Low-Level Laser Therapy for Herpesvirus Infections: A Narrative Literature Review

Introduction: Herpesvirus infection has a variety of clinical forms and is extremely widespread in the world while existing treatment methods are not always quite effective. The search for new treatment modalities is a relevant problem and numerous studies show the therapeutic effect of low-level laser therapy (LLLT) on different herpesvirus types. Methods: The mechanisms of laser light action and the impact of LLLT on the pathological pathways of herpes infections are described. A narrative review of the relevant papers is conducted. Results: The reviewed studies confirm that LLLT is a potential prospective treatment method for patients infected with the herpesvirus. However, it is necessary to improve the methodology and optimize the combination of laser action with antiviral medications. Conclusion: The review shows that it is most effective to combine laser impact on skin lesions with the application of topical antiviral gels or creams, additionally using a combined procedure of laser ultraviolet blood illumination (LUVBI, 365-405 nm) + intravenous laser blood irradiation (ILBI, 525 nm).

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Low-level laser therapy and narrative review of other treatment modalities in androgenetic alopecia

Lasers in Medical Science ◽

10.1007/s10103-020-02994-4 ◽

2020 ◽

Vol 35 (6) ◽

pp. 1239-1244 ◽

Cited By ~ 3

Author(s):

Hassan Galadari ◽

Swathi Shivakumar ◽

Torello Lotti ◽

Uwe Wollina ◽

Andy Goren ◽

...

Keyword(s):

Laser Therapy ◽

Narrative Review ◽

Androgenetic Alopecia ◽

Low Level Laser Therapy ◽

Treatment Modalities ◽

Low Level ◽

Low Level Laser ◽

Level Laser

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Low-level laser therapy in temporomandibular joint disorders: a systematic review

Journal of Medicine and Life ◽

10.25122/jml-2020-0169 ◽

2021 ◽

Vol 14 (2) ◽

pp. 148-164

Author(s):

Syed Ansar Ahmad ◽

◽

Shamimul Hasan ◽

Shazina Saeed ◽

Ateeba Khan ◽

...

Keyword(s):

Systematic Review ◽

Temporomandibular Joint ◽

Laser Therapy ◽

Temporomandibular Joint Disorders ◽

Low Level Laser Therapy ◽

Therapeutic Modality ◽

Treatment Modalities ◽

Low Level ◽

Low Level Laser ◽

Level Laser

Temporomandibular joint disorders (TMDs) encompass a wide array of ailments affecting the temporomandibular joint (TMJ), muscles of mastication, and the allied structural framework. Myofascial pain, internal derangement of the joint, and degenerative joint diseases constitute the majority of TMDs. TMDs usually have a multifactorial etiology, and treatment modalities range from conservative therapies to surgical interventions. Low-level laser therapy (LLLT) has evolved as an efficient non-invasive therapeutic modality in TMDs. Previously conducted systematic reviews and meta-analyses have shown variable results regarding the efficiency of LLLT in TMJ disorder patients. Hence, this systematic review was carried out as an attempt to evaluate the efficacy of LLLT in the treatment of temporomandibular joint disorder patients.

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Pemphigus vulgaris and laser therapy: Crucial role of dentists

Medicinski pregled ◽

10.2298/mpns1402038p ◽

2014 ◽

Vol 67 (1-2) ◽

pp. 38-42 ◽

Cited By ~ 5

Author(s):

Verica Pavlic ◽

Vesna Vujic-Aleksic ◽

Nina Zubovic ◽

Valentina Veselinovic

Keyword(s):

