TIME COURSE OF SYMPTOMATIC MANIFESTATIONS IN CHILDREN WITH BRONCHIAL ASTHNA RESIDING IN KHARKIV REGION ACCORDING TO THE ISAAC STUDY

TIME COURSE OF SYMPTOMATIC MANIFESTATIONS IN CHILDREN WITH BRONCHIAL ASTHNA RESIDING IN KHARKIV REGION ACCORDING TO THE ISAAC STUDYKlymenko V.A.,.Karpushenko Y.V., Kozhyna O.S.For the first time in Ukraine phase IV of the International ISAAC program was realized in Kharkiv Region in 2015-2017. 6330 of questionnaires were distributed. 6146 (97%) of schoolchildren took part in the program. 12.8% of them had respiratory complaints, 13.2% of children at the age from 6 to 7 years, 12.4% of children aged from 13 to 14 years old. A low level of asthma diagnosis in the region was observed. Only 0.5% of children in population were diagnosed with asthma. These results were compared with the data from phase I of ISAAC (V.A. Ognev, 1998) to determine the time course of respiratory symptoms incidence: over the last 19 years the prevalence of respiratory symptoms has decreased by 1.6 times in children of junior school age and by 2 times in adolescents. Significant fluctuations in wheezing prevalence in different districts of Kharkiv Region were revealed: from 5.5% (Barvinkivs’kyi District) to 14% (Derhachivs’kyi District). The study is aimed to improve early diagnosis of asthma in children.Keywords: children, bronchial asthma, prevalence, Kharkiv region, ISAACДинаміка симптоматичних проявів бронхіальної астми у дітей Харківської області за даними дослідження ISAACКлименко В. А., Карпушенко Ю.В., Кожина О.С.Вперше в Україні в Харківському регіоні в 2015-2017 роках виконано IV фаза Міжнародної програми ISAAC. Роздано 6330 анкет; взяли участь в програмі - 6146 (97%) школярів. Респіраторні скарги виявлені у 12,8%: серед дітей 6-7 років - 13,2%, 13-14 років - 12,4%. Відзначено низький рівень діагностики астми в регіоні - діагноз встановлений у 0,5% дітей у популяції. Для виявлення динаміки поширеності респіраторних симптомів проведено порівняння з даними І фази ISAAC (В.А. Огнєв, 1998) - за останні 19 років розповсюдженість респіраторних симптомів знизилася у 1,6 разів серед дітей молодшого шкільного віку, у 2 рази - в підлітковому віці. Виявлено значні коливання в розповсюдженості wheezing в різних районах Харківської області - від 5,5% (Барвінківський район) до 14% (Дергачівський район). Дослідження спрямовано на поліпшення ранньої діагностики астми у дітей.Ключові слова: діти, бронхіальна астма, поширеність, Харківська область, ISAAC Динамика симптоматических проявлений бронхиальной астмы у детей Харьковской области по данным исследования ISAACКлименко В. А., Карпушенко Ю.В., Кожина О.С.Впервые в Украине в Харьковском регионе в 2015-2017 годах выполнена IV фаза Международной программы ISAAC. Роздано 6330 анкет; приняли участие в программе – 6146 (97 %) школьников. Респираторные жалобы выявлены у 12,8 %: среди детей 6-7 лет - 13,2 %, 13-14 лет – 12,4%. Отмечен низкий уровень диагностики астмы в регионе – диагноз установлен у 0,5 % детей в популяции. Для выявления динамики распространения респираторных симптомов проведено сравнение с данными І фазы ISAAC (В.А. Огнев, 1998) - за последние 19 лет распространенность wheezing снизилась в 1,6 раз среди детей младшего школьного возраста, в 2 раза – у подростков. Выявлены значительные колебания в распространенности wheezing в разных районах Харьковской области - от 5,5 % (Барвенковский район) до 14 % (Дергачевский район). Исследование направлено на улучшение ранней диагностики астмы у детей.Ключевые слова: дети, бронхиальная астма, распространенность, Харьковская область, ISAAC.

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Assessment of Respiratory Health Symptoms and Asthma in Children near a Drying Saline Lake

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16203828 ◽

2019 ◽

Vol 16 (20) ◽

pp. 3828 ◽

Cited By ~ 1

Author(s):

Shohreh F. Farzan ◽

Mitiasoa Razafy ◽

Sandrah P. Eckel ◽

Luis Olmedo ◽

Esther Bejarano ◽

...

