Architecture of Hierarchical Stellar Systems and Their Formation

Accumulation of new data on stellar hierarchical systems and the progress in numerical simulations of their formation open the door to genetic classification of these systems, where properties of a certain group (family) of objects are tentatively related to their formation mechanisms and early evolution. A short review of the structure and statistical trends of known stellar hierarchies is given. Like binaries, they can be formed by the disk and core fragmentation events happening sequentially or simultaneously and followed by the evolution of masses and orbits driven by continuing accretion of gas and dynamical interactions between stars. Several basic formation scenarios are proposed and associated qualitatively with the architecture of real systems, although quantitative predictions for these scenarios are still pending. The general trend of increasing orbit alignment with decreasing system size points to the critical role of the accretion-driven orbit migration, which also explains the typically comparable masses of stars belonging to the same system. The architecture of some hierarchies bears imprints of chaotic dynamical interactions. Characteristic features of each family are illustrated by several real systems.

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Importance of gas-particle partitioning of ammonia in haze formation in the rural agricultural environment

Atmospheric Chemistry and Physics ◽

10.5194/acp-20-7259-2020 ◽

2020 ◽

Vol 20 (12) ◽

pp. 7259-7269 ◽

Cited By ~ 3

Author(s):

Jian Xu ◽

Jia Chen ◽

Na Zhao ◽

Guochen Wang ◽

Guangyuan Yu ◽

...

Keyword(s):

Fine Particles ◽

Critical Role ◽

Feedback Mechanism ◽

Water Soluble ◽

Formation Mechanisms ◽

Haze Pollution ◽

Inorganic Species ◽

High Ammonia ◽

Haze Formation

Abstract. Ammonia in the atmosphere is essential for the formation of fine particles that impact air quality and climate. Despite extensive prior research to disentangle the relationship between ammonia and haze pollution, the role of ammonia in haze formation in high ammonia-emitting regions is still not well understood. Aiming to better understand secondary inorganic aerosol (sulfate, nitrate, ammonium – SNA) formation mechanisms under high-ammonia conditions, 1-year hourly measurement of water-soluble inorganic species (gas and particle) was conducted at a rural supersite in Shanghai. Exceedingly high levels of agricultural ammonia, constantly around 30 µg m−3, were observed. We find that gas-particle partitioning of ammonia (ε(NH4+)), as opposed to ammonia concentrations, plays a critical role in SNA formation during the haze period. From an assessment of the effects of various parameters, including temperature (T), aerosol water content (AWC), aerosol pH, and activity coefficient, it seems that AWC plays predominant regulating roles for ε(NH4+). We propose a self-amplifying feedback mechanism associated with ε(NH4+) for the formation of SNA, which is consistent with diurnal variations in ε(NH4+), AWC, and SNA. Our results imply that a reduction in ammonia emissions alone may not reduce SNA effectively, at least at rural agricultural sites in China.

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New insights into nutrition and cognitive neuroscience

Proceedings of The Nutrition Society ◽

10.1017/s0029665109990188 ◽

2009 ◽

Vol 68 (4) ◽

pp. 408-415 ◽

Cited By ~ 58

Author(s):

M. J. Dauncey

Keyword(s):

Mental Health ◽

Brain Plasticity ◽

Critical Role ◽

Short Review ◽

Neural Pathways ◽

Brain Health ◽

Brain Structure And Function ◽

And Function ◽

The Brain

Nutrition can affect the brain throughout the life cycle, with profound implications for mental health and degenerative disease. Many aspects of nutrition, from entire diets to specific nutrients, affect brain structure and function. The present short review focuses on recent insights into the role of nutrition in cognition and mental health and is divided into four main sections. First, the importance of nutritional balance and nutrient interactions to brain health are considered by reference to the Mediterranean diet, energy balance, fatty acids and trace elements. Many factors modulate the effects of nutrition on brain health and inconsistencies between studies can be explained in part by differences in early environment and genetic variability. Thus, these two factors are considered in the second and third parts of the present review. Finally, recent findings on mechanisms underlying the actions of nutrition on the brain are considered. These mechanisms involve changes in neurotrophic factors, neural pathways and brain plasticity. Advances in understanding the critical role of nutrition in brain health will help to fulfil the potential of nutrition to optimise brain function, prevent dysfunction and treat disease.

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The Critical Role of TRIB2 in Cancer and Therapy Resistance

Cancers ◽

10.3390/cancers13112701 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2701

Author(s):

Victor Mayoral-Varo ◽

Lucía Jiménez ◽

Wolfgang Link

Keyword(s):

Critical Role ◽

Therapy Resistance ◽

Dependent Manner ◽

E3 Ligases ◽

Cancer Subtypes ◽

Evolutionarily Conserved ◽

The Family ◽

Ubiquitin Proteasome ◽

Characteristic Features

The Tribbles pseudokinases family consists of TRIB1, TRIB2, TRIB3 and STK40 and, although evolutionarily conserved, they have distinctive characteristics. Tribbles members are expressed in a context and cell compartment-dependent manner. For example, TRIB1 and TRIB2 have potent oncogenic activities in vertebrate cells. Since the identification of Tribbles proteins as modulators of multiple signalling pathways, recent studies have linked their expression with several pathologies, including cancer. Tribbles proteins act as protein adaptors involved in the ubiquitin-proteasome degradation system, as they bridge the gap between substrates and E3 ligases. Between TRIB family members, TRIB2 is the most ancestral member of the family. TRIB2 is involved in protein homeostasis regulation of C/EBPα, β-catenin and TCF4. On the other hand, TRIB2 interacts with MAPKK, AKT and NFkB proteins, involved in cell survival, proliferation and immune response. Here, we review the characteristic features of TRIB2 structure and signalling and its role in many cancer subtypes with an emphasis on TRIB2 function in therapy resistance in melanoma, leukemia and glioblastoma. The strong evidence between TRIB2 expression and chemoresistance provides an attractive opportunity for targeting TRIB2.

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POPDC proteins and cardiac function

Biochemical Society Transactions ◽

10.1042/bst20190249 ◽

2019 ◽

Vol 47 (5) ◽

pp. 1393-1404 ◽

Cited By ~ 4

Author(s):

Thomas Brand

Keyword(s):

Potential Role ◽

Striated Muscle ◽

Short Review ◽

Effector Proteins ◽

Muscle Disease ◽

Disease Genes ◽

Protein Protein Interaction ◽

Interaction Partners ◽

And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

Perspectives on Language Learning and Education ◽

10.1044/lle15.2.50 ◽

2008 ◽

Vol 15 (2) ◽

pp. 50-59 ◽

Cited By ~ 1

Author(s):

Amy Philofsky

Keyword(s):

Language Development ◽

Critical Role ◽

Children With Autism ◽

Autism Spectrum ◽

Children With Asd ◽

Prevalence Estimates ◽

Notable Increase ◽

Screening Assessment ◽

Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

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