Faculty Opinions recommendation of Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study.

2010 ◽  
Author(s):  
David Hay ◽  
Zara Hannoun
Keyword(s):  
Folic Acid ◽  
Early Pregnancy ◽  
Behavioural Problems ◽  
Folic Acid Supplement ◽  
Supplement Use ◽  
Acid Supplement ◽  
Child Behavioural Problems

scholarly journals Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study

2009 ◽  
Vol 103 (3) ◽  
pp. 445-452 ◽  
Author(s):  
Sabine J. Roza ◽  
Tamara van Batenburg-Eddes ◽  
Eric A. P. Steegers ◽  
Vincent W. V. Jaddoe ◽  
Johan P. Mackenbach ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Early Pregnancy ◽  
First Trimester ◽  
Child Behaviour ◽  
Folic Acid Supplement ◽  
Supplement Use ◽  
Acid Supplement ◽  
Folic Acid Supplements

Folate deficiency during embryogenesis is an established risk factor for neural tube defects in the fetus. An adequate folate nutritional status is also important for normal fetal growth and brain development. The aim of the present research was to study the association between folic acid use of the mother during pregnancy and child behavioural development. Within a population-based cohort, we prospectively assessed folic acid supplement use during the first trimester by questionnaire. Child behavioural and emotional problems were assessed with the Child Behaviour Checklist at the age of 18 months in 4214 toddlers. Results showed that children of mothers who did not use folic acid supplements in the first trimester had a higher risk of total problems (OR 1·44; 95 % CI 1·12, 1·86). Folic acid supplement use protected both from internalising (OR of no supplement use 1·65; 95 % CI 1·24, 2·19) and externalising problems (OR 1·45; 95 % CI 1·17, 1·80), even when adjusted for maternal characteristics. Birth weight and size of the fetal head did not mediate the association between folic acid use and child behaviour. In conclusion, inadequate use of folic acid supplements during early pregnancy may be associated with a higher risk of behavioural problems in the offspring. Folic acid supplementation in early pregnancy, aimed to prevent neural tube defects, may also reduce mental health problems in children.

scholarly journals Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles

Reproduction ◽  
2014 ◽  
Vol 148 (6) ◽  
pp. 581-592 ◽  
Author(s):  
Nina H van Mil ◽  
Marieke I Bouwland-Both ◽  
Lisette Stolk ◽  
Michael M P J Verbiest ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Early Pregnancy ◽  
Large Population ◽  
White Blood Cells ◽  
Folic Acid Supplement ◽  
Blood Concentrations ◽  
Supplement Use ◽  
Acid Supplement ◽  
C Metabolism

Maternal one-carbon (1-C) metabolism provides methylgroups for fetal development and programing by DNA methylation as one of the underlying epigenetic mechanisms. We aimed to investigate maternal 1-C biomarkers, folic acid supplement use, andMTHFRC677T genotype as determinants of 1-C metabolism in early pregnancy in association with newborn DNA methylation levels of fetal growth and neurodevelopment candidate genes. The participants were 463 mother–child pairs of Dutch national origin from a large population-based birth cohort in Rotterdam, The Netherlands. In early pregnancy (median 13.0 weeks, 90% range 10.4–17.1), we assessed the maternal folate and homocysteine blood concentrations, folic acid supplement use, and theMTHFRC677T genotype in mothers and newborns. In newborns, DNA methylation was measured in umbilical cord blood white blood cells at 11 regions of the seven genes:NR3C1, DRD4, 5-HTT, IGF2DMR, H19, KCNQ1OT1, andMTHFR. The associations between the 1-C determinants and DNA methylation were examined using linear mixed models. An association was observed between maternal folate deficiency and lower newborn DNA methylation, which attenuated after adjustment for potential confounders. The maternalMTHFRTT genotype was significantly associated with lower DNA methylation. However, maternal homocysteine and folate concentrations, folic acid supplement use, and the MTHFR genotype in the newborn were not associated with newborn DNA methylation. The maternalMTHFRC677T genotype, as a determinant of folate status and 1-C metabolism, is associated with variations in the epigenome of a selection of genes in newborns. Research on the implications of these variations in methylation on gene expression and health is recommended.

scholarly journals Epidemiology and (Patho)Physiology of Folic Acid Supplement Use in Obese Women before and during Pregnancy

