scholarly journals Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

2019 ◽  
Vol 4 (4) ◽  
pp. 155-162
Author(s):  
Fatemeh Dalayi ◽  
Leila Hajiaghababaei ◽  
Alireza Badiei ◽  
Elham Boorboor Azimi ◽  
Mohammad Reza Ganjali ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Ph Value ◽  
Drug Carrier ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Nanoporous Silica ◽  
Release Process ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.

Controlled Drug Release from Biodegradable Bone Fillers

2012 ◽  
Vol 430-432 ◽  
pp. 677-680
Author(s):  
Yong Li Zhang ◽  
Chen Xu ◽  
Zhi Ming Sun ◽  
Mao Cong Yi ◽  
Yu Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Drug Release Rate ◽  
Rapid Degradation ◽  
Bone Filler ◽  
Structure Of Coatings

Plaster of Pairs is a common used implanting material. However, its rapid degradation or drug releasing rate as a bone filler or drug carrier does not meet the requirement of clinic application. In this paper, plaster of Pairs bone fillers loaded with drug was prepared and their degradation and the drug release period were adjusted by coating their surface with polymers. The results show that the structure of coatings can effectively control the degradation period of the bone fillers, and consequently the drug release rate.

scholarly journals Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2267 ◽  
Author(s):  
Giulia Neri ◽  
Carmelo Corsaro ◽  
Enza Fazio
Keyword(s):  
Drug Release ◽  
Laser Irradiation ◽  
Drug Carrier ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Experimental Conditions ◽  
Power Intensity ◽  
Acid Sodium Salt ◽  
Demand Control ◽  
Smart Drug

Silver (Ag)-grafted PMA (poly-methacrylic acid, sodium salt) nanocomposite loaded with sorafenib tosylate (SFT), an anticancer drug, showed good capability as a drug carrier allowing on-demand control of the dose, timing and duration of the drug release by laser irradiation stimuli. In this study, the preparation of Ag-PMA capsules loaded with SFT by using sacrificial silica microparticles as templates was reported. A high drug loading (DL%) of ∼13% and encapsulation efficiency (EE%) of about 76% were obtained. The photo-release profiles were regulated via the adjustment of light wavelength and power intensity. A significant improvement of SFT release (14% vs. 21%) by comparing SFT-Ag-PMA capsules with Ag-PMA colloids under the same experimental conditions was observed. Moreover, an increase of drug release by up to 35% was reached by tuning the laser irradiation wavelength near to Ag nanoparticles’ surface plasmon resonance (SPR). These experimental results together with more economical use of the active component suggest the potentiality of SFT-Ag-PMA capsules as a smart drug delivery system.

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Preparation, evaluation, and in vitro release of chitosan-alginate tanshinone self-microemulsifying sustained-release microcapsules

2020 ◽  
pp. 1-9
Author(s):  
Yunhong Wang ◽  
Rong Hu ◽  
Yanlei Guo ◽  
Weihan Qin ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Rate ◽  
Orthogonal Design ◽  
Drug Loading ◽  
In Vitro Release ◽  
Core Material ◽  
Evaluation Indexes ◽  
Vitro Release

OBJECTIVE: In this study we explore the method to prepare tanshinone self-microemulsifying sustained-release microcapsules using tanshinone self-microemulsion as the core material, and chitosan and alginate as capsule materials. METHODS: The optimal preparation technology of chitosan-alginate tanshinone self-microemulsifying sustained-release microcapsules was determined by using the orthogonal design experiment and single-factor analysis. The drug loading and entrapment rate were used as evaluation indexes to assess the quality of the drug, and the in vitro release rate was used to evaluate the drug release performance. RESULTS: The best technology of chitosan-alginate tanshinone self-microemulsifying sustained-release microcapsules is as follows: the concentration of alginate is 1.5%, the ratio of tanshinone self-microemulsion volume to alginate volume to chitosan mass is 1:1:0.5 (ml: ml: g), and the best concentration of calcium chloride is 2.0%. To prepare the microcapsules using this technology, the drug loading will be 0.046%, the entrapment rate will be 80.23%, and the 24-hour in vitro cumulative release rate will be 97.4%. CONCLUSION: The release of the microcapsules conforms to the Higuchi equation and the first-order drug release model and has a good sustained-release performance.

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

scholarly journals Biological Properties of Ti-Nb-Zr-O Nanostructures Grown on Ti35Nb5Zr Alloy

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Zhaohui Li ◽  
Congqin Ning ◽  
Dongyan Ding ◽  
Hegang Liu ◽  
Lin Huang
Keyword(s):  
Stem Cell ◽  
Drug Release ◽  
Drug Loading ◽  
Biological Properties ◽  
Prolonged Release ◽  
Apatite Formation ◽  
Release Process ◽  
Oxide Nanostructures ◽  
Implant Alloys

Surface modification of low modulus implant alloys with oxide nanostructures is one of the important ways to achieve favorable biological behaviors. In the present work, amorphous Ti-Nb-Zr-O nanostructures were grown on a peak-aged Ti35Nb5Zr alloy through anodization. Biological properties of the Ti-Nb-Zr-O nanostructures were investigated throughin vitrobioactivity testings, stem cell interactions, and drug release experiments. The Ti-Nb-Zr-O nanostructures demonstrated a good capability of inducing apatite formation after immersion in simulated body fluids (SBFs). Drug delivery experiment based on gentamicin and the Ti-Nb-Zr-O nanostructures indicated that a high drug loading content could result in a prolonged release process and a higher quantity of drug residues in the oxide nanostructures after drug release. Quick stem cell adhesion and spreading, as well as fast formation of extracellular matrix materials on the surfaces of the Ti-Nb-Zr-O nanostructures, were found. These findings make it possible to further explore the biomedical applications of the Ti-Nb-Zr-O nanostructure modified alloys especially clinical operation of orthopaedics by utilizing the nanostructures-based drug-release system.

