scholarly journals A Hydrophobic Derivative of Ciprofloxacin as a New Photoinitiator of Two-Photon Polymerization: Synthesis and Usage for the Formation of Biocompatible Polylactide-Based 3D Scaffolds

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3385
Author(s):  
Kseniia N. Bardakova ◽  
Yaroslav V. Faletrov ◽  
Evgenii O. Epifanov ◽  
Nikita V. Minaev ◽  
Vladislav S. Kaplin ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Bone Tissue Regeneration ◽  
Good Thermal Stability ◽  
Two Photon ◽  
Processing Window ◽  
Good Solubility ◽  
Low Cytotoxicity ◽  
First Time ◽  
High Absorption ◽  
Two Photon Polymerization

A hydrophobic derivative of ciprofloxacin, hexanoylated ciprofloxacin (CPF-hex), has been used as a photoinitiator (PI) for two-photon polymerization (2PP) for the first time. We present, here, the synthesis of CPF-hex and its application for 2PP of methacrylate-terminated star-shaped poly (D,L-lactide), as well a systematic study on the optical, physicochemical and mechanical properties of the photocurable resin and prepared three-dimensional scaffolds. CPF-hex exhibited good solubility in the photocurable resin, high absorption at the two-photon wavelength and a low fluorescence quantum yield = 0.079. Structuring tests showed a relatively broad processing window and revealed the efficiency of CPF-hex as a 2PP PI. The prepared three-dimensional scaffolds showed good thermal stability; thermal decomposition was observed only at 314 °C. In addition, they demonstrated an increase in Young’s modulus after the UV post-curing (from 336 ± 79 MPa to 564 ± 183 MPa, which is close to those of a cancellous (trabecular) bone). Moreover, using CPF-hex as a 2PP PI did not compromise the scaffolds’ low cytotoxicity, thus they are suitable for potential application in bone tissue regeneration.

scholarly journals Two-photon polymerization nanolithography technology for fabrication of stimulus-responsive micro/nano-structures for biomedical applications

2020 ◽  
Vol 9 (1) ◽  
pp. 1118-1136
Author(s):  
Zhenjia Huang ◽  
Gary Chi-Pong Tsui ◽  
Yu Deng ◽  
Chak-Yin Tang
Keyword(s):  
Biomedical Applications ◽  
Three Dimensional ◽  
Water Soluble ◽  
Fabrication Technology ◽  
Nano Fabrication ◽  
Two Photon ◽  
Nano Structures ◽  
Wide Range ◽  
Stimulus Responsive ◽  
Two Photon Polymerization

AbstractMicro/nano-fabrication technology via two-photon polymerization (TPP) nanolithography is a powerful and useful manufacturing tool that is capable of generating two dimensional (2D) to three dimensional (3D) arbitrary micro/nano-structures of various materials with a high spatial resolution. This technology has received tremendous interest in cell and tissue engineering and medical microdevices because of its remarkable fabrication capability for sophisticated structures from macro- to nano-scale, which are difficult to be achieved by traditional methods with limited microarchitecture controllability. To fabricate precisely designed 3D micro/nano-structures for biomedical applications via TPP nanolithography, the use of photoinitiators (PIs) and photoresists needs to be considered comprehensively and systematically. In this review, widely used commercially available PIs are first discussed, followed by elucidating synthesis strategies of water-soluble initiators for biomedical applications. In addition to the conventional photoresists, the distinctive properties of customized stimulus-responsive photoresists are discussed. Finally, current limitations and challenges in the material and fabrication aspects and an outlook for future prospects of TPP for biomedical applications based on different biocompatible photosensitive composites are discussed comprehensively. In all, this review provides a basic understanding of TPP technology and important roles of PIs and photoresists for fabricating high-precision stimulus-responsive micro/nano-structures for a wide range of biomedical applications.

