scholarly journals Comparison of Patients with Hospital-recorded Nephrotic Syndrome and Patients with Nephrotic Proteinuria and Hypoalbuminemia: a Nationwide Study in Denmark

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0000362021
Author(s):  
Søren Viborg Vestergaard ◽  
Henrik Birn ◽  
Anette Tarp Hansen ◽  
Mette Nørgaard ◽  
Dorothea Nitsch ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Index Date ◽  
Medication Use ◽  
Laboratory Findings ◽  
National Patient Registry ◽  
Nephrotic Proteinuria ◽  
Lower Egfr ◽  
National Patient ◽  
One Year ◽  
First Time

Background: Registry-based studies of nephrotic syndrome (NS) may only include a subset of patients with biochemical features of NS. To address this, we compared patients with laboratory-recorded nephrotic proteinuria and hypoalbuminemia to patients with hospital-recorded NS. Methods: We identified adult patients with first-time hospital-recorded NS (inpatients, outpatients or emergency room visitors) in the Danish National Patient Registry and compared them to adults with first-time recorded nephrotic proteinuria and hypoalbuminemia in Danish laboratory databases during 2004-2018, defining date of admission or laboratory findings as index date. We characterised these cohorts by demographics, comorbidity, medication use, and laboratory and histopathological findings. Results: We identified 1,139 patients with hospital-recorded NS and 5,268 patients with nephrotic proteinuria and hypoalbuminemia of which 760 patients were identified with both. Within one year of the first recorded nephrotic proteinuria and hypoalbuminemia, 18% had recorded hospital diagnoses indicating the presence of NS, while 87% had diagnoses reflecting any kind of nephropathy. Among patients identified with nephrotic proteinuria and hypoalbuminemia, most recent eGFR was substantially lower (median of 35 vs. 61 ml/min/1.73 m2), fewer underwent kidney biopsies around index date (34% vs. 61%), and prevalence of thromboembolic disease (25% vs 17%) and diabetes (39% vs. 18%) was higher when compared to patients with hospital-recorded NS. Conclusions: Patients with nephrotic proteinuria and hypoalbuminemia are five-fold more common than patients with hospital-recorded NS, and they reveal a lower eGFR and more comorbidity. Selective and incomplete recording of NS may be an important issue when designing and interpreting studies of risks and prognosis of NS.

scholarly journals Myocarditis Incidence, Complications and Mortality in Sweden: A Retrospective Registry Study From 2000-2014

2021 ◽  
Author(s):  
Michael Fu ◽  
Silvana Kontogeorgos ◽  
Erik Thunström ◽  
Tatiana Zverkova Sandström ◽  
Christian Kroon ◽  
...  
Keyword(s):  
Total Population ◽  
Reference Population ◽  
Inflammatory Heart Disease ◽  
Hazard Ratios ◽  
Younger Men ◽  
National Patient ◽  
One Year ◽  
Complications And Mortality ◽  
First Time ◽  
Time Diagnosis

Abstract Objectives: Investigate trends in incidence and prognosis of myocarditis in Sweden during 2000-2014.Background: Myocarditis is an inflammatory heart disease, with scarce data concerning incidence and prognosis.Methods: Linking Swedish National Patient and Cause of Death Register, we identified individuals ≥16 years with first-time diagnosis of myocarditis during 2000-2014. Reference population, matched for age and birth year (n=16 622) was selected from the Swedish Total Population Register. Results: Among the 8 679 cases, (75% men, 64% <50 years), incidence rate/100 000 inhabitants rose from 6.3 to 8.6, mostly in men and those <50 years. Incident heart failure/dilated cardiomyopathy occurred in 6.2% within 1 year after index hospitalization and in 10.2% during 2000-2014, predominantly in those ≥50 years (12.1% within 1 year, 20.8% during 2000-2014). In all, 8.1% died within 1 year, 0.9% (<50 years) and 20.8% (≥50 years). Hazard ratios (adjusted for age, sex) for 1-year mortality comparing cases and controls were 4.00 (95% confidence interval 1.37-11.70), 4.48 (2.57-7.82), 4.57 (3.31-6.31) and 3.93 (3.39-4.57) for individuals aged <30, 30-<50, 50-<70, and ≥70 years, respectively. Conclusion: The incidence of myocarditis during 2000-2014 increased, predominantly in younger men. One-year mortality in the young was low, but fourfold higher compared with reference population.

