IgG Subclass and the FcG Receptor Iia Polymorphism Associate to Dengue Fever, Dengue Hemorrhagic Fever and Asymptomatic Dengue Infection in Cuba

This study compared the serum levels of IL-6, TNF-alpha and IFN-gamma, in children under 1 year of age with and without dengue. Sera were collected from a total of 41 children living in the Department of Antioquia, Colombia (27 patients with dengue and 14 controls). The results showed higher cytokine levels in children with dengue than without dengue, with statistically significant differences for IL-6 and IFN-gamma. No statistically significant differences were found between clinical forms, although IL-6 and IFN-gamma levels were higher in dengue fever cases than in dengue hemorrhagic fever cases. On the other hand, TNF-alpha levels were higher in dengue hemorrhagic fever than in dengue fever. The levels of IL-6 and TNF-alpha were higher in secondary infection than in primary infection, although IFN-gamma levels were higher in primary infection. These results suggest that IL-6, TNF-alpha and IFN-gamma are involved in dengue infection independently of the clinical form.

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Clinical profile of dengue infection at a teaching hospital in North India

The Journal of Infection in Developing Countries ◽

10.3855/jidc.2010 ◽

2011 ◽

Vol 6 (07) ◽

pp. 551-554 ◽

Cited By ~ 29

Author(s):

Ritu Karoli ◽

Jalees Fatima ◽

Zeba Siddiqi ◽

Khursheed I Kazmi ◽

Amit R Sultania

Keyword(s):

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Indian Subcontinent ◽

Dengue Infection ◽

Hemorrhagic Fever ◽

North India ◽

World Health ◽

Health Concern ◽

Neurological Involvement ◽

Atypical Manifestations

Introduction: Dengue viral infections are among the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public health concern. Spread of disease has led to increased recognition of atypical manifestations apart from the classical clinical features of dengue infection. Methodology: A cross-sectional study of admitted patients suspected to have dengue infection was conducted during the monsoon and post-monsoon seasons in the year 2010. Patients who had serological confirmation of dengue infection were classified according to World Health Organization definitions of dengue fever and dengue hemorrhagic fever. Clinical and biochemical parameters were compared between the two groups. Results: Out of 356 patients with suspected dengue fever enrolled in the study, 138 (39%) had serologically confirmed dengue infection. Eighty (58%) patients were males and 58 (42%) were females. Ninety-six (70%) patients had classical dengue fever while 42 (30%) had dengue hemorrhagic fever. The most common symptoms were headache (105, 76%), abdominal pain (87, 63%), vomiting (80, 58%), rash (36, 26%), and cutaneous hypersensitivity (22, 16%). Hemorrhagic manifestations were present in 55 (40%) patients. Atypical manifestations were recorded. Notably, 14% of patients had neurological involvement and 4% had acute hepatic failure. Overall mortality was 6% and all fatal cases were due to multi-organ failure. Conclusion: Dengue infection poses a huge burden to the health-care system; its spectrum ranges from mild self-limiting illness to severe fatal disease. It can have varied and multi-systemic manifestations which can go unrecognized. Clinicians should have a high index of suspicion for atypical manifestations.

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Importance of Platelet Count and Hematocrit in Dengue Fever in Children

Bangladesh Journal of Child Health ◽

10.3329/bjch.v44i2.51129 ◽

2021 ◽

Vol 44 (2) ◽

pp. 74-77

Author(s):

Farhana Rahat ◽

Morsheda Khanam ◽

Kazi Iman ◽

UK Ghosh ◽

NK Ghosh

Keyword(s):

Platelet Count ◽

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Dengue Infection ◽

Tertiary Care ◽

Dengue Shock Syndrome ◽

Hemorrhagic Fever ◽

Warning Signs ◽

Care Hospital ◽

Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

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Gene Expression Profiling of Early Acute Febrile Stage of Dengue Infection and Its Comparative Analysis With Streptococcus pneumoniae Infection

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.707905 ◽

2021 ◽

Vol 11 ◽

Author(s):

Leena H. Bajrai ◽

Sayed S. Sohrab ◽

Thamir A. Alandijany ◽

Mohammad Mobashir ◽

Muddassir Reyaz ◽

...

