scholarly journals The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas

2011 ◽  
Vol 1 (1) ◽  
pp. 7189 ◽  
Author(s):  
Megan A. Mahlke ◽  
Lisa A. Cortez ◽  
Melanie A. Ortiz ◽  
Marisela Rodriguez ◽  
Koji Uchida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Calorie Restriction

Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury

2001 ◽  
Vol 280 (5) ◽  
pp. H2094-H2102 ◽  
Author(s):  
B. Chandrasekar ◽  
J. F. Nelson ◽  
J. T. Colston ◽  
G. L. Freeman
Keyword(s):  
Oxidative Stress ◽  
Dna Binding ◽  
Antioxidant Enzyme ◽  
Calorie Restriction ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Binding Activity ◽  
Dna Binding Activity ◽  
Myocardial Oxidative Stress

The life-prolonging effects of calorie restriction (CR) may be due to reduced damage from cumulative oxidative stress. Our goal was to determine the long-term effects of moderate dietary CR on the myocardial response to reperfusion after a single episode of sublethal ischemia. Male Fisher 344 rats were fed either an ad libitum (AL) or CR (40% less calories) diet. At age 12 mo the animals were anaesthetized and subjected to thoracotomy and a 15-min left-anterior descending coronary artery occlusion. The hearts were reperfused for various periods. GSH and GSSG levels, nuclear factor-κB (NF-κB) DNA binding activity, cytokine, and antioxidant enzyme expression were assessed in the ischemic zones. Sham-operated animals served as controls. Compared with the AL diet, chronic CR limited oxidative stress as seen by rapid recovery in GSH levels in previously ischemic myocardium. CR reduced DNA binding activity of NF-κB. The κB-responsive cytokines interleukin-1β and tumor necrosis factor-α were transiently expressed in the CR group but persisted longer in the AL group. Furthermore, expression of manganese superoxide dismutase, a key antioxidant enzyme, was significantly delayed in the AL group. Collectively these data indicate that CR significantly attenuates myocardial oxidative stress and the postischemic inflammatory response.

Calorie Restriction and Aging

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. SCI-2-SCI-2
Author(s):  
Rafael de Cabo
Keyword(s):  
Oxidative Stress ◽  
Life Span ◽  
Calorie Restriction ◽  
Stress Proteins ◽  
Conflicts Of Interest ◽  
Caloric Intake ◽  
Tissue Growth ◽  
Age Related ◽  
Underlying Mechanisms ◽  
And Oxidative Stress

Abstract Abstract SCI-2 A prominent manifestation of aging is a reduced ability to respond to environmental stressors, including heat and oxidative stress. Reduced stress tolerance and decreased ability to maintain homeostasis are at least partially responsible for the increased morbidity and mortality that occurs with advancing age. The age-related attenuation of stress pathways and increased expression of stress-response genes with aging are examples of the growing body of evidence linking reduced stress responsiveness to aging. In 1935, McCay and colleagues first reported that reducing the caloric intake of rodents could significantly lengthen their mean and maximal life span, slowing down basic aging processes. The effect of calorie restriction (CR) on delaying aging has been replicated in many animal species including nonhuman primates, although in these, potential life span alterations cannot be ascertained for several more years due to their longevity CR causes a reduction in body weight, tissue growth, blood glucose, insulin levels and body temperature. In addition, CR prevents the age-related decline in tolerance to different stressors such as oxidative and heat, and the age-related reduction in expression of protective heat shock and oxidative stress proteins. While CR is the only intervention that has consistently been shown to increase maximum life span and prevent or delay the onset of age-associated pathophysiological changes in laboratory rodents, the underlying mechanisms remain elusive. Using calorie restriction (CR) as their benchmark research tool, gerontologists are making progress in identifying dietary and pharmacologic interventions that may be applicable to retarding aging processes in humans. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice

2021 ◽  
Vol 9 (11) ◽  
pp. 933-933
Author(s):  
Shaohong Zhang ◽  
Mengxiao Zhang ◽  
Shuoshuo Sun ◽  
Xiao Wei ◽  
Yu Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Calorie Restriction ◽  
Obese Mice ◽  
Induced Apoptosis

scholarly journals Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Katherine Esposito ◽  
Carmen Di Palo ◽  
Maria Ida Maiorino ◽  
Michela Petrizzo ◽  
Giuseppe Bellastella ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Calorie Restriction ◽  
Intervention Program ◽  
Diet Group ◽  
Biomarkers Of Aging ◽  
Significant Difference ◽  
Conventional Diet ◽  
Significant Amelioration ◽  
Overweight Group ◽  
And Oxidative Stress

We report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of a Mediterranean dietary pattern in the overweight group (MED diet group), associated with calorie restriction and increased physical activity in the obese group (lifestyle group). Both groups were compared with participants in two matched control groups (advice groups). After 2 years, there was a significant difference in weight loss between groups, which was −14 kg (95% CI −20 to −8) in lifestyle groups and −2.0 kg (−4.4 to 0) in the advice groups, with a difference of −11.9 kg (CI −19 to −4.7 kg, ); moreover, there was a significant difference between groups at 2 years for insulin (), 8-iso-PGF2α(), glucose (), and adiponectin (). Prolonged adherence to a Mediterranean-style diet, with or without caloric restriction, in overweight or obese men is associated with significant amelioration of multiple risk factors, including a better cardiovascular risk profile, reduced oxidative stress, and improved insulin sensitivity.

scholarly journals Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria

2005 ◽  
Vol 288 (4) ◽  
pp. E674-E684 ◽  
Author(s):  
Kevork Hagopian ◽  
Mary-Ellen Harper ◽  
Jesmon J. Ram ◽  
Stephen J. Humble ◽  
Richard Weindruch ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Expenditure ◽  
Life Span ◽  
Calorie Restriction ◽  
Proton Leak ◽  
Control Analysis ◽  
Ros Production ◽  
Protein Carbonyl Content ◽  
Markers Of Oxidative Stress

Calorie restriction (CR) without malnutrition increases maximal life span in diverse species. It has been proposed that reduction in energy expenditure and reactive oxygen species (ROS) production could be a mechanism for life span extension with CR. As a step toward testing this theory, mitochondrial proton leak, H2O2 production, and markers of oxidative stress were measured in liver from FBNF1 rats fed control or 40% CR diets for 12 or 18 mo. CR was initiated at 6 mo of age. Proton leak kinetics curves, generated from simultaneous measures of oxygen consumption and membrane potential, indicated a decrease in proton leak after 18 mo of CR, while only a trend toward a proton leak decrease was observed after 12 mo. Significant shifts in phosphorylation and substrate oxidation curves also occurred with CR; however, these changes occurred in concert with the proton leak changes. Metabolic control analysis indicated no difference in the overall pattern of control of the oxidative phosphorylation system between control and CR animals. At 12 mo, no significant differences were observed between groups for H2O2 production or markers of oxidative stress. However, at 18 mo, protein carbonyl content was lower in CR animals, as was H2O2 production when mitochondria were respiring on either succinate alone or pyruvate plus malate in the presence of rotenone. These results indicate that long-term CR lowers mitochondrial proton leak and H2O2 production, and this is consistent with the idea that CR may act by decreasing energy expenditure and ROS production.

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