scholarly journals Dexmedetomidine and Tear Production: Evaluation in Dogs as Spontaneous Model for Ocular Surface Disorders

2021 ◽  
Vol 8 (2) ◽  
pp. 28
Author(s):  
Simona Di Pietro ◽  
Claudia Giannetto ◽  
Annastella Falcone ◽  
Giuseppe Piccione ◽  
Fulvio Congiu ◽  
...  
Keyword(s):  
Analysis Of Variance ◽  
Drug Administration ◽  
Ocular Surface ◽  
Tear Film ◽  
Experimental Period ◽  
Radiologic Assessment ◽  
Tear Production ◽  
Bonferroni Test ◽  
Post Hoc

Tear film provides lubrication and protection to the ocular surface. The sedation reduces tear production, often leading to perioperative exposure keratopathy. The aim of the present study was to report the effects of intramuscular dexmedetomidine on canine tear production, measured by STT-1, for an experimental period of 8 h after sedation. Ten dogs who underwent sedation for routine radiologic assessment were recruited for the study. In all animals, tear production in right and left eyes was measured 15 min before sedation (T0: basal values) and 20 min (T20), 1 h (T1), 2 h (T2), 4 h (T4) and 8 h (T8) after drug administration. Analysis of variance and post hoc Bonferroni test (p < 0.05) were performed. A significant effect of time on canine tear production was found. The tear production returned to basal values at T8. So, it is recommended to treat the canine eyes with tear substitutes during and up to 12 h after sedation.

scholarly journals Profilo farmacologico clinico e farmacoeconomico di un gel oftalmico a base di carbomero 974P e PVA (Siccafluid®) nella terapia della cheratocongiuntivite secca

2005 ◽  
Vol 6 (3) ◽  
pp. 185-196
Author(s):  
Lorenzo Pradelli ◽  
Letizia Vacchini
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Lubricating Film ◽  
Tear Production ◽  
Ocular Discomfort ◽  
Ophthalmic Solutions

BACKGROUND: The dry eye sindrome refers to a group of disorders of the tear film due to reduced tear production or excessive tear evaporation that is associated with symptoms of ocular discomfort and may cause disease of the ocular surface. Dry eye syndrome varies in severity, duration and etiology. The cornerstone of dry eye syndrome therapies includes the intraocular gel or ophthalmic solutions instillation, reaching correct artificial lubrication. Molecules that can produce a stable lubricating film are the carbomers. METHODS: In the first step of our work we reviewed the data from literature reporting about carbomers’ characteristics in respect to other lacrimal substitutes. Then, a pharmacoeconomical analysis has been performed on ophtalmic gels derived from carbomers 974P and PVA. RESULTS: Dry eye sindrome, if not adequately treated, determines a deterioration of the patient’s quality of life, other than high secondary costs. CONCLUSION: The high therapeutical index of carbomers 974P and PVA-based gels, in addition to the their limited cost (totally free for Sjögren patients in Italy), suggests that this product is characterized by one of the best benefits-to-costs ratios in the treatment of dry eye sindrome.

scholarly journals Location of Scoliosis and Postural Reactions Among Girls Aged 7-18 Years

2018 ◽  
Vol 12 (9) ◽  
pp. 19
Author(s):  
Jacek Wilczynski ◽  
Natalia Habik ◽  
Sylwia Janecka ◽  
Przemyslaw Karolak ◽  
Alicja Sliwa ◽  
...  
Keyword(s):  
Analysis Of Variance ◽  
Repeated Measures ◽  
Postural Reactions ◽  
Eyes Closed ◽  
Significant Relationships ◽  
Lateral Curvature ◽  
Bonferroni Test ◽  
Post Hoc ◽  
Ellipse Area ◽  
Selection Of

The objective of the study was evaluation of the relationships between location of scoliosis and postural reactions in girls aged 7-18. The study included 28 girls aged 7-18 with lateral curvature of the spine and scoliotic posture. Selection of the examined girls was targeted. The children were treated in the Inter-School Centre for Corrective and Compensatory Gymnastics in Starachowice. The study was conducted in June 2011. Digital Exhibeon radiograms were applied to determine the location of the curvature. Postural reactions were evaluated using the static-dynamic platform Tecnobody ST 310 Plus Stability System. The variables were verified for normality of the distribution by means of Shapiro-Wilk test. The variability of the quantitative characteristics with respect to categorial characteristics was verified by using one-way and two-way repeated measures ANOVA. In the case of significant main results or interactions, the Bonferroni test and Tukey test were applied as a post hoc analysis. The p values p&lt;0.05 were considered statistically significant. Analysis of variance showed significant relationships between Average Forward-Backward Speed, Perimeter, Ellipse Area in open eyes test (OE), and location of the curvature. The highest amplitudes of the reactions Average Forward-Backward Speer, Perimeter, Ellipse Area in open eyes test (OE) were observed in lumbar curvatures. In examination with eyes closed (CE), a correlation was found between the location of the curvature and Forward-Backward Standard Deviation, Average Forward-Backward Speer, and Perimeter. The highest amplitudes of reactions Average Forward-Backward Speer, Perimeter, Ellipse Area in eyes closed test (CE) were noted also in lumbar curvatures. The comparative analysis of variance of postural reactions with respect to the location of the secondary curvature showed significant results only for Average Forward-Backward Speed (OE). Average Forward-Backward Speed (OE) was the highest in curvatures with thoracic location. 