Keyword(s):

Gene Expression ◽

Streptococcus Pneumoniae ◽

Infectious Diseases ◽

Gene Expression Profiling ◽

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Expression Profiling ◽

Antigen Processing ◽

Dengue Infection ◽

Hemorrhagic Fever

Infectious diseases are the disorders caused by organisms such as bacteria, viruses, fungi, or parasites. Although many of them are permentantly hazardous, a number of them live in and on our bodies and they are normally harmless or even helpful. Under certain circumstances, some organisms may cause diseases and these infectious diseases may be passed directly from person to person or via intermediate vectors including insects and other animals. Dengue virus and Streptococcus pneumoniae are the critical and common sources of infectious diseases. So, it is critical to understand the gene expression profiling and their inferred functions in comparison to the normal and virus infected conditions. Here, we have analyzed the gene expression profiling for dengue hemorrhagic fever, dengue fever, and normal human dataset. Similar to it, streptococcus pneumoniae infectious data were analyzed and both the outcomes were compared. Our study leads to the conclusion that the dengue hemorrhagic fever arises in result to potential change in the gene expression pattern, and the inferred functions obviously belong to the immune system, but also there are some additional potential pathways which are critical signaling pathways. In the case of pneumoniae infection, 19 pathways were enriched, almost all these pathways are associated with the immune system and 17 of the enriched pathways were common with dengue infection except platelet activation and antigen processing and presentation. In terms of the comparative study between dengue virus and Streptococcus pneumoniae infection, we conclude that cell adhesion molecules (CAMs), MAPK signaling pathway, natural killer cell mediated cytotoxicity, regulation of actin cytoskeleton, and cytokine-cytokine receptor interaction are commonly enriched in all the three cases of dengue infection and Streptococcus pneumoniae infection, focal adhesion was enriched between classical dengue fever — dengue hemorrhagic fever, dengue hemorrhagic fever—normal samples, and SP, and antigen processing and presentation and Leukocyte transendothelial migration were enriched in classical dengue fever —normal samples, dengue hemorrhagic fever—normal samples, and Streptococcus pneumoniae infection.

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DENGUE PREDOMINANCE IN INDIA: A REPORT

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i7.37602 ◽

2020 ◽

pp. 5-9

Author(s):

LOUIS COJANDARAJ ◽

HILAL SULTAN PARA ◽

TENZIN TSEPAL ◽

SUMAN KUMARI

Keyword(s):

Vector Control ◽

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Disease Transmission ◽

Dengue Infection ◽

Dynamic Network ◽

Hemorrhagic Fever ◽

Government Official ◽

Distributed Information ◽

Fever Episode

Dengue keeps on being a significant reason for infection trouble in India, influencing the population in their typical pace of the life. Dengue in India has drastically extended in the course of the most recent couple of decades, with quickly evolving the study of disease transmission. The pervasiveness of dengue is diverse in different examinations in India, as a result of thought of a population of specific district or state at various purposes of times. The principal major dengue hemorrhagic fever episode in the whole country happened in 1996 by dengue infection serotype 2, and after a hole of very nearly 10 years, the nation confronted one more dengue fever flare-up in the year 2003 by dengue infection serotype 3. An emotional increment in the number and repeat of scenes followed, and, at present, in a huge part of the states of India, dengue is basically endemic. At present, all the four serotypes are discovered accessible for use; however, the prevalent serotype continues evolving. In spite of this pattern, observation, revealing, and conclusion of dengue remain to a great extent uninvolved in India. Progressively dynamic network-based epidemiological investigations with escalated vector control and activities for dengue immunization improvement ought to be outfitted to control the spread of dengue in India. All the distributed information related to dengue from audit of all zones of India from 2015 to 2018 is available on government official websites. Despite the fact that, the quantity of dengue cases has demonstrated a consistent ascent as time passes, the mortality has decreased. The general death pace of 1.2% in 2015 dropped to 0.25% in 2018.

