scholarly journals KARAKTERISASI EKSTRAK DAUN SIRIH MERAH (PIPER CROCATUM, RUIZ&PAV) SEBAGAI OBAT ANTIDIABETES MENUJU OBAT HERBAL TERSTANDAR

2019 ◽  
pp. 71-76
Author(s):  
Eka Wisnu Kusuma ◽  
Disa Andriani
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Raw Materials ◽  
Raw Material ◽  
Traditional Medicines ◽  
Betel Leaf ◽  
Aflatoxin Content ◽  
Medicinal Plant Extracts

Daun sirih merah (Piper crocatum Ruiz & Pav) merupakan salah satu tanaman obat potensial yang digunakan masyarakat untuk pengobatan diabetes. Penelitian ini bertujuan untuk meningkatkan kualitas daun sirih merah (Piper crocatum Ruiz & Pav) menjadi raw material yang memenuhi standar ekstrak tumbuhan obat dalam pemenuhan mutu ekstrak menjadi obat herbal terstandar (OHT) antidiabetes. Pembuatan ekstrak dengan metode maserasi dengan pelarut etanol 96% selama 3 hari. Karakterisasi mengacu pada standarisasi dan analisa data berdasarkan Parameter Ekstrak Tumbuhan Obat (Kepmenkes RI No: 55/Menkes/SK/I/2000) dan Peraturan Kepala BPOM RI Nomor 12 tahun 2014 tentang Persyaratan Mutu Obat Tradisional. Ekstrak daun sirih merah (Piper crocatum Ruiz & Pav) memenuhi standar raw material sediaan OHT dengan organoleptis berbentuk serbuk kering, warna coklat tua, bau aromatis, dan memiliki rasa asam sepat pahit. Kadar air(%) 6,795±0,0017(<10%). Uji angka lempeng total 0,9 x 102 koloni/g. Uji kapang khamir 1 x 102 koloni/g. dan pada pengujian cemaran mikroba didalam ekstrak hasilnya negatif. aflatoksin B1<0,23(<5 ug/kg), B2 <0,19 ug/kg, G1<0,23 ug/kg, G2<0,84 ug/kg dan aflatoksin total <0,84 ( <20 ug/kg). Pada pengujian logam berat didapatkan logam Pb <0,165ppm, Cd <0,159 ppm, As <0,0217ppm dan Hg <0,018ppm Kata kunci: daun sirih merah, standardisasi, diabetes melitus Piper crocatum Ruiz & Pav known as “Daun sirih merah” is one of the potential medicinal plants thatused for the treatment of diabetes mellitus. This study aims to improve the quality of red betel leaves (Piper crocatum Ruiz & Pav) into raw materials that meet the standards of medicinal plant extracts in fulÞ lling the quality of the extract into antidiabetic standardized herbal medicine (OHT). Making extract with maceration method with 96% ethanol as much as 10 L for 3 days. Characterization refers to the standardization and analysis of data based on Parameter of Medicinal Plant Extracts (Kepmenkes RI No: 55 / Menkes / SK / I / 2000) and the Regulation of the Head of BPOM RI Number 12 of 2014 concerning Quality Requirements for Traditional Medicines. Red betel leaf extract (Piper crocatum Ruiz & Pav) meets the standard raw material for OHT preparations with organoleptis in the form of dry powder, dark brown color, aromatic odor, and has a bitter acid taste. Moisture content (%) 6,795 ± 0,0017 ( <10%). Test the total plate number 0.9 x 102 colonies / g. Test of yeasts contamination 1 x 102 colonies / g.The total bacteria test in the extract was negative. The aflatoxin content B1<0,23( 5 ug/kg), B2 <0,19 ug/kg, G1<0,23 ug/kg, G2<0,84 ug/kg and total aflatoxin content <0,84 ( <20 ug/kg). The heavy metal tests resulted Pb metal of <0,165ppm,Cd <0,159 ppm, As <0,0217ppm and Hg <0,018ppm Keywords: piper crocatum Ruiz & Pav, Standardization, diabetes mellitus

scholarly journals MEDICINAL PLANTS AND HEALTH IN HUMAN HISTORY: FROM EMPIRICAL USE TO MODERN PHYTOTHERAPY

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Elisabetta Miraldi ◽  
Giulia Baini
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Herbal Medicines ◽  
World Population ◽  
Efficacy And Safety ◽  
Herbal Products ◽  
Treatment And Prevention ◽  
Medicinal Plant Extracts

