Faculty Opinions recommendation of Effect of linaclotide on severe abdominal symptoms in patients with irritable bowel syndrome with constipation.

After elective sigmoidectomy for diverticulitis, patients may experience persistent abdominal symptoms. This study aimed to determine the incidence and characteristics of persistent symptoms (PSs) and their risk factors in patients who had no reported recurrence after elective sigmoidectomy. Patients who underwent elective sigmoidectomy for diverticulitis from 2002 to 2016 at a tertiary academic colorectal surgery practice were included. After retrospective review of medical records, patients were contacted with a questionnaire to inquire about recurrence of diverticulitis and persistent abdominal symptoms since resection. Outcomes examined were prevalence of and risk factors for PSs after elective sigmoidectomy. Of 662 included patients, 346 completed the questionnaire and had no recurrent diverticulitis. PSs were reported by 43.9 per cent of the patients. The mean follow-up was 87 months. Female gender and preoperative diagnosis of irritable bowel syndrome were independent risk factors for PSs (Relative Risk 1.65, P < 0.001 and Relative Risk 1.41, P = 0.014). Previous IVantibiotics treatment was associated with PSs ( P = 0.034) but not with a significant risk factor. As the follow-up interval increased, prevalence of PSs decreased ( P = 0.006). More than 40 per cent of patients experienced persistent abdominal symptoms after sigmoidectomy for diverticulitis. Female patients and those with irritable bowel syndrome were at significantly increased risk.

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Faculty of 1000 evaluation for Effect of Linaclotide on Severe Abdominal Symptoms in Patients with Irritable Bowel Syndrome with Constipation.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718122956.793488143 ◽

2013 ◽

Author(s):

David Alpers

Keyword(s):

Irritable Bowel Syndrome ◽

Abdominal Symptoms ◽

Irritable Bowel

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Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS)

Nutrients ◽

10.3390/nu11061415 ◽

2019 ◽

Vol 11 (6) ◽

pp. 1415 ◽

Cited By ~ 7

Author(s):

Magdy El-Salhy ◽

Trygve Hausken ◽

Jan Gunnar Hatlebakk

Keyword(s):

Quality Of Life ◽

Irritable Bowel Syndrome ◽

Response Rate ◽

High Dose ◽

Faecal Microbiota ◽

Abdominal Symptoms ◽

Faecal Samples ◽

Irritable Bowel ◽

Faecal Microbiome

Background: Faecal microbiome transplantation (FMT) appears to be an effective method for treating irritable bowel syndrome (IBS) patients. However, it is not clear if a high transplant dose and/or repeating FMT are/is needed to ensure a response. The present study was undertaken to clarify this matter. Methods: Ten IBS patients who did not respond to a 30-g transplant subsequently received a 60-g transplant into the duodenum via a gastroscope. The patients provided faecal samples before and 1 month after FMT. They completed five questionnaires measuring symptoms, fatigue and quality of life at baseline and then at 2 weeks, 1 month and 3 months after FMT. The dysbiosis index (DI) was measured using the GA-map Dysbiosis Test®. Results: Seven patients (70%) responded to the 60-g transplant, with significant clinical improvements in the abdominal symptoms, fatigue and quality of life in 57%, 80% and 67% of these patients. The 60-g transplant also reduced the DI. Conclusion: FMT is an effective treatment for IBS. A high-dose transplant and/or repeated FMT increase the response rate and the intensity of the effects of FMT.

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Evaluation Of Irritable Bowel Syndrome Symptoms Amongst Warsaw University Students

Polish Journal of Surgery ◽

10.1515/pjs-2015-0050 ◽

2015 ◽

Vol 87 (5) ◽

Cited By ~ 3

Author(s):

Sylwia Niemyjska ◽

Anna Ukleja ◽

Michał Ławiński

Keyword(s):

Physical Activity ◽

Irritable Bowel Syndrome ◽

Abdominal Pain ◽

University Students ◽

Functional Gastrointestinal Disorders ◽

Chi Square ◽

Abdominal Symptoms ◽

Intestinal Infections ◽

Chi Square Test ◽

Irritable Bowel

AbstractIrritable bowel syndrome (IBS) belongs to functional gastrointestinal disorders and is characterized by abdominal pain and change in stool consistency and/or bowel habits. Etiological factors include gastrointestinal peristalsis disturbances, visceral hypersensitivity, chronic inflammation of the mucous membrane, dysbacteremia, intestinal infections, psychosomatic and nutritional factors. Gastrointestinal motility disturbances in case of IBS are manifested by the inhibition of the intestinal passage, which favors the development of constipation or occurrence of diarrhea.was to evaluate IBS symptoms and demonstrate the relationship between physical activity and place of residence amongst Warsaw University students.The study was conducted in march, 2014 using a specific questionnaire, amongst Warsaw University students. The study group comprised 120 female patients, aged between 19 and 27 years (M=23.43; SD=1.29). The chi-square test was used for analysis, p<0.05 was considered as statistically significant.The BMI of investigated patients ranged between 16.30-31.22 kg/mIBS symptoms are common amongst Warsaw University students. In case of respondents with low physical activity, abdominal pain or discomfort occurred more often. It has been demonstrated that diet and stress might contribute to the occurrence of abdominal symptoms, being evidence of IBS.

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