scholarly journals Dengue virus: A review

2022 ◽  
Vol 8 (4) ◽  
pp. 243-247
Author(s):  
Narinder Singh ◽  
Ajeet Pal Singh ◽  
Amar Pal Singh
Keyword(s):  
Public Health ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Rna Virus ◽  
Hemorrhagic Fever ◽  
Health Concern ◽  
Virus Infections ◽  
Public Health Concern ◽  
Viral Illness ◽  
Life Threatening

Dengue fever is a mosquito-borne viral illness that is quickly spreading over the globe, with significant death and morbidity rates. Dengue fever is an acute viral infection transmitted by Aedes mosquitos and caused by an RNA virus from the Flaviviridae family. The symptoms might vary from asymptomatic fever to life-threatening complications including hemorrhagic fever and shock. Although dengue virus infections are normally self-limiting, the disease has become a public health concern in tropical and subtropical countries. Dengue fever is a major public health concern owing to its rapid worldwide spread, and its burdens are now unmet due to a lack of accurate therapy and a simple diagnostic approach for the early stages of illness.

scholarly journals Surveillance of the major pathogenic arboviruses of public health concern in Gabon, Central Africa: increased risk of West Nile virus and dengue virus infections

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuri Ushijima ◽  
Haruka Abe ◽  
Georgelin Nguema Ondo ◽  
Rodrigue Bikangui ◽  
Marguerite Massinga Loembé ◽  
...  
Keyword(s):  
Public Health ◽  
West Nile Virus ◽  
Dengue Virus ◽  
Central Africa ◽  
Fever Virus ◽  
Health Concern ◽  
Virus Infections ◽  
Public Health Concern ◽  
Serum Samples ◽  
West Nile

Abstract Background Increasing arbovirus infections have been a global burden in recent decades. Many countries have experienced the periodic emergence of arbovirus diseases. However, information on the prevalence of arboviruses is largely unknown or infrequently updated because of the lack of surveillance studies, especially in Africa. Methods A surveillance study was conducted in Gabon, Central Africa, on arboviruses, which are a major public health concern in Africa, including: West Nile virus (WNV), dengue virus (DENV), Zika virus (ZIKV), yellow fever virus (YFV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV). Serological and molecular assays were performed to investigate past infection history and the current status of infection, using serum samples collected from healthy individuals and febrile patients, respectively. Results The overall seroprevalence during 2014˗2017 was estimated to be 25.3% for WNV, 20.4% for DENV, 40.3% for ZIKV, 60.7% for YFV, 61.2% for CHIKV, and 14.3% for RVFV. No significant differences were found in the seroprevalence of any of the viruses between the male and female populations. However, a focus on the mean age in each arbovirus-seropositive individual showed a significantly younger age in WNV- and DENV-seropositive individuals than in CHIKV-seropositive individuals, indicating that WNV and DENV caused a relatively recent epidemic in the region, whereas CHIKV had actively circulated before. Of note, this indication was supported by the detection of both WNV and DENV genomes in serum samples collected from febrile patients after 2016. Conclusions This study revealed the recent re-emergence of WNV and DENV in Gabon as well as the latest seroprevalence state of the major arboviruses, which indicated the different potential risks of virus infections and virus-specific circulation patterns. This information will be helpful for public health organizations and will enable a rapid response towards these arbovirus infections, thereby preventing future spread in the country.

Phthalimide Analogs for Antimalarial Drug Discovery

2021 ◽  
Author(s):  
Meenakshi Bansal ◽  
Charu Upadhyay ◽  
Poonam Singh ◽  
Sumit Kumar ◽  
Brijesh Rathi
Keyword(s):  
Public Health ◽  
Drug Discovery ◽  
Antimalarial Drug ◽  
Health Concern ◽  
Public Health Concern ◽  
Major Public Health Concern ◽  
The World ◽  
Life Threatening

Malaria remains as one of the most life-threatening diseases and thus major public health concern all around the world. The disease becomes devastating if not treated with proper medication on...

