Lymphatic Filariasis Increases Tissue Compressibility and Extracellular Fluid in Lower Limbs of Asymptomatic Young People in Central Myanmar

The aim of the study was features of ultrastructural changes in cellular elements and connective tissue carcass of the great saphenous vein (GSV) at varicose disease in depending on the duration of the disease in persons of different ages. An examination by light microscopy of 133 fragments of BPV, excised during phlebectomy in 19 patients, and an electron microscopic examination of 532 preparations were performed. Depending on the age of the patients, four age groups was distinguished: 18-44 years old (young people); 45-59 years (middle-aged people); 60-74 years old (the elderly), 75-90 years old (persons of senile age). In the wall of the GSV of young people with a small duration of the disease, there were poorly expressed pathomorphological changes characterized by moderately expressed endothelial dysfunction and minor hypertrophy of smooth muscle cells (SMC) of the middle shell. In the group of middle-aged people, in addition to age-related changes in the structure of the wall of varicose dilated GSV, pathological changes are noted that are characteristic of the long course of the disease with the development of endothelial dysfunction. The phenotypic heterogeneity of the SMC in the middle shell intensifies, and the communication links between them is altered. Disorganization of connective tissue leads to a decrease in the strength of the connective tissue vein skeleton. Hypertrophy of SMC, as a universal compensatory-adaptive response of cells, develops in response to an increase in functional load with hemodynamic disturbances in the veins of the lower limbs and to compensate for the quantitative deficiency of SMC as a result of their death. In elderly and senile age the duration of varicose disease is more than 10 years, on average - up to 25-30 years. The number of destructively altered SMC is increasing, degenerative processes and sclerotic changes are progressing. The ultrastructural analysis of biopsies showed that at the initial stage of development of varicose disease in young people with a small duration of varicose disease, morphological changes in the structure of the GSV wall are poorly expressed. With the increase in the age of the patient and the duration of the disease, changes in GSV are progressed. Involute degenerative-dystrophic changes are most pronounced in patients over 60 years of age and are an aggravating factor during varicose transformation of the GSV wall. In elderly and senile age, the compensatory possibilities of the cells decrease, the sclerotic degenerative changes in the wall of the GSV are progressed.

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Can the Neuromuscular Performance of Young Athletes Be Influenced by Hormone Levels and Different Stages of Puberty?

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17165637 ◽

2020 ◽

Vol 17 (16) ◽

pp. 5637 ◽

Cited By ~ 3

Author(s):

Paulo Francisco de Almeida-Neto ◽

Dihogo Gama de Matos ◽

Vanessa Carla Monteiro Pinto ◽

Paulo Moreira Silva Dantas ◽

Tatianny de Macêdo Cesário ◽

...

Keyword(s):

Muscle Strength ◽

Young People ◽

Young Male ◽

Lower Limbs ◽

Young Athletes ◽

Testosterone Levels ◽

Neuromuscular Performance ◽

Lower Limb Strength ◽

Determining Factor ◽

Hormonal Levels

Background: Endocrine mechanisms can be a determining factor in the neuromuscular performance of young athletes. Objective: The objective of the present study was to relate maturational and hormonal markers to neuromuscular performance, as well as to verify whether young athletes with different testosterone levels show differences in muscle strength. Methods: The sample consisted of 37 young male Brazilian athletes (11.3 ± 0.94 years) who were members of a sports initiation project. Hormonal markers were analyzed biochemically by blood samples, and maturation markers by mathematical models based on anthropometry. Body composition was verified by tetrapolar bioimpedance. The performance of upper and lower limb strength and body speed were analyzed. Results: Hormonal and maturational markers were related to neuromuscular performance (p < 0.05). Young people with higher testosterone levels showed higher muscle strength (p < 0.05). Artificial neural networks showed that testosterone predicted the performance of upper limbs by 49%, and maturation by 60%. Maturation foreshadowed the performance of lower limbs by 30.3%. Conclusion: Biological maturation and hormonal levels can be related to neuromuscular performance, and young people with higher testosterone levels show superior muscle strength in relation to the others.

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Association of congenital anomalies with fracture of spine, trunk, and upper and lower limbs among young people

Medicine ◽

10.1097/md.0000000000007980 ◽

2017 ◽

Vol 96 (36) ◽

pp. e7980

Author(s):

Chia-Man Ma ◽

Lih-Hwa Lin ◽

Hsing-Yi Chang ◽

Pei-Chi Chou ◽

Po-Chi Liao ◽

...