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 331
Author(s):  
Melissa van der Windt ◽  
Sam Schoenmakers ◽  
Bas van Rijn ◽  
Sander Galjaard ◽  
Régine Steegers-Theunissen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Scientific Evidence ◽  
Folate Deficiency ◽  
Folate Intake ◽  
Low Grade ◽  
Obese Women ◽  
Folic Acid Supplement ◽  
Physiological Uptake ◽  
Supplement Use ◽  
Acid Supplement

Preconception folic acid supplement use is a well-known method of primary prevention of neural tube defects (NTDs). Obese women are at a higher risk for having a child with a NTD. As different international recommendations on folic acid supplement use for obese women before and during pregnancy exist, this narrative review provides an overview of epidemiology of folate deficiency in obese (pre)pregnant women, elaborates on potential mechanisms underlying folate deficiency, and discusses considerations for the usage of higher doses of folic acid supplements. Women with obesity more often suffer from an absolute folate deficiency, as they are less compliant to periconceptional folic acid supplement use recommendations. In addition, their dietary folate intake is limited due to an unbalanced diet (relative malnutrition). The association of obesity and NTDs also seems to be independent of folate intake, with studies suggesting an increased need of folate (relative deficiency) due to derangements involved in other pathways. The relative folate deficiency, as a result of an increased metabolic need for folate in obese women, can be due to: (1) low-grade chronic inflammation (2) insulin resistance, (3) inositol, and (4) dysbiotic gut microbiome, which plays a role in folate production and uptake. In all these pathways, the folate-dependent one-carbon metabolism is involved. In conclusion, scientific evidence of the involvement of several folate-related pathways implies to increase the recommended folic acid supplementation in obese women. However, the physiological uptake of synthetic folic acid is limited and side-effects of unmetabolized folic acid in mothers and offspring, in particular variations in epigenetic (re)programming with long-term health effects, cannot be excluded. Therefore, we emphasize on the urgent need for further research and preconception personalized counseling on folate status, lifestyle, and medical conditions.

scholarly journals Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study

2006 ◽  
Vol 84 (5) ◽  
pp. 1134-1141 ◽  
Author(s):  
Roy M Nilsen ◽  
Stein E Vollset ◽  
Håkon K Gjessing ◽  
Per Magnus ◽  
Helle M Meltzer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Folic Acid ◽  
Pregnant Women ◽  
Folic Acid Supplement ◽  
Supplement Use ◽  
Acid Supplement ◽  
Mother And Child

scholarly journals Preconceptional folic acid supplement use in Lebanon

2009 ◽  
Vol 12 (5) ◽  
pp. 687-692 ◽  
Author(s):  
H Tamim ◽  
G Harrison ◽  
M Atoui ◽  
G Mumtaz ◽  
F El-Kak ◽  
...  
Keyword(s):  
Folic Acid ◽  
Economic Status ◽  
National Level ◽  
Folic Acid Supplementation ◽  
Folic Acid Supplement ◽  
Awareness Campaigns ◽  
Supplement Use ◽  
Acid Supplement ◽  
Trained Personnel ◽  
History Of

AbstractObjectiveThe objective of the present study was to assess the prevalence and determinants of preconceptional folic acid supplement use among pregnant women in Lebanon.Design/setting/subjectsThe study was a descriptive epidemiological study. Analysis was performed on 5280 deliveries admitted to twelve member hospitals of the National Collaborative Perinatal Neonatal Network during the period September 2003–January 2005. Information on folic acid intake and maternal and neonatal characteristics were obtained from obstetric charts along with direct interviews performed by trained personnel. Logistic regression was performed to determine the predictors of preconceptional folic acid use.ResultsThe overall use of preconceptional folic acid supplementation was 14·0 % (18·6 % in urban hospitals v. 2·7 % in rural hospitals). Higher socio-economic status, lower parity and having a history of previous spontaneous abortions were significantly associated with preconceptional folic acid use.ConclusionOur study shows that Lebanon currently has a low rate of preconceptional folic acid supplement use. Intervention through the means of awareness campaigns needs to be implemented on a national level.