Keyword(s):

Respiratory Symptoms ◽

Saline Lake ◽

Respiratory Health ◽

Explanatory Power ◽

Border Region ◽

Asthma Prevalence ◽

School Age ◽

Imperial Valley ◽

Respiratory Impairment ◽

Asthma Symptoms

Residents of the Imperial Valley, a rural, agricultural border region in California, have raised concerns over high rates of pediatric asthma symptoms. There is an urgent need to understand the influences and predictors of children’s respiratory health in Imperial Valley. We assessed the impacts of sociodemographic, lifestyle, and household factors on children’s respiratory health and asthma prevalence by administering a survey to parents of elementary school children (n = 357) in northern Imperial Valley. We observed an overall asthma prevalence of 22.4% and respiratory symptoms and allergies were widely reported, including wheezing (35.3%), allergies (36.1%), bronchitic symptoms (28.6%), and dry cough (33.3%). Asthmatics were significantly more likely to report respiratory symptoms, but high rates of wheezing, allergies, and dry cough were observed among nonasthmatics, suggesting the possibility for underdiagnosis of respiratory impairment in our school-age population. Having an asthmatic mother and exposure to environmental tobacco smoke were also associated with greater odds of asthma. Our findings provide evidence to support community concerns about children’s respiratory health, while also suggesting that household and demographic characteristics have limited explanatory power for assessing asthma in this population. This work provides critical baseline data with which to evaluate local environmental factors and their influence on asthma and respiratory symptoms.

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A strategy for improvement in diagnosis and treatment of bronchial asthma in primary care

Russian Pulmonology ◽

10.18093/0869-0189-2019-29-4-457-467 ◽

2019 ◽

Vol 29 (4) ◽

pp. 457-467

Author(s):

S. N. Avdeev ◽

S. R. Aisanov ◽

A. S. Belevskiy ◽

A. V. Emel’yanov ◽

O. M. Kurbacheva ◽

...

Keyword(s):

Primary Care ◽

Bronchial Asthma ◽

Primary Care Physicians ◽

Respiratory Symptoms ◽

Respiratory Diseases ◽

Diagnosis And Treatment ◽

Diagnostic Tools ◽

Chronic Obstructive ◽

Asthma Diagnosis ◽

Chronic Respiratory Diseases

Recently, bronchial asthma is considered as a heterogeneous disease characterized by chronic airway inflammation and respiratory symptoms, which vary in time and intensity and manifest together with variable obstruction of the airways. Asthma is one of the most common chronic respiratory diseases in primary care. Patients with certain respiratory symptoms seek for medical aid initially in primary care physicians, such as therapeutists, general practitioners, and family physicians, who can suspect and diagnose chronic respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, etc. Currently, untimely diagnosis of asthma and late initiation of anti-inflammatory treatment are widespread, mainly due to insufficient knowledge of primary care physicians on diagnostic criteria and therapeutic standards for asthma. Feasible and convenient algorithms for asthma diagnosis and treatment in primary care were developed by experts of Russian Respiratory Society and Russian Association of Allergologists and Clinical Immunologists. A therapeutic algorithm for asthma treatment in primary care institutions uses an approach considering symptom severity both in patients with newly diagnosed and previously treated for asthma. Diagnostic tools, such as a questionnaire for asthma diagnosis and an algorithm for differential diagnosis between asthma and COPD are mainly intended to facilitate diagnosis of chronic respiratory disease, particularly bronchial asthma, by a primary care physician and to improve the healthcare quality for these patients.

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Thinking beyond infections in children with recurrent/persistent pneumonia

Tropical Doctor ◽

10.1177/00494755211002029 ◽

2021 ◽

pp. 004947552110020

Author(s):

Devki Nandan ◽

Hema Mittal ◽

Anu Sharma ◽

Kavita Srivastava

Keyword(s):

Interstitial Lung Disease ◽

Early Diagnosis ◽

Lung Disease ◽

Bronchial Asthma ◽

Reflux Disease ◽

Morbidity And Mortality ◽

Oesophageal Reflux ◽

Cardiac Diseases ◽

Cardiopulmonary Disease ◽

Underlying Causes

Children with recurrent or persistent pneumonia often have underlying chronic cardiopulmonary disease, but few reports on this subject have been published. Children with isolated common cardiac diseases, uncomplicated bronchial asthma or with incomplete records were excluded. Of 4361 children followed during a five-year period, 107 were included in our study. Underlying causes were identified in 99.0%: immunodeficiency disorders (20.2%), cardiothoracic malformations (18.3%), syndromic conditions (14.4%), infections (10.6%) bronchiectasis (10.6%), gastro-oesophageal reflux disease (6.6%), interstitial lung disease (3.8%) and other miscellaneous conditions (15.4%). Thus, children with recurrent or persistent pneumonia should be carefully evaluated for an underlying aetiology, as early diagnosis and appropriate management will decrease morbidity and mortality in most of these children.

