DENGUE FEVER: CLINICO-PATHOLOGICAL CORRELATION WITH SEROLOGICAL MARKERS AND PLATELET COUNT
Dengue is an acute viral illness caused by RNA virus of the family Flaviviridae and spread by Aedes mosquitoes. Presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. A decreased number of white blood cells (leukopenia) accompanied by a decreased number of platelet count (thrombocytopenia) and metabolic acidosis are the initial changes on laboratory examinations. Microbiological laboratory testing conrms the diagnosis of Dengue Fever. Virus segregation in cell cultures, nucleic acid demonstration by polymerase chain reaction (PCR), and serological detection of viral antigens (such as NS1) or particular antibodies are the preferred microbiological assays. This study focuses on the importance of platelet counts and other platelet parameters in dengue infection. Also platelet counts are compared with clinical, radiological and other serological markers.