Keyword(s):

Young People ◽

Congenital Anomalies ◽

Lower Limbs

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Influence of skeletal maturation on physical fitness of young people with Down syndrome

Revista Brasileira de Educação Física e Esporte ◽

10.11606/issn.1981-4690.v34i3p373-383 ◽

2020 ◽

Vol 34 (3) ◽

pp. 373-383

Author(s):

Everaldo Lambert Modesto ◽

Leonardo dos Santos Oliveira ◽

Bruna Barboza Seron ◽

Eloise Werle de Almeida ◽

Márcia Greguol

Keyword(s):

Down Syndrome ◽

Resistance Training ◽

Muscle Strength ◽

Young People ◽

Physical Fitness ◽

Intervention Program ◽

Training Group ◽

Lower Limbs ◽

Skeletal Maturation ◽

Control Group

Individuals with Down syndrome (DS) tend to prematurely reach the skeletal maturation period. In addition, young people with this condition have poor physical fitness and few opportunities to practice physical activity when compared to those without disabilities. The aim of this study was to investigate the skeletal maturation of young people with Down syndrome and its influence on the behavior of physical fitness related to health, after aerobic and resistance training programs. Forty people with DS, with an average age of 15.4 (± 2.6) years, were divided into three groups for a 12 weeks intervention program, AT - aerobic training group (3 times/week; 50 minutes/session), RT - resistance training group (twice/week ; 50 minutes/session) and CG - control group, 9 participants. Determination of skeletal age (EA) was performed using the Greulich-Pyle method. Anthropometric variables, muscle strength and peak VO2 were measured pre and post intervention. It was found that skeletal maturation influenced the effects of training, only being significant for body weight and strength in the upright row variables. In addition, the muscle strength of upper and lower limbs increased significantly after 12 weeks of aerobic or resistance training. Then, we can conclude that the effects of physical training on physical fitness of young people with Down syndrome appear to improve as the bone age increases.

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Acute Kidney Injury due to Rhabdomyolysis Followed by Alcohol Intake and Physical Aggression: Case Report and Literature Review

Journal of Medicine ◽

10.3329/jom.v13i2.12759 ◽

2012 ◽

Vol 13 (2) ◽

pp. 212-215

Author(s):

Elizabeth De Francesco Daher ◽

Neiberg De Alcantara Lima ◽

Rafael Siqueira Athayde Lima ◽

Pedro Henrique de Oliveira Filgueira ◽

Meissa Kretzman ◽

...

Keyword(s):

Acute Kidney Injury ◽

Emergency Room ◽

Case Reports ◽

Extracellular Fluid ◽

Supportive Therapy ◽

Kidney Injury ◽

Initial Therapy ◽

Lower Limbs ◽

Fluid Replacement ◽

Laboratory Findings

Rhabdomyolysis is defined as a skeletal muscle injury, with subsequent release of cellular constituents into the extracellular fluid and the circulation. Several conditions can lead to rhabdomyolysis, and new causes are constantly expanded with new case reports. The aim of this paper is to report on a case of acute kidney injury (AKI) induced by rhabdomyolysis due to alcohol abuse and physical agression. A 48-year-old man was admitted to the emergency room with dyspnea, lower limbs edema, weakness, oliguria and dark brown urine. Four days before admission he was physically attacked, after drinking almost 2.5 liters of beer. The diagnosis of AKI due to rhabdomyolysis was made through clinical and laboratory findings (creatine kinase 184,376 IU/l, serum urea 275 mg/dL, creatinine 14.6 mg/ dL, potassium 7.9 mEq/L). Urgency hemodyalisis was started due to anuria, refractory hiperkalemia and hypercatabolism. Recovery of renal function was recorded, after fourteen hemodialysis sessions. Patients with rhabdomyolysis are common in the emergency room. Initial therapy of fluid replacement is essential to prevent progression to renal failure. Once established, the dialysis is indicated early. The prognosis is good, when early supportive therapy is adequate. DOI: http://dx.doi.org/10.3329/jom.v13i2.12759 J Medicine 2012; 13 : 212-215

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An outbreak of acute skin and soft tissue infections including necrotizing fasciitis in Kalwala village, India, 2018: Public health implications for the lymphatic filariasis elimination program

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/traa046 ◽

2020 ◽

Vol 114 (10) ◽

pp. 742-750

Author(s):

Kiran Kumar Maramraj ◽

Kavitha Latha ML ◽

Tanzin Dikid ◽

Sushma Choudhary ◽

Sukrutha Reddy ◽

...

Keyword(s):