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Late diagnosis of pulmonary agenesis

BMJ Case Reports ◽

10.1136/bcr-2021-245233 ◽

2021 ◽

Vol 14 (10) ◽

pp. e245233

Author(s):

Diana Alexandra Pimenta ◽

Filipa Lemos Aguiar ◽

Beatriz Celeiros Fernandes ◽

Rui Rolo

Keyword(s):

Early Childhood ◽

Clinical Presentation ◽

Lung Parenchyma ◽

Asthma Diagnosis ◽

Cardiovascular Malformations ◽

Surgical Interventions ◽

Pulmonary Agenesis ◽

History Of ◽

Lung Infections ◽

Respiratory Complaints

Pulmonary agenesis is defined as the complete absence of one or both lungs, including the bronchi, bronchioles, vasculature and lung parenchyma. Most of these malformations are detected in early childhood. A residual number remains asymptomatic and undiagnosed until adulthood. The clinical presentation is wide, ranging from asymptomatic to respiratory complaints like dyspnoea, respiratory distress and a history of recurrent lung infections. This case presents a 54-year-old woman with complaints of coughing, dyspnoea for medium exertion and wheezing for a couple of months. Based on the results of complementary diagnosis methods, right pulmonary agenesis was diagnosed without other malformations. Simultaneously, an asthma diagnosis was also performed. The treatment of pulmonary agenesis is symptomatic. Simultaneous cardiovascular malformations could require surgical interventions. This case demonstrates that pulmonary agenesis may remain undiagnosed, be identified incidentally, and have a good and long prognosis.

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A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held

Scientific Reports ◽

10.1038/srep09517 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 8

Author(s):

Jun Guo ◽

Jian-long Ge ◽

Mei Hao ◽

Zhi-cheng Sun ◽

Xin-sheng Wu ◽

...

Keyword(s):

Time Course ◽

Current View ◽

Vesicle Recycling ◽

Releasable Pool ◽

Readily Releasable Pool ◽

Central Synapse ◽

Pool Model ◽

Underlying Mechanisms ◽

First Time ◽

Intense Stimulation

Abstract Although vesicle replenishment is critical in maintaining exo-endocytosis recycling, the underlying mechanisms are not well understood. Previous studies have shown that both rapid and slow endocytosis recycle into a very large recycling pool instead of within the readily releasable pool (RRP) and the time course of RRP replenishment is slowed down by more intense stimulation. This finding contradicts the calcium/calmodulin-dependence of RRP replenishment. Here we address this issue and report a three-pool model for RRP replenishment at a central synapse. Both rapid and slow endocytosis provide vesicles to a large reserve pool (RP) ~42.3 times the RRP size. When moving from the RP to the RRP, vesicles entered an intermediate pool (IP) ~2.7 times the RRP size with slow RP-IP kinetics and fast IP-RRP kinetics, which was responsible for the well-established slow and rapid components of RRP replenishment. Depletion of the IP caused the slower RRP replenishment observed after intense stimulation. These results establish, for the first time, a realistic cycling model with all parameters measured, revealing the contribution of each cycling step in synaptic transmission. The results call for modification of the current view of the vesicle recycling steps and their roles.

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Bronchial Asthma: Diagnosis

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.1995.42.5.635 ◽

1995 ◽

Vol 42 (5) ◽

pp. 635 ◽

Cited By ~ 2

Author(s):

Sung Hak Park

Keyword(s):

Bronchial Asthma ◽

Asthma Diagnosis

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Long-term presence of a denture fragment in the airway

The Journal of Laryngology & Otology ◽

10.1017/s0022215100104499 ◽

1988 ◽

Vol 102 (2) ◽

pp. 190-193 ◽

Cited By ~ 16

Author(s):

A. Poukkula ◽

E.-M. Ruotsalainen ◽

K. Jokinen ◽

A. Palva ◽

J. Nuorviita

Keyword(s):

Foreign Body ◽

Bronchial Asthma ◽

Respiratory Symptoms ◽

First Case ◽

Denture Fragment

AbstractTwo cases are reported in which a denture fragment was lodged in the bronchus for a period of six years. Bronchial asthma which did not worsen immediately after inhalation and other misleading factors made the diagnosis more difficult in the first case, whilst the respiratory symptoms in the second case appeared only 4 years after inhalation. Haemoptysis 2 years later led to a bronchoscopy and the removal of the foreign body.

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