scholarly journals Validity of First-Time Diagnoses of Inherited Ichthyosis in the Danish National Patient Registry and the Danish Pathology Registry

2020 ◽  
Vol Volume 12 ◽  
pp. 651-657
Author(s):  
Mattias Hedegaard Kristensen ◽  
Sigrún Alba Jóhannesdóttir Schmidt ◽  
Line Kibsgaard ◽  
Hanne Hove ◽  
Mette Sommerlund ◽  
...  
Keyword(s):  
Patient Registry ◽  
National Patient Registry ◽  
Danish National Patient Registry ◽  
Inherited Ichthyosis ◽  
National Patient ◽  
First Time

scholarly journals The effect of parathyroidectomy compared to non-surgical surveillance on kidney function in primary hyperparathyroidism: a nationwide historic cohort study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Josephine Matzen ◽  
Lise Sofie Bislev ◽  
Tanja Sikjær ◽  
Lars Rolighed ◽  
Mette Friberg Hitz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Primary Hyperparathyroidism ◽  
Kidney Function ◽  
Estimated Glomerular Filtration Rate ◽  
National Patient Registry ◽  
Severe Hypercalcemia ◽  
Lower Egfr ◽  
National Patient ◽  
Historic Cohort

Abstract Background Patients with primary hyperparathyroidism (pHPT) and impaired kidney function (estimated glomerular filtration rate (eGFR) < 60 mL/min) are offered parathyroidectomy (PTX) to protect them from further complications. Surprisingly, two recent uncontrolled cohort studies have suggested a further decrease in kidney function following PTX. We aimed to examine the effects of PTX compared to non-surgical surveillance on kidney function in pHPT patients. Methods Historic cohort study. From the Danish National Patient Registry (NPR) and major medical biochemistry laboratories in Denmark, we identified 3585 patients with biochemically confirmed pHPT among whom n = 1977 (55%) were treated with PTX (PTX-group) whereas n = 1608 (45%) were followed without surgery (non-PTX group). Baseline was defined as time of diagnosis and kidney function was re-assessed 9–15 months after PTX (PTX group) or 9–15 months after diagnosis (non-PTX group). Results At follow-up, eGFR had decreased significantly in the PTX- compared to the non-PTX-group (median − 4% vs. − 1%, p < 0.01). Stratification by baseline eGFR showed that the decrease was significant for those with a baseline eGFR value of 80–89 and > 90 mL/min, but not for those with lower eGFR values. Findings did not differ between patients with mild compared to moderate/severe hypercalcemia. However, after mutual adjustments, we identified baseline levels of calcium, PTH, and eGFR as well as age and treatment (PTX vs. no-PTX) as independent predictors for changes in kidney function. Conclusion Compared to non-surgical surveillance, PTX is associated with a small but significant decrease in kidney function in pHPT patients with an initial normal kidney function.

scholarly journals Validity of first-time diagnoses of congenital epidermolysis bullosa in the Danish National Patient Registry and the Danish Pathology Registry

2019 ◽  
Vol Volume 11 ◽  
pp. 115-124
Author(s):  
Mattias Hedegaard Kristensen ◽  
Sigrún Alba Jóhannesdóttir Schmidt ◽  
Line Kibsgaard ◽  
Mette Mogensen ◽  
Mette Sommerlund ◽  
...  
Keyword(s):  
Epidermolysis Bullosa ◽  
Patient Registry ◽  
National Patient Registry ◽  
Danish National Patient Registry ◽  
National Patient ◽  
First Time

scholarly journals Validity of First-Time Diagnoses of Darier’s Disease in the Danish National Patient Registry

