Overcoming optimization constraint for J c by hybrid pinning in YBa2Cu3O7 films containing nanorods

2021 ◽  
Vol 60 (2) ◽  
pp. 023001
Author(s):  
Tomoya Horide ◽  
Kenta Torigoe ◽  
Ryusuke Kita ◽  
Satoshi Awaji ◽  
Kaname Matsumoto
Author(s):  
Luís C. Lamb ◽  
Artur d’Avila Garcez ◽  
Marco Gori ◽  
Marcelo O.R. Prates ◽  
Pedro H.C. Avelar ◽  
...  

Neural-symbolic computing has now become the subject of interest of both academic and industry research laboratories. Graph Neural Networks (GNNs) have been widely used in relational and symbolic domains, with widespread application of GNNs in combinatorial optimization, constraint satisfaction, relational reasoning and other scientific domains. The need for improved explainability, interpretability and trust of AI systems in general demands principled methodologies, as suggested by neural-symbolic computing. In this paper, we review the state-of-the-art on the use of GNNs as a model of neural-symbolic computing. This includes the application of GNNs in several domains as well as their relationship to current developments in neural-symbolic computing.


2020 ◽  
Vol 54 (2) ◽  
pp. 488-511
Author(s):  
Edward Lam ◽  
Pascal Van Hentenryck ◽  
Phil Kilby

Traditional vehicle routing problems implicitly assume that only one crew operates a vehicle for the entirety of its journey. However, this assumption is violated in many applications arising in humanitarian and military logistics. This paper considers a joint vehicle and crew routing and scheduling problem in which crews are able to interchange vehicles, resulting in space and time interdependencies between vehicle routes and crew routes. The problem is formulated as a mixed integer programming (MIP) model and a constraint programming (CP) model that overlay crew routing constraints over a standard vehicle routing problem. The constraint program uses a novel optimization constraint to detect infeasibility and to bound crew objectives. This paper also explores methods using large neighborhood search over the MIP and CP models. Experimental results indicate that modeling the vehicle and crew routing problems jointly and supporting vehicle interchanges for crews may bring significant benefits in cost reduction compared with a method that sequentializes these decisions.


1995 ◽  
Vol 3 ◽  
pp. 223-248 ◽  
Author(s):  
G. Pinkas ◽  
R. Dechter

Symmetric networks designed for energy minimization such as Boltzman machines and Hopfield nets are frequently investigated for use in optimization, constraint satisfaction and approximation of NP-hard problems. Nevertheless, finding a global solution (i.e., a global minimum for the energy function) is not guaranteed and even a local solution may take an exponential number of steps. We propose an improvement to the standard local activation function used for such networks. The improved algorithm guarantees that a global minimum is found in linear time for tree-like subnetworks. The algorithm, called activate, is uniform and does not assume that the network is tree-like. It can identify tree-like subnetworks even in cyclic topologies (arbitrary networks) and avoid local minima along these trees. For acyclic networks, the algorithm is guaranteed to converge to a global minimum from any initial state of the system (self-stabilization) and remains correct under various types of schedulers. On the negative side, we show that in the presence of cycles, no uniform algorithm exists that guarantees optimality even under a sequential asynchronous scheduler. An asynchronous scheduler can activate only one unit at a time while a synchronous scheduler can activate any number of units in a single time step. In addition, no uniform algorithm exists to optimize even acyclic networks when the scheduler is synchronous. Finally, we show how the algorithm can be improved using the cycle-cutset scheme. The general algorithm, called activate-with-cutset, improves over activate and has some performance guarantees that are related to the size of the network's cycle-cutset.


2020 ◽  
Author(s):  
Kaori Hiraga ◽  
Petr Mejzlik ◽  
Matej Marcisin ◽  
Nikita Vostrosablin ◽  
Anna Gromek ◽  
...  

AbstractProtein engineering is the discipline of developing useful proteins for applications in research, therapeutic and industrial processes by modification of naturally occurring proteins or by invention of de novo proteins. Modern protein engineering relies on the ability to rapidly generate and screen diverse libraries of mutant proteins. However, design of mutant libraries is typically hampered by scale and complexity, necessitating development of advanced automation and optimization tools that can improve efficiency and accuracy. At present, automated library design tools are functionally limited or not freely available. To address these issues, we developed Mutation Maker, an open source mutagenic oligo design software for large-scale protein engineering experiments. Mutation Maker is not only specifically tailored to multi-site random and directed mutagenesis protocols, but also pioneers bespoke mutagenic oligo design for de novo gene synthesis workflows. Enabled by a novel bundle of orchestrated heuristics, optimization, constraint-satisfaction and backtracking algorithms, Mutation Maker offers a versatile toolbox for gene diversification design at industrial scale. Supported by in-silico simulations and compelling experimental validation data, Mutation Maker oligos produce diverse gene libraries at high success rates irrespective of genes or vectors used. Finally, Mutation Maker was created as an extensible platform on the notion that directed evolution techniques will continue to evolve and revolutionize current and future-oriented applications.


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