scholarly journals Estudo dos efeitos tóxicos de preparações farmacêuticas abortivas / Study of the toxic effects of abortive pharmaceutical preparations

2021 ◽  
Vol 5 (4) ◽  
pp. 1781-1794
Author(s):  
Kelma Klarisse Souza Pacheco Nunes ◽  
Maynara Regina de Sousa Batista ◽  
Rafaela Prestes Da Silva ◽  
Antônio Taylon Aguiar Gomes ◽  
Gleicy Kelly China Quemel
Keyword(s):  
Pharmaceutical Preparations ◽  
Toxic Effects ◽  
On Line

As práticas de aborto clandestino podem ocasionar vários efeitos prejudiciais a saúde da mulher. Em muitos casos, as condições políticas, religiosas e sociais do Brasil são propícias para a automedicação e a busca de preparações caseiras e populares para a indução do aborto. Atualmente, medicamentos e plantas são alguns dos métodos para a interrupção da gravidez.  O uso ilegal e/ou indiscriminado de fármacos e/ou plantas medicinais é um fator que corrobora ao aumento dos casos de aborto clandestino. Assim, o objetivo deste trabalho é realizar a revisão bibliográfica dos efeitos tóxicos de preparações farmacêuticas abortivas. A metodologia abordada foi a revisão integrativa da literatura, baseada na análise crítica, meticulosa e ampla de publicações nas bases de dados on-line. Dentre o período do estudo, foram incluídos artigos que tenham sido publicados no período de julho de 2011 a junho de 2021, utilizando-se de palavras chaves reconhecidas nos descritores em Ciência da Saúde (DeCS) que estão vinculadas ao tema: gestação, misoprostol, produtos fitoterápicos e efeitos tóxicos. A partir das bases eletrônicas pesquisadas foram selecionados os artigos que se adequam a temática proposta. Aplicando-se os critérios de inclusão e exclusão, resultou em 4 publicações na base de dados da Pubmed, 3 na base Scielo e 2 do Google acadêmico. Finalizando com 9 artigos contemplados para a construção do presente trabalho. Diante disso, faz-se necessário promover pesquisas sobre a avaliação da toxicidade dos fármacos e fitoterápicos para que possam servir de informação à população quanto aos efeitos tóxicos na gestação.

scholarly journals Automatic continuous on-line monitoring of salicylic acid and acetylsalicylic acid in pharmaceuticals

1990 ◽  
Vol 12 (6) ◽  
pp. 263-266 ◽  
Author(s):  
J. M. López Fernández ◽  
M. D. Luque de Castro ◽  
M. Valcárcel
Keyword(s):  
Salicylic Acid ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Preparations ◽  
Sampling Frequency ◽  
The Other ◽  
Dissolution Test ◽  
On Line

An asymmetrical FIA merging-zones manifold based on the dual injection of two sample microvolumes was developed for the simultaneous determination of salicylic acid and acetylsalicylic acid in pharmaceutical preparations at a sampling frequency of 30/h. The complex formed between the Fe(III) reagent continuously introduced in the system and salicylic acid was monitored photometrically at 520 nm. One of the sample plugs was prehydrolysed on injection into an NaOH stream and was circulated through a longer channel than the other plug. This yielded two FIA peaks corresponding to salicylic acid and the overall content, respectively. The proposed manifold was successfully used to control the dissolution test of a pharmaceutical preparation.

scholarly journals The Influence of Oxime Selection on the Efficacy of Antidotal Treatment of Soman-Poisoned Rats

2002 ◽  
Vol 45 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Jiří Kassa ◽  
Josef Fusek
Keyword(s):  
Rat Model ◽  
The Other ◽  
Toxic Effects ◽  
Experimental Animals ◽  
Hi 6 ◽  
Other Hand ◽  
On Line ◽  
Acetylcholinesterase Reactivators

1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with supralethal dose of soman (1.5 × LD50) was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2. Obidoxime or pralidoxime in combination with atropine were insufficient to enable soman-poisoned rats to survive for 2 hours when given 1 minute after the administration of soman. 3. On the other hand, the ability of the oxime HI-6 in combination with atropine to prevent soman-induced alteration of respiration and circulation was significantly higher. Some rats treated with HI-6 in combination with atropine were fully protected against the lethal toxic effects of soman within 2 hours following soman administration. 4. Our findings confirm that the oxime HI-6 seems to be a much more suitable and efficacious acetylcholinesterase reactivator for the antidotal treatment of severe acute soman-induced poisoning than currently used obidoxime or pralidoxime.