2021 ◽  
Vol Volume 13 ◽  
pp. 1063-1069
Author(s):  
Inger LH Dorf ◽  
Sigrún AJ Schmidt ◽  
Mette Sommerlund ◽  
Uffe Koppelhus
Keyword(s):  
Patient Registry ◽  
National Patient Registry ◽  
Darier’S Disease ◽  
Darier's Disease ◽  
Danish National Patient Registry ◽  
National Patient ◽  
First Time

scholarly journals Are Chronic Myeloproliferative Neoplasms Associated with Age-Related Macular Degeneration?

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4444-4444
Author(s):  
Marie Bak ◽  
Torben Lykke Sørensen ◽  
Esben Meulengracht Flachs ◽  
Ann-Dorthe Olsen Zwisler ◽  
Knud Juel ◽  
...  
Keyword(s):  
General Population ◽  
Macular Degeneration ◽  
Index Date ◽  
Myeloproliferative Neoplasms ◽  
Age Related Macular Degeneration ◽  
National Patient Registry ◽  
Chronic Myeloproliferative Neoplasms ◽  
Age Related ◽  
Danish National Patient Registry ◽  
National Patient

Abstract Background. Patients with Chronic Myeloproliferative Neoplasms (MPNs) already have increased comorbidity at time of diagnosis, and studies show association with ophthalmic manifestations. Retinal vascular symptoms including vascular occlusions and hemorrhages are present, but other manifestations of the eye have not been thoroughly investigated in these patients. Previously reported studies show signs of systemic inflammation in patients with MPN as well as in patients with Age-Related Macular Degeneration (AMD). Our hypothesis is that the presence of MPN predisposes some individuals to develop AMD and this might be explained by the degree of systemic inflammation. Objective. To describe the prevalence of Age-Related Macular Degeneration in patients with Chronic Myeloproliferative cancer at time of diagnosis compared to the general population in Denmark. Materials and Methods. We conducted a retrospective population-based matched cohort study using Danish registries. We included all patients age 18+ or older with a first listed diagnosis of MPN in the Danish National Patient Registry between 1994 and 2013. Patients with Essential Thrombocythemia (ET), Polycythemia Vera (PV), Myelofibrosis (MF), Unclassifiable MPN (MPN-U) and Chronic Myeloid Leukemia (CML) were included. To compare the prevalence of AMD with the general population we identified 10 sex-and-age matched individuals without MPN, for each corresponding patient. The controls were identified through the Danish Civil Registration System. Index date was defined as date of MPN diagnosis, and controls had to be alive at their corresponding patient's index date. We searched for all primary AMD diagnoses in the Danish National Patient Registry within a ten-year period preceding index date + 30 days. For all patients and controls, baseline characteristics, including smoking-related conditions (yes/no), were registered. We calculated number of events in all groups, including only patients' and controls' first AMD diagnosis. Prevalence of AMD at time of diagnosis was calculated using descriptive statistics. Results. We included 9679 patients (ET=2714; PV=3170; MF=600; MPN-U=1839; CML=1356) and a total of 96737 sex-and-age matched controls in the study. Mean age of included patients with MPN at time of diagnosis was: 64 years (ET); 66 (PV); 71 (MF); 70 (MPN-U) and 61 (CML) − all with comparable age-distribution in the matched control groups. There was a higher percentage of females in the ET group (65%), an equal sex-distribution in PV (females 49 %) and MPN-U (females 51 %) and a higher percentage of men in the CML group (59 %). Significant more patients with ET, PV and MPN-U had smoking related diagnoses compared to controls (p<0.05), but no differences were seen for patients with CML and MF. We found 220 MPN patients and 6 controls, who had AMD at time of diagnosis. Patients in all subgroups had a higher prevalence of AMD with 64 ET patients vs. 3 controls; 74 PV patients vs. 2 controls; 16 MF patients vs. 0 controls; 51 MPN-U patients vs. 1 control and 15 CML patients vs. 0 controls. Our results show that 2.3 % of all patients with MPN were diagnosed with AMD, including 2.6 % of Philadelphia-negative patients (ET, PV, MF and MPN-U) and 1.1 % of Philadelphia-positive CML patients. The corresponding values for controls with AMD diagnoses were: 0.006 % (Philadelphia-negative controls 0.007 % and CML controls 0 %). In summary, we found that the patients with MPN had a higher prevalence of AMD, at time of diagnosis, compared to the general population in Denmark. Conclusion. Chronic Myeloproliferative cancers are associated with Age-Related Macular Degeneration at time of diagnosis. Patients with all MPN subtypes have an increased prevalence of AMD compared to the general population. Our results show the need for further studies to establish if the association is present, not only at time of diagnosis, but also during the course of the cancer diseases. We are currently analyzing incidence rates after diagnosis, and influence of potential confounders and effect modifiers. Our preliminary results suggest that the association between AMD and MPN is also present after diagnosis. Clinical studies are needed to investigate whether the association represents a causal relationship or if confounders are accountable for the findings. Disclosures Hasselbalch: Novartis: Research Funding.

