Riccardo Beninatto ◽  
...  
Keyword(s):  
Residence Time ◽  
Rabbit Model ◽  
Diglycidyl Ether ◽  
In Vitro Cytotoxicity ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Process Comparison ◽  
Hygroscopic Properties

The success of hyaluronic acid (HA)-based dermal fillers, with more than 2 million minimally invasive procedures conducted in 2016 in the US alone, is due to their hygroscopic properties of biocompatibility and reversibility. The type and density of HA cross-linkage, as well as the manufacturing technology, may influence not only the in vivo persistence but also the safety profile of dermal fillers. 1,4-Butanediol diglycidyl ether (BDDE) is the cross-linker used in most market-leading HA fillers; 1,4-butanediol di-(propan-2,3-diolyl) ether (BDPE) is the major impurity obtained from the HA–BDDE cross-linking (HBC) process. In this work, a new process to obtain high purity HBC fillers was developed. A new HPLC-MS method was validated for the quantification of BDPE content in HBC dermal fillers. In vitro cytotoxicity of BDPE was evaluated in fibroblasts (IC50 = 0.48 mg/mL). The viscoelasticity was monitored during the shelf-life of the HBC-10% hydrogel and was correlated with in vitro hyaluronidase resistance and in vivo residence time in a rabbit model. This analysis showed that elasticity is the best parameter to predict the in vivo residence time. Finally, a series of parameters were investigated in certain marketed dermal fillers and were compared with the results of the HBC-10% hydrogel.

Synthesis and characterization of polyethylene glycol polyacrylamide copolymer (PEGA) resins containing carbohydrate ligands. Evaluation as supports for affinity chromatography

1998 ◽  
Vol 76 (8) ◽  
pp. 1109-1118 ◽  
Author(s):  
France-Isabelle Auzanneau ◽  
Mette Knak Christensen ◽  
Shannon L Harris ◽  
Morten Meldal ◽  
B Mario Pinto
Keyword(s):  
Polyethylene Glycol ◽  
Radical Copolymerization ◽  
Cross Linking ◽  
Carbohydrate Binding ◽  
Streptococcus Group ◽  
Group A ◽  
Carbohydrate Ligands ◽  
Immunoaffinity Columns ◽  
Cross Linker

The PEGA resin, a beaded polyethylene glycol dimethylacrylamide copolymer, was evaluated as an affinity support for the purification of carbohydrate-binding macromolecules, namely, the cation-independent mannosyl phosphate receptor (CI-MPR) and a polyclonal antibody directed against a Streptococcus Group A oligosaccharide. Two polyethylene glycol (PEG) derivatives, a di-acryloylated PEG1900derivative or a longer di-acryloylated PEG4000derivative, were used as cross-linkers. The longer cross-linker was synthesized in four steps from polyethylene glycol 4000. The mannosyl 6-phosphate (M6P)-containing immunoaffinity columns were prepared through the inverse suspension radical copolymerization of the corresponding allyl glycoside with acrylamide and the PEG cross-linker. The resin with the shorter cross-linker (PEG1900derivative) had a 6.3% molar cross-linking while that with the longer cross-linker (PEG4000derivative) had a 3.8% molar cross-linking. For the Streptococcus Group A trisaccharide-containing immunoaffinity columns, three PEGA affinity supports bearing free amino groups were prepared and subsequently substituted with a trisaccharide activated as its squarate adduct. While one resin contained the shorter cross-linker PEG1900and had a 3% molar cross-linking, the other two resins contained the longer cross-linker PEG4000 with a molar cross-linking of 5% and 3%, respectively. In affinity chromatographic studies, the M6P-containing columns were ineffective in retaining the cation-independent mannosyl phosphate receptor (CI-MPR, ~ 215kDa), whereas antibody (~ 150kDa) retention was observed with two of the three Streptococcus Group A trisaccharide-containing immunoaffinity columns. Key words: PEGA resins, immunoaffinity supports, carbohydrate ligands, antibody purification.

Rheological characterization of polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus®) water dispersions

2013 ◽  
Vol 292 (1) ◽  
pp. 235-241 ◽  
Author(s):  
Marco Cespi ◽  
Luca Casettari ◽  
Giovanni Filippo Palmieri ◽  
Diego Romano Perinelli ◽  
Giulia Bonacucina
Keyword(s):  
Polyethylene Glycol ◽  
Graft Copolymer ◽  
Polyvinyl Acetate ◽  
Rheological Characterization

scholarly journals Dermal Filler types, Effect on soft tissue and Life Style correlation

2020 ◽  
Vol 3 ◽  
pp. 1
Author(s):  
Dalia A Mohamed
Keyword(s):  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Life Style ◽  
Dermal Filler ◽  
Dermal Fillers ◽  
Bovine Collagen ◽  
The World ◽  
History Of ◽  
Facial Contours ◽  
Common Manifestation

One of the most common manifestation in our time, especially among girls, is those procedures on the skin or maintaining or to modify some of the changes in the skin, such as those that come due to aging or any other cosmetic reasons. Fillers and Botox are two of the most popular procedures. Dermal fillers are effective treatments used to soften and reduce wrinkles and deep lines, fill out the cheeks and smooth facial contours. There are four main types of injectable dermal fillers, including fat, collagen, hyaluronic acid, and microsphere-containing carriers of another material such as polymethyl methacrylate (PMMA). So that to understand any type of injection, it is important to look at its history for valuable lessons and for successful progress. Honestly, it is very interesting to see what and where the world gets in the last 40 years of injectable. Today, we will be examining the brief history of dermal fillers from their bovine collagen roots, to the advanced fillers that are available today. In this review, we aimed to show some types of dermal fillers including a variety of its complication in soft tissue. Also, we try to correlate the factor of lifestyle  with its variant effects.

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