EFFICACY OF ERYLIK ON TREATMENT OF ACNE VULGARIS

2015 ◽  
pp. 53-56
Author(s):  
Ba Hoang Anh Mai ◽  
Thi Lan Pham
Keyword(s):  
Side Effect ◽  
Acne Vulgaris ◽  
Post Treatment ◽  
Controlled Study ◽  
Common Disease ◽  
Pilosebaceous Unit ◽  
National Hospital ◽  
Inflammatory Lesions ◽  
Good Grade ◽  
Good For

Introduction: Acne vulgaris is a common disease that is an inflammation of pilosebaceous unit, frequent in adolescent. Objective: evaluate efficacy of Erylik on treatment of acne vulgaris. Methodology: this is a clinical controlled study comparing pre and post-treatment, including 31 patients treated at National hospital of Dermatology and Venereology from 4/2012-8/2012. Results: after 4 weeks, comedones decreased 17,9%, inflammatory lesions decreased 30,1%, total lesions decreased 22,5%; mild grade 70,9%, moderated grade 29,1. After 8 weeks: comedones decreased 35,2%, inflammatory lesions decreased 52,3%, total lesions decreased 41,4.%; moderate grade 80,6%, good grade 19,4%. Side-effect of Erylik: erythema, dryness, desquamation, burning. Conclusion: Erylik is good for treatment Acne vulgaris, has a good result with clearly ameliorated lesions.

scholarly journals A COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF 12 % GLYCOLIC ACID CREAM AND 10% AZELAIC ACID CREAM IN THE TREATMENT OF POST ACNE HYPERPIGMENTATION.

2021 ◽  
pp. 34-35
Author(s):  
Archana Rede ◽  
Sanjay N. Agrawal ◽  
Yoganand Kulkarni
Keyword(s):  
Comparative Study ◽  
Azelaic Acid ◽  
Glycolic Acid ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Common Complication ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Post inflammatory hyperpigmentation is a most common complication seen after post acne. Therapeutic goal of treatment include promoting degradation of melanosomes and inhibiting their formation. Patient treated with Azelaic acid / Glycolic acid experienced of significant greater reduction in number of inflammatory lesions. This study focuses on the comparison of efficacy of 12% Glycolic acid and 10% Azelaic acid in treating post acne hyperpigmentation.

scholarly journals Efficacy of Dapsone 5% gel in treatment of Acne vulgaris

2016 ◽  
Vol 2 (4) ◽  
pp. 77
Author(s):  
Sugat A. Jawade ◽  
Adarshlata Singh
Keyword(s):  
Success Rate ◽  
Acne Vulgaris ◽  
Inflammatory Disorder ◽  
Inclusion Criteria ◽  
Pilosebaceous Unit ◽  
Open Label ◽  
Inflammatory Lesions ◽  
Chronic Inflammatory Disorder ◽  
Medical College ◽  
Jawaharlal Nehru

<p class="abstract"><strong>Background:</strong> Acne vulgaris is chronic inflammatory disorder of pilosebaceous unit mainly characterized by comedones, papules and nodulocystic lesions affecting face and upper trunk. Topical dapsone 5% gel is approved to treat acne vulgaris because of its anti-inflammatory and anti-bacterial activities.</p><p class="abstract"><strong>Methods:</strong> A single center, open label interventional study was conducted during 1 year period in dermatology OPD of Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra. Patients were enrolled in the study considering inclusion criteria. Patients were asked to apply dapsone 5% gel twice daily on face for 12 week. Efficacy was evaluated by mean percent reduction in total, inflammatory and non-inflammatory lesions and success rate on change in investigator global acne severity assessment scale while tolerability was assessed by evaluating skin dryness, erythema, stinging or burning sensation and scaling at baseline, 1, 2, 4, 8 and 12 week.<strong></strong></p><p class="abstract"><strong>Results:</strong> At end of 12 week, success rate reached to 31.54%. Dapsone 5% gel was effective in reduction of total, non-inflammatory and inflammatory lesions by 57.75%, 52% and 63.1% respectively. Side effects with dapsone gel were tolerable, mild and transient.</p><p><strong>Conclusions:</strong> Dapsone 5% gel was efficacious and well tolerated in non-inflammatory as well as inflammatory acne lesions. </p>

scholarly journals Efficacy of Adapalene 0.1% Versus Tretinoin 0.025% Cream as Treatment of Mild Acne Vulgaris

2020 ◽  
Vol 4 (2) ◽  
pp. 18-25
Author(s):  
Sarah Diba ◽  
Zahra Ayu Lukita Sari ◽  
Muhammad Athuf Thaha
Keyword(s):  
Acne Vulgaris ◽  
Inflammatory Lesion ◽  
Inclusion Criteria ◽  
First Line ◽  
Pilosebaceous Unit ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
Topical Retinoid ◽  
Double Blind Clinical Trial ◽  
First Line Treatment

Abstract   Introduction: Acne vulgaris (AV) is a chronic inflammatory of the pilosebaceous unit. Topical retinoid is a mainstay of mild AV first-line treatment. Aim of study: To assess the efficacy of topical retinoid for the treatment of mild AV. Method: The randomized double-blind clinical trial was conducted from June to September 2019 at Dr. Mohammad Hoesin General Hospital Palembang. A total of 70 mild AV patients who fulfilled inclusion criteria were enroled consecutively. Patients randomly treated with adapalene 0.1% cream or tretinoin 0.025% cream and evaluated every 2 weeks for 8 weeks to examine the number of AV lesion (inflammation, non-inflammation and total lesion). Result: There are reduction in number of inflammatory and non-inflammatory lesions at both groups but only inflammatory lesion was statistically significant (p <0.05). Total lesions also decrease in adapalene and retinoin group (21.66 vs 5.75, 22.21 vs 7.96, respectively) and statistically significant (p <0.05). Conclusion: Adapalen 0.1% cream showed non-inferiority to tretinoin 0.025% cream in efficacy, especially in the reduction of non-inflammatory and total lesions.