Dry Eye and Clinical Disease of Tear Film, Diagnosis and Management

2014 ◽  
Vol 07 (02) ◽  
pp. 109
Author(s):  
Vasilis Achtsidis ◽  
Eleftheria Kozanidou ◽  
Panos Bournas ◽  
Nicholas Tentolouris ◽  
Panos G Theodossiadis ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Sjögren's Syndrome ◽  
Tear Film ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Tear Production ◽  
Sjögren‘S Syndrome

Dry eye disease (DED) is a clinically significant multifactorial disorder of the ocular surface and tear film as it results in ocular discomfort and visual impairment and predisposes the cornea to infections. It is important for the quality of life and tends to be a chronic disease. It is also common, as the prevalence is estimated between 5 % to 30 % and this increases with age. Therefore, it is recognized as a growing public health problem that requires correct diagnosis and appropriate treatment. There are two main categories of DED: the deficiency of tear production (hyposecretive), which includes Sjögren’s syndrome, idiopathic or secondary to connective tissue diseases (e.g. rheumatoid arthritis), and non-Sjögren’s syndrome (e.g. age-related); and the tear evaporation category, where tears evaporate from the ocular surface too rapidly due to intrinsic causes (e.g. meibomian gland disease or eyelid aperture disorders) or extrinsic causes (e.g. vitamin A deficiency, contact lenses wear, ocular allergies). Management of the disease aims to enhance the corneal healing and reduce patient’s discomfort. This is based on improving the balance of tear production and evaporation by increasing the tear film volume (lubrication drops) and improving quality of tear film (ex omega-3 supplements, lid hygiene, tetracyclines), reducing the tear film evaporation (paraffin ointments, therapeutic contact lenses), reducing tear’s drainage (punctal plugs, cautery), and finally by settling down the ocular surface inflammation (steroids, cyclosporine, autologous serous), as appropriate. In this article we will review the clinical presentation, differential diagnosis, and treatment options for DED.

scholarly journals Fracture Resistance of Commonly Used Self-drilling Mini-implants of Various Diameters

2020 ◽  
Vol 54 (1) ◽  
pp. 31-38
Author(s):  
Vinodh S. ◽  
B. Sangamesh ◽  
Neelakantha Patil V. ◽  
Sameer Ahmed ◽  
Venkat Naidu B.
Keyword(s):  
Analysis Of Variance ◽  
Fracture Resistance ◽  
Insertion Torque ◽  
Limited Information ◽  
Mini Implants ◽  
Significant Difference ◽  
Bonferroni Test ◽  
Different Diameters ◽  
Treatment Procedures ◽  
Post Hoc

Context: Self-drilling mini-implants are commonly used in orthodontic treatment procedures, but there is limited information regarding their fracture resistance in areas of high-density bone without predrilling. Aims: The objective of this study is to compare and evaluate the maximum insertion torque and fracture resistance of 3 commonly used self-drilling mini-implants in India, and to assess the influence of variation in diameter in torque generation. Materials and methods: 90 mini-implants from 3 different manufacturers with 2 different diameters were drilled into acrylic blocks using a dial indicating torque screwdriver. All mini-implants were drilled at the rate of 20-30 rotations/min, implants were drilled until they fractured. Torque generated at the point of fracture is shown on the dial of the screwdriver. Measurements of the peak insertion torque value for each manufacturer were recorded separately. Statistical analysis: Analysis of variance, post hoc Bonferroni test. Results: Analysis of variance test showed a significant difference among all the manufacturers in both the diameters with P < .05. Implants of 1.6 mm diameter of Ancer group have the highest fracture resistance value when compared with the same diameter of JJ Orthodontics and SK Surgicals. Implants with higher diameter have more resistance than those with lower diameter. Conclusions: The observed highest fracture resistance is 47 Ncm by Ancer and least fracture resistance is 16 Ncm by JJ Orthodontics. The values are higher than the torque required to place mini-implants intraorally. Ancer mini-implants have the highest peak fracture torque, thus more than SK Surgicals and JJ Orthodontics.

