SERUM URIC ACID LEVELS IN NEWLY DIAGNOSED CASES OF TYPE 2 DIABETES MELLITUS IN ASSAM: A CASE CONTROL STUDY

2021 ◽  
pp. 10-12
Author(s):  
Madhurima Bora ◽  
Siddiqul Alom Akand ◽  
Sherin Gogoi
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Newly Diagnosed ◽  
Healthy Individuals ◽  
The Mean ◽  
Sugar Levels ◽  
Control Study

INTRODUCTION: T DM is a metabolic disorder characterized by hyperglycemia with disturbances of carbohydrate, 2 fats and protein metabolism. Hyperuricaemia has often been associated with diabetes mellitus. 100 patients METHOD: with T DM diagnosed according to ADA guidelines and 100 age sex matched normal healthy individuals as controls were selected. Serum Uric 2 acid and Fasting blood sugar levels were measured and the results were analyzed statistically Statistical analysis of the results shows RESULTS: signicant increase in Serum Uric acid in the cases (P<0.001) the mean S CONCLUSION: erum Uric acid level was found to be signicantly higher in newly diagnosed cases of T DM

scholarly journals Serum uric acid level in type 2 diabetes mellitus

2019 ◽  
Vol 6 (4) ◽  
pp. 1265
Author(s):  
D. Vasantha Kalyani ◽  
M. Ilamaran ◽  
P. Suresh Kumar ◽  
Saranya Nagalingam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
The Mean ◽  
Artery Disease

Background: Diabetes mellitus is the most important risk factor associated with two to four fold increased incidence of coronary artery disease. The major risk factors for CAD are hypercholesterolemia, hypertension, diabetes mellitus, and cigarette smoking Objectives: To study the level of serum uric acid in type 2 diabetes mellitus and the correlation between elevated serum uric acid level and the component of metabolic syndrome like obesity, hypertension, dyslipidemia.Methods: The study was done as descriptive analytical study among the diabetic patients in a tertiary care setting during the period January 2018 to February 2019. The inclusion and exclusion criteria were clearly defined and the study participants were recruited for the study after getting the informed consent. The socio demographic profile, clinical and laboratory data were collected from the blood sample obtained from the patients with the standardized procedures. Data was entered in Microsoft excel spread sheet and analyzed statistically using SPSS statistical software. Student ‘t’ test and Chi-square test values were applied for significance.Results: Serum uric acid in the study population and control varied from 3.0 to 8.1 and 2.7 to 5.5 mg/dl respectively. The mean and standard deviation of uric acid among cases was 5.08±1.42 while in control it was 3.55±0.62 respectively. The serum uric acid level of diabetics was very much elevated compare with controls and it was highly significant. Significant correlation was noticed between serum uric acid and BMI as well as WHR. Elevated uric acid levels were significantly noticed among those with hypertension, dyslipidemia, coronary artery disease and chronicity of the diabetes.Conclusions: Uric acid was significantly elevated in diabetic population and the mean value of serum uric acid level was higher in longer duration of diabetes, hypertension, dyslipidemia, central obesity which are the components of metabolic syndrome.

scholarly journals Comparative Study of Level of Serum Uric Acid in Type 2 Diabetes Mellitus Associated with Hypertension

2018 ◽  
Vol 9 (2) ◽  
pp. 96-101
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Nazneen Sultana ◽  
Md Jamil Hasan Karami ◽  
Ayatunnessa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Exercise Time ◽  
The Mean ◽  
And Control

Background: The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to beassociated with cardiovascular disease, hypertension, and chronic kidney disease. However, conflicting data exist asregards the serum uric acid (UA) levels in type 2 diabetes mellitus, which are associated with risk factors andcomplications.Material & Methods: The present study was designed to look for any association of serum uric acid with hypertension in type 2diabetes mellitus, taking into consideration the relevant clinical, biochemical and the anthropometric data. 110 patientswith type 2 male diabetes mellitus as case and 100 healthy malecontrols were included in this study.Results: This study shows that there were significant differences in mean of age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure within case and control but no significant differences of mean BMI was found between and control. The mean age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure and BMI were (51.83±9.911 years, 6.87±5.54 years, 1.94±.831 hours, .92±.03, 140±6.75 mm of Hg,90±2.41 mm of Hg and 25.43±3.19 Kg/m2 respectively), where as in controls these were (44.81±9.66 yrs, 00 years, 1.12±.327 hours, .91±.03, 130±1.28 mm of Hg, 80±6.18 mm of Hg and 24.96±3.02 Kg/m2 respectively). This table also shows that significant differences in mean of FBS, ABF, HbA1C and S. Uric acid between case and control, but there was no significant differences of mean TG, Cholesterol, HDL and LDL. The mean of FBS, ABF, HbA1C and S. Uric acid among the cases were (8.19±2.48 mmol/L, 11.29±3.47 mmol/L, 7.96±6.04 mg%, 189.72±111.36 mg/dl, 179±43 mg/dl, 38.38±13.77 mg/dl, 102.10±35.79 mg/dl and 8.39±2.61 mg/dl respectively, on the other hand among the control these were 5.91±1.13 mmol/L, 9.19±1.95 mmol/L, 5.93±1.01 mg%, 200±104.49 mg/dl, 183±42.25 mg/dl, 38.14±5.52 mg/dl, 110±33.23 mg/dl and 5.14±.84 mg/dl respectively.Anwer Khan Modern Medical College Journal Vol. 9, No. 2: Jul 2018, P 96-101