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PENGARUH PELATIHAN PENGENDALIAN VEKTOR DEMAM BERDARAH TERHADAP MAYA INDEX PADA SISWA SEKOLAH DASAR DI MAJALENGKA

Jurnal Ilmu dan Teknologi Kesehatan ◽

10.33666/jitk.v11i1.271 ◽

2020 ◽

Vol 11 (1) ◽

Author(s):

Wawan Kurniawan

Keyword(s):

Vector Control ◽

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Intervention Group ◽

Hemorrhagic Fever ◽

Control Group ◽

Control Group Design ◽

Group Design ◽

Quasi Experimental ◽

Dengue Vector Control

ABSTRAK Latar belakang: Demam Berdarah Dengue (DBD) disebabkan oleh virus Dengue dapat menyebabkan kematian. Pencegahan DBD yang dianggap paling tepat adalah Pemberantasan Sarang Nyamuk (PSN). Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan pengendalian vektor Demam Berdarah pada siswa sekolah dasar terhadap Maya Index di Majalengka. Metode: Penelitian ini menggunakan desain quasi experiment (pretest-posttest control group design). Sebanyak 4 sekolah terpilih sebagai kelompok intervensi dan 4 sekolah lainnya sebagai kontrol. Subyek penelitian adalah siswa kelas IV-VI yang terdiri dari 171 siswa pada kelompok intervensi dan 163 pada kelompok kontrol. Instrumen yang digunakan adalah formulir pemantauan jentik berkala. Hasil: Jumlah rumah dengan kategori Maya Index tinggi berkurang dari 27,5% menjadi 9,4%. Terjadi penurunan angka BRI kategori tinggi pada kelompok intervensi dari 20,5% menjadi 1,8%. Pada kelompok kontrol tidak terjadi penurunan angka BRI kategori tinggi (22,1%), sebaliknya terjadi penurunan kategori rendah dari 34,4% menjadi 3,7%. Tidak terjadi penurunan angka HRI pada kelompok intervensi maupun kontrol. Kesimpulan: Pelatihan pengendalian vektor Demam Berdarah dapat menurunkan nilai BRI dan Maya Index, tetapi tidak berpengaruh terhadap nilai HRI. Tidak adanya perubahan nilai HRI menunjukkan bahwa kebersihan dan sanitasi lingkungan merupakan faktor yang berpengaruh terhadap probabilitas kejadian demam berdarah. Kata Kunci : Demam Berdarah, Maya Index, pelatihan, pengendalian vektor ABSTRACT Background: Dengue Hemorrhagic Fever (DHF) caused by Dengue virus could cause death. The most appropriate prevention of Dengue is eradication of mosquito nests (PSN). This study aims to determine the effect of Dengue vector control training on elementary students towards Maya Index in Majalengka. Method: This study used quasi-experimental design (pretest-posttest control group design). A total of 4 schools were selected as intervention groups and 4 other schools as controls. The subjects were students in grades IV-VI consisting of 171 students in the intervention group and 163 in the control group. The instrument used was periodic larva monitoring form. Results: The number of houses with a high Maya Index category in the intervention group decreased from 27.5% to 9.4%. There was a decrease in the high BRI category in the intervention group from 20.5% to 1.8%. In the control group, there was no decrease in the high BRI category (22.1%), on the contrary, there was a decrease in the low category from 34.4% to 3.7%. There was no decrease in HRI rates both of intervention or control groups. Conclusion: Dengue Fever vector control training could decrease the value of BRI and Maya Index, but does not affect the value of HRI. The absence of changes in HRI indicate that environmental hygiene and sanitation are factors that influence the probability of dengue fever occurrence. Keywords: Dengue Hemorrhagic Fever, Maya Index, training, vector control

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COMMUNITY KNOWLEDGE OF DENGUE FEVER IN ALLAMA IQBAL TOWN, LAHORE

Asian Journal of Allied Health Sciences (AJAHS) ◽

10.52229/ajahs.v5i2.629 ◽

2020 ◽

pp. 52-58

Author(s):

OJS Admin

Keyword(s):

Public Health ◽

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Health Problem ◽

Public Health Problem ◽

Hemorrhagic Fever ◽

Community Knowledge

Globally, dengue is an emerging serious public health problem with a million infections occurring annually including significant number of dengue hemorrhagic fever cases.