Laser Therapy ◽

Crucial Role ◽

Pemphigus Vulgaris ◽

Low Level Laser Therapy ◽

Treatment Modalities ◽

Adjunctive Treatment ◽

Low Level ◽

Low Level Laser ◽

Level Laser

Introduction. Pemphigus vulgaris is a relatively rare, chronic, autoimmune vesiculobullous disorder characterized by formation of intraepithelial vesiculae and/or bullae in the skin and mucous membrane. Systemic steroids are considered to be the standard first-line therapy for pemphigus vulgaris. However, for patients unresponsive to standard therapy, the new treatment modalities are being sought. Low-level laser therapy has been accepted as an alternative or adjunctive treatment modality for many conditions in medicine and dentistry. Therefore, this study was aimed at presenting the effects of low-level laser therapy in the treatment of pemphigus vulgaris and to emphasize the crucial role of dentists in early recognition and diagnosis of pemphigus vulgaris. Material and Methods. The articles published until May 2013 were obtained from the Medline/PubMed online database, using following search terms and key words: ?laser therapy? and ?pemphigus vulgaris?, ?low-level laser irradiation? and ?pemphigus vulgaris?, ?lasers? and ?pemphigus vulgaris? and ?pemphigus vulgaris?. Results. Low-level laser therapy could result in immediate and significant analgesia and improved wound healing within the observation period and follow-up. Furthermore, a decrease in patients? discomfort as well as the absence of recurrence of the pemphigus vulgaris lesions has been claimed. Conclusion. Even though available literature suggests that low-level laser therapy can be efficiently used in treatment of oral pemphigus vulgaris, either independently or as a part of combined therapy approach, these results should be interpreted with caution since there are no solid evidence-based proofs to provide the guidelines for the treatment of pemphigus vulgaris with low-level laser therapy. Therefore, further long-term randomized controlled clinical studies are necessary in order to give any solid recommendations on the use of low-level laser therapy in the treatment of pemphigus vulgaris.

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Assessing the impact of low level laser therapy (LLLT) on biological systems: a review

International Journal of Radiation Biology ◽

10.1080/09553002.2019.1524944 ◽

2019 ◽

Vol 95 (2) ◽

pp. 120-143 ◽

Cited By ~ 21

Author(s):

Ruwaidah A. Mussttaf ◽

David F. L. Jenkins ◽

Awadhesh N. Jha

Keyword(s):

Laser Therapy ◽

Biological Systems ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

The Impact

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Effect of Low Level Laser Therapy (LLLT) on muscle pain in temporomandibular disorders – an update of literature

Balneo Research Journal ◽

10.12680/balneo.2020.309 ◽

2020 ◽

pp. 14-19

Author(s):

Andreea KUI ◽

Corina TISLER ◽

Alexandru CIUMASU ◽

Oana ALMASAN ◽

Daniela CONDOR ◽

...

Keyword(s):

Laser Therapy ◽

Temporomandibular Disorders ◽

Muscle Pain ◽

Musculoskeletal Diseases ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Short Period ◽

The Impact

Introduction: Temporomandibular disorders are complex pathologies with multifactorial aetiology. Due to this matter, different therapeutic approaches have been developed, one of them being physical therapy (also known as physiotherapy). Low-level laser therapy is often used in treating musculoskeletal diseases, TMJ pain and, although the exact mechanism of LLLT has not yet been completely elucidated, it seems that this kind of therapy induces analgesic, anti-inflammatory and bio-stimulating effects. The aim of this study was to create an update of scientific literature regarding the clinical use of LLLT in patients with temporomandibular disorders, and to identify the impact of this therapy on reducing pain in the masticatory muscles. Methods: A research of literature was performed - articles published over the last 10 years (January 2009 until December 2019) were searched for by introducing a combination of different keywords on the PubMed and ScienceDirect databases. Results: A total number of 294 articles were found. After applying inclusion and exclusion criteria, 28 articles were taken into consideration for our study, and among them, 9 were systematic meta-analyses or literature reviews and 19 were clinical studies. Conclusion: Low level laser therapy may effectively reduce pain in patients suffering from muscular- and/or joint-specific TMDs, but the effect appears to last only for a short period of time, and can be achieved only in less complex cases. LLLT may also improve oro-facial functions by reducing muscular activity. This research also reveals the need for better-designed clinical trials with larger sample sizes, in order to evaluate the efficacy of LLLT on improving the signs and symptoms of TMDs. Key words: Low-level laser therapy, temporomandibular disorders, muscle pain,

