CLINICOPATHOLOGICAL STUDY OF PAPILLARY CARCINOMA THYROID IN TERTIARY CARE CENTRE- THREE YEAR STUDY.

INTRODUCTION: Papillary carcinoma thyroid (PTC) is the predominant form of thyroid cancer in both adults and children [1]. The incidence of thyroid cancer is increasing [2]. Incidence of PTC is 3 times more common in female than male, but this disparity decreases with increasing patient age [1]. AIM: To analyse the clinicopathological profile of PTC in Madras Medical College located in Chennai, TamilNadu, India. MATERIALS AND METHODS: Data on age, sex, size, histological subtype, centricity of the tumor, nodal metastasis, extra thyroidal extension and associated non malignant condition of all cases of PTC diagnosed in Madras Medical College, Chennai from January 2016 to December 2018 were obtained clinicopathological documents. Histopathological slides were analysed and Immunohistochemistry was done to differentiate PTC from other non malignant lesion. The cases were divided into four catagories based on age and sex. RESULT: Totally 189 thyroid malignancies were reported of which 161 were PTC (85%). Female: male ratio was 3.5: 1. This disparity decreases after 50 years of age. In males above 50years of age had nodal metastasis (47%) and extra thyroidal extension (47%) which was high when compared with other groups. Extrathyroidal extension (50%) was found to be more frequent in cases with tumor size more than >4cm. CONCLUSION: Papillary thyroid carcinoma was common in female. Extra thyroidal extension (P =0.014996), nodal metastasis (P =0.030258) was most common in elderly male (> 50 years).

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Papillary carcinoma thyroid - A 11 year epidemiological study with histopathological correlation in a tertiary care centre in South Malabar Region in Kerala, India

Journal of Pathology of Nepal ◽

10.3126/jpn.v5i10.15661 ◽

2015 ◽

Vol 5 (10) ◽

pp. 798-805

Author(s):

A Ponniah ◽

LM Ilias ◽

P Vijayan ◽

BA Mohammed ◽

T Deeshma ◽

...

Keyword(s):

Thyroid Cancer ◽

Papillary Carcinoma ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Thyroid Cancers ◽

Medical College ◽

Papillary Carcinoma Thyroid ◽

Histopathological Correlation ◽

Common Cancer

Background: Thyroid cancer is the commonest endocrine malignancy. Based on recent data, thyroid cancer is the fifth most common cancer in women. To our knowledge the present study is the first of its kind, correlating epidemiological and histomorphological data so as to assess the major cause hypothesis for thyroid cancers, focusing more on papillary carcinoma and its variants, comparing it with each other and with other thyroid carcinomas and also correlating with gender, life style and religion.Materials and methods: This study was conducted in the Department of Pathology, MES Medical College, Perinthalmanna, Kerala, India, from January 2004 to June 2015.Two thousand and fifty thyroidectomy cases were studied.Results: Out of the total 2050 cases, thyroid cancers constituted 295 (14.39%); of which 10.1% (208 cases) were Papillary carcinoma thyroid (PCT) and its variants; 165 cases were seen in females (79.33%) and the incidence in males were only 20.68% (43 cases).The commonest variant encountered was classical papillary carcinoma (113 cases, 54.32%).Conclusion: Our study of papillary thyroid carcino

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OUR INSTIUTIONAL EXPERIENCE IN VISCERAL ARTERY ANEURYSMS

International Journal of Advanced Research ◽

10.21474/ijar01/12620 ◽

2021 ◽

Vol 9 (03) ◽

pp. 605-606

Author(s):

Srinivasan a ◽

Prathap Kumar ◽

Velladuraichi a ◽

Ilaya Kumar ◽

Sritharan b

Keyword(s):