Race and ethnicity and preconception folic acid supplement use among pregnant women in Georgia, PRAMS 2009 to 2011

2017 ◽  
Vol 109 (1) ◽  
pp. 38-48 ◽  
Author(s):  
Ayesha Mukhtar ◽  
Michael R. Kramer ◽  
Godfrey P. Oakley ◽  
Vijaya Kancherla
Keyword(s):  
Folic Acid ◽  
Pregnant Women ◽  
Race And Ethnicity ◽  
Folic Acid Supplement ◽  
Supplement Use ◽  
Acid Supplement

scholarly journals Validation of self-reported folic acid use in a multiethnic population: results of the Amsterdam Born Children and their Development study

2011 ◽  
Vol 14 (11) ◽  
pp. 2022-2028 ◽  
Author(s):  
Jonne J Sikkens ◽  
Manon van Eijsden ◽  
Gouke J Bonsel ◽  
Martina C Cornel
Keyword(s):  
Folic Acid ◽  
Pregnant Women ◽  
Serum Folate ◽  
Folic Acid Supplement ◽  
Folic Acid Intake ◽  
Development Study ◽  
Supplement Use ◽  
Acid Intake ◽  
Acid Supplement ◽  
Multiethnic Population

AbstractObjectiveTo assess folic acid supplementation rates and validate the self-reporting of folic acid supplement use among pregnant women in a multiethnic cohort.DesignSecondary analysis of a prospective cohort study.SettingSelf-reported folic acid supplement use in the Amsterdam Born Children and their Development study cohort was compared with serum folate concentrations using non-parametric trend analysis and linear and logistic regression.SubjectsA total of 4234 pregnant women of various ethnic backgrounds.ResultsSerum folate levels showed a significant positive linear trend as reported use of folic acid increased (P < 0·001), which was supported by linear regression (r = 0·49). Odds of having low serum folate concentration decreased with reported early start of folic acid intake. Young, multiparous or non-Western women reported less pre-conception folic acid intake. Non-Western women showed lower serum folate concentrations. The overall rate of over-reporting, i.e. serum folate concentrations ≤20 nmol/l while reporting the use of folic acid supplements, was 20·7 %. Women of Surinamese and Moroccan ancestry had higher odds of over-reporting (OR = 2·3; 95 % CI 1·5, 3·5 and OR = 2·3; 95 % CI 1·3, 4·0, respectively). The odds for Surinamese women remained significant after adjusting for the onset of supplement use, parity and age (OR = 1·7; 95 % CI 1·1, 2·6).ConclusionsAlthough self-reporting is a valid method for assessing folic acid supplement use in a multiethnic population, some participants do over-report. Surinamese and possibly Moroccan women appear to over-report more often. Rates of supplementation are low, especially in non-Western women. This suggests the need for intensifying current campaigns or perhaps even additional advice to start or continue to use folic acid post-conceptionally.

Prevalence and correlates of high red blood cell folate concentrations in the Canadian population using 3 proposed cut-offs

2015 ◽  
Vol 40 (10) ◽  
pp. 1025-1030 ◽  
Author(s):  
Cynthia K. Colapinto ◽  
Deborah L. O’Connor ◽  
Lise Dubois ◽  
Mark S. Tremblay
Keyword(s):  
Folic Acid ◽  
Blood Cell ◽  
Health Outcomes ◽  
Red Blood Cell ◽  
Folic Acid Supplement ◽  
Cross Sectional ◽  
Folate Status ◽  
Supplement Use ◽  
Acid Supplement ◽  
Nationally Representative

A distinct shift towards higher folate concentrations has emerged in Canada. These higher concentrations have known benefits, including prevention of neural tube defects, but concerns have been raised regarding potential associations with adverse health outcomes. The aim of this research was to propose cut-offs for high red blood cell (RBC) folate concentrations and identify their correlates. RBC folate was measured in a nationally representative cross-sectional sample of Canadians (N = 5248) aged 6 to 79 years. RBC folate concentrations were adjusted from the IMMULITE 2000 immunoassay to a microbiologic assay. The population was characterized at 3 RBC folate cut-offs: 1450 nmol/L, 1800 nmol/L, and 2150 nmol/L. We used t tests to examine differences by age, sex, income, and body mass index (BMI) at each cut-off and logistic regression to explore associations with folic acid supplement intake. The prevalence of high RBC folate was 16%, 6%, and 2% at thresholds of 1450 nmol/L, 1800 nmol/L, and 2150 nmol/L, respectively. Females, those aged 60 to 79 years, and overweight or obese participants had the greatest prevalence of having high RBC folate at each cut-off. Folic acid supplement users were more likely than non-users to have high RBC folate concentrations. Older age, higher BMI, and folic acid supplement use were identified as correlates of high folate status. A high RBC folate concentration cut-off will advance the field towards consistent measurement and reporting of high folate status. This may facilitate future investigation of associations between RBC folate concentrations at the upper end of the distribution and health outcomes.

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