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Low-Level Laser Therapy in Prevention of the Development of Endothelial Dysfunction and Clinical Experience of Treatment and Rehabilitation of COVID-19 Patients

Rehabilitation Research and Practice ◽

10.1155/2021/6626932 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Sergey Moskvin ◽

Evgeniy Askhadulin ◽

Andrey Kochetkov

Keyword(s):

Endothelial Dysfunction ◽

Laser Therapy ◽

Clinical Experience ◽

Treatment Method ◽

Low Level Laser Therapy ◽

Good Tolerability ◽

Effective Prevention ◽

Low Level ◽

Low Level Laser ◽

Level Laser

Objectives. The aim of the article is to justify the application of low-level laser therapy (LLLT) to prevent the development of endothelial dysfunction in COVID-19 patients. The results of treating and rehabilitating patients with COVID-19 and prevention of the disease using low-level laser therapy (LLLT) are evaluated. Methods. A literature review is conducted on mechanisms of vascular homeostasis regulation, biomodulating effect of laser light, and LLLT methods for preventing endothelial dysfunction. A total of 106 patients were treated in two COVID-19 healthcare centers in Russia. 22 patients with SARS (+) pneumonia at the stage of resolving the pathological lesion were admitted to rehabilitation using pulsed IR laser. 14 patients with acute forms of COVID-19 were treated using LASMIK device: wavelength 904 nm, pulsed mode, externally and ILBI-525 (intravenous laser blood illumination) + LUVBI (ultraviolet laser blood illumination). 70 persons underwent preventive courses of noninvasive LLLT. Results. It was shown that LLLT is effective in preventing the development of endothelial dysfunction. Clinical experience demonstrated good tolerability of the treatment, improvement in sputum discharge, and an improvement in overall health. The severity of general hypoxia decreased by the 5th procedure. The procedures for prevention of the disease were well tolerated; there were no cases of COVID-19. Conclusion. Low-level laser therapy is a justified treatment method that promotes lung tissue regeneration and mitigates the consequences of the disease. The obtained results confirm that LLLT can be used for the effective prevention and treatment of COVID-19 patients.

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Effects of Buprenorphine, Chlorhexidine, and Low-level Laser Therapy on Wound Healing in Mice

Comparative Medicine ◽

10.30802/aalas-cm-20-000104 ◽

2021 ◽

Author(s):

Donna R Webb ◽

Sheba R Churchill ◽

Georgette D Hill ◽

Christopher A McGee ◽

Min Shi ◽

...

Keyword(s):

Wound Healing ◽

Laser Therapy ◽

Punch Biopsy ◽

Low Level Laser Therapy ◽

Treatment Modalities ◽

Wound Area ◽

Treatment Groups ◽

Low Level ◽

Low Level Laser ◽

Level Laser

Systemic buprenorphine and topical antiseptics such as chlorhexidine are frequently used in research animals to aid inpain control and to reduce infection, respectively. These therapeutics are controversial, especially when used in wound healing studies, due to conflicting data suggesting that they delay wound healing. Low-level laser therapy (LLLT) has been used to aid in wound healing without exerting the systemic effects of therapies such as buprenorphine. We conducted 2 studies to investigate the effects of these common treatment modalities on the rate of wound healing in mice. The first study used models of punch biopsy and dermal abrasion to assess whether buprenorphine HCl or 0.12% chlorhexidine delayed woundhealing. The second study investigated the effects of sustained-released buprenorphine, 0.05% chlorhexidine, and LLLT on excisional wound healing. The rate of wound healing was assessed by obtaining photographs on days 0, 2, 4, 7, and 9 for the punch biopsy model in study 1, days 0, 1, 2, 4, 6, 8, 11, and 13 for the dermal abrasion model in study 1, and days 0, 3, 6, and 10 for the mice in study 2. Image J software was used to analyze the photographed wounds to determine the wound area.When comparing the wound area on the above days to the original wound area, no significant differences in healing wereobserved for any of the treatment groups at any time period for either study. Given the results of these studies, we believe that systemic buprenorphine, topical chlorhexidine, and LLLT can be used without impairing or delaying wound healing in mice.