Acoustic Field-Assisted Two-Photon Polymerization Process

2021 ◽  
Vol 143 (10) ◽  
Author(s):  
Ketki M. Lichade ◽  
Yayue Pan
Keyword(s):  
Polymer Composite ◽  
Acoustic Field ◽  
Laser Power ◽  
Liquid Droplet ◽  
Three Dimensional ◽  
Polymerization Process ◽  
Photothermal Effect ◽  
Full Potential ◽  
Two Photon ◽  
Two Photon Polymerization

Abstract This study successfully integrates acoustic patterning with the Two-Photon Polymerization (TPP) process for printing nanoparticle–polymer composite microstructures with spatially varied nanoparticle compositions. Currently, the TPP process is gaining increasing attention within the engineering community for the direct manufacturing of complex three-dimensional (3D) microstructures. Yet the full potential of TPP manufactured microstructures is limited by the materials used. This study aims to create and demonstrate a novel acoustic field-assisted TPP (A-TPP) process, which can instantaneously pattern and assemble nanoparticles in a liquid droplet, and fabricate anisotropic nanoparticle–polymer composites with spatially controlled particle–polymer material compositions. It was found that the biggest challenge in integrating acoustic particle patterning with the TPP process is that nanoparticles move upon laser irradiation due to the photothermal effect, and hence, the acoustic assembly is distorted during the photopolymerization process. To cure acoustic assembly of nanoparticles in the resin through TPP with the desired nanoparticle patterns, the laser power needs to be carefully tuned so that it is adequate for curing while low enough to prevent the photothermal effect. To address this challenge, this study investigated the threshold laser power for polymerization of TPP resin (Pthr) and photothermal instability of the nanoparticle (Pthp). Patterned nanoparticle–polymer composite microstructures were fabricated using the novel A-TPP process. Experimental results validated the feasibility of the developed acoustic field-assisted TPP process on printing anisotropic composites with spatially controlled material compositions.

scholarly journals Rapid Fabrication of Continuous Surface Fresnel Microlens Array by Femtosecond Laser Focal Field Engineering

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 112 ◽  
Author(s):  
Linyu Yan ◽  
Dong Yang ◽  
Qihuang Gong ◽  
Yan Li
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Fresnel Lens ◽  
Two Dimensional ◽  
Direct Writing ◽  
Lens Array ◽  
Two Photon ◽  
Rapid Fabrication ◽  
Continuous Surface ◽  
Two Photon Polymerization

Femtosecond laser direct writing through two-photon polymerization has been widely used in precision fabrication of three-dimensional microstructures but is usually time consuming. In this article, we report the rapid fabrication of continuous surface Fresnel lens array through femtosecond laser three-dimensional focal field engineering. Each Fresnel lens is formed by continuous two-photon polymerization of the two-dimensional slices of the whole structure with one-dimensional scan of the corresponding two-dimensional engineered intensity distribution. Moreover, we anneal the lens array to improve its focusing and imaging performance.

scholarly journals Three-Dimensional Cell Growth on Structures Fabricated from ORMOCER® by Two-Photon Polymerization Technique

2007 ◽  
Vol 22 (3) ◽  
pp. 275-287 ◽  
Author(s):  
Sabrina Schlie ◽  
Anaclet Ngezahayo ◽  
Aleksandr Ovsianikov ◽  
Tilman Fabian ◽  
Hans-Albert Kolb ◽  
...  
Keyword(s):  
Cell Growth ◽  
Three Dimensional ◽  
Two Photon ◽  
Dimensional Cell ◽  
Two Photon Polymerization

An Exhaustive Analysis of the Characterization of Photopolymer Material (SZ2080) by Two-Photon Polymerization, Waves Moving in a Periodic Potential, and Two-Photon Absorption

2020 ◽  
Vol 1003 ◽  
pp. 165-172 ◽  
Author(s):  
Ritu Walia ◽  
Kamal Nain Chopra
Keyword(s):  
Photonic Crystals ◽  
Quantum Coherence ◽  
Periodic Potential ◽  
Three Dimensional ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Polymerization Waves ◽  
Two Photon Polymerization

This paper presents an Exhaustive Analysis of the Characterization of Photopolymer Material (SZ2080) by Two-Photon Polymerization, and some of the modern concepts like Characterization of Photonic Crystals in Photopolymer SZ2080 by Two-Photon Polymerization, Waves Moving in a Periodic Potential, and Optical Quantum metamaterials. Two-photon polymerization for fabricating three-dimensional subdiffraction-limited structures has been discussed. Experimental and Computed Curves of line thickness (nm) vs feed rate (μm/s) have been technically analyzed. Waves moving in a Periodic Potential and Photonic Crystals have been technically discussed. In addition, Optical Quantum metamaterials have been discussed in terms of quantum coherence, and quantum dots with emphasis on cavity array metamaterial.

Sign in / Sign up

Export Citation Format

Share Document