Tertiary Care ◽

Current Status ◽

Visceral Artery ◽

Interventional Treatment ◽

Tertiary Care Centre ◽

Medical College ◽

Visceral Artery Aneurysms ◽

Coeliac Trunk ◽

Madras Medical College

Objectives: To evaluate the incidence, management, and outcome of visceral artery aneurysms (VAA) over the 5. years in our institution, a tertiary care centre, Madras Medical College. Methods 14 patients with 19 VAA were analysed according to location, diameter, aneurysm type, aetiology, rupture, management, and outcome. Results: VAA were localised at the splenic artery, coeliac trunk, renal artery, hepatic artery, superior mesenteric artery, and other locations. The aetiology was mostly degenerative, connective tissue disease. The rate of rupture was higher in pseudo-aneurysms than true aneurysms (66% vs 5%). 18 VAA were treated by intervention {coil embolisation} (n=3) or surgery (n=9) or hybrid [n=1] and one patient was managed conservatively. Three cases with ruptured VAA were treated on an emergency basis. The largest aneurysm was about 16cm and smallest one was about 1mm . After interventional treatment, the 30-day mortality was 21.4 % in ruptured VAA compared to no mortality in non-ruptured cases. Follow-up included USG and/or CT after a mean period of 7 months. The current status of the patient was obtained by a structured telephone survey. Conclusions: There is increase incidence of Celiac and SMA aneurysms. Aneurysm size seems to be a reliable predictor for rupture. Young patient need vasculitic workup for further management.

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A clinicopathological study and management of tumor and tumor like lesions of larynx

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20214683 ◽

2021 ◽

Vol 7 (12) ◽

pp. 1906

Author(s):

Varunkumar Jayakumar ◽

Jaiswal Shubhalaxmi Atmaram

Keyword(s):

Tertiary Care ◽

Malignant Lesion ◽

Tobacco Consumption ◽

Diagnostic Tools ◽

Benign Lesions ◽

Tertiary Care Centre ◽

Medical College ◽

Neoplastic Lesion ◽

Male Preponderance ◽

Malignant Lesions

Background: The aim of the study was to (a) determine the incidence and distribution of cases according to age, sex, etiology etc; (b) to know common etiology for the different diseases; (c) to understand pathophysiology of the disease; (d) to know various presentations of the disease; (e) to determine various diagnostic tools; and (f) to know modalities of treatment available.Methods: Prospective observational study, method of sampling: non-random, purposive. department of ENT, Government medical college and tertiary care centre. Fifty-one patients with benign and malignant lesion of larynx were analysed. Only cases with persistent hoarseness for more than three weeks were selected. Benign lesions included neoplastic and non-neoplastic lesions. All cases underwent a thorough ENT examination. Once suspected the cases were examined under direct laryngoscope, fibreoptic laryngoscope and if needed microlaryngeal examination was also done. Results: The study showed 86.6% benign lesions and 41.1% malignant lesions of larynx with male preponderance. It was observed that vocal polyp was the commonest benign non-neoplastic lesion and papilloma was the commonest neoplastic lesion. Squamous cell carcinoma accounted predominantly in malignant lesions and was commonly found in glottis.Conclusions: Thus, this study reflects there is an urge to raise awareness and educate people regarding detrimental effects of vocal abuse, alcohol and tobacco consumption, preventive measures, early symptoms and availability of diagnostic tools, so that early diagnosis and appropriate treatment can be executed to reduce the morbidity and mortality.

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Peripartum hysterectomy: a five year review at a tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20173490 ◽

2017 ◽

Vol 6 (8) ◽

pp. 3590

Author(s):

Deepak A. V. ◽

K. J. Jacob ◽

Sumi P. Maria

Keyword(s):

Tertiary Care ◽

Case Series ◽

Case Fatality ◽

Tertiary Care Centre ◽

Retrospective Case ◽

College Hospital ◽

Peripartum Hysterectomy ◽

Medical College ◽

Obstetric Haemorrhage ◽

Suboptimal Care

Background: Peripartum hysterectomy is a life-saving procedure resorted to when conservative measures fail to control obstetric haemorrhage. Several predisposing factors, suboptimal care and lack of infrastructure may lead to this emergency procedure. We wanted to find out factors associated with peripartum hysterectomy and the adverse maternal outcomes at our centre.Methods: A retrospective case series analysis of 40 cases of peripartum hysterectomy performed over a period of 5 years from January 2010 to December 2014 at Government Medical College Hospital, Thrissur, Kerala was done.Results: The incidence of peripartum hysterectomy was 0.29%. The most common indication for peripartum hysterectomy was hysterectomy was uterine atony (50%). Thirty-five women (88%) were between 20 and 35 years. Most of the subjects were unbooked. There were two maternal deaths (case fatality rate of 5%) following peripartum hysterectomy during this period. All the subjects required blood transfusion.Conclusions: Prompt performance hysterectomy before the patient’s clinical condition deteriorates is the key to success. The incidence of adherent placenta is increasing, so every effort should be taken to reduce the caesarean section rates globally.

