Faculty Opinions recommendation of Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds.

Author(s):  
David Calfee
Keyword(s):  
2021 ◽  
Vol 417 ◽  
pp. 125951
Author(s):  
Xiaomin Shi ◽  
Yiming Li ◽  
Yuying Yang ◽  
Zhangqi Shen ◽  
Chang Cai ◽  
...  

Author(s):  
Reynier Suardíaz ◽  
Emily Lythell ◽  
Philip Hinchliffe ◽  
Marc van der Kamp ◽  
James Spencer ◽  
...  

Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.


2021 ◽  
Vol 24 ◽  
pp. 383-386
Author(s):  
Masaru Usui ◽  
Yohei Nozawa ◽  
Akira Fukuda ◽  
Tomomi Sato ◽  
Michi Yamada ◽  
...  

2014 ◽  
Vol 40 (7) ◽  
pp. 1066-1067 ◽  
Author(s):  
Matteo Bassetti ◽  
Elda Righi
Keyword(s):  

Diseases ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 44
Author(s):  
Ozioma Forstinus Nwabor ◽  
Pawarisa Terbtothakun ◽  
Supayang P. Voravuthikunchai ◽  
Sarunyou Chusri

Colistin is a last resort antibiotic medication for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae. In recent years, various mechanisms have been reported to mediate colistin resistance in K. pneumoniae. This study reports a bibliometric analysis of published articles retrieved from the Scopus database relating to colistin resistance in K. pneumoniae. The research trends in colistin resistance and mechanisms of resistance were considered. A total of 1819 research articles published between 1995 and 2019 were retrieved, and the results indicated that 50.19% of the documents were published within 2017–2019. The USA had the highest participation with 340 (14.31%) articles and 14087 (17.61%) citations. Classification based on the WHO global epidemiological regions showed that the European Region contributed 42% of the articles while the American Region contributed 21%. The result further indicated that 45 countries had published at least 10 documents with strong international collaborations amounting to 272 links and a total linkage strength of 735. A total of 2282 keywords were retrieved; however, 57 keywords had ≥15 occurrences with 764 links and a total linkage strength of 2388. Furthermore, mcr-1, colistin resistance, NDM, mgrB, ceftazidime-avibactam, MDR, combination therapy, and carbapenem-resistant Enterobacteriaceae were the trending keywords. Concerning funders, the USA National Institute of Health funded 9.1% of the total research articles, topping the list. The analysis indicated poor research output, collaboration, and funding from Africa and South-East Asia and demands for improvement in international research collaboration.


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