scholarly journals JUDICIAL UTILIZATION OF KUPIPAKWA AND POTTALI RASAYANAS BOON FOR AYURVEDIC PRACTICE

2021 ◽  
Vol p5 (5) ◽  
pp. 3003-3011
Author(s):  
Kannan Mani ◽  
Priyanka K. Dighde ◽  
Sheetal Agrawal ◽  
Ashish Agrawal
Keyword(s):  
Therapeutic Efficacy ◽  
Synergistic Effects ◽  
Pharmaceutical Preparations ◽  
Toxic Effects ◽  
Low Doses ◽  
Herbal Drugs ◽  
Acute Conditions ◽  
Modern Era ◽  
Lack Of Knowledge

Parada Murchana (Mercurial Preparations) forms the backbone of Rasashastra which signifies the formulations of mercury after Shodhan (purification) termed as Rasachikitsa which includes Kharaliya, Parpati Kupipakwa & Pottali Rasayanas. Amongst them, Kupipakwa Rasayana (KPR) & Pottali Rasayana (PTR) are unique pharmaceutical preparations designed to achieve potential therapeutic efficacy by stabilizing the stronger bonds between ingredients. Judicial utilization of these mercurial preparations provides quicker action and synergistic effects with suitable Anupana (adjuvants), Kala (time) at low doses without producing toxic effects. KPR and PTR give miraculous results in Complicated, Chronic as well as Acute conditions. In the present era, people hesitate to use these medicines due to a lack of knowledge & awareness. This review aims to bring into the limelight the importance of KPR & PTR in the modern era where modern medicines have failed or attained resistance against diseases and also to overcome difficulties that may arise because of the extinction of many herbal drugs. Keywords: Kupipakwa, Pottali, Rasayana, Rasachikitsa, Murchana, Mercurial preparations

Ultrastructure of the effect of T-514 obtained from Karwinskia humboldtiana on assembly and integrity of yeast's peroxisomes

1991 ◽  
Vol 49 ◽  
pp. 136-137
Author(s):  
J. Sepulveda-Saavedra ◽  
I. Vander-Klei ◽  
M. Venhuis ◽  
Y. Piñeyro-Lopez
Keyword(s):  
Culture Conditions ◽  
Toxic Effects ◽  
Candida Boidinii ◽  
Central Mexico ◽  
Poisonous Plant ◽  
Biological Behaviour ◽  
Enzyme Content ◽  
Fat Deposits ◽  
Yeast Model

Karwinskia humboldtiana is a poisonous plant that grows in semi desertic areas in north and central México. It produces several substances with different toxic effects. One of them designated T-514 damages severely the lung, kidney and liver, producing in the hepatoeyte large intracellular fat deposits and necrosis. Preliminary observations demonstrated that three is a decrease in the amount of peroxisomes in the hepatocytes of experimentally intoxicated rats and monkeys. To study the effect exerted by the T-514 on peroxisomes, a yeast model was selected, thus, three species: Saccha romices cerevisiae, Ilansenula polymorpha and Candida boidinii were used, because there is information concerning their peroxisome's morphology, enzyme content, biological behaviour under different culture conditions and biogenesis.

Some Conditions Necessary for Pinocytosis

1968 ◽  
Vol 26 ◽  
pp. 142-143
Author(s):  
M. W. Brightman
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Toxic Effects ◽  
Cytological Evidence ◽  
Cell Processes

The cytological evidence for pinocytosis is the focal infolding of the cell membrane to form surface pits that eventually pinch off and move into the cytoplasm. This activity, which can be inhibited by oxidative and glycolytic poisons, is performed only by cell processes that are at least 300A wide. However, the interpretation of such toxic effects becomes equivocal if the membrane invaginations do not normally lead to the formation of migratory vesicles, as in some endothelia and in smooth muscle. The present study is an attempt to set forth some conditions under which pinocytosis, as distinct from the mere inclusion of material in surface invaginations, can take place.

The on-line use of histogram data for high-speed correction and alignment of electron microscope images

1984 ◽  
Vol 42 ◽  
pp. 556-557
Author(s):  
William Krakow
Keyword(s):  
Power Spectrum ◽  
High Speed ◽  
Direct Memory Access ◽  
Digital Television ◽  
Contrast Transfer Function ◽  
The Past ◽  
High Resolution Tem ◽  
On Line ◽  
Correction Of Astigmatism ◽  
The Fourier Transform

In the past few years on-line digital television frame store devices coupled to computers have been employed to attempt to measure the microscope parameters of defocus and astigmatism. The ultimate goal of such tasks is to fully adjust the operating parameters of the microscope and obtain an optimum image for viewing in terms of its information content. The initial approach to this problem, for high resolution TEM imaging, was to obtain the power spectrum from the Fourier transform of an image, find the contrast transfer function oscillation maxima, and subsequently correct the image. This technique requires a fast computer, a direct memory access device and even an array processor to accomplish these tasks on limited size arrays in a few seconds per image. It is not clear that the power spectrum could be used for more than defocus correction since the correction of astigmatism is a formidable problem of pattern recognition.

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