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HISTOPATHOLOGICAL EVALUATION OF WHO CLASSIFIED MULTIBACILLARY LEPROSY CASES IN A TERTIARY CARE CENTRE, SOUTH KERALA

10.36106/ijsr/9403958 ◽

2021 ◽

pp. 32-34

Author(s):

Anita Sanker ◽

G Nandakumar ◽

Swapna Balkrishnan

Keyword(s):

Immune Response ◽

Histopathological Examination ◽

Tertiary Care ◽

Newly Diagnosed ◽

Epithelioid Cells ◽

Tertiary Care Centre ◽

Medical College ◽

Leprosy Patients ◽

Epidermal Atrophy ◽

Multibacillary Leprosy

There are signicant differences in the histopathology of leprosy lesions which is inuenced by the host immune response to Mycobacterium leprae. Objective - To nd the histopathological changes in newly diagnosed multibacillary leprosy(MB) cases registered in the skin department Government Medical College, Thiruvananthapuram. Method- skin biopsy performed in 40 multibacillary leprosy cases and histopathological ndings were evaluated. 70% showed epidermal atrophy. Granulomas, composed of sheets of foamy macro Results- phages, lymphocytes and epithelioid cells, were seen in 21 cases & twenty two cases were AFB positive. Eight cases each were lepromatous, borderline tuberculoid, mid boderline, borderline lepromatous types. Conclusion- Presence of 60% cases of borderline leprosy indicates the unstable immune response in leprosy patients. Majority were either borderline lepromatous or lepromatous showing the infective nature of multibacillary leprosy. Histopathological examination with Fite- Foroco staining is a crucial method and the gold standard for accurate diagnosis and typing of leprosy.

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A STUDY OF THE CLINICAL PROFILE OF PATIENTS WITH HYPOSPADIAS AT A TERTIARY CARE CENTRE AT KANPUR, INDIA

10.36106/ijar/2102597 ◽

2021 ◽

pp. 65-66

Author(s):

R. K. Maurya ◽

Shraddha Verma ◽

R. K. Tripathi ◽

Amit Yadav

Keyword(s):

Prospective Observational Study ◽

Undescended Testis ◽

Tertiary Care ◽

Care Centre ◽

Common Site ◽

Tertiary Care Centre ◽

Medical College ◽

Treatment History ◽

Congenital Hernia ◽

Distal Hypospadias

Background: Hypospadias is a common congenital anomaly in which the anterior urethra is incompletely developed and does not extend to the tip of the glans penis. The present study was aimed to study the clinical prole of hypospadias. Settings and Design:This was a prospective, observational study. Methods: This prospective study was conducted at Department of General Surgery, LLR & Associated Hospitals, GSVM Medical College, Kanpur, India, from January 2019 to October 2020, on 72 patients of hypospadias, after taking clearance from the Institutional Ethical Committee, and taking proper informed consent for participation. Data collected for each patient included age, sex, demography, symptoms with duration, and relevant past and treatment history. Results: The most common age of presentation was between 1-5years of age (48.61%, n=35). Distal hypospadias (DH) was the most common site. (47.22%, n=34). 4.16% (n=3) patients presented with urethrocutaneous stula. Chordee was more commonly seen in patients with mid & proximal penile hypospadias (64.70%, n=33). In the present study, 4.1% (n=3) had associated undescended testis, 4.1% (n=3) had an associated bid scrotum and 1.3% (n=1) had an associated congenital hernia. Conclusions: Most cases of hypospadias present before 10 years of age. Distal hypospadias is the most common type. Chordee is associated most commonly with proximal penile and mid penile hypospadias. It may also be associated with other congenital anomalies like, undescended testis, bid scrotum or congenital hernias

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Limited adequacy of thyroid cancer patient follow-up at a Canadian tertiary care centre

Canadian Journal of Surgery ◽

10.1503/cjs.018112 ◽

2013 ◽

Vol 56 (6) ◽

pp. 385-392 ◽

Cited By ~ 4

Author(s):

Elaine Lam ◽

Scott S. Strugnell ◽

Chris Bajdik ◽

Daniel Holmes ◽

Sam M. Wiseman

Keyword(s):

Thyroid Cancer ◽

Cancer Patient ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Thyroid Cancer Patient

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Clinical and Etiological Profile of Mycotic Keratitis from a Tertiary Care Centre in South India

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/410 ◽

2021 ◽

Vol 10 (27) ◽

pp. 2001-2006

Author(s):

John Britto Augustin ◽

Sureshbaboo Variamkandi

Keyword(s):

Risk Factors ◽

Corneal Ulcer ◽

Fusarium Species ◽

Tertiary Care ◽

Government Medical College ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Medical College ◽

