Navigating Disease : Cholera and British Naval Operations in the Mediterranean, Black Sea and East Asia, 1848-1877

2021 ◽  
Vol 25 ◽  
pp. 39-79
Author(s):  
Mark Harrison
Author(s):  
Simon Hornblower

Political and literary considerations alike suggest that the Alexandra dates from about 190 BC and that its closing sections celebrate the victory of the Roman consul Titus Quinctius Flamininus over Philip V of Macedon at the battle of Kynoskephalai in 197 BC. Lykophron’s world is essentially the Mediterranean and Black Sea zones. It ranges from Spain across to Phoenicia. All the kingdoms which succeeded Alexander the Great are featured in the poem, but the Seleukids less prominently than the rest. The poem’s Spartan and Theban myths are shown to have resonance for the Hellenistic period. Only Athens is regarded as a place of memory. Some great federations, notably the Boiotian, Aitolian, and Lokrian, are traceable in the poem, and with a particularly Hellenistic twist.


2001 ◽  
Vol 139 (3) ◽  
pp. 431-445 ◽  
Author(s):  
Shiganova T. ◽  
Mirzoyan Z. ◽  
Studenikina E. ◽  
Volovik S. ◽  
Siokou-Frangou I. ◽  
...  

2011 ◽  
Vol 108 (3) ◽  
pp. 424-430 ◽  
Author(s):  
Mu Yao ◽  
Chanlu Xie ◽  
Maryrose Constantine ◽  
Sheng Hua ◽  
Brett D. Hambly ◽  
...  

We have developed a blend of food extracts commonly consumed in the Mediterranean and East Asia, named blueberry punch (BBP), with the ultimate aim to formulate a chemoprevention strategy to inhibit prostate cancer progression in men on active surveillance protocol. We demonstrated previously that BBP inhibited prostate cancer cell proliferation in vitro and in vivo. The purpose of this study was to determine the molecular mechanism responsible for the suppression of prostate cancer cell proliferation by BBP. Treatment of lymph node-metastasised prostate cancer cells (LNCaP) and bone-metastasised prostate cancer cells (PC-3 and MDA-PCa-2b) with BBP (up to 0·8 %) for 72 h increased the percentage of cells at the G0/G1 phase and decreased those at the S and G2/M phases. The finding was supported by the reduction in the percentage of Ki-67-positive cells and of DNA synthesis measured by the incorporation of 5-ethynyl-2′-deoxyuridine. Concomitantly, BBP treatment decreased the protein levels of phosphorylated retinoblastoma, cyclin D1 and E, cyclin-dependent kinase (CDK) 4 and 2, and pre-replication complex (CDC6 and MCM7) in LNCaP and PC-3 cells, whereas CDK inhibitor p27 was elevated in these cell lines. In conclusion, BBP exerts its anti-proliferative effect on prostate cancer cells by modulating the expression and phosphorylation of multiple regulatory proteins essential for cell proliferation.


Check List ◽  
2015 ◽  
Vol 11 (3) ◽  
pp. 1646 ◽  
Author(s):  
F. Tiralongo ◽  
R. Baldacconi

Microlipophrys adriaticus (Steindachner & Kolombatovic, 1883) is an endemic blenny of the Mediterranean Sea. It is also known from the Sea of Marmara and the Black Sea. However, unlike other species of combtooth blennies, M. adriaticus is a fish with a limited distribution in Adriatic Sea, especially in the north, where it can be common. We report here the first record of this species from the waters of the Ionian Sea.


Sign in / Sign up

Export Citation Format

Share Document