DENGUE FEVER: CLINICO-PATHOLOGICAL CORRELATION WITH SEROLOGICAL MARKERS AND PLATELET COUNT

2021 ◽  
pp. 1-2
Author(s):  
Gunjan Jain ◽  
Saloni Savani ◽  
Hardik Jain
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Rna Virus ◽  
Dengue Infection ◽  
White Blood Cells ◽  
Hemorrhagic Fever ◽  
Serological Markers ◽  
Platelet Counts ◽  
Microbiological Laboratory ◽  
Viral Illness

Dengue is an acute viral illness caused by RNA virus of the family Flaviviridae and spread by Aedes mosquitoes. Presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. A decreased number of white blood cells (leukopenia) accompanied by a decreased number of platelet count (thrombocytopenia) and metabolic acidosis are the initial changes on laboratory examinations. Microbiological laboratory testing conrms the diagnosis of Dengue Fever. Virus segregation in cell cultures, nucleic acid demonstration by polymerase chain reaction (PCR), and serological detection of viral antigens (such as NS1) or particular antibodies are the preferred microbiological assays. This study focuses on the importance of platelet counts and other platelet parameters in dengue infection. Also platelet counts are compared with clinical, radiological and other serological markers.

scholarly journals Chikungunya-Dengue Co-Infection: Reports of Two Cases from Bangladesh

2019 ◽  
Vol 37 (2) ◽  
pp. 86-88
Author(s):  
Muhammad Abdur Rahim ◽  
Shahana Zaman ◽  
Khwaja Nazim Uddin
Keyword(s):  
Public Health ◽  
Pain Management ◽  
Dengue Virus ◽  
Chikungunya Virus ◽  
Temporal Relationship ◽  
Viral Infections ◽  
Dengue Infection ◽  
Health Concern ◽  
Global Public Health ◽  
Public Health Concern

Chikungunya and dengue are the two most rapidly spreading mosquito-borne viral infections of global public health concern. Dengue is endemic in Bangladesh and here chikungunya is anemerging infection. Because of the spacio-temporal relationship between chikungunya virus and dengue virus, their co-existence and concurrent outbreaks are not unlikely. Here, we report two cases of chikungunya-dengue co-infections occurring among young Bangladeshi patients. Such co-infectionsneed special attention because pain management of chikungunyamay have adverse implications on patients with concurrent dengue infection. J Bangladesh Coll Phys Surg 2019; 37(2): 86-88

scholarly journals Surveillance of The Major Pathogenic Arboviruses of Public Health Concern in Gabon, Central Africa: Increased Risk of West Nile Virus and Dengue Virus Infection

2020 ◽  
Author(s):  
Yuri Ushijima ◽  
Haruka Abe ◽  
Georgelin Ondo ◽  
Rodrigue Bikangui ◽  
Marguerite Loembe ◽  
...  
Keyword(s):  
Public Health ◽  
West Nile Virus ◽  
Dengue Virus ◽  
Central Africa ◽  
Fever Virus ◽  
Health Concern ◽  
Public Health Concern ◽  
Serum Samples ◽  
West Nile ◽  
Increased Risk

Abstract Background: Increasing arbovirus infections have been a global burden in recent decades. Many countries have experienced the periodic emergence of arbovirus diseases. However, information on the prevalence of arboviruses is largely unknown or infrequently updated because of the lack of surveillance studies, especially in Africa. Methods: A surveillance study was conducted in Gabon, Central Africa, on arboviruses, which are a major public health concern in Africa, including: West Nile virus (WNV), dengue virus (DENV), Zika virus (ZIKV), yellow fever virus (YFV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV). Serological and molecular assays were performed to investigate past infection history and the current status of infection, using serum samples collected from healthy individuals and febrile patients, respectively. Results: The overall seroprevalence during 2014˗2017 was estimated to be 25.3% for WNV, 20.4% for DENV, 40.3% for ZIKV, 60.7% for YFV, 61.2% for CHIKV, and 14.3% for RVFV. No significant differences were found in the seroprevalence of any of the viruses between the male and female populations. However, a focus on the mean age in each arbovirus-seropositive individual showed a significantly younger age in WNV- and DENV-seropositive individuals than in CHIKV-seropositive individuals, indicating that WNV and DENV caused a relatively recent epidemic in the region, whereas CHIKV had actively circulated before. Of note, this indication was supported by the detection of both WNV and DENV genomes in serum samples collected from febrile patients after 2016. Conclusions: This study revealed the recent re-emergence of WNV and DENV in Gabon as well as the latest seroprevalence state of the major arboviruses, which indicated the different potential risks of virus infections and virus-specific circulation patterns. This information will be helpful for public health organizations and will enable a rapid response towards these arbovirus infections, thereby preventing future spread in the country.