Phytotherapy is the science that deals with the treatment and prevention of diseases through medicinal plants and herbal products. The use of herbs as medicine is the oldest form of healthcare known to humanity and has been used in all cultures throughout history. It is known that even today over 80% of the world population depends on herbal medicines. The quality of herbal medicines is believed to be directly related to its active principles, but herbal medicines can be variable in their composition. Therefore, it is necessary to use an extract that is well defined in its chemical composition and in the quantity of specific active principles; and actually, to obtain constant efficacy and safety, standardized medicinal plant extracts are being used. Clinically confirmed efficacy and best tolerability and safety of standardized or quantified medicinal plant extracts are the key for a successful phytotherapic approach.

scholarly journals Studies on decontamination for herbal eyebright raw material and product by gamma radiation

2014 ◽  
Vol 4 (2) ◽  
pp. 27-31
Author(s):  
Phuong Thao Hoang ◽  
Van Binh Nguyen ◽  
Bang Diep Tran ◽  
Dang Sang Hoang ◽  
Thuy Huong Trang Nguyen ◽  
...  
Keyword(s):  
Vitamin A ◽  
Gamma Radiation ◽  
Radiation Source ◽  
Low Dose ◽  
Radiation Treatment ◽  
Raw Materials ◽  
Raw Material ◽  
Health Ministry ◽  
Traditional Medicines

Herbal eyebright products and their raw materials have been irradiated with 1, 2, 3 and 5 kGy by Co-60 gamma radiation source at Hanoi Irradiation Center for decontamination. Initial bioburdens were under the limitation levels established for the traditional medicines according to the decree of 16/2011/TT-BYT issued by Vietnam Health Ministry. These values for both bacteria and fungus slightly increased during storage to three months, reach to about 103 and 102 CFU/g for bacteria and molds, respectively. However, there are no microbial colonies that could be observed in the samples irradiated with dose higher than 3 kGy. Results suggested that the dose of 3 kGy was enough for decontamination of eyebright raw powders and products. At dose of 5 kGy, the moisture and vitamin A content of the samples were insignificantly changed. These mean the radiation treatment with low dose did not influenced the quality of eyebright products, and radiation treatment can be applied to prolong the storage of not only eyebright, but also other traditional medicines.

Screening of 50 medicinal plant extracts for quercetin-3-rutinoside

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
E Sofic ◽  
M Salihovic ◽  
S Huseinovic ◽  
S Cavar ◽  
A Copra-Janicijevic ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Plant Extracts ◽  
Medicinal Plant Extracts

Screening of Venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against tumour cell lines

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
P Taylor ◽  
M Arsenak ◽  
MJ Abad ◽  
Á Fernández ◽  
R Gonto ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Plant Extracts ◽  
Tumour Cell ◽  
Medicinal Plant Extracts ◽  
Tumour Cell Lines

TECHNOLOGICAL ASPECTS OF HIGH QUALITY RAW MATERIAL OBTAINING FOR PECTIN PRODUCTION

1970 ◽  
pp. 47-50
Author(s):  
I. A. Ilina ◽  
I. A. Machneva ◽  
E. S. Bakun
Keyword(s):  
Raw Materials ◽  
Thermal Characteristics ◽  
Environmental Safety ◽  
Raw Material ◽  
High Quality ◽  
Temperature Conductivity ◽  
Drying Temperature ◽  
Plant Raw Materials ◽  
Gel Forming Ability

  The article is devoted to the study of the chemical composition, physical and thermal-pfysical characteristics of damp apple pomaces and the identifying patterns of influence of drying temperature the functional composition and gel-forming ability of pectin. The research is aimed at obtaining initial data for the subsequent calculation of the main technological, hydro-mechanical, thermal, structural and economic characteristics of devices for drying the plant raw materials, ensuring the environmental safety and high quality of pectin-containing raw materials, the reducing heat and energy costs. As a result of the study of the thermal characteristics of apple pomaces, the critical points (temperature conductivity – 16.5 x 10-8 m2/s, thermal conductivity – 0.28 W/m K, heat capacity – 1627 j/(kg K)) at a humidity of 56 % are determined, which characterizing the transition from the extraction of weakly bound moisture to the extraction of moisture with strong bonds (colloidal, adsorption). It was found that the pomaces obtained from apples of late ripening have a higher content of solids (21-23 %), soluble pectin and protopectin (2.5-4.5 %). Dried pomaces obtained from apple varieties of late ripening contain up to 25 % pectin, which allow us to recommend them as a source of raw materials for the production of pectin. The optimum modes of preliminary washing of raw materials are offered, allowing to the remove the ballast substances as much as possible. It is established that when the drying temperature increases, the destructive processes are catalyzed: the strength of the pectin jelly and the uronide component and the degree of pectin esterification are reduced. The optimum drying temperature of damp apple pomaces is 80 0C, at which the quality of pectin extracted from the dried raw materials is maintained as much as possible. It is shown that the most effective for the pectin production is a fraction with a particle size of 3-5 mm, which allow us to extract up to 71 % of pectin from raw materials.

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