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Business Intelligence Development in Distributed Information Systems to Visualized Predicting and Give Recommendation for Handling Dengue Hemorrhagic Fever

Journal of Information Systems Engineering and Business Intelligence ◽

10.20473/jisebi.6.1.55-69 ◽

2020 ◽

Vol 6 (1) ◽

pp. 55

Author(s):

Radityo Prasetianto Wibowo ◽

Wiwik Anggraeni ◽

Tresnaning Arifiyah ◽

Edwin Riksakomara ◽

Febriliyan Samopa ◽

...

Keyword(s):

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Business Intelligence ◽

Success Factors ◽

Hemorrhagic Fever ◽

Distributed Information ◽

Development Method ◽

Fever Patient ◽

Number Of Patients ◽

Using Data

Background: Indonesia has 150 dengue cases every month, and more than one person dies every day from 2017 to 2020. One of the factors of Dengue Hemorrhagic Fever (DHF) patients dying is due to the late handling of patients in hospitals or clinics. Health Office of Malang Regency recorded 1,114 cases of DHF that occurred during 2016, and the number of patients room available is limited. Therefore, Malang Regency is used as a case study in this research.Objective: This study aims to make a dashboard to display the predictions, visualize the distribution of DHF patients, and give mitigation recommendations for handling DHF patients in Malang Health Office.Methods: This study used the Business Intelligence (BI) Development method, which consists of two main phases, namely the making of Business Intelligence and the use of Business Intelligence. This research used the making of the BI phase, which consists of four stages, which are BI development strategies, identification and preparation of data sources, selecting BI tools, and designing and implementing BI. In the Extract, Load, and Transform process, this study used essential transformation and forecast.Results: BI method has succeeded in building the dashboard. The dashboard displays the visualization of Dengue Hemorrhagic Fever predicted results, detail of Dengue Fever Patient number, Dengue Fever patient trends per year and predictions 2 Monthly patient, and mitigation recommendation for each Community Health Office.Conclusion: We have built the BI Dashboard using the BI development method. It needs some treatment to get better performance. These are improving ETL performance using data virtualization technology, considering the use of cloud computing technology, conducting further evaluations by understanding the critical success factors to determine the level of success and weaknesses.

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Cytokine Expression in Dengue Fever and Dengue Hemorrhagic Fever Patients with Bleeding and Severe Hepatitis

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.19-0487 ◽

2020 ◽

Vol 102 (5) ◽

pp. 943-950 ◽

Cited By ~ 2

Author(s):

Hisham Ahmed Imad ◽

Weerapong Phumratanaprapin ◽

Benjaluck Phonrat ◽

Kesinee Chotivanich ◽

Prakaykaew Charunwatthana ◽

...

Keyword(s):

Dengue Fever ◽

Dengue Hemorrhagic Fever ◽

Hemorrhagic Fever ◽

Cytokine Expression ◽

Severe Hepatitis

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Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20184293 ◽

2018 ◽

Vol 5 (6) ◽

pp. 2265 ◽

Cited By ~ 1

Author(s):

Senthil Kumar K. ◽

Rajendran N. K. ◽

Ajith Brabhukumar C.

Keyword(s):

Dengue Fever ◽

Dengue Infection ◽

Tertiary Care ◽

Hemorrhagic Fever ◽

Warning Signs ◽

Clinical Profile ◽

Severe Dengue ◽

High Morbidity ◽

Care Hospital ◽

High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

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