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Experimental justification of laser therapy efficiency of men's infertility

Urologicheskie vedomosti ◽

10.17816/uroved7444-53 ◽

2017 ◽

Vol 7 (4) ◽

pp. 44-53 ◽

Cited By ~ 1

Author(s):

Sergej V Moskvin ◽

Sergej Ju Borovets ◽

Viktor A Toropov

Keyword(s):

Laser Therapy ◽

High Efficiency ◽

Experimental Studies ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser ◽

Wide Range ◽

Experimental Justification ◽

The Impact

Male infertility is a multifactorial syndrome, which includes a wide range of disorders. It is a symptom of many different pathological conditions affecting both the reproductive and other body systems: endocrine, nervous, blood-vascular, and immune systems. Low level laser therapy is a method of modern physiotherapy, in which the impact is carried out by low-intensity laser irradiation (LILI). It is widely used in all areas of modern medicine, due to its high efficiency, simplicity of use, the absence of contraindications and side effects. The results of russian and foreign experimental studies on the article subject were analyzed. A definite conclusion is drawn that low level laser therapy should be used as much as possible in the complex treatment of men with infertility, since the effectiveness of the method is not just high, but often has no alternatives. At the same time, the available low level laser therapy techniques should be widely used: locally, rectally, laser acupuncture, ILBI (intravenous laser blood irradiation), on the projection of various organs, paravertebrally, etc. All parameters of laser action should be set (wavelength; mode of operation; frequency for pulsed lasers; power; power density, determined by the method of exposure; exposure, localization), which are specified by the relevant regulatory documents and clinical recommendations. (For citation: Moskvin SV, Borovets SJu, Toropov VA. Experimental justification of laser therapy efficiency of men's infertility. Urologicheskie vedomosti. 2017;7(4):44-53. doi: 10.17816/uroved7444-53).

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Assessment of healing of dental implant surgical site following Low-Level Laser Therapy using Bio-Clinical parameters: An Exploratory Study

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-18-00316 ◽

2020 ◽

Author(s):

VARSHA PALLED ◽

DR. JITENDRA RAO ◽

DR. RAGHUWAR DAYAL SINGH ◽

DR. SHUCHI TRIPATHI ◽

DR. KALPANA SINGH ◽

...

Keyword(s):

Laser Therapy ◽

Test Group ◽

Low Level Laser Therapy ◽

Control Group ◽

Clinical Parameters ◽

Implant Stability ◽

Low Level ◽

Implant Stability Quotient ◽

Low Level Laser ◽

Level Laser

The purpose of this study was to evaluate whether Low-Level Laser Therapy (LLLT) improves the healing of the implant surgical site with clinical and biochemical parameters.Thirty patients with an edentulous space spanning a single tooth were selected. The patients were randomly allocated to two groups - the control group and the test group. The test group received laser energy at a power of 2J/cm 2 with a total of 4-6J energy over each implant. Clinical parameters (Implant Stability Quotient, probing index, modified sulcus bleeding index)and osteoprotegerin (OPG) were assessed at baseline and follow-up intervals (2 weeks, 6 weeks, and 3 months).The test group showed significantly higher implant stability quotient compared to thecontrol group at 2 weeks(57.93±3.95 and 35.67±3.08; p<0.01) and 3months(58.86±3.75 and 67.06±3.78; p<0.01). A significant rise in OPG levels of the test group(686.30±125.36pg/ml at baseline and 784.25±108.30pg/ml at 3months;p<0.01) was seen contrary to significant decline in the control group (839.50±249.08pg/ml at baseline,415.30±78.39pg/ml at 3months;p<0.01). Within the limitations of the study, the study suggests that the healing of peri-implant hard and soft tissues may be enhanced with the use of LLLT as an explicit modality during the post-operative period.

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