Soft Tissue ◽

Necrotizing Fasciitis ◽

Lymphatic Filariasis ◽

Wound Dressing ◽

Bacterial Infections ◽

Lower Limbs ◽

Soft Tissue Infections ◽

Health Seeking ◽

Health Seeking Behavior ◽

Seeking Behavior

Abstract Background A cluster of 15 acute skin and soft tissue infections (SSTIs), including two cases of necrotizing fasciitis, reported in July 2018 from Kalwala village, led us to investigate and describe their epidemiology and to provide recommendations. Methods Cases, defined as localized painful swelling and redness in Kalwala residents from 1 December 2017 to 20 August 2018, were identified from hospital records and house-to-house surveys. We conducted an unmatched case-control study to identify risk factors for severity. We cultured wound samples and environmental samples from wound-dressing stations. Results We identified 36 cases (median age: 55 [range 17–80] y; 78% male), village attack rate 1% (36/4337) and no deaths. In 34 cases (94%), lower limbs were involved. Lymphatic filariasis (LF) was a common predisposing condition (67%). Comorbidities (diabetes or hypertension) (OR=9; 95% CI 2.0 to 41.1), poor limb hygiene (OR=16; 95% CI 2.8 to 95.3) and poor health-seeking behavior (OR=5; 95% CI 1.6 to 30.8) were associated with severity. All seven wound samples and 8/11 samples from wound-dressing stations showed atypical polymicrobial growth (Pseudomonas, Proteus, Klebsiella, Escherichia coli and Clostridium). Conclusion The outbreak of SSTIs among older males with LF was due to secondary bacterial infections and severity was associated with comorbidities, poor hygiene and health-seeking behavior, and likely contamination during wound-dressing. The LF elimination program managers was alerted, programmatic interventions were scaled up, home/facility-based morbidity and comorbidity management was facilitated and the outbreak was rapidly contained.

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Supine equilibration of extracellular fluid in peritoneal dialysis varies with intra-abdominal pressure

Peritoneal Dialysis International ◽

10.1177/0896860819895176 ◽

2020 ◽

Vol 40 (5) ◽

pp. 477-486 ◽

Cited By ~ 1

Author(s):

Daniel Schneditz ◽

Notburga Sauseng ◽

Ezgi Pütün ◽

Alexander R Rosenkranz ◽

Werner Ribitsch

Keyword(s):

Peritoneal Dialysis ◽

Body Position ◽

Extracellular Fluid ◽

Volume Overload ◽

Venous Congestion ◽

Lower Limbs ◽

Column Height ◽

Abdominal Pressure ◽

Multifrequency Bioimpedance ◽

Extracellular Resistance

Background: Increased intra-abdominal pressure (PIA) leads to venous congestion in splanchnic and adjoining circulations. The aim is to examine whether PIA in peritoneal dialysis (PD) affects the mobilization of extracellular fluid from the lower body in supine body position. Methods: Patients were studied during a regular peritoneal equilibration test (PET) in supine body position using multifrequency bioimpedance analysis to determine extracellular resistance and absolute volume overload (AVO) in wrist-to-ankle (W2A) as well as in ankle-to-ankle (A2A) configurations. Measurements were taken at baseline (T0) after draining the peritoneal cavity, at T1 shortly after filling with 2 L of standard dialysate, and at T2 before taking the 2 h PET samples. PIA was measured from the column height in the PD catheter. Extracellular resistance in the lower extremities (RL) was taken as half of the A2A resistance. Results: Eighteen patients (56 ± 15 years, 76 ± 21 kg, body mass index (BMI) 26.4 ± 7 kg/m2, 13 men) were studied. After having assumed a supine body position for the duration of 17, 77, and 155 min, AVO continuously decreased from 1.6 ± 1.3 (T0) to 1.2 ± 1.5 (T1) and 1.0 ± 1.4 L (T2). RL significantly increased from 238 ± 57 (T0) to 254 ± 62 (T1) and 264 ± 67 Ohm (T2). This increase was negatively correlated to BMI and PIA measured at any time point, but not to net ultrafiltration volume. Conclusions: Orthostatic fluid shifts from the lower limbs may take up to 2 h in supine PD patients, especially with high BMI and PIA because of venous congestion in splanchnic and adjoining circulations.

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Influence of skeletal maturation on physical fitness of young people with Down syndrome

Revista Brasileira de Educação Física e Esporte ◽

10.11606/1807-5509202000030373 ◽

2020 ◽

Vol 34 (3) ◽

pp. 373-383

Author(s):

Everaldo Lambert Modesto ◽

Leonardo dos Santos Oliveira ◽

Bruna Barboza Seron ◽

Eloise Werle de Almeida ◽

Márcia Greguol

Keyword(s):

Down Syndrome ◽

Resistance Training ◽

Muscle Strength ◽

Young People ◽

Physical Fitness ◽

Intervention Program ◽

Training Group ◽

Lower Limbs ◽

Skeletal Maturation ◽

Control Group

Individuals with Down syndrome (DS) tend to prematurely reach the skeletal maturation period. In addition, young people with this condition have poor physical fitness and few opportunities to practice physical activity when compared to those without disabilities. The aim of this study was to investigate the skeletal maturation of young people with Down syndrome and its influence on the behavior of physical fitness related to health, after aerobic and resistance training programs. Forty people with DS, with an average age of 15.4 (± 2.6) years, were divided into three groups for a 12 weeks intervention program, AT - aerobic training group (3 times/week; 50 minutes/session), RT - resistance training group (twice/week ; 50 minutes/session) and CG - control group, 9 participants. Determination of skeletal age (EA) was performed using the Greulich-Pyle method. Anthropometric variables, muscle strength and peak VO2 were measured pre and post intervention. It was found that skeletal maturation influenced the effects of training, only being significant for body weight and strength in the upright row variables. In addition, the muscle strength of upper and lower limbs increased significantly after 12 weeks of aerobic or resistance training. Then, we can conclude that the effects of physical training on physical fitness of young people with Down syndrome appear to improve as the bone age increases.

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