Pseudolatex from STR 5L Block Rubber for Drug Delivery

2013 ◽  
Vol 844 ◽  
pp. 166-169 ◽  
Author(s):  
Prapaporn Boonme ◽  
Kamon Panrat ◽  
Wiwat Pichayakorn
Keyword(s):  
Drug Release ◽  
Contact Allergy ◽  
Drug Loading ◽  
Methyl Cellulose ◽  
Controlled Drug Release ◽  
Colloidal Dispersion ◽  
Mineral Oil ◽  
Lauryl Sulfate ◽  
Drug Encapsulation

Pseudolatex is colloidal dispersion containing spherical solid or semisolid particles and can be prepared from any existing thermoplastic water-insoluble polymers. It is useful for drug encapsulation and controlled drug release. In this study, pseudolatex base was prepared from STR 5L block rubber. The various parameters such as speed and time of homogenization, type and concentration of surfactants, amount of mineral oil, and type of drug loading were studied to prepare the stable pseudolatex. These preparations were evaluated in particle size, pH, viscosity, emulsion stability, drug encapsulation, and in vitro drug release. It was found that the most stable formulation contained 3.5% block rubber, 0.2% methyl cellulose, 6% mineral oil, 4% dibutyl phthalate, 2% sodium lauryl sulfate, and 2% Uniphen P-23 using the speed and time of homogenizer as 20000 rpm and 20 minutes, respectively. Furthermore, the pseudolatex bases reduced the protein impurity form 0.5516% to 0.2108% in formulation with mineral oil and to 0.1781% in formulation without mineral oil, that could decrease contact allergy caused by the protein allergens. Dichloromethane residues in pseudolatex bases were 22.05 mg/L and 7.85 mg/L in formulations with and without mineral oil, respectively, that were satisfied from USP recommendation value of lower than 600 mg/L. Propranolol HCl, lidocaine HCl, and indomethacin could be loaded into pseudolatex only in the concentration of 1%. However, lidocaine base in the concentration of 1-5% could be loaded into pseudolatex which had the similar physical properties and stability to pseudolatex base. The in vitro drug release from pseudolatexs provided the controlled drug release for more than 24 hr.

Micelles with Cyclic Poly(ε-caprolactone) Moieties: Greater Stability, Larger Drug Loading Capacity, and Slower Degradation Property for Controlled Drug Release

Langmuir ◽  
2019 ◽  
Vol 35 (38) ◽  
pp. 12509-12517 ◽  
Author(s):  
Guiying Kang ◽  
Lu Sun ◽  
Yuping Liu ◽  
Chao Meng ◽  
Wei Ma ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Loading Capacity

scholarly journals Drug Release from a Spherical Matrix: Theoretical Analysis for a Finite Dissolution Rate Affected by Geometric Shape of Dispersed Drugs

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 582
Author(s):  
Yung-Sheng Lin ◽  
Ruey-Yug Tsay
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Shape Factor ◽  
Numerical Solutions ◽  
Drug Loading ◽  
Spherical Geometry ◽  
Detailed Comparison ◽  
Release Profile ◽  
Drug Release Profile ◽  
Drug Release Rate

Amending the neglect of finite dissolution in traditional release models, this study proposed a more generalized drug release model considering the simultaneous dissolution and diffusion procedure from a drug-loaded spherical matrix. How the shape factor (n = 0, 1/2, and 2/3 for the planar, cylindrical, and spherical geometry, respectively) of dispersed drug particles affected the release from the matrix was examined for the first time. Numerical solutions of this generalized model were validated by consensus with a short-time analytical solution for planar drugs and by the approach of the diffusion-controlled limits with Higuchi’s model. The drug release rate increases with the ratio of dissolution/diffusion rate (G) and the ratio of solubility/drug loading (K) but decreases with the shape factor of drug particles. A zero-order release profile is identified for planar drugs before starting the surface depletion layer, and also found for cylindrical and spherical dispersed drugs when K and G are small, i.e. the loaded drug is mainly un-dissolved and the drug release rate is dissolution-controlled. It is also shown that for the case of a small G value, the variation of drug release profile, due to the drug particle geometry, becomes prominent. Detailed comparison with the results of the traditional Higuchi’s model indicates that Higuchi’s model can be applied only when G is large because of the assumption of an instantaneous dissolution. For K = 1/101–1/2, the present analysis suggests an error of 33–85% for drug release predicted by Higuchi’s model for G = 100, 14–44% error for G = 101, while a less than 5% error for G ≧ 103.

scholarly journals Preparation and Drug-Release Kinetics of Porous Poly(L-lactic acid)/Rifampicin Blend Particles

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Takashi Sasaki ◽  
Hiroaki Matsuura ◽  
Kazuki Tanaka
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Solution Concentration ◽  
Porous Polymer ◽  
High Porosity ◽  
Original Solution ◽  
Kinetics Of

Porous polymer spheres are promising materials as carriers for controlled drug release. As a new drug-carrier material, blend particles composed of poly(L-lactic acid) (PLLA) and rifampicin were developed using the freeze-drying technique. The blend particles exhibit high porosity with a specific surface area of 10–40 m2 g−1. Both the size and porosity of the particles depend on the concentration of the original solution and on the method of freezing. With respect to the latter, we used the drop method (pouring the original solution dropwise into liquid nitrogen) and the spray method (freezing a mist of the original solution). The release kinetics of rifampicin from the blend particles into water depends significantly on the morphology of the blend particles. The results show that the release rate can be controlled to a great extent by tuning the size and porosity of the blend particles, both of which are varied by parameters such as the solution concentration and the method of freezing.

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