Corneal Ulcers ◽

Prompt Treatment

BACKGROUND Corneal ulcer is the leading cause of ocular morbidity and monocular blindness worldwide. To effectively prevent blindness in patients with corneal ulcer, a proper understanding of the risk factors predisposing to ulceration, its clinical and microbiological characteristics are essential. Timely identification of aetiological agents causing corneal ulcers and their prompt treatment helps to save the vision. We wanted to detect aetiological agents of corneal ulcer with special references to fungal causes and characterize the fungal aetiological agents to species level. METHODS This is a cross sectional study, conducted in Government Medical college, Kozhikode, between January 2016 and June 2017. All patients who were clinically diagnosed as cases of infectious corneal ulcer in the Ophthalmology department, Government Medical College, Kozhikode were included in the study. Corneal scrapings collected from the infected eye were subjected to microbiological examination and culture. A total of 120 cases were analysed. Each patient was examined with the slit lamp bio microscope after staining with fluorescein. Scrapings from cornea at the site of corneal ulcer were collected by ophthalmologist after a detailed clinical history and examination of the affected eye. The laboratory procedures used in the diagnosis of infectious keratitis were based on direct visualization of organisms by subjecting corneal scrapings to Gram stain and KOH wet mount and inoculation of material on to blood agar and Sabouraud dextrose agar. RESULTS Among the 120 cases, a total of 49 cases were culture positive. Twenty-one [17.5 %] were bacterial, twenty-two [18.34 %] were fungal and six [5.0 %] were poly microbial [bacteria and fungus]. Among the fungal aetiology, fusarium species was most common [32.14 %], followed by aspergillus species - 25.0 %. Trauma was the major risk factor. Diabetes mellitus, exposure keratitis were the other comorbidities / risk factors. CONCLUSIONS This study shows majority of infected corneal ulcers are associated with risk factors and the aetiology are mainly fungi. Microscopy, culture, and clinical correlation helped in adequate management. Thus, prognosis and outcome of corneal ulcers rely on timely identification of their aetiology and prompt treatment. KEY WORDS Corneal ulcer, Fungal Keratitis

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Comparative assessment of fetomaternal outcome in twin pregnancy with singleton pregnancy at tertiary care centre

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20172319 ◽

2017 ◽

Vol 6 (6) ◽

pp. 2395

Author(s):

Divya Gupta ◽

Premlata Mital ◽

Bhanwar Singh Meena ◽

Devendra Benwal ◽

. Saumya ◽

...

Keyword(s):

Twin Pregnancy ◽

Tertiary Care ◽

Comparative Assessment ◽

P Value ◽

Care Centre ◽

Tertiary Care Centre ◽

Singleton Pregnancy ◽

Medical College ◽

Obstetrics And Gynaecology ◽

Twin Pregnancies

Background: Multiple pregnancy remains one of the highest risk situations for the mother, foetus and neonate despite recent advances in obstetrics, perinatal and neonatal care. Twin pregnancies have increased rates of obstetric and perinatal complications compared to singletons Objective of present study was comparative assessment of fetomaternal outcome in twin pregnancy with singleton pregnancy in Obstetrics and Gynaecology Department of S.M.S. Medical College, Jaipur.Methods: This was a hospital based, prospective observational study done in the Department of Obstetrics and Gynaecology. S.M.S. Medical College, Jaipur from April 2015 to March 2016. 150 women with twin pregnancy and 150 women with singleton pregnancies at gestation age of 28 weeks and above coming for delivery and consented for the study were included in the study. Women with chronic medical disorder or chronic hypertension were excluded from the study. Maternal and neonatal outcome recorded and analysed.Results: Occurrence of twin in our study was 2.82%. Risk of preterm labour was about nine times higher in twin pregnancies than the singleton (OR: 2.74, 95% CI; 1.4494-5.1884, P value 0.001). The risk of premature rupture of membrane was increased by 2.74 times in twin pregnancies (OR:2.74; 95% CI: 1.4494-5.1884, p value .001). There was 3-time increased risk of malpresentation (OR 3.14; CI:1.7184-5.7480, p value .00002) and 2.28 times increase in hypertensive disorder (OR 2.28; 95% CI: 1.0727-4.8823, p value .03) in twin pregnancies. The risk of asphyxia and septicaemia was 2.5 times more in twins.Conclusions: Twin pregnancy is a high-risk pregnancy with more complications in mother and foetus and is a great challenge for obstetrician. So, it should be managed carefully at tertiary care centre to reduce the maternal and perinatal mortality and morbidity.

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