Acne

2018 ◽  
Author(s):  
Ben Esdaile
Keyword(s):  
Hair Follicle ◽  
Sebaceous Gland ◽  
Acne Vulgaris ◽  
Psychological Effects ◽  
Inflammatory Disorder ◽  
Pilosebaceous Unit ◽  
Inflammatory Lesions ◽  
Severe Acne ◽  
Chronic Inflammatory Disorder

Acne vulgaris is a common, chronic inflammatory disorder of the pilosebaceous unit (the hair follicle and accompanying sebaceous gland). It can be classified as mild, moderate, or severe. Mild acne is characterized by comedones (non-inflammatory lesions: ‘blackheads’ and ‘whiteheads’) being the predominant lesions. Papules and pustules may also be present but are few in number. Moderate acne is defined by more inflammatory lesions such as papules and pustules, with comedones also usually present. Severe acne is defined as widespread inflammatory lesions, nodules, cysts, and scarring. Moderate acne that has not settled within 6 months of treatment, or acne that is causing serious psychological effects, is also categorized as severe.

scholarly journals A Comparative Study of Efficacy of Fractional CO2 Laser vs Microdermabrasion in Treatment of Acne Scars (Total 100 Patients)

2022 ◽  
Vol 9 (1) ◽  
pp. 34-38
Author(s):  
Jinali Makwana ◽  
Deval Vora ◽  
Vijay Soyal
Keyword(s):  
Co2 Laser ◽  
Acne Vulgaris ◽  
Treatment Modalities ◽  
P Value ◽  
Common Disease ◽  
Grading System ◽  
Pilosebaceous Unit ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Non Surgical Treatment

Introduction: Acne vulgaris is a common disease affecting pilosebaceous unit that can lead to significant scarring. Fractional CO2 Laser and microdermabrasion are effective non-surgical treatment modalities for acne scars. Aims and objectives: To study and compare the efficacy of fractional CO2 Laser and microdermabrasion therapy in acne scars. Material and methods: Total 100 patients were selected in our study. 50 patients were allotted into each group. Scar grading assessment was done by Goodman and Baron qualitative scar grading system. Result: 50 patients were taken in each group. There was a significant improvement in grading of acne scars at the end of 6months of treatment. On comparison of fractional CO2 Laser with microdermabrasion, p-value was <0.05 that is significant. Conclusion: Fractional CO2 Laser showed better improvement in grading of acne scars then microdermabrasion, though none of these treatments are 100% effective in treating acne scars. Keywords: Acne scars, fractional CO2 laser, microdermabrasion, Goodman and baron grading.

Sidharthakadi Lepa in Mukhadushika - A Clinical Study

2018 ◽  
Vol 3 (01) ◽  
Author(s):  
Ravindra Angadi ◽  
Rekha J.
Keyword(s):  
Skin Disorder ◽  
Acne Vulgaris ◽  
Response To Therapy ◽  
Inclusion Criteria ◽  
Pilosebaceous Unit ◽  
External Application ◽  
Acne Lesion ◽  
Common Skin ◽  
The Face ◽  
Inflammatory Component

Background: Acne vulgaris is a very common malady of adolescents. It is common enough to be called as a physiological process but is better regarded as a disease due to its inflammatory component and the disfigurement. Acne vulgaris is a common skin disorder of pilosebaceous unit that primarily affects the face which if not treated leads to pigmentation. Mukhadushika is a Kshudra Roga which mainly involves Kapha and Vatadosa with Raktha. This is a common illness affecting 80 % of adolescents. Lepa is one of the external therapies explained in Ayurvedic classics. Objectives: To evaluate the efficacy of Sidharthakadilepa in the management of mukhadushikaw.s.r. to acne vulgaris. Methods: 30 patients fulfilling the inclusion criteria were selected. They were given Sidharthakadi Lepa for external application over face for one month. Patients were observed for changes on 7th, 14th, 21st and 28th day. The response to therapy was evaluated at the end of 28 days by calculating acne lesion score and the efficacy was determined by the percentage reduction in ALS. Results: The analysis revealed that 40% of patients had complete remission, 30% patients showed marked improvement and 30% showed moderate improvement.

scholarly journals Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 567
Author(s):  
Ivona Tomić ◽  
Sandra Miočić ◽  
Ivan Pepić ◽  
Dubravka Šimić ◽  
Jelena Filipović-Grčić
Keyword(s):  
Azelaic Acid ◽  
Controlled Trial ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
Adverse Event Rate ◽  
Double Blind ◽  
Inflammatory Lesions ◽  
First Choice ◽  
In Situ Hydrogel

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

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