scholarly journals Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis

2021 ◽  
Vol 8 ◽  
Author(s):  
Maya Hites
Keyword(s):  
Public Health ◽  
Treatment Options ◽  
Health Concern ◽  
Public Health Concern ◽  
Standard Dosage ◽  
Dosage Regimens ◽  
Drug Concentrations ◽  
Life Threatening ◽  
Drug Regimens ◽  
Do So

Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics are one of the cornerstones of the treatment of sepsis; administering appropriate antibiotics in a rapid fashion to obtain adequate drug concentrations at the site of the infection can improve survival of patients. Nevertheless, it is a challenge for clinicians to do so. Indeed, clinicians today are regularly confronted with infections due to very resistant pathogens, and standard dosage regimens of antibiotics often do not provide adequate antibiotic concentrations at the site of the infection. We provide a narrative minireview of different anti-infectious treatments currently available and suggestions on how to deliver optimized dosage regimens to septic patients. Particular emphasis will be made on newly available anti-infectious therapies.

"Stand down for the homeless". Podiatric screening of a homeless population in Cleveland

1996 ◽  
Vol 86 (6) ◽  
pp. 275-279 ◽  
Author(s):  
JM Robbins ◽  
LS Roth ◽  
MC Villanueva
Keyword(s):  
Public Health ◽  
Health Risks ◽  
Medical Community ◽  
Health Concern ◽  
Homeless Population ◽  
Public Health Concern ◽  
Antibiotic Resistant ◽  
Resistant Tuberculosis ◽  
Immunodeficiency Virus ◽  
Life Threatening

Health care for the homeless is a major public health concern. With the rise in antibiotic-resistant tuberculosis, the increase of human immunodeficiency virus (HIV) diseases, and other health risks, the medical community has begun to recognize the urgency of taking a proactive role in providing care for this population. Lower extremity pathology can result in limb-threatening and, in some cases, life-threatening sequelae for homeless populations. This patient group has limited access to regular hygiene, appropriate shoes, and podiatric medical care. Participation in the "Stand Down for the Homeless" projects provided an opportunity to evaluate the podiatric needs of a homeless population and to project a response to those needs. The authors define and compare this homeless population with the national homeless population, compare the podiatric needs of this homeless populations versus the general population, and respond to those needs.

scholarly journals Dengue Fever: An Overview

2020 ◽  
Author(s):  
Ramalingam Kothai ◽  
Balasubramanian Arul
Keyword(s):  
Dengue Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Severe Form ◽  
The Body ◽  
Immune Systems ◽  
Treatment And Prevention ◽  
The World ◽  
Viral Illness ◽  
Life Threatening

Dengue fever is a disease caused by a family of viruses transmitted by mosquitoes. Dengue virus (DENV), a member of the Flaviviridae family, causes the most widespread mosquito-borne viral infection in humans around the world today. Dengue can affect anyone but tends to be more severe in people with compromised immune systems. Dengue hemorrhagic fever is a more severe form of a viral illness. Symptoms include headache, fever, rash, and evidence of bleeding (hemorrhage) in the body. This form of dengue fever can be life-threatening and can progress to the most severe form of the illness, dengue shock syndrome. This chapter reviews the etiology, epidemiology, diagnosis, pathophysiology, transmissions, manifestations, diagnosis, treatment, and prevention of dengue.

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