Dry Eye and Clinical Disease of Tear Film, Diagnosis and Management

2014 ◽  
Vol 08 (01) ◽  
pp. 17 ◽  
Author(s):  
Vasilis Achtsidis ◽  
Eleftheria Kozanidou ◽  
Panos Bournas ◽  
Nicholas Tentolouris ◽  
Panos G Theodossiadis ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Connective Tissue Diseases ◽  
Tear Film ◽  
Public Health Problem ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Tear Production

Dry eye disease (DED) is a clinically significant multifactorial disorder of the ocular surface and tear film as it results in ocular discomfort and visual impairment and predisposes the cornea to infections. It is important for the quality of life and tends to be a chronic disease. It is also common, as the prevalence is estimated between 5 % to 30 % and this increases with age. Therefore, it is recognised as a growing public health problem that requires correct diagnosis and appropriate treatment. There are two main categories of DED: the deficiency of tear production (hyposecretive), which includes Sjögren syndrome, idiopathic or secondary to connective tissue diseases (e.g. rheumatoid arthritis), and non-Sjögren syndrome (e.g. age-related); and the tear evaporation category, where tears evaporate from the ocular surface too rapidly due to intrinsic causes (e.g. meibomian gland disease or eyelid aperture disorders) or extrinsic causes (e.g. vitamin A deficiency, contact lenses wear, ocular allergies). Management of the disease aims to enhance the corneal healing and reduce patient’s discomfort. This is based on improving the balance of tear production and evaporation by increasing the tear film volume (lubrication drops) and improving quality of tear film (ex omega-3 supplements, lid hygiene, tetracyclines), reducing the tear film evaporation (paraffin ointments, therapeutic contact lenses), reducing tear’s drainage (punctal plugs, cautery) and finally by settling down the ocular surface inflammation (steroids, cyclosporine, autologous serous), as appropriate. In this article we will review the clinical presentation, differential diagnosis and treatment options for DED.

scholarly journals Tear Proteomics Study of Dry Eye Disease: Which Eye Do You Adopt as the Representative Eye for the Study?

2021 ◽  
Vol 22 (1) ◽  
pp. 422
Author(s):  
Ming-Tse Kuo ◽  
Po-Chiung Fang ◽  
Shu-Fang Kuo ◽  
Alexander Chen ◽  
Yu-Ting Huang
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Mechanistic Studies ◽  
Clinical Tests ◽  
Tear Proteins ◽  
Proteomic Data ◽  
Surface Performance

Most studies about dry eye disease (DED) chose unilateral eye for investigation and drew conclusions based on monocular results, whereas most studies involving tear proteomics were based on the results of pooling tears from a group of DED patients. Patients with DED were consecutively enrolled for binocular clinical tests, tear biochemical markers of DED, and tear proteome. We found that bilateral eyes of DED patients may have similar but different ocular surface performance and tear proteome. Most ocular surface homeostatic markers and tear biomarkers were not significantly different in the bilateral eyes of DED subjects, and most clinical parameters and tear biomarkers were correlated significantly between bilateral eyes. However, discrepant binocular presentation in the markers of ocular surface homeostasis and the associations with tear proteins suggested that one eye’s performance cannot represent that of the other eye or both eyes. Therefore, in studies for elucidating tear film homeostasis of DED, we may lose some important messages hidden in the fellow eye if we collected clinical and proteomic data only from a unilateral eye. For mechanistic studies, it is recommended that researchers collect tear samples from the eye with more severe DED under sensitive criteria for identifying the more severe eye and evaluating the tear biochemical and proteomic markers with binocular concordance drawn in prior binocular studies.

Psychophysically Based Physical Capability Limits For Right Angle Power Tool Operation

2020 ◽  
Vol 64 (1) ◽  
pp. 910-914
Author(s):  
Jonathan Valencia ◽  
Joel Cort
Keyword(s):  
Analysis Of Variance ◽  
The Other ◽  
Mixed Design ◽  
Joint Orientation ◽  
Physical Capability ◽  
Subject Variables ◽  
Group A ◽  
Repeated Analysis ◽  
Post Hoc