The Effect of Parathyroidectomy Compared to Non-Surgical Surveillance on Kidney Function in Primary Hyperparathyroidism: A Nationwide Historic Cohort Study

2021 ◽  
Author(s):  
Josephine Matzen ◽  
Lise Sofie Bislev ◽  
Tanja Sikjær ◽  
Lars Rolighed ◽  
Mette Friberg Hitz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Primary Hyperparathyroidism ◽  
Kidney Function ◽  
Estimated Glomerular Filtration Rate ◽  
National Patient Registry ◽  
Severe Hypercalcemia ◽  
Lower Egfr ◽  
National Patient ◽  
Historic Cohort

Abstract Background: Patients with primary hyperparathyroidism (pHPT) and impaired kidney function (estimated glomerular filtration rate (eGFR) <60 mL/min) are offered parathyroidectomy (PTX) to protect them from further complications. Surprisingly, two recent uncontrolled cohort studies have suggested a further decrease in kidney function following PTX. We aimed to examine the effects of PTX compared to non-surgical surveillance on kidney function in pHPT patients.Methods: Historic cohort study. From the Danish National Patient Registry (NPR) and major medical biochemistry laboratories in Denmark, we identified 3585 patients with biochemically confirmed pHPT among whom n=1977 (55%) were treated with PTX (PTX-group) whereas n=1608 (45%) were followed without surgery (non-PTX group). Baseline was defined as time of diagnosis and kidney function was re-assessed 9-15 months after PTX (PTX group) or 9-15 months after diagnosis (non-PTX group).Results: At follow-up, eGFR had decreased significantly in the PTX- compared to the non-PTX-group (median -4% vs. -1%, p<0.01). Stratification by baseline eGFR showed that the decrease was significant for those with a baseline eGFR value of 80-89 and >90 mL/min, but not for those with lower eGFR values. Findings did not differ between patients with mild compared to moderate/severe hypercalcemia. However, after mutual adjustments, we identified baseline levels of calcium, PTH, and eGFR as well as age and treatment (PTX vs. no-PTX) as independent predictors for changes in kidney function.Conclusion: Compared to non-surgical surveillance, PTX is associated with a small but significant decrease in kidney function in pHPT patients with an initial normal kidney function.