scholarly journals Study on Association of Serum Uric Acid and Calcium with Insulin and its Resistance in Newly Diagnosed Type 2 Diabetes Mellitus Patients

2021 ◽  
Author(s):  
Saffalya Nayak ◽  
Roma Rattan ◽  
Manmath Kumar Mandal ◽  
Debjyoti Mohapatra
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Serum Insulin ◽  
Model Assessment ◽  
Newly Diagnosed

Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial pathological condition associated with insulin resistance and insulin deficiency. Uric acid and calcium have shown inconsistent association with occurrence of diabetes. Aim: To evaluate the role of uric acid and calcium in development of T2DM. Materials and Methods: This was a case-control study conducted in Department of Biochemistry from March to November 2019 in Sriram Chandra Bhanja, Medical College and Hospital, Cuttack, Odisha, India. A 180 subjects undertaken with the objective of finding any association of serum uric acid and calcium with insulin and its resistance in newly diagnosed T2DM cases. Newly diagnosed T2DM patients were taken as cases. Age and sex matched healthy individuals were taken as controls. Fasting Plasma Glucose (FPG), serum insulin, serum uric acid and ionised calcium were measured in autoanalyser and insulin resistance was calculated using Homeostasis Model Assessment for Insulin Resistance (HOMA- IR). Other confounding risk factors for T2DM like Body Mass Index (BMI), family history was taken into account. Results: A significant positive correlation of serum uric acid with serum insulin (p=0.029) and its resistance (p=0.032) in cases. Serum calcium was negatively associated with insulin and its resistance in both cases and controls. Regression models showed serum uric acid as a strong independent risk factor for levels of insulin and its resistance. Conclusion: The findings of the study showed that regular evaluation of serum uric acid and calcium should be done in those who are at risk of developing T2DM. Larger prospective studies will be required for definite assessment.

Leptinemia among Obese Omani Adults Newly Diagnosed with Type 2 Diabetes Mellitus: A Case-control Study

2013 ◽  
Vol 13 (3) ◽  
pp. 208-214
Author(s):  
Mostafa I. Waly ◽  
Amanat Ali ◽  
Yahya M. Al-Farsi ◽  
Neeru Bhatt ◽  
Hashim Al-Kilani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Case Control ◽  
Newly Diagnosed ◽  
Control Study

scholarly journals Association of Serum Uric Acid and Parkinson’s Disease: A Case Control Study

2015 ◽  
Vol 31 (1) ◽  
pp. 9-14
Author(s):  
Md Enayetul Islam ◽  
Aminur Rahman ◽  
Farhana Salam ◽  
Takib Uddin Ahmed ◽  
Uttam Kumar Saha ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Colorimetric Method ◽  
Case Control ◽  
Control Group ◽  
The Mean ◽  
Control Study

Aim: Recent studies have provided evidence that uric acid (UA) is supposed to play a neuro-protective role in Parkinson’s disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. This study aimed to evaluate whether the serum UA level was associated with PD in a relatively small population of Bangladeshi patients. Materials and methods: An observational prospective case control Study was conducted in Neurology department of Sir Salimullah Medical College & Mitford Hospital including both the male and female wards during July 2012 to December 2013. Serum uric acid were determined from 40 PD patients and compared with 70 age and sex matched control; following the uric acid colorimetric method, the serum creatinine (Scr) levels were also measured to reduce the bias caused by possible differences in renal excretion function. Data were analyzed with software SPSS 16 and statistical descriptive methods (mean percentage, SD) and t-test. Result: In this study, 22 men (55%) and 18 women (45%) with PD were evaluated. The mean serum uric acid in patients was 3.7±0.97 and in the control group was 5.32 ±0.44. This difference was statistically significant.(p=0.001) Also, the mean serum uric acid in both men (3.48±0.98) and women (4.1±1.17) patients group was statistically lower than both men (5.39±0.46) and women (5.17±0.35) in control group.(p=0.001). Conclusion: This present study showed a positive association between low serum UA and PD . Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 9-14

Sign in / Sign up

Export Citation Format

Share Document