Faculty Opinions recommendation of Pre and post-injury environmental enrichment effects functional recovery following medial frontal cortical contusion injury in rats.

2014 ◽  
Author(s):  
Jose V Lafuente ◽  
Enrike Argandoña
Keyword(s):  
Functional Recovery ◽  
Environmental Enrichment ◽  
Post Injury ◽  
Contusion Injury ◽  
Cortical Contusion

scholarly journals Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

10.3791/61852 ◽  
2020 ◽  
Author(s):  
Johannes Heinzel ◽  
Nicole Swiadek ◽  
Mohamed Ashmwe ◽  
Alexander Rührnößl ◽  
Viola Oberhauser ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Gait Analysis ◽  
Functional Recovery ◽  
Contusion Injury ◽  
Spinal Cord Contusion

scholarly journals A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury

2017 ◽  
Vol 38 (10) ◽  
pp. 1818-1827 ◽  
Author(s):  
Raghavendar Chandran ◽  
TaeHee Kim ◽  
Suresh L Mehta ◽  
Eshwar Udho ◽  
Vishal Chanana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Motor Function ◽  
Neurological Dysfunction ◽  
Vehicle Group ◽  
Lesion Volume ◽  
Post Injury ◽  
Cortical Contusion ◽  
Nrf2 Activator

Uncontrolled oxidative stress contributes to the secondary neuronal death that promotes long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both NADPH oxidase 2 (NOX2) that increases and transcription factor Nrf2 that decreases reactive oxygen species (ROS) are induced after TBI. As the post-injury functional outcome depends on the balance of these opposing molecular pathways, we evaluated the effect of TBI on the motor and cognitive deficits and cortical contusion volume in NOX2 and Nrf2 knockout mice. Genetic deletion of NOX2 improved, while Nrf2 worsened the post-TBI motor function recovery and lesion volume indicating that decreasing ROS levels might be beneficial after TBI. Treatment with either apocynin (NOX2 inhibitor) or TBHQ (Nrf2 activator) alone significantly improved the motor function after TBI, but had no effect on the lesion volume, compared to vehicle control. Whereas, the combo therapy (apocynin + TBHQ) given at either 5 min/24 h or 2 h/24 h improved motor and cognitive function and decreased cortical contusion volume compared to vehicle group. Thus, both the generation and disposal of ROS are important modulators of oxidative stress, and a combo therapy that prevents ROS formation and potentiates ROS disposal concurrently is efficacious after TBI.

scholarly journals Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury

2009 ◽  
Vol 215 (3) ◽  
pp. 267-279 ◽  
Author(s):  
Siobhan S. McMahon ◽  
Silke Albermann ◽  
Gemma E. Rooney ◽  
Cathal Moran ◽  
Jacqueline Hynes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cyclosporin A ◽  
Functional Recovery ◽  
Contusion Injury

Erratum to “Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury”

2003 ◽  
Vol 964 (1) ◽  
pp. 168
Author(s):  
Marie E Rose ◽  
Michele B Huerbin ◽  
John Melick ◽  
Donald W Marion ◽  
Alan M Palmer ◽  
...  
Keyword(s):  
Amino Acid ◽  
Excitatory Amino Acid ◽  
Contusion Injury ◽  
Cortical Contusion ◽  
Amino Acid Concentrations
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