The Probability of A1C Goal Attainment in Patients with Uncontrolled Type-2 Diabetes in a Large Integrated Delivery System: A Prediction Model

2020 ◽  
Author(s):  
Kevin M Pantalone ◽  
Anita D Misra-Hebert ◽  
Todd M Hobbs ◽  
Sheldon X Kong ◽  
Xinge Ji ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Goal Attainment ◽  
Index Date ◽  
Cleveland Clinic ◽  
Patient Characteristics ◽  
Psychiatric Disease ◽  
Lower Probability ◽  
Factors Associated ◽  
One Year

<b>Objective:</b> To assess patient characteristics and treatment factors associated with uncontrolled type 2 diabetes (T2D) and the probability of A1C goal attainment. <p><b>Research Design and Methods</b>: Retrospective cohort study using the electronic health record at Cleveland Clinic. Patients with uncontrolled T2D (A1C>9%) were identified on the index date of 12/31/2016 (n=6,973), grouped by attainment (n=1,653 [24.7%) or non-attainment (n=5,320 [76.3%]) of A1C<8% by 12/31/2017, and subgroups compared on a number of demographic and clinical variables. Based on these variables, a nomogram was created for predicting probability of A1C goal attainment. </p> <p><b>Results:</b> For the entire population, median age at index date was 57.7 years (53.3% male), and the majority were white (67.2%). Median A1C was 10.2%. Obesity (50.6%), cardiovascular disease (46.9%) and psychiatric disease (61.1%) were the most common comorbidities. Metformin (62.7%) and sulfonylureas (38.7%) were the most common anti-diabetes medications. Only 1,653 (24%) patients achieved an A1C <8%. Predictors of increased probability of A1C goal attainment were older age, white/non-Hispanic race/ethnicity, Medicare health insurance, lower baseline A1C, higher frequency of endocrinology/primary care visits, DPP-4i use, thiazolidinedione use, metformin use, GLP-1RA use, and fewer classes of anti-diabetes drugs. Factors associated with lower probability included insulin use and longer time in the T2D database (both presumed as likely surrogates for duration of T2D). </p> <p><b>Conclusions:</b> A minority of patients with an A1C>9% achieved an A1C<8% at one year. While most identified predictive factors are non-modifiable by the clinician, pursuit of frequent patient engagement and tailored drug regimens may help improve A1C goal attainment. </p>

Peculiarities of the juvenile period of the native Chechen genotypes of willow leaf pear (Pyrus salicifolia Pall.)

2020 ◽  
Vol 62 ◽  
pp. 32-38
Author(s):  
E. A. Dolmatov ◽  
R. B. Borzayev ◽  
A. N. Shaipov
Keyword(s):  
Chestnut Soil ◽  
Crop Breeding ◽  
Juvenile Period ◽  
Period 2 ◽  
Russian Research Institute ◽  
The Common ◽  
One Year ◽  
First Time ◽  
Selection Of ◽  
Creative Cooperation

The results of the study of the duration of the juvenile period of indigenous Chechen willow leaf pear genotypes (Pyrus salicifolia Pall.) are given in connection with the acceleration of the breeding process and the use of selected forms in pear breeding for high precocity. The studies were carried out in 2016-2019 at OOO “Orchards of Chechnya” in accordance with the Agreement on creative cooperation with the Russian Research Institute of Fruit Crop Breeding. The work was carried out in accordance with generally accepted programs and methods. The objects of the study were one-year and two-year-old pear seedlings obtained from sowing seeds of selected dwarf and low-growing local Chechen forms of willow pear (P. salicifolia Pall.), laying fruit buds on annual growths and seedlings of Caucasian pear (P. caucasica Fed.), 20 500 pcs. of each specie. The aim of the research was to study the potential of precocity of willow pear seedlings and to reveal of selected forms with the greatest degree of this trait. Stratified seeds were sown in the sowing department of the OOO “Orchards of Chechnya” production nursery in April, 2017. The seedlings were grown according to the common technology in dryland conditions on the plot with chestnut soil. The first fl owering of plants was noted in the spring, 2019. As a result of the research, for the first time on a large number of the experimental material it was found that in the off spring of the indigenous Chechen willow leaf pear genotypes, the selection of a little more than 2% of seedlings with a very short juvenile period (2 years) was possible. They are of great interest in accelerating the breeding process and in the selection of new pear varieties with high precocity. 20 willow leaf pear genotypes were selected for the further use in breeding for high precocity and as sources of the trait of short juvenile period.

Sign in / Sign up

Export Citation Format

Share Document