A psychophysical methodology was utilized to examine 40 non-skilled female participants performing right-angle power tool (RAPT) fastening tasks. A combination of two between subject variables were examined for a total of four between-subject groups: joint orientation (horizontal and vertical planes) and joint hardness (hard and soft joints). Participants were evenly distributed into one of four joint orientation- hardness groups. Within each group, a combination of three fastening strategies and three fastening frequencies were performed by each participant. The chosen target torque determined the physical capability limits (PCL). A mixed-design repeated analysis of variance with Tukey’ significance post hoc test were used to determine any significance with the measured variables ( p<0.05). Fastening strategy and frequency influenced the chosen torque magnitude. Participants chose significantly higher target torques with the Turbo Tight strategy in comparison to the other two strategies. Furthermore, participants chose to accept lower target torques and forces as fastening frequency increased.

scholarly journals Characteristics of anteroposterior curvatures of the spine in soccer and futsal players

2017 ◽  
Vol 18 (4) ◽  
Author(s):  
Krystyna Chromik ◽  
Anna Burdukiewicz ◽  
Jadwiga Pietraszewska ◽  
Aleksandra Stachoń ◽  
Paweł Wolański ◽  
...  
Keyword(s):  
College Students ◽  
Statistical Analysis ◽  
Injury Prevention ◽  
Analysis Of Variance ◽  
Statistical Significance ◽  
Body Posture ◽  
Soccer Players ◽  
Prevention Training ◽  
The Difference ◽  
Post Hoc

AbstractPurpose. The aim of the study was to determine differences in anteroposterior spine curvatures between futsal players, soccer players, and non-training students. The results may contribute to the development of present-day knowledge of posturometry, and its implementation in training can help reduce the risk of body posture disorders in athletes. Methods. The examined group consisted of 48 athletes and 38 non-training college students. Body posture parameters were measured with the use of Posturometr-S. The normality of distribution was checked with the Shapiro-Wilk test, and the differences between the groups were measured with ANOVA and the Bonferroni post-hoc test. The level of statistical significance was set at p < 0.05. Results. The analysis of angle values revealed the widest and most similar measurements in the group of futsal players and soccer players. The analysis of variance proved statistically significant differences between the soccer players and futsal players (p = 0.003). The difference between the soccer players and non-training students was statistically significant. The highest γ angular value was measured in non-training students, followed by futsal players and soccer players. The statistical analysis revealed significant differences between the non-training students and futsal players, as well as non-training students and soccer players (p < 0.001). Conclusions. A complex assessment of athletes’ body posture is crucial in injury prevention. Training overloads may often lead to disorders of the organ of locomotion and affect the correct body posture in athletes. This, in turn, may result in pains and injuries.

scholarly journals Dynamic smile evaluation in different skeletal patterns

2016 ◽  
Vol 86 (6) ◽  
pp. 1019-1025 ◽  
Author(s):  
Noshi Siddiqui ◽  
Pradeep Tandon ◽  
Alka Singh ◽  
Jitesh Haryani
Keyword(s):  
Analysis Of Variance ◽  
Upper Lip ◽  
Chi Square ◽  
Causative Factors ◽  
Skeletal Pattern ◽  
Width Change ◽  
Positive Correlations ◽  
Post Hoc ◽  
Cephalometric Measurements ◽  
Horizontal Pattern

ABSTRACT Objective: To evaluate dynamic smile in different skeletal patterns and to correlate vertical smile parameters with the underlying causative factors. Materials and Methods: A total of 150 participants ranging in age from 16–25 years were selected and divided into one of three groups—horizontal, average, and vertical skeletal pattern—using the following three cephalometric parameters: SN-MP, FMA, and Jarabak ratio. Videographic records of smile were obtained, and measurements were recorded and analyzed at rest, including upper lip length, and during smile, including maxillary incisal display, interlabial gap, intercommisural width, change in upper lip length, and smile arc. Differences among the three groups were subjected to two-way analysis of variance and post hoc and chi-square tests for smile arc. Correlations between vertical smile variables and vertical skeletal (N-ANS, N-Me) and dental cephalometric measurements (U1 to palatal plane) were also investigated. Results: Vertical parameters were significantly increased in the vertical pattern when compared with the horizontal pattern, ie, upper lip length (P &lt; .01), maxillary incisal display (P &lt; .001), interlabial gap (P &lt; .001), and change in upper lip length (P &lt; .001), whereas intercommisural width was significantly decreased in vertical pattern when compared with the horizontal pattern (P &lt; .001). Flat smile arc was seen more frequently in the horizontal pattern. Positive correlations were found between the N-Me, U1-PP, and change in upper lip length with vertical smile parameters. Conclusions: Different skeletal patterns exhibit their characteristic smile features. Upper lip length is not responsible for increased incisal display during smile. Increased incisal display during smile is more closely associated with upper lip elevation than vertical skeletal and dental factors.

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